Protein: PLPL6
Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase)

Gene: PLPL6, PNPLA6
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q8IY17

Gene Ontology (top 5):
GO:0004622 - lysophospholipase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1221532

KCNS3
Potassium voltage-gated channel subfamily S member 3

2

0

High-throughput

0.770

High

1033505

ILK
Integrin-linked protein kinase

1

2

High-throughput

0.691

High

1039110

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

3

High-throughput

0.691

High

1172935

PLPL7
Patatin-like phospholipase domain-containing protein 7

1

17

High-throughput

0.691

High

885934

EVA1C
Protein eva-1 homolog C

3

1

High-throughput

0.667

High

1221523

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

3

0

High-throughput

0.638

High

702779

CADH5
Cadherin-5

2

6

High-throughput

0.628

High

1221538

PCDBG
Protocadherin beta-16

2

6

High-throughput

0.628

High

1221551

RPKL1
Ribosomal protein S6 kinase-like 1

1

20

High-throughput

0.618

High

714554

GRK5
G protein-coupled receptor kinase 5

1

20

High-throughput

0.618

High

1199478

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

0

High-throughput

0.602

High

1221530

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.602

High

369964

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

588787

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

2

3

High-throughput

0.558

High

1108702

ANR55
Ankyrin repeat domain-containing protein 55

1

1

High-throughput

0.553

High

253895

LRP3
Low-density lipoprotein receptor-related protein 3

1

1

High-throughput

0.536

High

354862

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

3

High-throughput

0.536

High

654522

CALX
Calnexin

1

1

High-throughput

0.536

High

678371

GDIA
Rab GDP dissociation inhibitor alpha

1

1

High-throughput

0.536

High

854194

JAK3
Tyrosine-protein kinase JAK3

1

5

High-throughput

0.536

High

1040162

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.536

High

1053718

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

4

High-throughput

0.536

High

1136823

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

1215836

INLR1
Interferon lambda receptor 1

1

2

High-throughput

0.536

High

1221539

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.536

High

1221544

PCDB6
Protocadherin beta-6

1

6

High-throughput

0.536

High

1221545

PCDB3
Protocadherin beta-3

1

6

High-throughput

0.536

High

1221546

PCDBB
Protocadherin beta-11

1

5

High-throughput

0.536

High

614378

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.515

High

170893

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.513

High

992018

BAX
Apoptosis regulator BAX

1

0

High-throughput

0.513

High

1125048

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1166333

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.513

High

1218803

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1221518

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

1221520

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.513

High

1221534

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

476030

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

895671

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.489

High

1103637

HFE
Hereditary hemochromatosis protein

1

2

High-throughput

0.489

High

1221547

PCDGM
Protocadherin gamma-C5

1

5

High-throughput

0.489

High

1221548

PCDGL
Protocadherin gamma-C4

1

5

High-throughput

0.489

High

1221549

PCDGH
Protocadherin gamma-B5

1

6

High-throughput

0.489

High

228001

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

779714

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

829029

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

891885

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.479

High

900670

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

929918

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.479

High

1041988

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1165740

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1217041

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1221525

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1221527

GASP2
G-protein coupled receptor-associated sorting protein 2

1

1

High-throughput

0.479

High

1221531

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1221535

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1221537

ANLN
Anillin

1

1

High-throughput

0.479

High

1221541

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

122870

MEN1
Menin

1

0

High-throughput

0.458

High

838967

EMD
Emerin

1

0

High-throughput

0.458

High

1085312

FSCN1
Fascin

1

0

High-throughput

0.458

High

1085602

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1101154

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1221519

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1221526

FAF2
FAS-associated factor 2

1

0

High-throughput

0.458

High

1221536

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1221550

TX264
Testis-expressed protein 264

1

0

High-throughput

0.458

High

129794

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

2

High-throughput

0.437

High

319257

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

347277

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

385140

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

1170729

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1221524

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

771212

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1067920

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.328

High

1221521

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.328

High

1221529

TSN17
Tetraspanin-17

2

0

High-throughput

0.318

High

49465

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

245254

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

274756

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.279

Low

560078

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.279

Low

686327

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

713119

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

856551

EFNB2
Ephrin-B2

1

0

High-throughput

0.279

Low

989628

ACHD
Acetylcholine receptor subunit delta

1

0

High-throughput

0.279

Low

1117552

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

1221528

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1221540

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1221542

NGN3
Neurogenin-3

1

0

High-throughput

0.279

Low

1221543

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

1221533

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

352178

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1221522

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1221517

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024