Protein: SIN3
Paired amphipathic helix protein sin-3 (Histone deacetylase complex subunit sin-3) (Transcriptional corepressor sin-3)

Gene: SIN3, sin-3
Organism: Caenorhabditis elegans
Interactions: 139
UniProt ID: A5JYW9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001708 - cell fate specification
GO:0003714 - transcription corepressor activity
GO:0034976 - response to endoplasmic reticulum stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

63423

SIN3
Paired amphipathic helix protein sin-3

1

3

High-throughput

0.618

High

63432

LE418
Protein let-418

1

14

High-throughput

0.618

High

63435

G5ECH0
Histone deacetylase

1

19

High-throughput

0.618

High

63459

HDA1
Histone deacetylase 1

1

20

High-throughput

0.618

High

63503

Q18605
PHD-type domain-containing protein

1

19

High-throughput

0.618

High

63537

Q9N4H7
Coatomer subunit alpha

1

1

High-throughput

0.553

High

63454

FOXO
Forkhead box protein O

1

2

High-throughput

0.508

High

63457

EYA1
Protein phosphatase eya-1

1

1

High-throughput

0.508

High

63460

MAB3
Protein male abnormal 3

1

1

High-throughput

0.508

High

63477

NHR23
Nuclear hormone receptor family member nhr-23

1

4

High-throughput

0.508

High

63506

ZTF2
Zinc finger protein ztf-2

1

0

High-throughput

0.486

High

63433

HCF1
Host cell factor homolog hcf-1

1

3

High-throughput

0.479

High

63438

DCP66
Transcription factor dcp-66

1

5

High-throughput

0.479

High

63442

SWSN4
SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4

1

17

High-throughput

0.479

High

63505

Q19007
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.479

High

63557

HBL1
Hunchback-like protein

1

2

High-throughput

0.479

High

63501

FLH2
FLYWCH transcription factor 2

1

1

High-throughput

0.464

High

63504

MXL3
Protein mxl-3

1

19

High-throughput

0.464

High

63507

Q19496
Nuclear Hormone Receptor family

1

2

High-throughput

0.464

High

63541

Q9NAE4
BZIP domain-containing protein

1

5

High-throughput

0.464

High

63543

Q9TXN8
DM domain-containing protein

1

1

High-throughput

0.464

High

63510

MAB21
Protein male abnormal 21

1

0

Small-scale

0.460

High

63436

G5ECR1
Methyl-CpG binding protein 2/3 C-terminal domain-containing protein

1

0

High-throughput

0.458

High

63475

TLK1
Serine/threonine-protein kinase tousled-like 1

1

0

High-throughput

0.458

High

63515

MEP1
MOG interacting and ectopic P-granules protein 1

1

0

High-throughput

0.458

High

63444

H2KYD4
C2H2-type domain-containing protein

1

3

High-throughput

0.451

High

63077

A5A8Q6
C2H2-type domain-containing protein

1

3

High-throughput

0.439

High

63427

D3YT85
DM domain-containing protein

1

1

High-throughput

0.439

High

47213

FPEB1
FLYWCH-type zinc finger-containing protein peb-1

1

0

High-throughput

0.438

High

63430

G5EBR7
exodeoxyribonuclease III

1

1

High-throughput

0.437

High

63434

ZTF6
Zinc finger protein ztf-6

1

1

High-throughput

0.437

High

63441

G5EF11
E2F/DP family winged-helix DNA-binding domain-containing protein

1

2

High-throughput

0.437

High

63443

G5EFX8
Not3 domain-containing protein

1

1

High-throughput

0.437

High

63448

H2L031
NOT2/NOT3/NOT5 C-terminal domain-containing protein

1

2

High-throughput

0.437

High

63473

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.437

High

63479

YKI5
Germ layers disorganized gldi-3

1

2

High-throughput

0.437

High

63488

P91482
RING-type domain-containing protein

1

2

High-throughput

0.437

High

63489

P91494
Transcription termination factor 2

1

17

High-throughput

0.437

High

63499

WDR51
WD repeat-containing protein wdr-5.1

1

2

High-throughput

0.437

High

63502

Q18241
Helicase ARIP4

1

3

High-throughput

0.437

High

63509

Q19818
RING-type E3 ubiquitin transferase

1

2

High-throughput

0.437

High

63516

Q21831
SWI/SNF Subunit INI1 DNA binding domain-containing protein

1

2

High-throughput

0.437

High

63517

NUF2
Kinetochore protein Nuf2 homolog

1

1

High-throughput

0.437

High

63528

Q95Y97
Replication protein A C-terminal domain-containing protein

1

1

High-throughput

0.437

High

63536

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.437

High

63539

Q9N4N4
Actin-related protein 4

1

2

High-throughput

0.437

High

63548

SET26
Histone-lysine N-methyltransferase set-26

1

5

High-throughput

0.437

High

63556

FLH3
FLYWCH transcription factor 3

1

1

High-throughput

0.437

High

63471

O62159
DM domain-containing protein

1

1

High-throughput

0.417

High

63495

CEH62
Homeobox protein ceh-62

1

0

High-throughput

0.265

Low

63500

Q18056
BHLH domain-containing protein

1

0

High-throughput

0.265

Low

63546

Q9TZ37
ZSWIM3 N-terminal domain-containing protein

1

0

High-throughput

0.265

Low

63382

A5HWB1
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.249

Low

63424

B1GRK6
Protein TALPID3

1

0

High-throughput

0.249

Low

63425

B9ZSG9
C2H2-type domain-containing protein

1

0

High-throughput

0.249

Low

63426

D3YT78
AF-9 ANC1 homology domain-containing protein

1

0

High-throughput

0.249

Low

63428

G2HK17
STING ER exit protein

1

0

High-throughput

0.249

Low

63429

G3MU54
Claspin

1

0

High-throughput

0.249

Low

63431

G5EBY3
Myosin-11

1

0

High-throughput

0.249

Low

63439

G5EE62
BEN domain-containing protein

1

0

High-throughput

0.249

Low

63440

G5EF02
PIP-1

1

0

High-throughput

0.249

Low

63445

H2KZ79
Ig-like domain-containing protein

1

0

High-throughput

0.249

Low

63446

H2KZH7
Retrotransposon gag protein

1

0

High-throughput

0.249

Low

63447

H2L025
RNA-directed RNA polymerase

1

0

High-throughput

0.249

Low

63449

H2L0E0
SET domain-containing protein

1

0

High-throughput

0.249

Low

63450

H2L2E3
DUF3452 domain-containing protein

1

0

High-throughput

0.249

Low

63451

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.249

Low

63452

O02074
HOOK domain-containing protein

1

0

High-throughput

0.249

Low

63453

P2R31
Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1

1

0

High-throughput

0.249

Low

63455

O17149
Alcohol dehydrogenase transcription factor myb/sant-like protein

1

0

High-throughput

0.249

Low

63456

O17643
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.249

Low

63458

O17687
Tetratricopeptide SHNi-TPR domain-containing protein

1

0

High-throughput

0.249

Low

63461

O44139
Chromo domain-containing protein

1

0

High-throughput

0.249

Low

63462

O44175
Replication factor C subunit 2

1

0

High-throughput

0.249

Low

63463

O44512
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.249

Low

63464

O45069
Queuosine 5'-phosphate N-glycosylase/hydrolase

1

0

High-throughput

0.249

Low

63465

O45548
Phosphoprotein

1

0

High-throughput

0.249

Low

63466

O45578
NR LBD domain-containing protein

1

0

High-throughput

0.249

Low

63467

O45950
C2H2-type domain-containing protein

1

0

High-throughput

0.249

Low

63468

ERGO1
Piwi-like protein ergo-1

1

0

High-throughput

0.249

Low

63469

IF4E3
Eukaryotic translation initiation factor 4E-3

1

0

High-throughput

0.249

Low

63470

LAP1
Protein Scribble homolog let-413

1

0

High-throughput

0.249

Low

63472

SYQ
Probable glutamine--tRNA ligase

1

0

High-throughput

0.249

Low

63474

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2

1

0

High-throughput

0.249

Low

63476

KLE2
Condensin-2 complex subunit kle-2

1

0

High-throughput

0.249

Low

63478

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.249

Low

63480

SUMV1
Protein sumv-1

1

0

High-throughput

0.249

Low

63481

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.249

Low

63482

CYP10
Peptidyl-prolyl cis-trans isomerase 10

1

0

High-throughput

0.249

Low

63483

P90786
Piwi-like protein 1

1

0

High-throughput

0.249

Low

63484

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.249

Low

63485

DJ11
Glutathione-independent glyoxalase DJR-1.1

1

0

High-throughput

0.249

Low

63486

SPD5
Spindle-defective protein 5

1

0

High-throughput

0.249

Low

63487

P91350
Nuclear Pore complex Protein

1

0

High-throughput

0.249

Low

63490

YP68
LUC7-related splicing factor homolog

1

0

High-throughput

0.249

Low

63491

NOP1
Pseudocleavage protein nop-1

1

0

High-throughput

0.249

Low

63492

PCF11
Polyadenylation and cleavage factor homolog 11

1

0

High-throughput

0.249

Low

63493

YRS4
Uncharacterized protein T05H10.4

1

0

High-throughput

0.249

Low

63494

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.249

Low

63496

SYLC
Leucine--tRNA ligase

1

0

High-throughput

0.249

Low

63497

Q10050
Mitochondrial ornithine transporter 1

1

0

High-throughput

0.249

Low

63498

Q17792
Homeobox domain-containing protein

1

0

High-throughput

0.249

Low

63508

Q19805
Non-structural maintenance of chromosomes element 4

1

0

High-throughput

0.249

Low

63511

SIP1
Stress-induced protein 1

1

0

High-throughput

0.249

Low

63512

MEGG1
Protein meg-1

1

0

High-throughput

0.249

Low

63513

Q21234
Integrase zinc-binding domain-containing protein

1

0

High-throughput

0.249

Low

63514

NOP56
Nucleolar protein 56

1

0

High-throughput

0.249

Low

63518

Q22047
TRansport of membrane to Cell Surface

1

0

High-throughput

0.249

Low

63519

Q22662
UBR-type domain-containing protein

1

0

High-throughput

0.249

Low

63520

TFDP1
Transcription factor dpl-1

1

0

High-throughput

0.249

Low

63521

Q23191
PUM-HD domain-containing protein

1

0

High-throughput

0.249

Low

63522

Q27GU1
Piwi domain-containing protein

1

0

High-throughput

0.249

Low

63523

Q564Z8
DUF2040 domain-containing protein

1

0

High-throughput

0.249

Low

63524

Q7KX00
nucleoside-diphosphate kinase

1

0

High-throughput

0.249

Low

63525

GLS1
Germline survival defective-1

1

0

High-throughput

0.249

Low

63526

Q93520
AAA domain-containing protein

1

0

High-throughput

0.249

Low

63527

PLP1
Transcriptional activator plp-1

1

0

High-throughput

0.249

Low

63529

Q965V4
Exportin-2

1

0

High-throughput

0.249

Low

63530

Q9BL15
tRNA

1

0

High-throughput

0.249

Low

63531

Q9BL64
Protein HGH1 homolog

1

0

High-throughput

0.249

Low

63532

Q9GYQ9
CCR4-NOT transcription complex subunit 4

1

0

High-throughput

0.249

Low

63533

Q9N3F7
C3H1-type domain-containing protein

1

0

High-throughput

0.249

Low

63534

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.249

Low

63535

Q9N492
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.249

Low

63538

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.249

Low

63540

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.249

Low

63542

Q9TXM1
Uncharacterized protein

1

0

High-throughput

0.249

Low

63544

GAR1
Probable H/ACA ribonucleoprotein complex subunit 1-like protein

1

0

High-throughput

0.249

Low

63545

Q9TYL9
Coatomer subunit beta

1

0

High-throughput

0.249

Low

63547

Q9U229
Pyr_redox_2 domain-containing protein

1

0

High-throughput

0.249

Low

63549

Q9XUR4
F-box associated domain-containing protein

1

0

High-throughput

0.249

Low

63550

Q9XUW5
RNA helicase

1

0

High-throughput

0.249

Low

63551

RPB11
Probable DNA-directed RNA polymerase II subunit RPB11

1

0

High-throughput

0.249

Low

63552

Q9XVS2
RRM domain-containing protein

1

0

High-throughput

0.249

Low

63553

LS14H
Protein LSM14 homolog car-1

1

0

High-throughput

0.249

Low

63554

Q9XWG2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.249

Low

63555

Q9XWK6
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.249

Low

63437

JUN
Transcription factor jun-1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025