Protein: UROK
Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]

Gene: UROK, PLAU
Organism: Homo sapiens
Interactions: 46
UniProt ID: P00749

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341482

GDN
Glia-derived nexin

4

20

Small-scale

0.899

High

341479

PAI1
Plasminogen activator inhibitor 1

4

20

Small-scale

0.896

High

341499

UPAR
Urokinase plasminogen activator surface receptor

6

0

Small-scale

0.895

High

341478

PAI2
Plasminogen activator inhibitor 2

2

20

Small-scale

0.799

High

341495

SLUR1
Secreted Ly-6/uPAR-related protein 1

2

2

Small-scale

0.799

High

341480

IPSP
Plasma serine protease inhibitor

2

20

Small-scale

0.778

High

341500

BTK
Tyrosine-protein kinase BTK

1

2

High-throughput

0.698

High

146311

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

7

High-throughput

0.691

High

341481

KLK1
Kallikrein-1

1

16

High-throughput

0.691

High

341504

FSTL4
Follistatin-related protein 4

1

4

High-throughput

0.691

High

341477

A4
Amyloid-beta precursor protein

1

14

High-throughput

0.665

High

341475

TPA
Tissue-type plasminogen activator

1

16

Small-scale

0.647

High

341498

LRP2
Low-density lipoprotein receptor-related protein 2

1

7

Small-scale

0.647

High

341516

PDGFC
Platelet-derived growth factor C

1

14

Small-scale

0.647

High

341510

OIT3
Oncoprotein-induced transcript 3 protein

1

9

High-throughput

0.618

High

341512

TX101
Testis-expressed protein 101

1

1

Small-scale

0.618

High

341517

ADA28
Disintegrin and metalloproteinase domain-containing protein 28

2

8

High-throughput

0.606

High

341476

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.561

High

341503

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.547

High

60264

POTEF
POTE ankyrin domain family member F

1

3

High-throughput

0.536

High

319483

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

341483

CFC1
Cryptic protein

1

1

High-throughput

0.536

High

341484

PSPC
Surfactant protein C

1

3

High-throughput

0.536

High

341487

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.536

High

341488

PGFRA
Platelet-derived growth factor receptor alpha

1

5

High-throughput

0.536

High

341489

CAH6
Carbonic anhydrase 6

1

2

High-throughput

0.536

High

341496

MFAP4
Microfibril-associated glycoprotein 4

1

7

High-throughput

0.536

High

341501

KLRD1
Natural killer cells antigen CD94

1

2

High-throughput

0.536

High

341502

PTC1
Protein patched homolog 1

1

2

High-throughput

0.536

High

341513

CST11
Cystatin-11

1

2

High-throughput

0.536

High

341486

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.513

High

341493

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

341509

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.513

High

341485

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

2

High-throughput

0.494

High

341515

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.489

High

341508

SCAM5
Secretory carrier-associated membrane protein 5

1

1

High-throughput

0.481

High

341490

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

7

High-throughput

0.479

High

341507

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

341494

CEBPG
CCAAT/enhancer-binding protein gamma

1

1

High-throughput

0.457

High

341492

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

High-throughput

0.445

High

341491

PBX1
Pre-B-cell leukemia transcription factor 1

1

2

Small-scale

0.437

High

341497

PKNX1
Homeobox protein PKNOX1

1

2

Small-scale

0.437

High

341511

MOCOS
Molybdenum cofactor sulfurase

3

0

High-throughput

0.347

High

341514

KAT8
Histone acetyltransferase KAT8

1

0

Small-scale

0.261

Low

341505

PP4R4
Serine/threonine-protein phosphatase 4 regulatory subunit 4

1

0

High-throughput

0.249

Low

341506

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024