Protein: ATRX
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)

Gene: ATRX
Organism: Homo sapiens
Interactions: 187
UniProt ID: P46100

Gene Ontology (top 5):
GO:0000212 - meiotic spindle organization
GO:0000228 - nuclear chromosome
GO:0000779 - condensed chromosome, centromeric region
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

802423

H33
Histone H3.3

10

20

Small-scale

0.974

High

802415

H4
Histone H4

5

18

Small-scale

0.915

High

802419

H31
Histone H3.1

5

20

Small-scale

0.909

High

802408

BLM
RecQ-like DNA helicase BLM

2

20

Small-scale

0.806

High

802449

H32
Histone H3.2

2

20

Small-scale

0.792

High

260792

H2AY
Core histone macro-H2A.1

2

20

Small-scale

0.789

High

802442

H2B2E
Histone H2B type 2-E

2

20

Small-scale

0.789

High

800312

CBX5
Chromobox protein homolog 5

2

20

Small-scale

0.768

High

802512

DAXX
Death domain-associated protein 6

22

3

Small-scale

0.767

High

802426

RAD51
DNA repair protein RAD51 homolog 1

11

18

Small-scale

0.759

High

391590

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.754

High

802429

CBX3
Chromobox protein homolog 3

2

20

High-throughput

0.754

High

802422

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.691

High

386276

P53
Cellular tumor antigen p53

4

14

Small-scale

0.688

High

802428

SSRP1
FACT complex subunit SSRP1

4

20

Small-scale

0.686

High

802525

SP16H
FACT complex subunit SPT16

4

7

Small-scale

0.686

High

802418

CSK21
Casein kinase II subunit alpha

3

18

High-throughput

0.675

High

246189

NBN
Nibrin

4

1

Small-scale

0.672

High

802435

IF4A2
Eukaryotic initiation factor 4A-II

1

20

High-throughput

0.665

High

802441

EZH2
Histone-lysine N-methyltransferase EZH2

3

20

Small-scale

0.660

High

61321

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.656

High

802434

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

20

Small-scale

0.647

High

802496

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

2

3

Small-scale

0.639

High

244078

BRD4
Bromodomain-containing protein 4

3

20

High-throughput

0.633

High

802406

MRE11
Double-strand break repair protein MRE11

3

3

Small-scale

0.633

High

586609

CSK22
Casein kinase II subunit alpha'

2

15

High-throughput

0.628

High

241471

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

802403

ATRX
Transcriptional regulator ATRX

1

19

Small-scale

0.618

High

802404

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

802416

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

802472

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.618

High

802490

H2B1L
Histone H2B type 1-L

1

20

Small-scale

0.618

High

802515

DDX20
Probable ATP-dependent RNA helicase DDX20

1

20

High-throughput

0.618

High

802519

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

20

Small-scale

0.614

High

802447

IFIX
Pyrin and HIN domain-containing protein 1

2

8

High-throughput

0.611

High

802505

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

2

4

Small-scale

0.611

High

802413

SUMO2
Small ubiquitin-related modifier 2

2

20

High-throughput

0.602

High

802471

RAD50
DNA repair protein RAD50

2

20

Small-scale

0.594

High

523579

XRCC6
X-ray repair cross-complementing protein 6

2

13

Small-scale

0.584

High

650602

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

15

Small-scale

0.584

High

668503

PML
Protein PML

2

19

Small-scale

0.584

High

802458

SLX4
Structure-specific endonuclease subunit SLX4

2

17

High-throughput

0.584

High

802493

FACD2
Fanconi anemia group D2 protein

2

7

Small-scale

0.584

High

254058

WDR1
WD repeat-containing protein 1

2

11

High-throughput

0.574

High

369150

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

330550

ZBED1
E3 SUMO-protein ligase ZBED1

1

4

Small-scale

0.561

High

322304

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

19

High-throughput

0.553

High

802448

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

663964

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

3

High-throughput

0.541

High

723956

CBS
Cystathionine beta-synthase

1

2

High-throughput

0.541

High

802411

RBM11
Splicing regulator RBM11

1

12

High-throughput

0.541

High

449590

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

595132

LMNB1
Lamin-B1

1

20

High-throughput

0.536

High

785739

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.536

High

802444

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.536

High

802486

TCPQM
T-complex protein 1 subunit theta-like 2

1

10

High-throughput

0.536

High

802516

ING1
Inhibitor of growth protein 1

1

20

High-throughput

0.536

High

802500

BRD9
Bromodomain-containing protein 9

1

20

Small-scale

0.527

High

802433

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.515

High

802438

SMC1A
Structural maintenance of chromosomes protein 1A

1

17

Small-scale

0.515

High

802479

Z512B
Zinc finger protein 512B

1

17

High-throughput

0.508

High

802484

NEK1
Serine/threonine-protein kinase Nek1

1

10

Small-scale

0.508

High

160434

AURKA
Aurora kinase A

1

5

Small-scale

0.501

High

802474

R51A1
RAD51-associated protein 1

1

1

Small-scale

0.501

High

802480

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.501

High

234484

DSCAM
Cell adhesion molecule DSCAM

1

1

High-throughput

0.494

High

597374

PTN
Pleiotrophin

1

1

High-throughput

0.494

High

802482

CLIC6
Chloride intracellular channel protein 6

1

3

High-throughput

0.494

High

802524

LC7L2
Putative RNA-binding protein Luc7-like 2

1

6

High-throughput

0.494

High

525454

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.493

High

802522

E41L3
Band 4.1-like protein 3

1

2

High-throughput

0.489

High

802410

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.481

High

802469

CBP
CREB-binding protein

1

20

Small-scale

0.481

High

119930

AP3B1
AP-3 complex subunit beta-1

1

3

High-throughput

0.479

High

122550

MEN1
Menin

1

6

Small-scale

0.479

High

123874

SPT5H
Transcription elongation factor SPT5

1

13

Small-scale

0.479

High

133372

NOP56
Nucleolar protein 56

1

10

Small-scale

0.479

High

154760

TCRG1
Transcription elongation regulator 1

1

9

Small-scale

0.479

High

158753

HAT1
Histone acetyltransferase type B catalytic subunit

1

3

High-throughput

0.479

High

209753

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

278751

DNJC8
DnaJ homolog subfamily C member 8

1

6

High-throughput

0.479

High

295958

MTA2
Metastasis-associated protein MTA2

1

20

Small-scale

0.479

High

300990

ABLM3
Actin-binding LIM protein 3

1

2

Small-scale

0.479

High

311499

SMC2
Structural maintenance of chromosomes protein 2

1

15

Small-scale

0.479

High

328505

MBD3
Methyl-CpG-binding domain protein 3

1

19

Small-scale

0.479

High

331741

NSD2
Histone-lysine N-methyltransferase NSD2

1

20

Small-scale

0.479

High

403608

AP2A
Transcription factor AP-2-alpha

1

1

Small-scale

0.479

High

487215

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

506540

BCR
Breakpoint cluster region protein

1

1

High-throughput

0.479

High

517123

PCNA
Proliferating cell nuclear antigen

1

9

Small-scale

0.479

High

524829

XRCC5
X-ray repair cross-complementing protein 5

1

13

Small-scale

0.479

High

552165

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.479

High

559344

H13
Histone H1.3

1

16

High-throughput

0.479

High

559598

H12
Histone H1.2

1

16

Small-scale

0.479

High

563034

YBOX3
Y-box-binding protein 3

1

4

Small-scale

0.479

High

658329

DPOD1
DNA polymerase delta catalytic subunit

1

4

High-throughput

0.479

High

672784

CDC27
Cell division cycle protein 27 homolog

1

6

Small-scale

0.479

High

681725

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.479

High

708393

MCM4
DNA replication licensing factor MCM4

1

11

Small-scale

0.479

High

708832

MCM7
DNA replication licensing factor MCM7

1

10

Small-scale

0.479

High

717533

BMI1
Polycomb complex protein BMI-1

1

18

Small-scale

0.479

High

719906

RFA3
Replication protein A 14 kDa subunit

1

10

High-throughput

0.479

High

722185

RFC1
Replication factor C subunit 1

1

10

Small-scale

0.479

High

722570

T2FA
General transcription factor IIF subunit 1

1

3

Small-scale

0.479

High

723673

HXD13
Homeobox protein Hox-D13

1

7

Small-scale

0.479

High

782499

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

802405

MCM2
DNA replication licensing factor MCM2

1

13

Small-scale

0.479

High

802407

MECP2
Methyl-CpG-binding protein 2

1

19

Small-scale

0.479

High

802409

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

802412

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

Small-scale

0.479

High

802414

RS7
Small ribosomal subunit protein eS7

1

4

High-throughput

0.479

High

802417

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.479

High

802420

PHC1
Polyhomeotic-like protein 1

1

12

Small-scale

0.479

High

802421

PRKDC
DNA-dependent protein kinase catalytic subunit

1

13

Small-scale

0.479

High

802425

CENPC
Centromere protein C

1

6

Small-scale

0.479

High

802430

TIF1B
Transcription intermediary factor 1-beta

1

18

Small-scale

0.479

High

802431

MTA1
Metastasis-associated protein MTA1

1

20

Small-scale

0.479

High

802432

SNW1
SNW domain-containing protein 1

1

10

High-throughput

0.479

High

802436

RBM39
RNA-binding protein 39

1

15

Small-scale

0.479

High

802437

MCM6
DNA replication licensing factor MCM6

1

12

Small-scale

0.479

High

802439

SETB1
Histone-lysine N-methyltransferase SETDB1

1

20

Small-scale

0.479

High

802445

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

2

Small-scale

0.479

High

802450

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

15

High-throughput

0.479

High

802451

ZFHX4
Zinc finger homeobox protein 4

1

8

Small-scale

0.479

High

802452

NAA40
N-alpha-acetyltransferase 40

1

7

High-throughput

0.479

High

802453

P66A
Transcriptional repressor p66-alpha

1

12

Small-scale

0.479

High

802454

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

12

Small-scale

0.479

High

802457

SMC5
Structural maintenance of chromosomes protein 5

1

19

High-throughput

0.479

High

802459

ZN687
Zinc finger protein 687

1

8

Small-scale

0.479

High

802460

SIR6
NAD-dependent protein deacylase sirtuin-6

1

14

High-throughput

0.479

High

802461

PAF1
RNA polymerase II-associated factor 1 homolog

1

6

Small-scale

0.479

High

802462

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

802463

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

6

Small-scale

0.479

High

802465

P66B
Transcriptional repressor p66-beta

1

12

Small-scale

0.479

High

802466

THAP4
Peroxynitrite isomerase THAP4

1

2

Small-scale

0.479

High

802467

ZN592
Zinc finger protein 592

1

8

Small-scale

0.479

High

802468

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

802470

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.479

High

802473

FUBP1
Far upstream element-binding protein 1

1

13

Small-scale

0.479

High

802475

ZN274
Neurotrophin receptor-interacting factor homolog

1

12

Small-scale

0.479

High

802476

TONSL
Tonsoku-like protein

1

10

High-throughput

0.479

High

802483

RBM14
RNA-binding protein 14

1

9

High-throughput

0.479

High

802485

WRIP1
ATPase WRNIP1

1

9

Small-scale

0.479

High

802488

FEV
Protein FEV

1

20

High-throughput

0.479

High

802491

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

7

High-throughput

0.479

High

802492

HIRP3
HIRA-interacting protein 3

1

2

High-throughput

0.479

High

802494

SETD2
Histone-lysine N-methyltransferase SETD2

1

20

Small-scale

0.479

High

802495

SENP6
Sentrin-specific protease 6

1

3

Small-scale

0.479

High

802497

ADNP
Activity-dependent neuroprotector homeobox protein

1

8

Small-scale

0.479

High

802498

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

802503

SALL1
Sal-like protein 1

1

12

Small-scale

0.479

High

802507

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

8

Small-scale

0.479

High

802510

ZMYM2
Zinc finger MYM-type protein 2

1

6

Small-scale

0.479

High

802511

CFDP1
Craniofacial development protein 1

1

2

Small-scale

0.479

High

802513

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

802514

TBK1
Serine/threonine-protein kinase TBK1

1

7

High-throughput

0.479

High

802518

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

Small-scale

0.479

High

802520

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

High-throughput

0.479

High

802521

SMC3
Structural maintenance of chromosomes protein 3

1

15

Small-scale

0.479

High

802523

ZN281
Zinc finger protein 281

1

3

Small-scale

0.479

High

802526

MORC2
ATPase MORC2

1

2

Small-scale

0.479

High

802508

RRBP1
Ribosome-binding protein 1

1

14

High-throughput

0.470

High

313774

SVIL
Supervillin

1

0

Small-scale

0.460

High

238261

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.458

High

802443

SPIN3
Spindlin-3

1

0

High-throughput

0.458

High

802456

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

Small-scale

0.458

High

802464

CATIN
Splicing factor Cactin

1

0

Small-scale

0.458

High

802477

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.458

High

802478

EAF1
ELL-associated factor 1

1

0

High-throughput

0.458

High

802481

ZMAT2
Zinc finger matrin-type protein 2

1

0

Small-scale

0.458

High

802489

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

802506

GID8
Glucose-induced degradation protein 8 homolog

1

0

High-throughput

0.458

High

802427

FMR1
Fragile X messenger ribonucleoprotein 1

1

13

High-throughput

0.457

High

802517

TNIK
TRAF2 and NCK-interacting protein kinase

1

7

High-throughput

0.457

High

484076

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

528733

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

802446

ANO7
Anoctamin-7

1

1

Small-scale

0.437

High

802424

MDM2
E3 ubiquitin-protein ligase Mdm2

1

6

Small-scale

0.408

High

802502

RASF1
Ras association domain-containing protein 1

1

1

Small-scale

0.408

High

802487

CK5P2
CDK5 regulatory subunit-associated protein 2

1

14

High-throughput

0.407

High

802504

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.292

High

802499

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.282

High

802509

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

802440

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.269

Low

802455

CCD71
Coiled-coil domain-containing protein 71

1

0

Small-scale

0.249

Low

802501

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024