Protein: GLI3
Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]

Gene: GLI3
Organism: Homo sapiens
Interactions: 70
UniProt ID: P10071

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001649 - osteoblast differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

234699

ZIC3
Zinc finger protein ZIC 3

2

20

Small-scale

0.778

High

214051

SPOP
Speckle-type POZ protein

8

5

Small-scale

0.745

High

313637

ZIC2
Zinc finger protein ZIC 2

1

18

Small-scale

0.724

High

485122

ZIC1
Zinc finger protein ZIC 1

1

18

Small-scale

0.724

High

485150

SUFU
Suppressor of fused homolog

4

11

Small-scale

0.697

High

485104

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

485153

FBW1A
F-box/WD repeat-containing protein 1A

3

9

Small-scale

0.670

High

485147

STK36
Serine/threonine-protein kinase 36

1

5

Small-scale

0.665

High

485138

CBP
CREB-binding protein

3

15

Small-scale

0.665

High

485103

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.647

High

485109

KC1A
Casein kinase I isoform alpha

1

5

Small-scale

0.647

High

485110

GSK3A
Glycogen synthase kinase-3 alpha

1

2

Small-scale

0.647

High

485039

GLI2
Zinc finger protein GLI2

1

18

High-throughput

0.646

High

485107

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.646

High

271726

PRDM1
PR domain zinc finger protein 1

1

18

Small-scale

0.618

High

436665

GLI1
Zinc finger protein GLI1

1

18

Small-scale

0.618

High

485151

CELA1
Chymotrypsin-like elastase family member 1

2

0

High-throughput

0.602

High

485101

SKI
Ski oncogene

1

3

Small-scale

0.573

High

62128

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.536

High

485108

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.536

High

485124

KIF7
Kinesin-like protein KIF7

1

4

High-throughput

0.536

High

485144

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

485140

MED12
Mediator of RNA polymerase II transcription subunit 12

1

5

Small-scale

0.527

High

485123

TAF9
Transcription initiation factor TFIID subunit 9

1

2

Small-scale

0.501

High

485131

RHOU
Rho-related GTP-binding protein RhoU

1

6

High-throughput

0.501

High

485114

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.500

High

485116

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

3

High-throughput

0.500

High

485118

EMX1
Homeobox protein EMX1

1

8

Small-scale

0.500

High

485142

WDR11
WD repeat-containing protein 11

1

1

Small-scale

0.500

High

485099

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.479

High

485111

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.479

High

61294

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.479

High

257310

CNOT3
CCR4-NOT transcription complex subunit 3

1

2

High-throughput

0.479

High

257555

ANR17
Ankyrin repeat domain-containing protein 17

1

3

High-throughput

0.479

High

319107

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

345771

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.479

High

485098

ANDR
Androgen receptor

1

13

Small-scale

0.479

High

485100

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

485102

SKIL
Ski-like protein

1

3

Small-scale

0.479

High

485105

TAF1
Transcription initiation factor TFIID subunit 1

1

12

High-throughput

0.479

High

485106

SP100
Nuclear autoantigen Sp-100

1

12

High-throughput

0.479

High

485112

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.479

High

485115

RNF4
E3 ubiquitin-protein ligase RNF4

1

16

High-throughput

0.479

High

485117

OTUD4
OTU domain-containing protein 4

1

1

High-throughput

0.479

High

485120

HDAC1
Histone deacetylase 1

1

10

Small-scale

0.479

High

485127

CEP85
Centrosomal protein of 85 kDa

1

5

High-throughput

0.479

High

485128

BCOR
BCL-6 corepressor

1

7

High-throughput

0.479

High

485130

SYNE3
Nesprin-3

1

6

High-throughput

0.479

High

485132

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.479

High

485133

KLHL7
Kelch-like protein 7

1

3

High-throughput

0.479

High

485135

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

485136

KDM2B
Lysine-specific demethylase 2B

1

2

High-throughput

0.479

High

485137

PHIP
PH-interacting protein

1

2

High-throughput

0.479

High

485139

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

Small-scale

0.479

High

485141

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.479

High

485148

HDAC6
Histone deacetylase 6

1

12

Small-scale

0.479

High

485149

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.479

High

485152

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.479

High

485154

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

485155

MAGD1
Melanoma-associated antigen D1

1

3

High-throughput

0.479

High

485126

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

485143

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

485145

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.458

High

485146

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

485119

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.457

High

485113

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.445

High

485125

PRC2B
Protein PRRC2B

1

3

High-throughput

0.437

High

485129

THSD4
Thrombospondin type-1 domain-containing protein 4

1

0

High-throughput

0.279

Low

485121

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

485134

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024