Protein: DICER
Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)

Gene: DICER, DICER1
Organism: Homo sapiens
Interactions: 235
UniProt ID: Q9UPY3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356627

AGO2
Protein argonaute-2

19

20

Small-scale

0.989

High

1075651

TRBP2
RISC-loading complex subunit TARBP2

13

20

Small-scale

0.981

High

1356717

AGO1
Protein argonaute-1

6

20

Small-scale

0.949

High

269939

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

4

20

Small-scale

0.881

High

1334291

AGO3
Protein argonaute-3

3

20

Small-scale

0.847

High

994402

DHX9
ATP-dependent RNA helicase A

3

17

Small-scale

0.839

High

323319

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

20

High-throughput

0.827

High

1302246

STRBP
Spermatid perinuclear RNA-binding protein

2

20

High-throughput

0.811

High

1336290

AGO4
Protein argonaute-4

2

20

Small-scale

0.789

High

1294948

PIWL1
Piwi-like protein 1

1

20

Small-scale

0.766

High

585588

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

9

High-throughput

0.757

High

1286223

DHX58
ATP-dependent RNA helicase DHX58

1

15

High-throughput

0.757

High

1189714

PIWL4
Piwi-like protein 4

2

20

Small-scale

0.743

High

160860

AURKA
Aurora kinase A

6

6

High-throughput

0.733

High

877391

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

20

Small-scale

0.715

High

1020005

ILF3
Interleukin enhancer-binding factor 3

1

19

High-throughput

0.691

High

1261134

TRI41
E3 ubiquitin-protein ligase TRIM41

1

7

High-throughput

0.691

High

1355469

DDX20
Probable ATP-dependent RNA helicase DDX20

1

19

High-throughput

0.691

High

375100

RAF1
RAF proto-oncogene serine/threonine-protein kinase

4

6

Small-scale

0.672

High

1110384

FX4L6
Forkhead box protein D4-like 6

3

6

High-throughput

0.667

High

1230769

FXL14
F-box/LRR-repeat protein 14

3

1

Small-scale

0.667

High

551022

RS2
Small ribosomal subunit protein uS5

3

5

Small-scale

0.650

High

1052806

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.647

High

456370

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

1

Small-scale

0.633

High

295411

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

1172294

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1189708

PIWL3
Piwi-like protein 3

1

20

Small-scale

0.618

High

1253320

PIWL2
Piwi-like protein 2

1

20

Small-scale

0.618

High

1346015

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

20

High-throughput

0.618

High

1357787

DICER
Endoribonuclease Dicer

1

16

High-throughput

0.618

High

861987

PLK1
Serine/threonine-protein kinase PLK1

2

3

High-throughput

0.611

High

1019692

ILF2
Interleukin enhancer-binding factor 2

2

8

High-throughput

0.611

High

1042857

CUL3
Cullin-3

2

17

High-throughput

0.611

High

1233352

PNKD
Probable hydrolase PNKD

2

1

High-throughput

0.611

High

1224083

TRM2A
tRNA

2

0

High-throughput

0.602

High

1327436

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

236138

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

2

7

Small-scale

0.601

High

1334605

LN28A
Protein lin-28 homolog A

2

11

High-throughput

0.601

High

533109

PRG2
Bone marrow proteoglycan

2

0

High-throughput

0.585

High

884109

GEMI4
Gem-associated protein 4

2

0

Small-scale

0.585

High

1304439

DNJC2
DnaJ homolog subfamily C member 2

2

1

Small-scale

0.584

High

1354882

ZRAN1
Ubiquitin thioesterase ZRANB1

2

8

High-throughput

0.584

High

172926

CASC3
Protein CASC3

1

6

Small-scale

0.575

High

195576

DHX15
ATP-dependent RNA helicase DHX15

1

13

Small-scale

0.575

High

571635

DDX5
Probable ATP-dependent RNA helicase DDX5

1

14

Small-scale

0.575

High

962463

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

15

Small-scale

0.575

High

980028

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

Small-scale

0.575

High

1158149

DHX57
Putative ATP-dependent RNA helicase DHX57

1

18

Small-scale

0.575

High

1184094

DHX30
ATP-dependent RNA helicase DHX30

1

16

Small-scale

0.575

High

1266151

DDX1
ATP-dependent RNA helicase DDX1

1

19

Small-scale

0.575

High

1271697

DDX17
Probable ATP-dependent RNA helicase DDX17

1

14

Small-scale

0.575

High

1272408

RENT1
Regulator of nonsense transcripts 1

1

3

Small-scale

0.575

High

1332461

YTDC2
3'-5' RNA helicase YTHDC2

1

18

Small-scale

0.575

High

257297

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

1

High-throughput

0.574

High

370726

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

1273100

FUBP2
Far upstream element-binding protein 2

2

19

Small-scale

0.571

High

1288055

HDA11
Histone deacetylase 11

1

11

High-throughput

0.554

High

181900

SOCS1
Suppressor of cytokine signaling 1

1

6

High-throughput

0.536

High

198073

PHF1
PHD finger protein 1

1

1

High-throughput

0.536

High

401181

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.536

High

607849

USF1
Upstream stimulatory factor 1

1

14

High-throughput

0.536

High

642680

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.536

High

708802

MCM5
DNA replication licensing factor MCM5

1

7

High-throughput

0.536

High

773633

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

805849

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

828944

SRP09
Signal recognition particle 9 kDa protein

1

3

High-throughput

0.536

High

897972

RAP1B
Ras-related protein Rap-1b

1

1

High-throughput

0.536

High

899409

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

913837

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

971634

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.536

High

1029200

NOGG
Noggin

1

1

High-throughput

0.536

High

1035153

MYO9B
Unconventional myosin-IXb

1

1

High-throughput

0.536

High

1048283

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

19

High-throughput

0.536

High

1219119

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1230651

SIX5
Homeobox protein SIX5

1

2

High-throughput

0.536

High

1272826

FGF11
Fibroblast growth factor 11

1

4

High-throughput

0.536

High

1304361

SORT
Sortilin

1

1

High-throughput

0.536

High

1332174

PIF1
ATP-dependent DNA helicase PIF1

1

2

High-throughput

0.536

High

1333483

ZMAT4
Zinc finger matrin-type protein 4

1

3

High-throughput

0.536

High

1334265

ARP5
Actin-related protein 5

1

5

High-throughput

0.536

High

1343168

SSF1
Suppressor of SWI4 1 homolog

1

1

High-throughput

0.536

High

1343269

TF7L2
Transcription factor 7-like 2

1

11

High-throughput

0.536

High

1345673

EMIL3
EMILIN-3

1

3

High-throughput

0.536

High

1355734

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

2

High-throughput

0.536

High

1356746

ZN346
Zinc finger protein 346

1

3

High-throughput

0.536

High

1173836

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

8

High-throughput

0.515

High

63952

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.513

High

159776

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.513

High

363947

ALBU
Albumin

1

0

High-throughput

0.513

High

1234800

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.513

High

1357793

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

163479

XPO1
Exportin-1

1

10

Small-scale

0.500

High

625102

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.500

High

1067656

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1176307

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

1

High-throughput

0.489

High

1283734

EMID1
EMI domain-containing protein 1

1

1

High-throughput

0.489

High

1290182

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

8

High-throughput

0.489

High

1328780

GHC2
Mitochondrial glutamate carrier 2

1

7

High-throughput

0.489

High

834688

NU153
Nuclear pore complex protein Nup153

1

15

Small-scale

0.484

High

206577

TNF12
Tumor necrosis factor ligand superfamily member 12

1

0

Small-scale

0.484

High

212551

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

2

High-throughput

0.481

High

378218

PRIO
Major prion protein

1

0

Small-scale

0.479

High

182955

R113A
E3 ubiquitin-protein ligase RNF113A

1

3

High-throughput

0.479

High

229076

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.479

High

260641

TP4A3
Protein tyrosine phosphatase type IVA 3

1

12

High-throughput

0.479

High

262623

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

319385

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

385731

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

418799

NPM
Nucleophosmin

1

5

High-throughput

0.479

High

554072

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

632955

TYY1
Transcriptional repressor protein YY1

1

4

Small-scale

0.479

High

649826

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.479

High

652622

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

760391

RL3
Large ribosomal subunit protein uL3

1

4

High-throughput

0.479

High

780335

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

835572

GSK3A
Glycogen synthase kinase-3 alpha

1

12

High-throughput

0.479

High

836098

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.479

High

909335

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

985203

DUS2
Dual specificity protein phosphatase 2

1

8

High-throughput

0.479

High

1025603

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

Small-scale

0.479

High

1035050

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

5

Small-scale

0.479

High

1043309

CUL4A
Cullin-4A

1

17

Small-scale

0.479

High

1044893

AAMP
Angio-associated migratory cell protein

1

9

High-throughput

0.479

High

1045736

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.479

High

1072895

MTFR1
Mitochondrial fission regulator 1

1

1

High-throughput

0.479

High

1084938

SMN
Survival motor neuron protein

1

2

High-throughput

0.479

High

1102509

LIN41
E3 ubiquitin-protein ligase TRIM71

1

20

Small-scale

0.479

High

1115769

CRY2
Cryptochrome-2

1

4

High-throughput

0.479

High

1138827

MYSM1
Deubiquitinase MYSM1

1

4

High-throughput

0.479

High

1153976

IFIX
Pyrin and HIN domain-containing protein 1

1

4

High-throughput

0.479

High

1167754

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

7

High-throughput

0.479

High

1189053

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1236579

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1237523

CGAS
Cyclic GMP-AMP synthase

1

1

Small-scale

0.479

High

1259538

NOC3L
Nucleolar complex protein 3 homolog

1

1

High-throughput

0.479

High

1260313

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

11

High-throughput

0.479

High

1271279

GOGA1
Golgin subfamily A member 1

1

3

High-throughput

0.479

High

1273969

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.479

High

1292302

AURKB
Aurora kinase B

1

6

High-throughput

0.479

High

1299488

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

3

High-throughput

0.479

High

1313491

DUS26
Dual specificity protein phosphatase 26

1

8

High-throughput

0.479

High

1317937

GTPB4
GTP-binding protein 4

1

2

High-throughput

0.479

High

1318527

TRI31
E3 ubiquitin-protein ligase TRIM31

1

10

High-throughput

0.479

High

1318773

IN80B
INO80 complex subunit B

1

1

High-throughput

0.479

High

1328307

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1328806

DUS15
Dual specificity protein phosphatase 15

1

7

High-throughput

0.479

High

1331645

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1332784

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1334635

ZMAT3
Zinc finger matrin-type protein 3

1

2

High-throughput

0.479

High

1344538

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

1355846

DS13B
Dual specificity protein phosphatase 13B

1

8

High-throughput

0.479

High

1357795

DUS10
Dual specificity protein phosphatase 10

1

8

High-throughput

0.479

High

718538

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

1151048

SFRP4
Secreted frizzled-related protein 4

1

0

High-throughput

0.458

High

1281977

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

1297218

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1303026

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1304667

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

1357789

MEMO1
Protein MEMO1

1

0

High-throughput

0.458

High

128344

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

20

Small-scale

0.445

High

165107

SC16A
Protein transport protein Sec16A

1

1

Small-scale

0.445

High

202323

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

7

Small-scale

0.445

High

397548

ADT2
ADP/ATP translocase 2

1

5

Small-scale

0.445

High

432997

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

16

Small-scale

0.445

High

453711

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

15

Small-scale

0.445

High

500217

CH60
60 kDa heat shock protein, mitochondrial

1

2

Small-scale

0.445

High

504969

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.445

High

516748

PABP1
Polyadenylate-binding protein 1

1

8

Small-scale

0.445

High

518533

ADT3
ADP/ATP translocase 3

1

5

Small-scale

0.445

High

610113

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

15

Small-scale

0.445

High

613618

SFPQ
Splicing factor, proline- and glutamine-rich

1

12

Small-scale

0.445

High

616589

RS3
Small ribosomal subunit protein uS3

1

4

Small-scale

0.445

High

718325

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

727098

FUS
RNA-binding protein FUS

1

20

Small-scale

0.445

High

727333

NU214
Nuclear pore complex protein Nup214

1

6

Small-scale

0.445

High

745346

RBMX
RNA-binding motif protein, X chromosome

1

17

Small-scale

0.445

High

751884

GRP75
Stress-70 protein, mitochondrial

1

10

Small-scale

0.445

High

794181

MATR3
Matrin-3

1

7

Small-scale

0.445

High

821092

PRC2A
Protein PRRC2A

1

11

Small-scale

0.445

High

843967

FXR1
RNA-binding protein FXR1

1

6

Small-scale

0.445

High

844290

FXR2
RNA-binding protein FXR2

1

6

Small-scale

0.445

High

853128

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

7

Small-scale

0.445

High

858075

NUP98
Nuclear pore complex protein Nup98-Nup96

1

7

Small-scale

0.445

High

878265

SEC13
Protein SEC13 homolog

1

12

Small-scale

0.445

High

898548

RS3A
Small ribosomal subunit protein eS1

1

3

Small-scale

0.445

High

923593

RL8
Large ribosomal subunit protein uL2

1

2

Small-scale

0.445

High

958258

RBM3
RNA-binding protein 3

1

19

Small-scale

0.445

High

967518

EWS
RNA-binding protein EWS

1

11

Small-scale

0.445

High

989197

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

Small-scale

0.445

High

1031498

PABP4
Polyadenylate-binding protein 4

1

8

Small-scale

0.445

High

1049925

UBP2L
Ubiquitin-associated protein 2-like

1

7

Small-scale

0.445

High

1054025

CAPR1
Caprin-1

1

3

Small-scale

0.445

High

1056781

PUM1
Pumilio homolog 1

1

2

Small-scale

0.445

High

1060967

IMB1
Importin subunit beta-1

1

4

Small-scale

0.445

High

1072067

PCBP1
Poly(rC)-binding protein 1

1

17

Small-scale

0.445

High

1116625

LARP7
La-related protein 7

1

14

Small-scale

0.445

High

1134163

UBAP2
Ubiquitin-associated protein 2

1

6

Small-scale

0.445

High

1145990

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.445

High

1153459

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1168013

GGYF2
GRB10-interacting GYF protein 2

1

3

Small-scale

0.445

High

1192412

YTHD3
YTH domain-containing family protein 3

1

3

Small-scale

0.445

High

1252141

PUM2
Pumilio homolog 2

1

2

Small-scale

0.445

High

1262739

ATX2L
Ataxin-2-like protein

1

6

Small-scale

0.445

High

1283869

FUBP1
Far upstream element-binding protein 1

1

15

Small-scale

0.445

High

1294281

FUBP3
Far upstream element-binding protein 3

1

19

Small-scale

0.445

High

1299419

RBM14
RNA-binding protein 14

1

10

Small-scale

0.445

High

1305723

ATX2
Ataxin-2

1

9

Small-scale

0.445

High

1316013

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

10

Small-scale

0.445

High

1349173

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

16

Small-scale

0.445

High

1357434

G3BP2
Ras GTPase-activating protein-binding protein 2

1

13

Small-scale

0.445

High

1357718

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

Small-scale

0.445

High

1357788

TR150
Thyroid hormone receptor-associated protein 3

1

9

Small-scale

0.445

High

1357790

YTHD2
YTH domain-containing family protein 2

1

3

Small-scale

0.445

High

1357794

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

20

Small-scale

0.445

High

721796

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1159611

MTFR2
Mitochondrial fission regulator 2

1

1

High-throughput

0.437

High

1166889

LRC31
Leucine-rich repeat-containing protein 31

1

10

High-throughput

0.437

High

1288003

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.437

High

1357792

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.437

High

556535

LEUK
Leukosialin

1

0

Small-scale

0.426

High

915120

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

Small-scale

0.426

High

1304566

NUP88
Nuclear pore complex protein Nup88

1

0

Small-scale

0.426

High

1347153

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.426

High

1347856

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.426

High

1348991

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

Small-scale

0.426

High

240273

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

274655

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

6

Small-scale

0.407

High

1233847

CBPA6
Carboxypeptidase A6

2

0

High-throughput

0.328

High

1134719

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

1262859

HPSE2
Inactive heparanase-2

1

0

High-throughput

0.279

Low

1302886

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1355446

IL17B
Interleukin-17B

1

0

High-throughput

0.279

Low

1357791

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.279

Low

1215952

CAHM1
Calcium homeostasis modulator protein 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024