Protein: EPS8
Epidermal growth factor receptor kinase substrate 8

Gene: EPS8
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q12929

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005886 - plasma membrane
GO:0005903 - brush border
GO:0005938 - cell cortex
GO:0007266 - Rho protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1020413

BAIP2
BAR/IMD domain-containing adapter protein 2

11

11

Small-scale

0.983

High

338351

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.925

High

992474

SOS1
Son of sevenless homolog 1

4

20

Small-scale

0.873

High

1020381

ABI1
Abl interactor 1

3

20

Small-scale

0.857

High

1020360

EPS8
Epidermal growth factor receptor kinase substrate 8

2

16

Small-scale

0.817

High

1020402

ITSN2
Intersectin-2

1

18

Small-scale

0.740

High

924530

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.740

High

666092

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.724

High

1020367

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

1020411

MYO15
Unconventional myosin-XV

1

4

High-throughput

0.698

High

522945

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.692

High

159199

CSKP
Peripheral plasma membrane protein CASK

1

8

Small-scale

0.665

High

610377

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.646

High

1020408

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

2

9

Small-scale

0.646

High

1020371

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

18

High-throughput

0.621

High

665590

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

968298

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.618

High

1020370

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

827785

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

2

0

Small-scale

0.605

High

397656

IPSP
Plasma serine protease inhibitor

2

3

High-throughput

0.576

High

996475

FGL1
Fibrinogen-like protein 1

2

2

High-throughput

0.574

High

150698

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.573

High

432679

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.573

High

1020368

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

1

15

High-throughput

0.573

High

369501

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

961376

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

10

High-throughput

0.555

High

166918

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

4

High-throughput

0.553

High

529048

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

1020378

MILR1
Allergin-1

1

17

High-throughput

0.536

High

1020401

GPC5B
G-protein coupled receptor family C group 5 member B

1

7

High-throughput

0.536

High

1020373

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.526

High

1020407

RSP14
Radial spoke head 14 homolog

2

4

High-throughput

0.526

High

1020386

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

3

High-throughput

0.523

High

1020412

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.518

High

823254

MRP
MARCKS-related protein

1

0

High-throughput

0.513

High

396584

ITB3
Integrin beta-3

1

8

Small-scale

0.501

High

574531

ITB5
Integrin beta-5

1

7

Small-scale

0.501

High

151302

IDLC
Axonemal dynein light intermediate polypeptide 1

1

1

High-throughput

0.494

High

1020390

HOOK2
Protein Hook homolog 2

1

8

High-throughput

0.494

High

154480

MEIS2
Homeobox protein Meis2

1

1

High-throughput

0.489

High

817991

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.489

High

1020394

MND1
Meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.489

High

1020403

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

17

High-throughput

0.481

High

127005

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

2

High-throughput

0.479

High

155340

NRP1
Neuropilin-1

1

8

High-throughput

0.479

High

349276

RASH
GTPase HRas

1

14

High-throughput

0.479

High

350122

RASK
GTPase KRas

1

16

High-throughput

0.479

High

403869

ITB1
Integrin beta-1

1

7

Small-scale

0.479

High

430697

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

5

Small-scale

0.479

High

891733

ACTB
Actin, cytoplasmic 1

1

8

High-throughput

0.479

High

892340

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

915637

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

925237

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

932128

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.479

High

965655

IFM3
Interferon-induced transmembrane protein 3

1

10

High-throughput

0.479

High

1020382

BICD2
Protein bicaudal D homolog 2

1

9

High-throughput

0.479

High

1020388

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

1020391

BICD1
Protein bicaudal D homolog 1

1

11

High-throughput

0.479

High

1000167

GOG8D
Putative golgin subfamily A member 8D

1

6

High-throughput

0.470

High

1020396

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.464

High

1020397

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.464

High

931611

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.460

High

1020372

TPRN
Taperin

1

0

High-throughput

0.460

High

1020375

S27A4
Long-chain fatty acid transport protein 4

1

0

High-throughput

0.460

High

1020362

STF1
Steroidogenic factor 1

1

10

High-throughput

0.457

High

523707

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.439

High

1020366

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.439

High

1020389

NACC2
Nucleus accumbens-associated protein 2

1

11

High-throughput

0.439

High

1020404

GULP1
PTB domain-containing engulfment adapter protein 1

1

20

High-throughput

0.439

High

1020409

CTNA3
Catenin alpha-3

1

1

High-throughput

0.439

High

100712

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

214241

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.437

High

233410

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

1020364

MDC1
Mediator of DNA damage checkpoint protein 1

1

6

High-throughput

0.437

High

1020376

FBX42
F-box only protein 42

1

5

High-throughput

0.437

High

1020377

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1020383

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

1020406

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

964779

AMPD2
AMP deaminase 2

2

0

High-throughput

0.328

High

1020384

US6NL
USP6 N-terminal-like protein

1

0

Small-scale

0.324

High

1020393

XAGE2
X antigen family member 2

2

0

High-throughput

0.310

High

1020410

RCAN3
Calcipressin-3

2

0

High-throughput

0.300

High

987409

MTG8
Protein CBFA2T1

1

0

High-throughput

0.299

High

1020363

BYST
Bystin

1

0

High-throughput

0.299

High

1020392

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.299

High

1020405

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.299

High

180590

TEX28
Testis-specific protein TEX28

1

0

High-throughput

0.282

High

316330

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.282

High

1020361

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.282

High

1020365

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.282

High

1020369

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

1020395

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.282

High

204315

MS18B
Protein Mis18-beta

1

0

High-throughput

0.279

Low

533451

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

623617

IBP5
Insulin-like growth factor-binding protein 5

1

0

High-throughput

0.279

Low

1020374

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.279

Low

1020385

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.279

Low

1020387

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.279

Low

1020398

LYRM4
LYR motif-containing protein 4

1

0

High-throughput

0.279

Low

1020400

TMM51
Transmembrane protein 51

1

0

High-throughput

0.279

Low

124328

RFXAP
Regulatory factor X-associated protein

1

0

High-throughput

0.251

Low

157322

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.251

Low

587780

CXCL2
C-X-C motif chemokine 2

1

0

High-throughput

0.251

Low

1012533

SCRN3
Secernin-3

1

0

High-throughput

0.251

Low

1020379

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.251

Low

1020380

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.251

Low

1020399

ARMC1
Armadillo repeat-containing protein 1

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024