Protein: THB
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)

Gene: THB, THRB
Organism: Homo sapiens
Interactions: 66
UniProt ID: P10828

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

500461

RXRA
Retinoic acid receptor RXR-alpha

9

20

Small-scale

0.968

High

500491

NCOA1
Nuclear receptor coactivator 1

8

20

Small-scale

0.963

High

500511

NCOA3
Nuclear receptor coactivator 3

3

20

Small-scale

0.861

High

500456

THB
Thyroid hormone receptor beta

3

19

Small-scale

0.845

High

500487

NCOA2
Nuclear receptor coactivator 2

3

20

Small-scale

0.840

High

261383

NCOR1
Nuclear receptor corepressor 1

9

20

Small-scale

0.752

High

500510

NCOR2
Nuclear receptor corepressor 2

8

20

Small-scale

0.747

High

490046

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

20

Small-scale

0.740

High

500485

NCOA6
Nuclear receptor coactivator 6

5

20

Small-scale

0.704

High

500475

PRS8
26S proteasome regulatory subunit 8

3

20

Small-scale

0.639

High

500473

ACTB
Actin, cytoplasmic 1

2

9

High-throughput

0.628

High

500507

PDLI7
PDZ and LIM domain protein 7

2

16

High-throughput

0.628

High

500465

RXRB
Retinoic acid receptor RXR-beta

1

18

High-throughput

0.621

High

500468

RXRG
Retinoic acid receptor RXR-gamma

1

20

High-throughput

0.621

High

500471

IMA5
Importin subunit alpha-5

1

7

Small-scale

0.618

High

245556

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

20

Small-scale

0.602

High

385976

P53
Cellular tumor antigen p53

2

6

Small-scale

0.595

High

500497

ROBO4
Roundabout homolog 4

1

6

Small-scale

0.579

High

500476

ACTA
Actin, aortic smooth muscle

2

8

High-throughput

0.574

High

500492

ACTBL
Beta-actin-like protein 2

2

9

High-throughput

0.574

High

500501

RANB9
Ran-binding protein 9

1

18

Small-scale

0.573

High

177178

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.561

High

500463

CCND1
G1/S-specific cyclin-D1

1

7

Small-scale

0.561

High

500478

PRKDC
DNA-dependent protein kinase catalytic subunit

1

11

Small-scale

0.561

High

500508

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

20

Small-scale

0.561

High

500489

TRIP4
Activating signal cointegrator 1

1

5

Small-scale

0.527

High

500506

BRD8
Bromodomain-containing protein 8

1

20

Small-scale

0.527

High

500498

ADAT3
Probable inactive tRNA-specific adenosine deaminase-like protein 3

1

0

High-throughput

0.518

High

500457

SRC
Proto-oncogene tyrosine-protein kinase Src

1

9

Small-scale

0.501

High

500460

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

9

Small-scale

0.501

High

500464

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

12

Small-scale

0.501

High

500467

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

7

Small-scale

0.501

High

500477

UBC9
SUMO-conjugating enzyme UBC9

1

10

Small-scale

0.501

High

500481

MED21
Mediator of RNA polymerase II transcription subunit 21

1

3

Small-scale

0.501

High

500483

C1D
Nuclear nucleic acid-binding protein C1D

1

1

Small-scale

0.501

High

500493

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

3

Small-scale

0.501

High

500495

PRGC2
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

1

20

Small-scale

0.501

High

500502

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

Small-scale

0.501

High

500504

ANM1
Protein arginine N-methyltransferase 1

1

18

Small-scale

0.501

High

348482

RASN
GTPase NRas

1

4

High-throughput

0.489

High

500509

DYN3
Dynamin-3

1

2

High-throughput

0.489

High

500469

NRIP1
Nuclear receptor-interacting protein 1

1

16

High-throughput

0.481

High

500474

CSN2
COP9 signalosome complex subunit 2

1

6

Small-scale

0.481

High

500482

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

6

High-throughput

0.481

High

500499

NRBF2
Nuclear receptor-binding factor 2

1

3

Small-scale

0.481

High

500500

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

455026

PARP1
Poly [ADP-ribose] polymerase 1

1

11

Small-scale

0.479

High

500458

XRCC6
X-ray repair cross-complementing protein 6

1

14

Small-scale

0.479

High

500459

XRCC5
X-ray repair cross-complementing protein 5

1

14

Small-scale

0.479

High

500462

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

500466

HSP74
Heat shock 70 kDa protein 4

1

18

Small-scale

0.479

High

500470

DNLI3
DNA ligase 3

1

3

Small-scale

0.479

High

500472

ANM2
Protein arginine N-methyltransferase 2

1

18

Small-scale

0.479

High

500480

GPS2
G protein pathway suppressor 2

1

4

Small-scale

0.479

High

500484

SMC1A
Structural maintenance of chromosomes protein 1A

1

10

Small-scale

0.479

High

500486

IMB1
Importin subunit beta-1

1

3

Small-scale

0.479

High

500488

MED1
Mediator of RNA polymerase II transcription subunit 1

1

20

Small-scale

0.479

High

500496

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

500505

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

20

Small-scale

0.479

High

242663

IF2P
Eukaryotic translation initiation factor 5B

1

8

High-throughput

0.470

High

500490

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

0

High-throughput

0.460

High

500503

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.460

High

61295

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

Small-scale

0.457

High

500479

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

500494

MED25
Mediator of RNA polymerase II transcription subunit 25

1

7

Small-scale

0.457

High


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Last updated: 15 Jul 2024