Protein: BCR
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)

Gene: BCR
Organism: Homo sapiens
Interactions: 220
UniProt ID: P11274

Gene Ontology (top 5):
GO:0002692 - negative regulation of cellular extravasation
GO:0003014 - renal system process
GO:0004674 - protein serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005085 - guanyl-nucleotide exchange factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

506565

GRB2
Growth factor receptor-bound protein 2

15

20

Small-scale

0.987

High

337325

ABL1
Tyrosine-protein kinase ABL1

4

20

Small-scale

0.899

High

506542

CRKL
Crk-like protein

3

20

Small-scale

0.864

High

426941

FES
Tyrosine-protein kinase Fes/Fps

2

20

Small-scale

0.806

High

506520

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

19

Small-scale

0.768

High

506541

CRK
Adapter molecule crk

2

20

Small-scale

0.768

High

506561

RHOA
Transforming protein RhoA

2

20

Small-scale

0.768

High

506566

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.768

High

506620

ARG39
Rho guanine nucleotide exchange factor 39

2

18

High-throughput

0.767

High

442768

HCK
Tyrosine-protein kinase HCK

2

20

Small-scale

0.754

High

506521

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

13

Small-scale

0.754

High

506564

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

506575

SOS1
Son of sevenless homolog 1

2

14

Small-scale

0.754

High

506640

AP2M1
AP-2 complex subunit mu

7

9

High-throughput

0.745

High

506649

DOK1
Docking protein 1

1

4

Small-scale

0.724

High

506513

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

5

2

Small-scale

0.724

High

506514

CSK22
Casein kinase II subunit alpha'

5

7

High-throughput

0.722

High

506573

1433F
14-3-3 protein eta

4

20

High-throughput

0.694

High

275167

GRAP2
GRB2-related adapter protein 2

1

20

High-throughput

0.691

High

506538

FRK
Tyrosine-protein kinase FRK

1

20

High-throughput

0.691

High

506660

SLAP2
Src-like-adapter 2

1

20

High-throughput

0.691

High

506525

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

506571

CSK21
Casein kinase II subunit alpha

4

10

High-throughput

0.691

High

506562

1433G
14-3-3 protein gamma

4

20

High-throughput

0.687

High

506515

CBL
E3 ubiquitin-protein ligase CBL

4

16

Small-scale

0.686

High

506555

AFAD
Afadin

3

20

Small-scale

0.674

High

262358

TULP3
Tubby-related protein 3

3

1

High-throughput

0.667

High

506556

SEC13
Protein SEC13 homolog

3

8

High-throughput

0.667

High

506563

1433E
14-3-3 protein epsilon

3

10

High-throughput

0.667

High

506603

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

3

20

Small-scale

0.662

High

506510

EZRI
Ezrin

3

13

High-throughput

0.656

High

506512

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

13

Small-scale

0.653

High

506557

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.647

High

431470

HS90A
Heat shock protein HSP 90-alpha

3

7

Small-scale

0.640

High

506568

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.628

High

506644

JPH4
Junctophilin-4

2

3

High-throughput

0.628

High

129182

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

158600

RGS12
Regulator of G-protein signaling 12

1

2

Small-scale

0.618

High

176363

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

6

High-throughput

0.618

High

436136

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

506522

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.618

High

506529

GRK5
G protein-coupled receptor kinase 5

1

4

High-throughput

0.618

High

506558

RAB2A
Ras-related protein Rab-2A

1

5

High-throughput

0.618

High

506560

ACTZ
Alpha-centractin

1

12

High-throughput

0.618

High

506634

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

7

Small-scale

0.618

High

506659

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

506664

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

9

Small-scale

0.618

High

506681

GAB2
GRB2-associated-binding protein 2

1

14

Small-scale

0.618

High

385982

P53
Cellular tumor antigen p53

2

8

High-throughput

0.614

High

345788

MYC
Myc proto-oncogene protein

2

10

Small-scale

0.611

High

506531

RADI
Radixin

2

12

High-throughput

0.611

High

506570

CSK2B
Casein kinase II subunit beta

2

3

High-throughput

0.611

High

506576

DDR1
Epithelial discoidin domain-containing receptor 1

2

20

High-throughput

0.611

High

506612

SH2D5
SH2 domain-containing protein 5

2

3

Small-scale

0.611

High

506605

CC183
Coiled-coil domain-containing protein 183

3

10

High-throughput

0.609

High

506622

COMD1
COMM domain-containing protein 1

2

0

High-throughput

0.602

High

506672

NAGK
N-acetyl-D-glucosamine kinase

2

0

High-throughput

0.602

High

506657

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

12

Small-scale

0.586

High

506583

SQSTM
Sequestosome-1

2

8

Small-scale

0.584

High

506646

ERBIN
Erbin

1

8

Small-scale

0.578

High

506586

GRAP
GRB2-related adapter protein

1

20

Small-scale

0.575

High

506650

TS101
Tumor susceptibility gene 101 protein

1

1

Small-scale

0.573

High

321473

AP2A1
AP-2 complex subunit alpha-1

2

18

High-throughput

0.571

High

503321

HSP7C
Heat shock cognate 71 kDa protein

1

3

Small-scale

0.561

High

506526

IL3RB
Cytokine receptor common subunit beta

1

6

Small-scale

0.561

High

506610

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

506628

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.553

High

475282

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

Small-scale

0.552

High

506582

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.541

High

130713

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.536

High

164763

SC16A
Protein transport protein Sec16A

1

5

High-throughput

0.536

High

506508

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

506518

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

506533

NU214
Nuclear pore complex protein Nup214

1

11

High-throughput

0.536

High

506536

NAA10
N-alpha-acetyltransferase 10

1

1

High-throughput

0.536

High

506539

RAGP1
Ran GTPase-activating protein 1

1

2

High-throughput

0.536

High

506543

MAP1B
Microtubule-associated protein 1B

1

5

High-throughput

0.536

High

506544

UTRN
Utrophin

1

20

High-throughput

0.536

High

506569

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.536

High

506572

TFAM
Transcription factor A, mitochondrial

1

7

High-throughput

0.536

High

506580

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.536

High

506587

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

4

High-throughput

0.536

High

506592

DPYL2
Dihydropyrimidinase-related protein 2

1

6

High-throughput

0.536

High

506593

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

8

High-throughput

0.536

High

506598

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

5

High-throughput

0.536

High

506600

RRP12
RRP12-like protein

1

1

High-throughput

0.536

High

506602

NU188
Nucleoporin NUP188

1

1

High-throughput

0.536

High

506607

EDC4
Enhancer of mRNA-decapping protein 4

1

12

High-throughput

0.536

High

506618

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

506624

PSD4
PH and SEC7 domain-containing protein 4

1

7

High-throughput

0.536

High

506627

DDX54
ATP-dependent RNA helicase DDX54

1

3

High-throughput

0.536

High

506631

GCN1
Stalled ribosome sensor GCN1

1

11

High-throughput

0.536

High

506637

ARRD3
Arrestin domain-containing protein 3

1

10

High-throughput

0.536

High

506641

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.536

High

506653

GTPB4
GTP-binding protein 4

1

2

High-throughput

0.536

High

506662

SYNCI
Syncoilin

1

16

High-throughput

0.536

High

506669

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

2

High-throughput

0.536

High

506671

DDX20
Probable ATP-dependent RNA helicase DDX20

1

10

High-throughput

0.536

High

506678

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.536

High

506686

BACE2
Beta-secretase 2

1

1

High-throughput

0.536

High

331366

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

20

Small-scale

0.534

High

506625

WDR48
WD repeat-containing protein 48

1

11

High-throughput

0.515

High

61297

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

506509

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.513

High

506524

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.513

High

506545

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.513

High

506559

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.513

High

506581

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.513

High

506604

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.513

High

506630

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.513

High

506642

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.513

High

506654

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.513

High

506666

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

506668

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.513

High

506679

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.501

High

506595

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.500

High

272981

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.489

High

506596

INF2
Inverted formin-2

1

3

High-throughput

0.489

High

506599

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

7

High-throughput

0.489

High

506639

P5CR2
Pyrroline-5-carboxylate reductase 2

1

2

High-throughput

0.489

High

506676

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.489

High

506685

TF3C3
General transcription factor 3C polypeptide 3

1

5

High-throughput

0.489

High

506574

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.480

High

151375

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

2

High-throughput

0.479

High

151476

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

2

High-throughput

0.479

High

162369

XPO1
Exportin-1

1

14

High-throughput

0.479

High

229621

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

13

High-throughput

0.479

High

231979

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

294304

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

296264

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

5

Small-scale

0.479

High

305927

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.479

High

309655

KAT7
Histone acetyltransferase KAT7

1

3

High-throughput

0.479

High

322115

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

384168

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

414140

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

430021

PROF1
Profilin-1

1

5

High-throughput

0.479

High

451349

CLCA
Clathrin light chain A

1

5

High-throughput

0.479

High

499221

KIT
Mast/stem cell growth factor receptor Kit

1

16

Small-scale

0.479

High

499488

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.479

High

506517

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

12

High-throughput

0.479

High

506523

WEE1
Wee1-like protein kinase

1

11

High-throughput

0.479

High

506527

MCM4
DNA replication licensing factor MCM4

1

9

High-throughput

0.479

High

506528

HSP74
Heat shock 70 kDa protein 4

1

7

Small-scale

0.479

High

506530

CTNA1
Catenin alpha-1

1

7

High-throughput

0.479

High

506535

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

506537

EPS15
Epidermal growth factor receptor substrate 15

1

15

High-throughput

0.479

High

506540

ATRX
Transcriptional regulator ATRX

1

1

High-throughput

0.479

High

506546

KC1A
Casein kinase I isoform alpha

1

10

High-throughput

0.479

High

506547

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

5

Small-scale

0.479

High

506548

PAXI
Paxillin

1

12

Small-scale

0.479

High

506550

MCM2
DNA replication licensing factor MCM2

1

9

High-throughput

0.479

High

506551

GSK3A
Glycogen synthase kinase-3 alpha

1

9

High-throughput

0.479

High

506552

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.479

High

506553

VASP
Vasodilator-stimulated phosphoprotein

1

6

High-throughput

0.479

High

506554

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.479

High

506567

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.479

High

506577

RBBP4
Histone-binding protein RBBP4

1

4

High-throughput

0.479

High

506578

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.479

High

506579

ANK3
Ankyrin-3

1

12

High-throughput

0.479

High

506584

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

506585

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

506588

MCM6
DNA replication licensing factor MCM6

1

9

High-throughput

0.479

High

506589

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

7

High-throughput

0.479

High

506590

TEBP
Prostaglandin E synthase 3

1

3

Small-scale

0.479

High

506591

CCDC6
Coiled-coil domain-containing protein 6

1

20

High-throughput

0.479

High

506594

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.479

High

506597

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

506601

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.479

High

506606

CP135
Centrosomal protein of 135 kDa

1

14

High-throughput

0.479

High

506629

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

506632

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

506633

REQU
Zinc finger protein ubi-d4

1

2

High-throughput

0.479

High

506635

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

9

High-throughput

0.479

High

506647

CCNL2
Cyclin-L2

1

3

High-throughput

0.479

High

506655

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.479

High

506658

PININ
Pinin

1

4

High-throughput

0.479

High

506661

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

506670

ZO2
Tight junction protein ZO-2

1

18

Small-scale

0.479

High

506673

DDX41
Probable ATP-dependent RNA helicase DDX41

1

3

High-throughput

0.479

High

506677

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.479

High

506682

NINL
Ninein-like protein

1

20

High-throughput

0.479

High

506683

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.479

High

506684

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.479

High

158145

GIPC1
PDZ domain-containing protein GIPC1

1

0

Small-scale

0.458

High

506516

GBRR1
Gamma-aminobutyric acid receptor subunit rho-1

1

0

Small-scale

0.458

High

506609

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.458

High

506616

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.458

High

506621

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.458

High

506674

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

Small-scale

0.458

High

383561

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.445

High

506645

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.445

High

506626

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.439

High

164347

TRI66
Tripartite motif-containing protein 66

1

8

High-throughput

0.437

High

506511

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

506519

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

506532

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

506534

TCF7
Transcription factor 7

1

2

Small-scale

0.437

High

506608

WDR82
WD repeat-containing protein 82

1

20

High-throughput

0.437

High

506611

CE128
Centrosomal protein of 128 kDa

1

17

High-throughput

0.437

High

506615

PCGF5
Polycomb group RING finger protein 5

1

2

High-throughput

0.437

High

506617

HOOK3
Protein Hook homolog 3

1

20

High-throughput

0.437

High

506623

SCAI
Protein SCAI

1

1

Small-scale

0.437

High

506636

VP33A
Vacuolar protein sorting-associated protein 33A

1

3

High-throughput

0.437

High

506638

PF21A
PHD finger protein 21A

1

4

High-throughput

0.437

High

506652

CECR2
Chromatin remodeling regulator CECR2

1

4

High-throughput

0.437

High

506665

SP110
Sp110 nuclear body protein

1

5

High-throughput

0.437

High

506675

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

506680

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.437

High

67905

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

20

High-throughput

0.407

High

506656

RSPH9
Radial spoke head protein 9 homolog

3

0

High-throughput

0.347

High

506643

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.282

High

506549

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.279

Low

506613

TRM1L
TRMT1-like protein

1

0

High-throughput

0.279

Low

506614

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.279

Low

506619

RM41
Large ribosomal subunit protein mL41

1

0

High-throughput

0.279

Low

506648

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.279

Low

444043

IL3
Interleukin-3

1

0

Small-scale

0.249

Low

506651

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.249

Low

506663

NRDE2
Nuclear exosome regulator NRDE2

1

0

High-throughput

0.249

Low

506667

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024