Protein: FRK
Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)

Gene: FRK
Organism: Homo sapiens
Interactions: 51
UniProt ID: P42685

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

782751

CSK
Tyrosine-protein kinase CSK

3

19

High-throughput

0.871

High

338084

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.858

High

789107

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

8

Small-scale

0.770

High

789111

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

5

5

High-throughput

0.720

High

320504

OXSR1
Serine/threonine-protein kinase OSR1

1

20

High-throughput

0.691

High

506538

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.691

High

626631

ARBK1
Beta-adrenergic receptor kinase 1

1

17

High-throughput

0.691

High

687019

GRK4
G protein-coupled receptor kinase 4

1

20

High-throughput

0.691

High

788974

TEC
Tyrosine-protein kinase Tec

1

19

High-throughput

0.691

High

789112

SNTB2
Beta-2-syntrophin

1

10

High-throughput

0.691

High

789116

KS6A1
Ribosomal protein S6 kinase alpha-1

1

20

High-throughput

0.691

High

789119

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

6

High-throughput

0.691

High

789125

PIM3
Serine/threonine-protein kinase pim-3

1

20

High-throughput

0.691

High

789128

TBCK
TBC domain-containing protein kinase-like protein

1

16

High-throughput

0.691

High

789130

AURKB
Aurora kinase B

1

13

High-throughput

0.691

High

789131

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

13

High-throughput

0.691

High

789133

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.691

High

789115

PCBP1
Poly(rC)-binding protein 1

3

12

High-throughput

0.667

High

789126

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

789117

SF3B4
Splicing factor 3B subunit 4

2

9

High-throughput

0.640

High

269519

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.621

High

412071

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.618

High

414204

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.578

High

789135

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

12

High-throughput

0.553

High

61319

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.536

High

196966

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

6

High-throughput

0.536

High

441930

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.536

High

789101

KI67
Proliferation marker protein Ki-67

1

9

High-throughput

0.536

High

789103

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

789105

RBP2
E3 SUMO-protein ligase RanBP2

1

3

High-throughput

0.536

High

789106

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.536

High

789108

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

High-throughput

0.536

High

789114

RRP5
Protein RRP5 homolog

1

2

High-throughput

0.536

High

789120

PDK4
[Pyruvate dehydrogenase

1

1

High-throughput

0.536

High

789124

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.536

High

789132

DDX23
Probable ATP-dependent RNA helicase DDX23

1

10

High-throughput

0.536

High

789134

SMC4
Structural maintenance of chromosomes protein 4

1

5

High-throughput

0.536

High

789136

TF3C4
General transcription factor 3C polypeptide 4

1

2

High-throughput

0.536

High

789104

COPD
Coatomer subunit delta

1

0

High-throughput

0.513

High

789113

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.513

High

789122

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.513

High

431627

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

437967

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

789102

YAP1
Transcriptional coactivator YAP1

1

17

Small-scale

0.479

High

789109

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.479

High

789118

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.458

High

789110

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

Small-scale

0.408

High

789121

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.279

Low

789123

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low

789129

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.279

Low

789127

JAGN1
Protein jagunal homolog 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024