Protein: TSC2
Tuberin (Tuberous sclerosis 2 protein)

Gene: TSC2
Organism: Homo sapiens
Interactions: 164
UniProt ID: P49815

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

835062

RHEB
GTP-binding protein Rheb

7

12

Small-scale

0.971

High

835090

TSC1
Hamartin

31

12

Small-scale

0.769

High

683209

1433B
14-3-3 protein beta/alpha

14

20

Small-scale

0.763

High

835039

1433Z
14-3-3 protein zeta/delta

9

20

Small-scale

0.755

High

646730

1433T
14-3-3 protein theta

8

20

Small-scale

0.747

High

835033

1433G
14-3-3 protein gamma

6

20

Small-scale

0.737

High

835037

RAP1A
Ras-related protein Rap-1A

2

14

Small-scale

0.737

High

835048

1433F
14-3-3 protein eta

6

20

Small-scale

0.729

High

835035

1433E
14-3-3 protein epsilon

6

8

Small-scale

0.728

High

835120

TBCD7
TBC1 domain family member 7

5

2

Small-scale

0.723

High

835026

GSK3B
Glycogen synthase kinase-3 beta

3

7

Small-scale

0.674

High

835054

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

3

1

Small-scale

0.670

High

369199

ESR1
Estrogen receptor

2

8

Small-scale

0.653

High

274076

XRP2
Protein XRP2

3

0

High-throughput

0.638

High

835059

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

3

10

High-throughput

0.633

High

835034

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

7

Small-scale

0.629

High

835049

UBE3A
Ubiquitin-protein ligase E3A

2

1

Small-scale

0.629

High

835063

KS6A1
Ribosomal protein S6 kinase alpha-1

2

3

Small-scale

0.629

High

506370

RALA
Ras-related protein Ral-A

1

12

Small-scale

0.618

High

835025

TSC2
Tuberin

1

8

High-throughput

0.618

High

835027

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.618

High

835028

RAB9A
Ras-related protein Rab-9A

1

7

High-throughput

0.618

High

835036

RHOB
Rho-related GTP-binding protein RhoB

1

19

Small-scale

0.618

High

804082

CDN1B
Cyclin-dependent kinase inhibitor 1B

2

3

Small-scale

0.612

High

835031

DAPK1
Death-associated protein kinase 1

2

4

Small-scale

0.601

High

270593

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

6

Small-scale

0.596

High

681741

AKT1
RAC-alpha serine/threonine-protein kinase

2

2

Small-scale

0.595

High

683908

1433S
14-3-3 protein sigma

2

20

Small-scale

0.595

High

835081

PNKD
Probable hydrolase PNKD

2

0

High-throughput

0.585

High

622401

CCND1
G1/S-specific cyclin-D1

2

5

Small-scale

0.584

High

835076

RRAGA
Ras-related GTP-binding protein A

2

5

Small-scale

0.584

High

835094

FBXW5
F-box/WD repeat-containing protein 5

2

1

Small-scale

0.584

High

658854

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.578

High

835053

FOXO1
Forkhead box protein O1

1

2

Small-scale

0.578

High

592159

RAB5A
Ras-related protein Rab-5A

1

2

Small-scale

0.575

High

835078

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

1

High-throughput

0.574

High

835123

COKA1

2

3

High-throughput

0.574

High

835042

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.561

High

835050

FAK1
Focal adhesion kinase 1

1

3

Small-scale

0.561

High

170621

AXIN1
Axin-1

2

0

Small-scale

0.559

High

835116

PICK1
PRKCA-binding protein

1

0

High-throughput

0.558

High

198184

SEPT4
Septin-4

1

1

High-throughput

0.541

High

725631

ACTN2
Alpha-actinin-2

1

1

High-throughput

0.541

High

736320

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.541

High

835079

PHLB1
Pleckstrin homology-like domain family B member 1

1

13

High-throughput

0.541

High

835080

ANR35
Ankyrin repeat domain-containing protein 35

1

3

High-throughput

0.541

High

835093

TRI63
E3 ubiquitin-protein ligase TRIM63

1

6

High-throughput

0.541

High

835107

TRI55
Tripartite motif-containing protein 55

1

6

High-throughput

0.541

High

171958

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

180018

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

1

High-throughput

0.536

High

835106

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

835084

INADL
InaD-like protein

1

9

Small-scale

0.529

High

580171

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

0

Small-scale

0.529

High

381862

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.518

High

445326

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.518

High

835061

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

835127

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.518

High

116987

SGK1
Serine/threonine-protein kinase Sgk1

1

1

Small-scale

0.515

High

414824

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.515

High

538495

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.515

High

590144

CCNA2
Cyclin-A2

1

1

Small-scale

0.515

High

835030

PLK1
Serine/threonine-protein kinase PLK1

1

3

Small-scale

0.515

High

835066

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.515

High

196744

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.513

High

362180

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

771146

TPOR
Thrombopoietin receptor

1

0

High-throughput

0.513

High

835043

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.513

High

835044

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

835086

ARRD2
Arrestin domain-containing protein 2

1

0

High-throughput

0.513

High

835095

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

0

High-throughput

0.513

High

835096

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

835100

OPALI
Opalin

1

0

High-throughput

0.513

High

835108

SEM4C
Semaphorin-4C

1

0

High-throughput

0.513

High

835113

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

835118

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

835121

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

835126

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.513

High

835129

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

835132

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

835133

TMED5
Transmembrane emp24 domain-containing protein 5

1

0

High-throughput

0.513

High

835135

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.513

High

835136

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

835137

NPTN
Neuroplastin

1

0

High-throughput

0.513

High

835038

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.508

High

835101

NEK1
Serine/threonine-protein kinase Nek1

1

2

Small-scale

0.508

High

787419

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.501

High

835052

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

2

Small-scale

0.501

High

835119

PLK2
Serine/threonine-protein kinase PLK2

1

4

Small-scale

0.501

High

835088

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

1

High-throughput

0.494

High

835098

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.493

High

835065

CD226
CD226 antigen

1

1

High-throughput

0.489

High

835109

DNAI2
Dynein axonemal intermediate chain 2

1

2

High-throughput

0.489

High

378653

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

835056

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.486

High

835085

LNX1
E3 ubiquitin-protein ligase LNX

1

11

Small-scale

0.481

High

835103

MDFI
MyoD family inhibitor

1

1

High-throughput

0.481

High

787870

EPS15
Epidermal growth factor receptor substrate 15

1

0

High-throughput

0.480

High

150912

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

12

Small-scale

0.479

High

205178

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

282854

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

High-throughput

0.479

High

384493

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

422153

NFL
Neurofilament light polypeptide

1

8

Small-scale

0.479

High

515377

CDK4
Cyclin-dependent kinase 4

1

3

Small-scale

0.479

High

527352

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

610298

CBL
E3 ubiquitin-protein ligase CBL

1

1

Small-scale

0.479

High

673040

CCND2
G1/S-specific cyclin-D2

1

5

Small-scale

0.479

High

673131

CCND3
G1/S-specific cyclin-D3

1

5

Small-scale

0.479

High

779025

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

835040

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

3

Small-scale

0.479

High

835046

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

835057

CUL3
Cullin-3

1

2

High-throughput

0.479

High

835058

CUL4A
Cullin-4A

1

2

Small-scale

0.479

High

835064

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

5

Small-scale

0.479

High

835067

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

835068

RRAGB
Ras-related GTP-binding protein B

1

5

Small-scale

0.479

High

835074

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

835087

RBCC1
RB1-inducible coiled-coil protein 1

1

5

Small-scale

0.479

High

835104

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

Small-scale

0.479

High

835105

LST8
Target of rapamycin complex subunit LST8

1

1

Small-scale

0.479

High

835111

Q9H4D1
Protein kinase

1

3

High-throughput

0.479

High

835112

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

835114

RRAGC
Ras-related GTP-binding protein C

1

5

Small-scale

0.479

High

835115

RRAGD
Ras-related GTP-binding protein D

1

5

Small-scale

0.479

High

835124

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.479

High

835130

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.479

High

835134

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

835041

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.460

High

196279

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.458

High

199871

SPIT2
Kunitz-type protease inhibitor 2

1

0

High-throughput

0.458

High

273727

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

503689

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

835029

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

835060

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

835070

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

835071

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

835072

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.458

High

835097

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

835117

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

835128

TBK1
Serine/threonine-protein kinase TBK1

1

0

Small-scale

0.458

High

835131

RUVB2
RuvB-like 2

1

0

High-throughput

0.458

High

835075

SPT6H
Transcription elongation factor SPT6

1

2

Small-scale

0.457

High

835032

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

835047

CAV1
Caveolin-1

1

1

Small-scale

0.445

High

835083

CBY2
Protein chibby homolog 2

1

1

High-throughput

0.439

High

835092

HTRA1
Serine protease HTRA1

1

0

Small-scale

0.438

High

536330

GLU2B
Glucosidase 2 subunit beta

3

0

High-throughput

0.347

High

61778

F221B
Protein FAM221B

2

0

High-throughput

0.328

High

771173

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

835045

CD83
CD83 antigen

2

0

High-throughput

0.328

High

835082

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

835069

USPL1
SUMO-specific isopeptidase USPL1

1

0

High-throughput

0.282

High

835077

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.282

High

835089

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.282

High

835102

NEUS
Neuroserpin

1

0

High-throughput

0.282

High

835051

ZP2
Zona pellucida sperm-binding protein 2

1

0

High-throughput

0.279

Low

835055

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

835110

TSN10
Tetraspanin-10

1

0

High-throughput

0.279

Low

835125

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

118236

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

835073

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

835091

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low

835099

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

835122

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024