Protein: TBP
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)

Gene: TBP
Organism: Homo sapiens
Interactions: 234
UniProt ID: P20226

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

589777

TAF1
Transcription initiation factor TFIID subunit 1

19

14

Small-scale

0.986

High

589812

TF2AA
Transcription initiation factor IIA subunit 1

14

10

Small-scale

0.983

High

589865

TAF11
Transcription initiation factor TFIID subunit 11

9

2

Small-scale

0.971

High

589904

TF3B
Transcription factor IIIB 90 kDa subunit

8

13

Small-scale

0.971

High

124164

TAF4
Transcription initiation factor TFIID subunit 4

10

4

Small-scale

0.970

High

589827

TF2B
Transcription initiation factor IIB

8

13

Small-scale

0.964

High

589813

T2AG
Transcription initiation factor IIA subunit 2

6

4

Small-scale

0.946

High

589834

NC2B
Protein Dr1

5

4

Small-scale

0.917

High

589861

NC2A
Dr1-associated corepressor

4

2

Small-scale

0.886

High

589864

TAF13
Transcription initiation factor TFIID subunit 13

3

3

Small-scale

0.877

High

589773

TBP
TATA-box-binding protein

3

4

Small-scale

0.817

High

589899

TAF4B
Transcription initiation factor TFIID subunit 4B

2

4

Small-scale

0.789

High

589893

TAF1L
Transcription initiation factor TFIID subunit 1-like

2

15

Small-scale

0.775

High

589863

TAF5
Transcription initiation factor TFIID subunit 5

16

8

Small-scale

0.760

High

589808

TAF6
Transcription initiation factor TFIID subunit 6

13

6

Small-scale

0.757

High

589874

TAF12
Transcription initiation factor TFIID subunit 12

9

2

Small-scale

0.755

High

589848

TAF10
Transcription initiation factor TFIID subunit 10

13

6

Small-scale

0.755

High

386078

P53
Cellular tumor antigen p53

10

1

Small-scale

0.754

High

589866

TAF7
Transcription initiation factor TFIID subunit 7

9

5

Small-scale

0.747

High

589868

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

6

1

Small-scale

0.737

High

589877

TAF9
Transcription initiation factor TFIID subunit 9

6

3

Small-scale

0.724

High

589781

NFYB
Nuclear transcription factor Y subunit beta

1

4

Small-scale

0.724

High

589867

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

5

1

Small-scale

0.718

High

589890

TAF8
Transcription initiation factor TFIID subunit 8

5

5

Small-scale

0.716

High

589880

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

4

1

Small-scale

0.702

High

589780

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

4

Small-scale

0.698

High

589921

CUED2
CUE domain-containing protein 2

4

1

High-throughput

0.695

High

589870

IKBB
NF-kappa-B inhibitor beta

4

1

High-throughput

0.694

High

61751

BDP1
Transcription factor TFIIIB component B'' homolog

1

2

High-throughput

0.691

High

589883

TAF3
Transcription initiation factor TFIID subunit 3

4

4

Small-scale

0.689

High

368973

ESR1
Estrogen receptor

4

7

Small-scale

0.680

High

589831

E2F1
Transcription factor E2F1

3

1

Small-scale

0.678

High

163560

BTAF1
TATA-binding protein-associated factor 172

3

6

Small-scale

0.676

High

589782

BRD2
Bromodomain-containing protein 2

3

7

Small-scale

0.674

High

589887

TAF2
Transcription initiation factor TFIID subunit 2

4

2

Small-scale

0.672

High

589797

T2FA
General transcription factor IIF subunit 1

4

0

Small-scale

0.671

High

345324

FOS
Protein c-Fos

3

2

Small-scale

0.670

High

589817

PSME3
Proteasome activator complex subunit 3

3

1

High-throughput

0.669

High

589922

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

4

0

Small-scale

0.667

High

242977

EDF1
Endothelial differentiation-related factor 1

3

2

Small-scale

0.663

High

589923

BRF2
Transcription factor IIIB 50 kDa subunit

3

13

Small-scale

0.656

High

589787

MSX1
Homeobox protein MSX-1

3

1

Small-scale

0.651

High

589840

TF65
Transcription factor p65

3

1

Small-scale

0.651

High

589938

TF2AY
TFIIA-alpha and beta-like factor

1

10

Small-scale

0.647

High

589778

TCEA1
Transcription elongation factor A protein 1

3

2

Small-scale

0.646

High

589788

T2EA
General transcription factor IIE subunit 1

3

0

Small-scale

0.639

High

572533

SPI1
Transcription factor PU.1

2

5

Small-scale

0.634

High

449535

HMGB1
High mobility group protein B1

2

1

Small-scale

0.629

High

589800

ZNF76
Zinc finger protein 76

2

1

Small-scale

0.620

High

589919

RPC6
DNA-directed RNA polymerase III subunit RPC6

2

1

Small-scale

0.619

High

589820

TBPL1
TATA box-binding protein-like 1

1

4

High-throughput

0.618

High

589830

MDM2
E3 ubiquitin-protein ligase Mdm2

2

1

Small-scale

0.613

High

589854

SNPC2
snRNA-activating protein complex subunit 2

2

0

Small-scale

0.612

High

401403

JUN
Transcription factor Jun

2

1

Small-scale

0.611

High

589881

TAF7L
Transcription initiation factor TFIID subunit 7-like

2

5

Small-scale

0.611

High

589917

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

Small-scale

0.611

High

589924

TAF9B
Transcription initiation factor TFIID subunit 9B

2

3

Small-scale

0.611

High

589873

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.603

High

589798

AHR
Aryl hydrocarbon receptor

2

1

Small-scale

0.602

High

434938

SP1
Transcription factor Sp1

2

1

Small-scale

0.594

High

447469

PO2F2
POU domain, class 2, transcription factor 2

1

3

Small-scale

0.589

High

540779

PO2F1
POU domain, class 2, transcription factor 1

1

4

Small-scale

0.589

High

589818

WDR5
WD repeat-containing protein 5

2

2

Small-scale

0.584

High

589789

T2EB
Transcription initiation factor IIE subunit beta

2

0

Small-scale

0.577

High

589902

RBP56
TATA-binding protein-associated factor 2N

2

1

Small-scale

0.571

High

542180

PLAK
Junction plakoglobin

1

2

Small-scale

0.561

High

589784

PAX6
Paired box protein Pax-6

1

3

Small-scale

0.561

High

589837

PAX5
Paired box protein Pax-5

1

3

Small-scale

0.561

High

589875

SNPC1
snRNA-activating protein complex subunit 1

1

1

Small-scale

0.561

High

589936

YETS2
YEATS domain-containing protein 2

1

2

Small-scale

0.561

High

589774

PO3F2
POU domain, class 3, transcription factor 2

1

3

Small-scale

0.552

High

589862

CND2
Condensin complex subunit 2

1

1

Small-scale

0.552

High

589900

TF2H4
General transcription factor IIH subunit 4

1

1

Small-scale

0.550

High

589832

SET
Protein SET

1

1

Small-scale

0.546

High

201903

WDR62
WD repeat-containing protein 62

1

1

High-throughput

0.541

High

589849

REST
RE1-silencing transcription factor

1

0

Small-scale

0.537

High

155990

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

4

High-throughput

0.536

High

169793

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.536

High

175953

FOXN1
Forkhead box protein N1

1

3

High-throughput

0.536

High

267619

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.536

High

267741

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

8

High-throughput

0.536

High

270179

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

1

High-throughput

0.536

High

364826

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

402710

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

1

High-throughput

0.536

High

473591

DC8L2
DDB1- and CUL4-associated factor 8-like protein 2

1

1

High-throughput

0.536

High

571304

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.536

High

583644

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

High-throughput

0.536

High

586562

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

589783

MOES
Moesin

1

1

High-throughput

0.536

High

589792

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.536

High

589814

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

589816

MAX
Protein max

1

2

High-throughput

0.536

High

589821

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.536

High

589833

FOXK2
Forkhead box protein K2

1

2

High-throughput

0.536

High

589842

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

589850

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.536

High

589851

MK07
Mitogen-activated protein kinase 7

1

1

High-throughput

0.536

High

589903

FOXJ1
Forkhead box protein J1

1

3

High-throughput

0.536

High

589920

FOXP1
Forkhead box protein P1

1

5

High-throughput

0.536

High

589927

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.536

High

589930

FOXJ2
Forkhead box protein J2

1

3

High-throughput

0.536

High

589944

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.536

High

589844

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.533

High

587114

RXRA
Retinoic acid receptor RXR-alpha

1

3

Small-scale

0.527

High

528525

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

394097

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

175521

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.513

High

181389

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

297897

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.513

High

313390

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.513

High

589785

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

589804

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

589811

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

589856

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

589885

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.513

High

589888

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

0

High-throughput

0.513

High

589892

RN168
E3 ubiquitin-protein ligase RNF168

1

0

High-throughput

0.513

High

589908

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.513

High

589910

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.513

High

589911

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.513

High

589916

SPT25
Spermatogenesis-associated protein 25

1

0

High-throughput

0.513

High

589918

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

589926

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.513

High

589934

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.513

High

589931

CXXC1
CXXC-type zinc finger protein 1

1

1

High-throughput

0.508

High

345906

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.501

High

377083

GCR
Glucocorticoid receptor

1

8

Small-scale

0.501

High

414436

PRGR
Progesterone receptor

1

7

Small-scale

0.501

High

487121

ANDR
Androgen receptor

1

7

Small-scale

0.501

High

534057

T2FB
General transcription factor IIF subunit 2

1

1

Small-scale

0.501

High

541981

ETS1
Protein C-ets-1

1

3

Small-scale

0.501

High

589776

BCL3
B-cell lymphoma 3 protein

1

1

Small-scale

0.501

High

589779

PAX3
Paired box protein Pax-3

1

3

Small-scale

0.501

High

589803

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

589826

ELF3
ETS-related transcription factor Elf-3

1

5

Small-scale

0.501

High

589829

HSF1
Heat shock factor protein 1

1

3

Small-scale

0.501

High

589835

SPIB
Transcription factor Spi-B

1

5

Small-scale

0.501

High

589841

REL
Proto-oncogene c-Rel

1

1

Small-scale

0.501

High

589847

FOXF2
Forkhead box protein F2

1

3

Small-scale

0.501

High

589857

KLF5
Krueppel-like factor 5

1

2

Small-scale

0.501

High

589858

NFYC
Nuclear transcription factor Y subunit gamma

1

2

Small-scale

0.501

High

589859

NCOA6
Nuclear receptor coactivator 6

1

1

Small-scale

0.501

High

589872

NCOA1
Nuclear receptor coactivator 1

1

1

Small-scale

0.501

High

589940

RUVB2
RuvB-like 2

1

5

Small-scale

0.501

High

589941

RUVB1
RuvB-like 1

1

5

Small-scale

0.501

High

589828

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.493

High

589947

EMIL1
EMILIN-1

1

1

High-throughput

0.489

High

589886

HMBX1
Homeobox-containing protein 1

1

5

High-throughput

0.481

High

589942

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.481

High

414163

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.480

High

579240

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.480

High

589786

TEAD1
Transcriptional enhancer factor TEF-1

1

0

Small-scale

0.480

High

589790

KDM5A
Lysine-specific demethylase 5A

1

0

Small-scale

0.480

High

589807

MCM2
DNA replication licensing factor MCM2

1

0

Small-scale

0.480

High

589823

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

589825

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.480

High

589838

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.480

High

589852

CTBP1
C-terminal-binding protein 1

1

0

Small-scale

0.480

High

589853

IKZF1
DNA-binding protein Ikaros

1

0

Small-scale

0.480

High

589882

SNPC4
snRNA-activating protein complex subunit 4

1

0

Small-scale

0.480

High

589889

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.480

High

589894

CTCFL
Transcriptional repressor CTCFL

1

0

Small-scale

0.480

High

589897

TF3C2
General transcription factor 3C polypeptide 2

1

0

Small-scale

0.480

High

589913

HTF4
Transcription factor 12

1

0

Small-scale

0.480

High

589915

CITE2
Cbp/p300-interacting transactivator 2

1

0

Small-scale

0.480

High

589932

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.480

High

589935

TF3C4
General transcription factor 3C polypeptide 4

1

0

Small-scale

0.480

High

589945

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.480

High

589946

TF3C3
General transcription factor 3C polypeptide 3

1

0

Small-scale

0.480

High

226501

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

294355

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

567632

UBF1
Nucleolar transcription factor 1

1

1

Small-scale

0.479

High

589793

ELF1
ETS-related transcription factor Elf-1

1

3

High-throughput

0.479

High

589796

MERL
Merlin

1

1

High-throughput

0.479

High

589799

PRS7
26S proteasome regulatory subunit 7

1

4

Small-scale

0.479

High

589805

CBX5
Chromobox protein homolog 5

1

1

Small-scale

0.479

High

589810

SMCA2
Probable global transcription activator SNF2L2

1

3

Small-scale

0.479

High

589819

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.479

High

589822

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

Small-scale

0.479

High

589824

H31
Histone H3.1

1

2

High-throughput

0.479

High

589836

MEF2A
Myocyte-specific enhancer factor 2A

1

1

Small-scale

0.479

High

589845

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

589855

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.479

High

589860

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

589871

ELF2
ETS-related transcription factor Elf-2

1

3

High-throughput

0.479

High

589901

CBP
CREB-binding protein

1

5

Small-scale

0.479

High

589937

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

589939

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.479

High

589906

COQA1
Collagen alpha-1(XXVI) chain

1

1

High-throughput

0.464

High

589801

SPB5
Serpin B5

1

0

Small-scale

0.460

High

173935

ATX7
Ataxin-7

1

0

Small-scale

0.458

High

179545

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.458

High

434560

ERCC1
DNA excision repair protein ERCC-1

1

0

Small-scale

0.458

High

455081

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

500993

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

589775

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

589791

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.458

High

589794

C2TA
MHC class II transactivator

1

0

Small-scale

0.458

High

589802

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

589806

CDX1
Homeobox protein CDX-1

1

0

Small-scale

0.458

High

589839

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.458

High

589843

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

589846

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

Small-scale

0.458

High

589869

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

Small-scale

0.458

High

589876

B2LA1
Bcl-2-related protein A1

1

0

Small-scale

0.458

High

589884

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.458

High

589891

MKX
Homeobox protein Mohawk

1

0

Small-scale

0.458

High

589895

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

Small-scale

0.458

High

589912

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

589914

EYA3
Eyes absent homolog 3

1

0

High-throughput

0.458

High

589929

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.458

High

271826

CREG1
Protein CREG1

1

1

Small-scale

0.457

High

589795

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

589925

CBX8
Chromobox protein homolog 8

1

2

Small-scale

0.445

High

352867

IFNB
Interferon beta

1

1

Small-scale

0.437

High

589878

H31T
Histone H3.1t

1

2

High-throughput

0.408

High

589909

LRC46
Leucine-rich repeat-containing protein 46

3

0

High-throughput

0.347

High

589905

FATE1
Fetal and adult testis-expressed transcript protein

1

0

High-throughput

0.282

High

224900

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

245310

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

354671

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.279

Low

526640

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.279

Low

589809

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.279

Low

589896

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

589898

OIT3
Oncoprotein-induced transcript 3 protein

1

0

High-throughput

0.279

Low

589907

K1143
Uncharacterized protein KIAA1143

1

0

High-throughput

0.279

Low

589928

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.279

Low

589815

HAP1
Huntingtin-associated protein 1

1

0

High-throughput

0.265

Low

352985

IL1B
Interleukin-1 beta

1

0

Small-scale

0.249

Low

438911

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

Small-scale

0.249

Low

589879

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

589933

GBG12

1

0

Small-scale

0.249

Low

589943

TMED7
Transmembrane emp24 domain-containing protein 7

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024