Protein: M4K4
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)

Gene: M4K4, MAP4K4
Organism: Homo sapiens
Interactions: 237
UniProt ID: O95819

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0004111 - creatine kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

324842

MINK1
Misshapen-like kinase 1

4

17

High-throughput

0.900

High

324711

RASK
GTPase KRas

4

20

High-throughput

0.873

High

324909

RAP2C
Ras-related protein Rap-2c

3

14

High-throughput

0.861

High

324724

RAP2A
Ras-related protein Rap-2a

2

20

High-throughput

0.789

High

324913

STK24
Serine/threonine-protein kinase 24

2

20

High-throughput

0.789

High

226172

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.754

High

324709

RASN
GTPase NRas

2

20

High-throughput

0.754

High

324776

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

324804

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.740

High

324791

KPCE
Protein kinase C epsilon type

1

20

High-throughput

0.698

High

324798

STRN3
Striatin-3

4

20

High-throughput

0.694

High

243237

DNJA2
DnaJ homolog subfamily A member 2

1

7

High-throughput

0.691

High

324744

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

20

High-throughput

0.691

High

324781

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

9

High-throughput

0.691

High

324895

STK26
Serine/threonine-protein kinase 26

1

20

High-throughput

0.691

High

324898

ZRAN1
Ubiquitin thioesterase ZRANB1

3

15

High-throughput

0.650

High

324806

SLMAP
Sarcolemmal membrane-associated protein

1

20

High-throughput

0.648

High

324707

LATS1
Serine/threonine-protein kinase LATS1

1

20

Small-scale

0.647

High

215181

STRN
Striatin

4

20

High-throughput

0.642

High

324890

STRN4
Striatin-4

2

20

High-throughput

0.639

High

324896

CT2NL
CTTNBP2 N-terminal-like protein

2

20

High-throughput

0.639

High

324767

NANO2
Nanos homolog 2

2

2

High-throughput

0.628

High

234459

DSCAM
Cell adhesion molecule DSCAM

1

3

High-throughput

0.625

High

324734

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.624

High

324818

RHG21
Rho GTPase-activating protein 21

1

9

High-throughput

0.618

High

120264

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

201156

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

14

Small-scale

0.618

High

255406

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.618

High

324706

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

16

High-throughput

0.618

High

324708

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

324710

RASH
GTPase HRas

1

20

High-throughput

0.618

High

324713

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

324717

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

324718

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

324719

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

324720

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

324721

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

324728

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

324732

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

324737

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.618

High

324738

EPHA1
Ephrin type-A receptor 1

1

19

High-throughput

0.618

High

324739

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

324742

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

324747

GRK5
G protein-coupled receptor kinase 5

1

20

High-throughput

0.618

High

324758

MUC18
Cell surface glycoprotein MUC18

1

12

High-throughput

0.618

High

324761

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.618

High

324762

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

324768

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

324774

RB11A
Ras-related protein Rab-11A

1

8

High-throughput

0.618

High

324783

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

324786

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.618

High

324787

CXAR
Coxsackievirus and adenovirus receptor

1

6

High-throughput

0.618

High

324789

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

324795

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.618

High

324800

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

20

Small-scale

0.618

High

324801

G3BP1
Ras GTPase-activating protein-binding protein 1

1

13

High-throughput

0.618

High

324809

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

324810

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

324817

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.618

High

324824

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.618

High

324829

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

324851

DNJC9
DnaJ homolog subfamily C member 9

1

9

High-throughput

0.618

High

324878

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

324899

TNIK
TRAF2 and NCK-interacting protein kinase

1

17

High-throughput

0.618

High

68219

HECA2
HEPACAM family member 2

3

3

High-throughput

0.609

High

324753

TNR3
Tumor necrosis factor receptor superfamily member 3

3

2

High-throughput

0.609

High

324873

GBP3
Guanylate-binding protein 3

1

1

Small-scale

0.586

High

208968

NCK2
Cytoplasmic protein NCK2

2

20

High-throughput

0.584

High

324748

CTNA1
Catenin alpha-1

2

6

Small-scale

0.584

High

324782

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.584

High

324833

MOB1B
MOB kinase activator 1B

2

20

High-throughput

0.584

High

324820

STRP1
Striatin-interacting protein 1

2

14

High-throughput

0.583

High

324716

ITB1
Integrin beta-1

1

8

Small-scale

0.573

High

324908

PHOCN
MOB-like protein phocein

1

20

High-throughput

0.561

High

324915

TX264
Testis-expressed protein 264

2

1

High-throughput

0.558

High

81963

HNRC3
Heterogeneous nuclear ribonucleoprotein C-like 3

1

19

High-throughput

0.553

High

318038

DIRA3
GTP-binding protein Di-Ras3

1

18

High-throughput

0.553

High

324730

RINI
Ribonuclease inhibitor

1

6

High-throughput

0.553

High

324756

RBM34
RNA-binding protein 34

1

11

High-throughput

0.553

High

324757

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

1

High-throughput

0.553

High

324764

AFAD
Afadin

1

20

High-throughput

0.553

High

324808

RAB35
Ras-related protein Rab-35

1

20

High-throughput

0.553

High

324853

CTTB2
Cortactin-binding protein 2

1

20

High-throughput

0.553

High

324876

DNJC5
DnaJ homolog subfamily C member 5

1

10

High-throughput

0.553

High

324877

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

324886

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.553

High

324887

TANC2
Protein TANC2

1

14

High-throughput

0.553

High

324897

ANFY1
Rabankyrin-5

1

11

High-throughput

0.553

High

324736

SL9A1
Sodium/hydrogen exchanger 1

1

4

High-throughput

0.541

High

324796

KIF5A
Kinesin heavy chain isoform 5A

1

12

High-throughput

0.541

High

324813

KI26B
Kinesin-like protein KIF26B

1

20

High-throughput

0.541

High

229268

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

14

High-throughput

0.536

High

324725

CCL3
C-C motif chemokine 3

1

2

High-throughput

0.536

High

324726

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.536

High

324729

TOP2A
DNA topoisomerase 2-alpha

1

2

High-throughput

0.536

High

324741

SMCA1
Probable global transcription activator SNF2L1

1

14

High-throughput

0.536

High

324805

NUMA1
Nuclear mitotic apparatus protein 1

1

20

High-throughput

0.536

High

324860

ARRD3
Arrestin domain-containing protein 3

1

8

High-throughput

0.536

High

324863

CNO6L
CCR4-NOT transcription complex subunit 6-like

1

8

High-throughput

0.536

High

324905

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

1

High-throughput

0.536

High

324914

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

324891

FGOP2
FGFR1 oncogene partner 2

2

15

High-throughput

0.533

High

324746

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

324859

LRC59
Leucine-rich repeat-containing protein 59

1

13

High-throughput

0.515

High

239680

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

10

High-throughput

0.514

High

324752

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

20

Small-scale

0.508

High

324770

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

Small-scale

0.508

High

324785

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

20

High-throughput

0.501

High

324812

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.494

High

324722

PARP1
Poly [ADP-ribose] polymerase 1

1

17

High-throughput

0.489

High

324723

H2AZ
Histone H2A.Z

1

16

High-throughput

0.489

High

324745

CD6
T-cell differentiation antigen CD6

1

4

High-throughput

0.489

High

324777

H4
Histone H4

1

3

High-throughput

0.489

High

324799

CBX3
Chromobox protein homolog 3

1

7

High-throughput

0.489

High

324807

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.489

High

324814

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

324819

SYT6
Synaptotagmin-6

1

4

High-throughput

0.489

High

324822

H2A2A
Histone H2A type 2-A

1

13

High-throughput

0.489

High

324825

RSBNL
Lysine-specific demethylase RSBN1L

1

1

High-throughput

0.489

High

324828

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.489

High

324832

H32
Histone H3.2

1

6

High-throughput

0.489

High

324840

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.489

High

324844

SYT2
Synaptotagmin-2

1

3

High-throughput

0.489

High

324854

H1X
Histone H1.10

1

1

High-throughput

0.489

High

324864

FACOS
FANCD2 opposite strand protein

1

1

High-throughput

0.489

High

324867

H2A1J
Histone H2A type 1-J

1

13

High-throughput

0.489

High

324871

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

324882

MANS1
MANSC domain-containing protein 1

1

3

High-throughput

0.489

High

324889

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.489

High

324900

CNO11
CCR4-NOT transcription complex subunit 11

1

1

High-throughput

0.489

High

324902

ABT1
Activator of basal transcription 1

1

3

High-throughput

0.489

High

324906

SL9A8
Sodium/hydrogen exchanger 8

1

4

High-throughput

0.489

High

324911

NGN3
Neurogenin-3

1

2

High-throughput

0.489

High

162314

XPO1
Exportin-1

1

15

High-throughput

0.479

High

279385

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

298021

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

308292

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

322039

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.479

High

324714

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

324727

LAMP1
Lysosome-associated membrane glycoprotein 1

1

13

High-throughput

0.479

High

324735

CXA1
Gap junction alpha-1 protein

1

11

High-throughput

0.479

High

324743

MARCS
Myristoylated alanine-rich C-kinase substrate

1

8

High-throughput

0.479

High

324750

RADI
Radixin

1

11

High-throughput

0.479

High

324759

CRKL
Crk-like protein

1

20

High-throughput

0.479

High

324760

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

324763

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

324769

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

324771

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

324772

1433E
14-3-3 protein epsilon

1

18

High-throughput

0.479

High

324773

ARF6
ADP-ribosylation factor 6

1

12

High-throughput

0.479

High

324779

RL30
Large ribosomal subunit protein eL30

1

4

High-throughput

0.479

High

324780

RL32
Large ribosomal subunit protein eL32

1

4

High-throughput

0.479

High

324784

DYL1
Dynein light chain 1, cytoplasmic

1

12

High-throughput

0.479

High

324790

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

High-throughput

0.479

High

324792

KIF23
Kinesin-like protein KIF23

1

17

High-throughput

0.479

High

324793

CAV1
Caveolin-1

1

7

High-throughput

0.479

High

324794

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

324797

STX4
Syntaxin-4

1

5

High-throughput

0.479

High

324802

BIRC2
Baculoviral IAP repeat-containing protein 2

1

7

Small-scale

0.479

High

324803

CUL3
Cullin-3

1

7

High-throughput

0.479

High

324815

AMOT
Angiomotin

1

20

High-throughput

0.479

High

324831

MOB3C
MOB kinase activator 3C

1

20

High-throughput

0.479

High

324837

MOB3B
MOB kinase activator 3B

1

20

High-throughput

0.479

High

324848

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

324857

FBXW7
F-box/WD repeat-containing protein 7

1

16

High-throughput

0.479

High

324861

MOB3A
MOB kinase activator 3A

1

20

High-throughput

0.479

High

324862

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

324870

PDC10
Programmed cell death protein 10

1

6

High-throughput

0.479

High

324872

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

324879

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

324883

MOB1A
MOB kinase activator 1A

1

20

High-throughput

0.479

High

324884

KT3K
Ketosamine-3-kinase

1

1

High-throughput

0.479

High

324888

E41LA
Band 4.1-like protein 4A

1

14

High-throughput

0.479

High

324892

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

3

High-throughput

0.479

High

324901

STRP2
Striatin-interacting protein 2

1

14

High-throughput

0.479

High

324903

MYO6
Unconventional myosin-VI

1

14

High-throughput

0.479

High

324904

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.479

High

324910

RL36
Large ribosomal subunit protein eL36

1

4

High-throughput

0.479

High

324827

TBPL2
TATA box-binding protein-like 2

1

0

Small-scale

0.460

High

324912

NDK7
Nucleoside diphosphate kinase homolog 7

1

0

High-throughput

0.460

High

324731

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.458

High

324845

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

324874

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

324841

RYBP
RING1 and YY1-binding protein

1

6

High-throughput

0.445

High

324865

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

12

High-throughput

0.445

High

61279

CNOT1
CCR4-NOT transcription complex subunit 1

1

2

High-throughput

0.437

High

119798

SMAP
Small acidic protein

1

2

High-throughput

0.437

High

119901

AP3B1
AP-3 complex subunit beta-1

1

9

High-throughput

0.437

High

132401

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

178351

STX7
Syntaxin-7

1

6

High-throughput

0.437

High

302463

CE152
Centrosomal protein of 152 kDa

1

20

High-throughput

0.437

High

305326

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

307754

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

1

High-throughput

0.437

High

324712

MYCN
N-myc proto-oncogene protein

1

14

High-throughput

0.437

High

324733

RFA2
Replication protein A 32 kDa subunit

1

11

High-throughput

0.437

High

324740

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

324751

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

324754

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.437

High

324766

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.437

High

324775

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

20

High-throughput

0.437

High

324778

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.437

High

324788

RT34
Small ribosomal subunit protein mS34

1

4

High-throughput

0.437

High

324811

OCLN
Occludin

1

6

High-throughput

0.437

High

324821

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.437

High

324823

LTOR1
Ragulator complex protein LAMTOR1

1

7

High-throughput

0.437

High

324830

PAXI1
PAX-interacting protein 1

1

11

High-throughput

0.437

High

324834

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.437

High

324836

CNTRL
Centriolin

1

20

High-throughput

0.437

High

324839

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

324843

S2541
Mitochondrial carrier protein SCaMC-3L

1

7

High-throughput

0.437

High

324846

FBX22
F-box only protein 22

1

2

High-throughput

0.437

High

324847

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.437

High

324849

BRX1
Ribosome biogenesis protein BRX1 homolog

1

8

High-throughput

0.437

High

324850

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.437

High

324852

CTBL1
Beta-catenin-like protein 1

1

1

High-throughput

0.437

High

324855

AP3S1
AP-3 complex subunit sigma-1

1

6

High-throughput

0.437

High

324856

CNOT9
CCR4-NOT transcription complex subunit 9

1

3

High-throughput

0.437

High

324858

CK052
Uncharacterized protein C11orf52

1

6

High-throughput

0.437

High

324866

FMNL2
Formin-like protein 2

1

3

High-throughput

0.437

High

324868

CG050
Uncharacterized protein C7orf50

1

4

High-throughput

0.437

High

324869

SIKE1
Suppressor of IKBKE 1

1

15

High-throughput

0.437

High

324875

CPVL
Probable serine carboxypeptidase CPVL

1

5

High-throughput

0.437

High

324880

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.437

High

324881

CH033
UPF0488 protein C8orf33

1

2

High-throughput

0.437

High

324885

CYBP
Calcyclin-binding protein

1

4

High-throughput

0.437

High

324893

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.437

High

324894

CWC15
Spliceosome-associated protein CWC15 homolog

1

1

High-throughput

0.437

High

324907

AP3M1
AP-3 complex subunit mu-1

1

6

High-throughput

0.437

High

324755

BRCA1
Breast cancer type 1 susceptibility protein

1

9

Small-scale

0.408

High

324715

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

324749

BMI1
Polycomb complex protein BMI-1

1

8

High-throughput

0.407

High

324816

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.407

High

324838

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

18

High-throughput

0.407

High

324765

DSCR6
Protein ripply3

1

0

High-throughput

0.282

High

324835

MYCPP
C-myc promoter-binding protein

1

0

High-throughput

0.279

Low

324826

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024