Protein: FEN1
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)

Gene: FEN1
Organism: Homo sapiens
Interactions: 153
UniProt ID: P39748

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding
GO:0003684 - damaged DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

517111

PCNA
Proliferating cell nuclear antigen

33

6

Small-scale

0.994

High

764379

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

4

2

Small-scale

0.717

High

238257

RAD1
Cell cycle checkpoint protein RAD1

4

0

Small-scale

0.651

High

764349

BLM
RecQ-like DNA helicase BLM

2

2

Small-scale

0.646

High

764370

EP300
Histone acetyltransferase p300

3

0

Small-scale

0.645

High

245885

HUS1
Checkpoint protein HUS1

3

0

Small-scale

0.639

High

331454

ACL6A
Actin-like protein 6A

2

1

High-throughput

0.628

High

664047

T2EB
Transcription initiation factor IIE subunit beta

2

1

High-throughput

0.628

High

764408

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

1

High-throughput

0.628

High

764353

WDR4
tRNA

1

1

Small-scale

0.604

High

764390

PTCRA
Pre T-cell antigen receptor alpha

2

0

High-throughput

0.602

High

764401

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

226726

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

764335

CCNF
Cyclin-F

2

9

High-throughput

0.584

High

764361

H31
Histone H3.1

2

4

High-throughput

0.584

High

590140

CCNA2
Cyclin-A2

1

6

Small-scale

0.578

High

453196

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

Small-scale

0.573

High

764411

RAD9A
Cell cycle checkpoint control protein RAD9A

2

0

Small-scale

0.569

High

652772

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.561

High

625189

CDK2
Cyclin-dependent kinase 2

1

6

Small-scale

0.536

High

338055

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.536

High

452660

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

455167

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

508377

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

528700

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

764336

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.536

High

764348

MSH6
DNA mismatch repair protein Msh6

1

7

High-throughput

0.536

High

764352

FOXA3
Hepatocyte nuclear factor 3-gamma

1

1

High-throughput

0.536

High

764366

FOXO4
Forkhead box protein O4

1

1

High-throughput

0.536

High

764369

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

764371

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.536

High

764378

TRA2A
Transformer-2 protein homolog alpha

1

3

High-throughput

0.536

High

764388

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.536

High

764409

MUS81
Crossover junction endonuclease MUS81

1

1

Small-scale

0.536

High

764416

FOXP3
Forkhead box protein P3

1

3

High-throughput

0.536

High

764421

GSX1
GS homeobox 1

1

1

High-throughput

0.536

High

643955

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.518

High

764347

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.518

High

275256

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.513

High

336402

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

426588

H10
Histone H1.0

1

0

High-throughput

0.513

High

508851

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

574263

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

611214

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

764337

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

764346

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

764364

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

764368

HXC5
Homeobox protein Hox-C5

1

0

High-throughput

0.513

High

764377

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

764387

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

764392

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.513

High

764410

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

764412

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

764343

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.508

High

414797

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.501

High

254876

CPNE3
Copine-3

1

0

High-throughput

0.493

High

764425

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.493

High

764350

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.481

High

174689

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

394248

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

224337

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

331736

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

Small-scale

0.479

High

346121

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

552116

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

569315

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

650547

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

719853

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

764338

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

764341

CENPA
Histone H3-like centromeric protein A

1

4

High-throughput

0.479

High

764345

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

7

Small-scale

0.479

High

764354

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

764356

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

764358

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

764359

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

764362

MAP1A
Microtubule-associated protein 1A

1

1

High-throughput

0.479

High

764363

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

764365

H33
Histone H3.3

1

4

High-throughput

0.479

High

764373

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.479

High

764375

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

764380

NUCG
Endonuclease G, mitochondrial

1

1

Small-scale

0.479

High

764381

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

764383

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

764384

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

764386

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

764395

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

764403

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

764406

DDX11
ATP-dependent DNA helicase DDX11

1

3

Small-scale

0.479

High

764417

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

764422

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.479

High

764423

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

764424

ANLN
Anillin

1

1

High-throughput

0.479

High

764426

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.479

High

764427

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

764428

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

161791

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

231850

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.458

High

359722

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

373814

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

384408

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

398832

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

487192

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

488930

H14
Histone H1.4

1

0

High-throughput

0.458

High

503584

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

523566

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

539783

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.458

High

725723

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

741953

TALDO
Transaldolase

1

0

High-throughput

0.458

High

742099

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

764339

GSH1
Glutamate--cysteine ligase catalytic subunit

1

0

High-throughput

0.458

High

764340

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

764344

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

764351

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

764355

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

764360

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

764367

VIGLN
Vigilin

1

0

High-throughput

0.458

High

764374

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

764376

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

764382

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

764394

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.458

High

764396

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

764397

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

764399

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

764402

DGCR8
Microprocessor complex subunit DGCR8

1

0

Small-scale

0.458

High

764413

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

764414

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

0

Small-scale

0.458

High

764415

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

764418

RHG39
Rho GTPase-activating protein 39

1

0

High-throughput

0.458

High

764419

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.458

High

764429

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

764430

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

764431

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

764385

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.457

High

60014

EME2
Probable crossover junction endonuclease EME2

1

1

Small-scale

0.445

High

401555

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

496474

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

764357

1433G
14-3-3 protein gamma

1

10

High-throughput

0.445

High

764372

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

764404

EME1
Crossover junction endonuclease EME1

1

1

Small-scale

0.445

High

764393

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

764405

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

764420

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

764407

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

764342

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

103896

G5E9W2
Hexosyltransferase

1

1

High-throughput

0.407

High

330891

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.407

High

764400

DUS19
Dual specificity protein phosphatase 19

3

0

High-throughput

0.347

High

361836

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

296878

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

362900

FINC
Fibronectin

1

0

High-throughput

0.279

Low

764398

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

100558

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

764389

DOC11
Dedicator of cytokinesis protein 11

1

0

High-throughput

0.249

Low

764391

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024