Protein: DCAF1
DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)

Gene: DCAF1
Organism: Homo sapiens
Interactions: 198
UniProt ID: Q9Y4B6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001650 - fibrillar center
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082470

DDB1
DNA damage-binding protein 1

25

14

Small-scale

0.767

High

1043326

CUL4A
Cullin-4A

15

20

Small-scale

0.759

High

1043648

CUL4B
Cullin-4B

8

20

Small-scale

0.750

High

719664

MERL
Merlin

7

8

Small-scale

0.749

High

1272730

CSN5
COP9 signalosome complex subunit 5

7

10

Small-scale

0.744

High

1185021

CSN6
COP9 signalosome complex subunit 6

6

4

Small-scale

0.732

High

1268612

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

5

14

Small-scale

0.720

High

1153989

IFIX
Pyrin and HIN domain-containing protein 1

5

7

High-throughput

0.718

High

1377765

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

4

1

Small-scale

0.692

High

1314436

DDA1
DET1- and DDB1-associated protein 1

4

1

Small-scale

0.686

High

1357585

CSN3
COP9 signalosome complex subunit 3

4

5

Small-scale

0.676

High

1158603

L2GL2
LLGL scribble cell polarity complex component 2

3

16

High-throughput

0.675

High

842740

RL14
Large ribosomal subunit protein eL14

3

6

High-throughput

0.667

High

1305364

CSN8
COP9 signalosome complex subunit 8

4

0

Small-scale

0.664

High

525254

UNG
Uracil-DNA glycosylase

3

1

Small-scale

0.660

High

1354433

CSN7A
COP9 signalosome complex subunit 7a

3

4

Small-scale

0.656

High

672368

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

9

Small-scale

0.653

High

1377832

DCAF1
DDB1- and CUL4-associated factor 1

3

16

Small-scale

0.651

High

921488

RBX1
E3 ubiquitin-protein ligase RBX1

3

1

Small-scale

0.646

High

230457

ZC3H1
Zinc finger C3H1 domain-containing protein

3

0

High-throughput

0.646

High

1311921

CSN4
COP9 signalosome complex subunit 4

3

1

Small-scale

0.640

High

161897

ZN263
Zinc finger protein 263

2

4

High-throughput

0.628

High

575236

RL7
Large ribosomal subunit protein uL30

2

5

High-throughput

0.628

High

899419

RL15
Large ribosomal subunit protein eL15

2

4

High-throughput

0.628

High

990017

RL18
Large ribosomal subunit protein eL18

2

5

High-throughput

0.628

High

1012659

ZN816
Zinc finger protein 816

2

1

High-throughput

0.628

High

171866

WDR46
WD repeat-containing protein 46

2

18

High-throughput

0.611

High

818651

SOX2
Transcription factor SOX-2

2

20

High-throughput

0.611

High

862000

PLK1
Serine/threonine-protein kinase PLK1

2

4

High-throughput

0.611

High

897333

CSN2
COP9 signalosome complex subunit 2

2

5

Small-scale

0.611

High

973305

RL6
Large ribosomal subunit protein eL6

2

4

High-throughput

0.611

High

1024244

CSN1
COP9 signalosome complex subunit 1

2

6

Small-scale

0.611

High

1079641

NEDD8
NEDD8

2

4

Small-scale

0.611

High

1128091

CEP78
Centrosomal protein of 78 kDa

3

4

Small-scale

0.606

High

387797

P53
Cellular tumor antigen p53

2

7

Small-scale

0.602

High

1132187

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

2

0

High-throughput

0.602

High

1297973

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

2

0

High-throughput

0.602

High

1347480

AKIP
Small ribosomal subunit protein mS38

2

0

High-throughput

0.602

High

1377179

T53G5
TP53-target gene 5 protein

2

0

High-throughput

0.602

High

1184721

MCM10
Protein MCM10 homolog

2

0

Small-scale

0.598

High

1038845

HDAC1
Histone deacetylase 1

2

10

Small-scale

0.595

High

551453

RAG1
V(D)J recombination-activating protein 1

1

15

Small-scale

0.586

High

154071

TERT
Telomerase reverse transcriptase

2

1

Small-scale

0.584

High

348335

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

1245000

TET1
Methylcytosine dioxygenase TET1

2

4

Small-scale

0.584

High

1246209

COP1
E3 ubiquitin-protein ligase COP1

2

20

High-throughput

0.584

High

1334414

CSN7B
COP9 signalosome complex subunit 7b

2

4

Small-scale

0.584

High

1344553

SIR7
NAD-dependent protein deacetylase sirtuin-7

2

3

Small-scale

0.584

High

265447

KTNA1
Katanin p60 ATPase-containing subunit A1

1

14

Small-scale

0.578

High

983948

KPCZ
Protein kinase C zeta type

2

12

High-throughput

0.571

High

1136005

CE162
Centrosomal protein of 162 kDa

2

18

High-throughput

0.571

High

271226

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

14

Small-scale

0.561

High

501097

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.561

High

993360

FOXM1
Forkhead box protein M1

1

6

Small-scale

0.561

High

1040855

PWP1
Periodic tryptophan protein 1 homolog

1

20

Small-scale

0.561

High

1154494

TET2
Methylcytosine dioxygenase TET2

1

4

Small-scale

0.561

High

1319442

BC11B
B-cell lymphoma/leukemia 11B

1

1

Small-scale

0.561

High

1357850

EXO1
Exonuclease 1

1

1

Small-scale

0.561

High

1301928

CCNL2
Cyclin-L2

1

5

Small-scale

0.552

High

1349396

PD1L1
Programmed cell death 1 ligand 1

1

0

Small-scale

0.537

High

299499

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.536

High

370796

ESR1
Estrogen receptor

1

18

Small-scale

0.536

High

528399

MYH6
Myosin-6

1

5

High-throughput

0.536

High

714475

HSP74
Heat shock 70 kDa protein 4

1

10

High-throughput

0.536

High

719792

RADI
Radixin

1

8

High-throughput

0.536

High

736831

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

739886

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

773646

RL13A
Large ribosomal subunit protein uL13

1

5

High-throughput

0.536

High

790633

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.536

High

805860

RL27A
Large ribosomal subunit protein uL15

1

7

High-throughput

0.536

High

807073

RS9
Small ribosomal subunit protein uS4

1

5

High-throughput

0.536

High

831092

CTCF
Transcriptional repressor CTCF

1

5

High-throughput

0.536

High

913859

RL7A
Large ribosomal subunit protein eL8

1

11

High-throughput

0.536

High

916452

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

916992

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.536

High

920408

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.536

High

951840

RL19
Large ribosomal subunit protein eL19

1

4

High-throughput

0.536

High

971644

RL18A
Large ribosomal subunit protein eL20

1

3

High-throughput

0.536

High

1030060

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.536

High

1040901

MTMR1
Myotubularin-related protein 1

1

3

High-throughput

0.536

High

1082661

MK14
Mitogen-activated protein kinase 14

1

8

High-throughput

0.536

High

1188159

ZN550
Zinc finger protein 550

1

1

High-throughput

0.536

High

1232300

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.536

High

1234138

ZN276
Zinc finger protein 276

1

5

High-throughput

0.536

High

1274092

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1295390

ZN462
Zinc finger protein 462

1

2

High-throughput

0.536

High

1313819

KIFC3
Kinesin-like protein KIFC3

1

3

High-throughput

0.536

High

1330201

TXNIP
Thioredoxin-interacting protein

1

6

High-throughput

0.536

High

1331215

SENP3
Sentrin-specific protease 3

1

6

High-throughput

0.536

High

1356234

ZN223
Zinc finger protein 223

1

2

High-throughput

0.536

High

1357102

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

325951

LATS1
Serine/threonine-protein kinase LATS1

1

5

Small-scale

0.515

High

893514

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.515

High

63954

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.513

High

454784

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

471677

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

1219148

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1292414

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

1377833

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.513

High

1377835

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

200713

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

Small-scale

0.512

High

895965

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

3

Small-scale

0.501

High

919915

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

3

Small-scale

0.501

High

935426

H31
Histone H3.1

1

10

Small-scale

0.501

High

944491

PRKDC
DNA-dependent protein kinase catalytic subunit

1

10

Small-scale

0.501

High

952723

H33
Histone H3.3

1

10

Small-scale

0.501

High

1031648

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.501

High

1038198

ATR
Serine/threonine-protein kinase ATR

1

11

Small-scale

0.501

High

1055180

HLTF
Helicase-like transcription factor

1

7

Small-scale

0.501

High

1086364

H31T
Histone H3.1t

1

10

Small-scale

0.501

High

1310385

PYGO2
Pygopus homolog 2

1

1

Small-scale

0.501

High

451619

CLCA
Clathrin light chain A

1

1

High-throughput

0.489

High

1232815

FGRL1
Fibroblast growth factor receptor-like 1

1

3

High-throughput

0.489

High

1313628

ZN747
Zinc finger protein 747

1

3

High-throughput

0.489

High

1377283

E41L3
Band 4.1-like protein 3

1

3

High-throughput

0.489

High

151266

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

177413

HDAC3
Histone deacetylase 3

1

9

Small-scale

0.479

High

195847

TET3
Methylcytosine dioxygenase TET3

1

13

Small-scale

0.479

High

260643

TP4A3
Protein tyrosine phosphatase type IVA 3

1

6

High-throughput

0.479

High

261048

H2AY
Core histone macro-H2A.1

1

9

High-throughput

0.479

High

295451

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

304411

UBR5
E3 ubiquitin-protein ligase UBR5

1

11

Small-scale

0.479

High

319395

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

385777

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

476621

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.479

High

554142

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

560025

H12
Histone H1.2

1

8

Small-scale

0.479

High

611533

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

15

High-throughput

0.479

High

617399

SP100
Nuclear autoantigen Sp-100

1

20

High-throughput

0.479

High

642699

RL13
Large ribosomal subunit protein eL13

1

4

High-throughput

0.479

High

649848

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.479

High

652702

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

672498

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

9

Small-scale

0.479

High

723199

RORA
Nuclear receptor ROR-alpha

1

13

Small-scale

0.479

High

760411

RL3
Large ribosomal subunit protein uL3

1

6

High-throughput

0.479

High

787996

EPS15
Epidermal growth factor receptor substrate 15

1

5

High-throughput

0.479

High

824577

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

Small-scale

0.479

High

896275

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

910198

1433E
14-3-3 protein epsilon

1

5

Small-scale

0.479

High

941614

RNF4
E3 ubiquitin-protein ligase RNF4

1

10

High-throughput

0.479

High

968020

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

971414

H11
Histone H1.1

1

8

Small-scale

0.479

High

978946

TF65
Transcription factor p65

1

5

Small-scale

0.479

High

985204

DUS2
Dual specificity protein phosphatase 2

1

2

High-throughput

0.479

High

1041300

CUL1
Cullin-1

1

20

Small-scale

0.479

High

1042914

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1081267

NF2L2
Nuclear factor erythroid 2-related factor 2

1

13

Small-scale

0.479

High

1134092

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

1146216

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.479

High

1148899

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1172410

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1189097

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1218007

KSR1
Kinase suppressor of Ras 1

1

8

High-throughput

0.479

High

1222444

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

9

High-throughput

0.479

High

1233574

MINK1
Misshapen-like kinase 1

1

4

High-throughput

0.479

High

1244592

NUP43
Nucleoporin Nup43

1

19

High-throughput

0.479

High

1266898

TOPB1
DNA topoisomerase 2-binding protein 1

1

11

Small-scale

0.479

High

1270543

HDAC2
Histone deacetylase 2

1

10

Small-scale

0.479

High

1271004

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.479

High

1286014

MOAP1
Modulator of apoptosis 1

1

2

Small-scale

0.479

High

1286321

ZN707
Zinc finger protein 707

1

2

High-throughput

0.479

High

1313494

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.479

High

1316069

HDAC8
Histone deacetylase 8

1

9

Small-scale

0.479

High

1327939

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

8

Small-scale

0.479

High

1331716

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

1332811

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1335104

SP110
Sp110 nuclear body protein

1

19

High-throughput

0.479

High

1344985

LATS2
Serine/threonine-protein kinase LATS2

1

7

Small-scale

0.479

High

1354983

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1357270

MYO6
Unconventional myosin-VI

1

7

Small-scale

0.479

High

1377213

DJC16
DnaJ homolog subfamily C member 16

1

11

High-throughput

0.470

High

1122709

ESCO2
N-acetyltransferase ESCO2

1

0

Small-scale

0.458

High

1281985

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

1290425

DTBP1
Dysbindin

1

0

High-throughput

0.458

High

1298955

MUS81
Crossover junction endonuclease MUS81

1

0

Small-scale

0.458

High

1299500

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1302961

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

1377834

MOFA1
MORF4 family-associated protein 1

1

0

Small-scale

0.458

High

1083648

ZNF74
Zinc finger protein 74

1

1

High-throughput

0.445

High

1222657

SLX4
Structure-specific endonuclease subunit SLX4

1

12

High-throughput

0.445

High

813879

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.437

High

1166891

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1287546

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.437

High

1313558

CP250
Centrosome-associated protein CEP250

1

16

High-throughput

0.437

High

1330685

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

5

Small-scale

0.437

High

879383

RAG2
V(D)J recombination-activating protein 2

1

0

Small-scale

0.426

High

970670

ZNF45
Zinc finger protein 45

1

0

High-throughput

0.426

High

69640

B0UZZ8
Chromosome 6 open reading frame 11

1

18

High-throughput

0.407

High

373087

VTNC
Vitronectin

2

0

High-throughput

0.328

High

1349093

RM35
Large ribosomal subunit protein bL35m

2

0

High-throughput

0.328

High

1336715

XAGE1
X antigen family member 1

2

0

High-throughput

0.313

High

1132359

F120S
Uncharacterized protein FAM120AOS

1

0

High-throughput

0.279

Low

1219548

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

1262860

HPSE2
Inactive heparanase-2

1

0

High-throughput

0.279

Low

1328342

SMG9
Nonsense-mediated mRNA decay factor SMG9

1

0

High-throughput

0.279

Low

1350338

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.279

Low

1033021

PLD1
Phospholipase D1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024