Protein: TPX2
Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)

Gene: TPX2
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q9ULW0

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000922 - spindle pole
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

160850

AURKA
Aurora kinase A

13

1

Small-scale

0.983

High

1082655

MK14
Mitogen-activated protein kinase 14

3

2

High-throughput

0.861

High

960261

CDK6
Cyclin-dependent kinase 6

1

2

Small-scale

0.735

High

596836

CD11B
Cyclin-dependent kinase 11B

1

2

High-throughput

0.691

High

1336454

KC1G1
Casein kinase I isoform gamma-1

1

1

High-throughput

0.691

High

1348699

CDK12
Cyclin-dependent kinase 12

1

3

High-throughput

0.691

High

1357085

KC1G3
Casein kinase I isoform gamma-3

1

1

High-throughput

0.691

High

360537

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

2

High-throughput

0.676

High

597555

GSTM3
Glutathione S-transferase Mu 3

3

1

High-throughput

0.667

High

158565

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

Small-scale

0.665

High

167629

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

7

Small-scale

0.665

High

1255613

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.665

High

749952

BRCA1
Breast cancer type 1 susceptibility protein

3

2

Small-scale

0.656

High

995300

GOGA2
Golgin subfamily A member 2

3

0

High-throughput

0.643

High

935366

H31
Histone H3.1

3

3

High-throughput

0.640

High

149413

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.618

High

375081

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.618

High

647981

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

High-throughput

0.618

High

1044267

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.618

High

1183147

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.618

High

1292291

AURKB
Aurora kinase B

1

1

Small-scale

0.618

High

1349679

MARK1
Serine/threonine-protein kinase MARK1

1

2

High-throughput

0.618

High

1355353

TBK1
Serine/threonine-protein kinase TBK1

1

6

High-throughput

0.618

High

348217

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

554044

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

918771

H2B1C
Histone H2B type 1-C/E/F/G/I

2

11

High-throughput

0.584

High

370697

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

1218354

ARHGJ
Rho guanine nucleotide exchange factor 19

2

5

High-throughput

0.571

High

652593

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

655503

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

High-throughput

0.559

High

721765

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

199156

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

0

Small-scale

0.549

High

876923

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.541

High

61907

MP3B2
Microtubule-associated proteins 1A/1B light chain 3 beta 2

1

5

High-throughput

0.536

High

176306

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.536

High

202318

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

2

High-throughput

0.536

High

259631

HMMR
Hyaluronan mediated motility receptor

1

4

Small-scale

0.536

High

455994

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

470205

H2AZ
Histone H2A.Z

1

5

High-throughput

0.536

High

470608

H2A1
Histone H2A type 1

1

4

High-throughput

0.536

High

565067

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

801463

KI67
Proliferation marker protein Ki-67

1

7

High-throughput

0.536

High

821084

PRC2A
Protein PRRC2A

1

7

High-throughput

0.536

High

833053

YLPM1
YLP motif-containing protein 1

1

5

High-throughput

0.536

High

967513

EWS
RNA-binding protein EWS

1

1

High-throughput

0.536

High

970750

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

1017366

BPTF
Nucleosome-remodeling factor subunit BPTF

1

6

High-throughput

0.536

High

1018440

SFSWA
Splicing factor, suppressor of white-apricot homolog

1

3

High-throughput

0.536

High

1034043

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

1

High-throughput

0.536

High

1049542

SAFB2
Scaffold attachment factor B2

1

9

High-throughput

0.536

High

1056642

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

5

High-throughput

0.536

High

1087481

H2B2E
Histone H2B type 2-E

1

11

High-throughput

0.536

High

1167444

MPRIP
Myosin phosphatase Rho-interacting protein

1

1

High-throughput

0.536

High

1254037

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

4

High-throughput

0.536

High

1259979

PHF10
PHD finger protein 10

1

2

High-throughput

0.536

High

1267654

PHF3
PHD finger protein 3

1

2

High-throughput

0.536

High

1271116

EZH1
Histone-lysine N-methyltransferase EZH1

1

6

High-throughput

0.536

High

1309971

BUD13
BUD13 homolog

1

4

High-throughput

0.536

High

1312012

DIDO1
Death-inducer obliterator 1

1

9

High-throughput

0.536

High

1327640

SP130
Histone deacetylase complex subunit SAP130

1

5

High-throughput

0.536

High

1327750

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.536

High

1336686

CHM1A
Charged multivesicular body protein 1a

1

1

High-throughput

0.536

High

1345273

HELLS
Lymphoid-specific helicase

1

2

High-throughput

0.536

High

1346282

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.536

High

1347213

SLTM
SAFB-like transcription modulator

1

5

High-throughput

0.536

High

1349605

RAI14
Ankycorbin

1

3

High-throughput

0.536

High

1354502

ZO2
Tight junction protein ZO-2

1

2

High-throughput

0.536

High

1356594

HDAC9
Histone deacetylase 9

1

1

High-throughput

0.536

High

1357078

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

3

High-throughput

0.536

High

1357081

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

2

High-throughput

0.536

High

1289776

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.518

High

739348

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.515

High

313908

SVIL
Supervillin

1

0

High-throughput

0.513

High

324115

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

574473

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

880069

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.513

High

987017

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

1029356

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1030548

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

1169201

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.513

High

1183375

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.513

High

1234154

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.513

High

1239290

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.513

High

1243232

NGDN
Neuroguidin

1

0

High-throughput

0.513

High

1250759

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

1251073

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.513

High

1260492

CATIN
Splicing factor Cactin

1

0

High-throughput

0.513

High

1261511

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1290350

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.513

High

1294490

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.513

High

1303850

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1316165

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.513

High

1335956

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.513

High

1347181

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.513

High

1347942

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.513

High

1357080

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.513

High

1357083

PAXB1
PAX3- and PAX7-binding protein 1

1

0

High-throughput

0.513

High

1273956

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

653769

CALR
Calreticulin

1

0

High-throughput

0.493

High

1067708

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

297429

MYO1D
Unconventional myosin-Id

1

1

High-throughput

0.489

High

665362

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.489

High

1021718

MYO1E
Unconventional myosin-Ie

1

1

High-throughput

0.489

High

1138160

PR38B
Pre-mRNA-splicing factor 38B

1

2

High-throughput

0.489

High

1289271

RMXL1
RNA binding motif protein, X-linked-like-1

1

2

High-throughput

0.489

High

1356906

NEB1
Neurabin-1

1

5

High-throughput

0.489

High

902808

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

200795

ARHG9
Rho guanine nucleotide exchange factor 9

1

3

High-throughput

0.479

High

203809

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

1

High-throughput

0.479

High

206159

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

233014

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

236993

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

1

High-throughput

0.479

High

245087

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

261040

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.479

High

309154

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

331903

NSD2
Histone-lysine N-methyltransferase NSD2

1

6

Small-scale

0.479

High

487837

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

524081

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

557824

NCK1
SH2/SH3 adapter protein NCK1

1

4

High-throughput

0.479

High

570176

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

707788

H2B1B
Histone H2B type 1-B

1

11

High-throughput

0.479

High

738123

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

802774

CRK
Adapter molecule crk

1

6

High-throughput

0.479

High

809018

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

853518

IMA1
Importin subunit alpha-1

1

3

Small-scale

0.479

High

853752

IMA5
Importin subunit alpha-5

1

3

Small-scale

0.479

High

914454

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

918132

H4
Histone H4

1

1

High-throughput

0.479

High

924946

GRB2
Growth factor receptor-bound protein 2

1

5

High-throughput

0.479

High

932450

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

952697

H33
Histone H3.3

1

3

High-throughput

0.479

High

962453

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

Small-scale

0.479

High

992524

SOS2
Son of sevenless homolog 2

1

3

High-throughput

0.479

High

999206

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1026583

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1027328

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.479

High

1036995

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1054108

GRB7
Growth factor receptor-bound protein 7

1

5

Small-scale

0.479

High

1057024

MDC1
Mediator of DNA damage checkpoint protein 1

1

5

High-throughput

0.479

High

1064252

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1067191

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.479

High

1080472

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

1189034

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1222640

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

1235277

NGEF
Ephexin-1

1

5

High-throughput

0.479

High

1269917

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1300996

CIC
Protein capicua homolog

1

5

High-throughput

0.479

High

1315395

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.479

High

1335046

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1343782

ANLN
Anillin

1

1

High-throughput

0.479

High

1344363

ARHG4
Rho guanine nucleotide exchange factor 4

1

5

High-throughput

0.479

High

1349381

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

1354843

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1357077

FZR1
Fizzy-related protein homolog

1

2

Small-scale

0.479

High

1357079

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

1357084

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.479

High

522265

CADH1
Cadherin-1

1

1

High-throughput

0.470

High

123088

MEN1
Menin

1

0

High-throughput

0.458

High

210364

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

614164

TBG1
Tubulin gamma-1 chain

1

0

Small-scale

0.458

High

653028

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

672925

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.458

High

799038

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

857516

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.458

High

916962

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

959758

VIGLN
Vigilin

1

0

High-throughput

0.458

High

961320

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1060964

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

1066865

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1081442

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1200754

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1221832

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1236568

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1256476

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1270524

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1315900

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1327608

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1332763

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1348389

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1348910

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

402610

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

1172247

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1331613

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1356988

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

200702

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

989185

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

134980

IMA3
Importin subunit alpha-3

1

3

High-throughput

0.408

High

831793

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

834545

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.279

Low

843478

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

0

High-throughput

0.279

Low

1023629

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1172914

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.279

Low

1299915

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

1357082

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024