Protein: CSN4
COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)

Gene: CSN4, COPS4
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q9BT78

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1184960

CSN6
COP9 signalosome complex subunit 6

15

12

Small-scale

0.985

High

1272576

CSN5
COP9 signalosome complex subunit 5

14

15

Small-scale

0.983

High

1311917

CSN3
COP9 signalosome complex subunit 3

10

17

Small-scale

0.974

High

897302

CSN2
COP9 signalosome complex subunit 2

10

20

Small-scale

0.972

High

1305342

CSN8
COP9 signalosome complex subunit 8

8

1

Small-scale

0.968

High

1311913

CSN7A
COP9 signalosome complex subunit 7a

6

9

Small-scale

0.947

High

1311900

CSN7B
COP9 signalosome complex subunit 7b

6

9

Small-scale

0.944

High

1024211

CSN1
COP9 signalosome complex subunit 1

6

19

Small-scale

0.940

High

1043547

CUL4B
Cullin-4B

9

12

Small-scale

0.752

High

1265891

DDB2
DNA damage-binding protein 2

7

2

Small-scale

0.746

High

1042418

CUL3
Cullin-3

7

12

Small-scale

0.745

High

1043195

CUL4A
Cullin-4A

6

12

Small-scale

0.726

High

1041179

CUL1
Cullin-1

4

12

Small-scale

0.694

High

1255949

DCA11
DDB1- and CUL4-associated factor 11

4

1

High-throughput

0.694

High

1289617

FBX17
F-box only protein 17

4

1

High-throughput

0.694

High

1082361

DDB1
DNA damage-binding protein 1

5

0

Small-scale

0.681

High

1028022

ERCC8
DNA excision repair protein ERCC-8

4

3

Small-scale

0.676

High

896204

UBC12
NEDD8-conjugating enzyme Ubc12

3

1

High-throughput

0.667

High

1311896

BTBD1
BTB/POZ domain-containing protein 1

3

5

High-throughput

0.667

High

1236693

USBP1
Harmonin-binding protein USHBP1

3

0

High-throughput

0.656

High

1311889

CSN4
COP9 signalosome complex subunit 4

1

5

Small-scale

0.647

High

1079140

STK11
Serine/threonine-protein kinase STK11

3

0

High-throughput

0.643

High

1311908

DTL
Denticleless protein homolog

3

2

Small-scale

0.640

High

1311921

DCAF1
DDB1- and CUL4-associated factor 1

3

1

Small-scale

0.640

High

1153792

KLH10
Kelch-like protein 10

2

3

High-throughput

0.628

High

1260894

DCAF4
DDB1- and CUL4-associated factor 4

2

1

High-throughput

0.628

High

921409

RBX1
E3 ubiquitin-protein ligase RBX1

3

0

Small-scale

0.619

High

1041454

CUL2
Cullin-2

2

12

High-throughput

0.611

High

1079591

NEDD8
NEDD8

2

2

Small-scale

0.611

High

1274036

CUL5
Cullin-5

2

12

High-throughput

0.611

High

1311892

BTBD2
BTB/POZ domain-containing protein 2

2

5

High-throughput

0.611

High

319417

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

0

High-throughput

0.602

High

1185086

DET1
DET1 homolog

2

0

High-throughput

0.602

High

1311919

FBX7
F-box only protein 7

2

0

High-throughput

0.602

High

1311911

KLH13
Kelch-like protein 13

2

3

High-throughput

0.588

High

228529

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

976504

ERCC6
DNA excision repair protein ERCC-6

2

1

Small-scale

0.584

High

1076913

PTN14
Tyrosine-protein phosphatase non-receptor type 14

2

4

Small-scale

0.584

High

262086

PEX14
Peroxisomal membrane protein PEX14

2

0

High-throughput

0.580

High

345534

FOS
Protein c-Fos

1

2

High-throughput

0.578

High

152034

TOR1A
Torsin-1A

1

3

Small-scale

0.561

High

1072440

ELOB
Elongin-B

2

0

High-throughput

0.559

High

1302550

CRBN
Protein cereblon

2

0

Small-scale

0.559

High

158537

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.552

High

497525

TAU
Microtubule-associated protein tau

2

4

High-throughput

0.552

High

387413

P53
Cellular tumor antigen p53

2

0

Small-scale

0.547

High

971751

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.536

High

1311906

KBTB4
Kelch repeat and BTB domain-containing protein 4

2

4

Small-scale

0.533

High

1311893

HEMGN
Hemogen

1

0

Small-scale

0.529

High

307275

RCBT2
RCC1 and BTB domain-containing protein 2

1

0

High-throughput

0.518

High

444468

K1C19
Keratin, type I cytoskeletal 19

1

0

High-throughput

0.518

High

883191

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

0

High-throughput

0.518

High

1079280

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

1295472

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

1311904

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.518

High

1311912

WRP73
WD repeat-containing protein WRAP73

1

1

High-throughput

0.515

High

1311918

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.515

High

50453

SYCE3
Synaptonemal complex central element protein 3

1

0

High-throughput

0.513

High

452867

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1075446

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

0

High-throughput

0.513

High

1263346

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

1292382

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

1311905

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

1311907

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.513

High

647232

1433T
14-3-3 protein theta

1

2

High-throughput

0.501

High

1121796

ANR39
Ankyrin repeat domain-containing protein 39

1

1

High-throughput

0.489

High

1311916

UBQL1
Ubiquilin-1

1

9

High-throughput

0.481

High

577501

IL1RA
Interleukin-1 receptor antagonist protein

1

0

Small-scale

0.480

High

1311901

RAB18
Ras-related protein Rab-18

1

0

Small-scale

0.480

High

1282412

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.479

High

205908

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

244868

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

295199

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

311001

SNAPN
SNARE-associated protein Snapin

1

1

Small-scale

0.479

High

324591

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

476293

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

553580

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

570018

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

652105

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

714577

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

721301

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

885055

FBXW4
F-box/WD repeat-containing protein 4

1

2

Small-scale

0.479

High

927473

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

999036

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1036024

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1039470

IRF5
Interferon regulatory factor 5

1

1

Small-scale

0.479

High

1148761

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1171476

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1174294

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1246163

COP1
E3 ubiquitin-protein ligase COP1

1

4

High-throughput

0.479

High

1251906

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

1262810

PHIP
PH-interacting protein

1

1

Small-scale

0.479

High

1263429

STON2
Stonin-2

1

1

Small-scale

0.479

High

1267131

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1281833

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1311895

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.479

High

1311899

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1311902

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

Small-scale

0.479

High

1311903

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

1311909

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

Small-scale

0.479

High

1311910

KLH42
Kelch-like protein 42

1

4

High-throughput

0.479

High

1311914

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1311923

MAFB
Transcription factor MafB

1

3

High-throughput

0.479

High

319048

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

913077

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

929048

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.458

High

934434

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.458

High

969022

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

Small-scale

0.458

High

1065776

LRC14
Leucine-rich repeat-containing protein 14

1

0

High-throughput

0.458

High

1072300

ELOC
Elongin-C

1

0

High-throughput

0.458

High

1200625

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1200836

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1243907

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1270683

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1296806

LLR1
Leucine-rich repeat protein 1

1

0

High-throughput

0.458

High

1311891

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1311897

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1311915

FEM1B
Protein fem-1 homolog B

1

0

High-throughput

0.458

High

1311920

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

402413

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

529656

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

951280

RHOG
Rho-related GTP-binding protein RhoG

1

1

Small-scale

0.445

High

1063115

ABRX2
BRISC complex subunit Abraxas 2

1

1

Small-scale

0.445

High

1120807

KLH12
Kelch-like protein 12

1

3

High-throughput

0.445

High

1153358

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

1295229

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

101132

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

297671

RHBT1
Rho-related BTB domain-containing protein 1

1

5

High-throughput

0.437

High

299532

KLH18
Kelch-like protein 18

1

3

High-throughput

0.437

High

1159429

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1239006

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

1

Small-scale

0.437

High

1311894

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

378153

PRIO
Major prion protein

1

0

High-throughput

0.426

High

831648

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

207741

DENR
Density-regulated protein

2

0

High-throughput

0.328

High

1311922

PCDBC
Protocadherin beta-12

2

0

High-throughput

0.316

High

1012463

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.304

High

1238345

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

1311890

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

385437

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1262559

DNJB3
DnaJ homolog subfamily B member 3

1

0

High-throughput

0.249

Low

1311898

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

886328

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

240163

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

1169468

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024