Protein: ICAL
Calpastatin (Calpain inhibitor) (Sperm BS-17 component)

Gene: ICAL, CAST
Organism: Homo sapiens
Interactions: 59
UniProt ID: P20810

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004866 - endopeptidase inhibitor activity
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

427843

CAN1
Calpain-1 catalytic subunit

5

5

Small-scale

0.925

High

595882

CPNS2
Calpain small subunit 2

3

6

High-throughput

0.861

High

62712

CAN8
Calpain-8

2

6

High-throughput

0.811

High

568946

CAN2
Calpain-2 catalytic subunit

2

5

Small-scale

0.789

High

595863

FNTB
Protein farnesyltransferase subunit beta

3

0

High-throughput

0.638

High

595874

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

3

High-throughput

0.628

High

565867

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

595861

BAG6
Large proline-rich protein BAG6

1

6

High-throughput

0.536

High

281142

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.515

High

398827

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

361819

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.513

High

528535

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

595866

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

595867

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

322178

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

337343

ABL1
Tyrosine-protein kinase ABL1

1

4

High-throughput

0.479

High

373672

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

412003

FYN
Tyrosine-protein kinase Fyn

1

4

High-throughput

0.479

High

521718

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

522767

SRC
Proto-oncogene tyrosine-protein kinase Src

1

4

High-throughput

0.479

High

546926

EZRI
Ezrin

1

3

High-throughput

0.479

High

557600

NCK1
SH2/SH3 adapter protein NCK1

1

8

High-throughput

0.479

High

569175

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

580920

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.479

High

582060

NUCL
Nucleolin

1

3

High-throughput

0.479

High

595857

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.479

High

595860

CRK
Adapter molecule crk

1

10

High-throughput

0.479

High

595862

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

595864

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.479

High

595865

F10A1
Hsc70-interacting protein

1

4

High-throughput

0.479

High

595868

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

595869

GRB2
Growth factor receptor-bound protein 2

1

10

High-throughput

0.479

High

595870

H31
Histone H3.1

1

12

High-throughput

0.479

High

595873

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

595877

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

595878

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

595879

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

595880

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

595881

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

595884

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

595887

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

595888

TBK1
Serine/threonine-protein kinase TBK1

1

3

High-throughput

0.479

High

595889

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

198224

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

241858

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.458

High

595859

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

595876

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

595886

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

595890

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

595883

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

595885

PDLI7
PDZ and LIM domain protein 7

1

5

High-throughput

0.445

High

470266

H2A1
Histone H2A type 1

1

5

High-throughput

0.437

High

595856

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

595858

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

595871

RON
Macrophage-stimulating protein receptor

1

4

High-throughput

0.437

High

377922

PRIO
Major prion protein

1

0

High-throughput

0.426

High

100470

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

595872

PAF15
PCNA-associated factor

1

0

Small-scale

0.249

Low

595875

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024