Protein: 4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)

Gene: 4EBP1, EIF4EBP1
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q13541

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008190 - eukaryotic initiation factor 4E binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416982

IF4E
Eukaryotic translation initiation factor 4E

56

15

Small-scale

0.997

High

237211

IF4E2
Eukaryotic translation initiation factor 4E type 2

5

15

Small-scale

0.935

High

787477

MTOR
Serine/threonine-protein kinase mTOR

31

7

Small-scale

0.771

High

1038220

RPTOR
Regulatory-associated protein of mTOR

21

2

Small-scale

0.768

High

64108

I4E1B
Eukaryotic translation initiation factor 4E type 1B

3

15

High-throughput

0.768

High

1038214

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

1

Small-scale

0.655

High

981569

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

1031514

ATM
Serine-protein kinase ATM

2

7

Small-scale

0.617

High

638283

RBTN2
Rhombotin-2

2

0

High-throughput

0.580

High

837799

MEOX1
Homeobox protein MOX-1

2

0

High-throughput

0.580

High

944022

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.580

High

1038221

ZN655
Zinc finger protein 655

2

0

High-throughput

0.580

High

1038223

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1038230

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

551139

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

884300

PCBP3
Poly(rC)-binding protein 3

1

1

High-throughput

0.536

High

1038218

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.536

High

1038227

BTBD1
BTB/POZ domain-containing protein 1

1

1

High-throughput

0.536

High

1038209

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.513

High

1038219

FBX11
F-box only protein 11

1

0

High-throughput

0.513

High

1038225

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.512

High

1038235

AGO2
Protein argonaute-2

1

0

Small-scale

0.512

High

325717

LATS1
Serine/threonine-protein kinase LATS1

1

1

Small-scale

0.501

High

658933

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.501

High

944228

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.501

High

1038213

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.501

High

1038226

LST8
Target of rapamycin complex subunit LST8

1

1

Small-scale

0.501

High

835733

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

566383

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.480

High

1027361

STK3
Serine/threonine-protein kinase 3

1

0

Small-scale

0.480

High

1038212

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.480

High

1038215

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.480

High

1038231

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

Small-scale

0.480

High

124853

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.479

High

176777

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

2

High-throughput

0.479

High

177017

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

3

High-throughput

0.479

High

203367

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

4

High-throughput

0.479

High

275865

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

3

High-throughput

0.479

High

338388

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

383787

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.479

High

879242

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.479

High

888358

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

High-throughput

0.479

High

979892

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

4

High-throughput

0.479

High

1032082

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.479

High

1038208

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

High-throughput

0.479

High

1038210

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.479

High

1038216

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.479

High

1038217

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.479

High

1038224

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.479

High

1038228

KLH25
Kelch-like protein 25

1

1

Small-scale

0.479

High

1038229

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

1038232

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

1

High-throughput

0.479

High

1038233

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1038236

ANGE1
Protein angel homolog 1

1

1

High-throughput

0.479

High

1038237

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.479

High

438143

HS90B
Heat shock protein HSP 90-beta

1

0

Small-scale

0.458

High

776673

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

908497

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

927807

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

Small-scale

0.458

High

1038206

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

0

High-throughput

0.458

High

1038207

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1038222

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

Small-scale

0.458

High

1038234

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

863064

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.438

High

1038211

SLMAP
Sarcolemmal membrane-associated protein

1

1

High-throughput

0.437

High

474577

CTF8
Chromosome transmission fidelity protein 8 homolog

1

0

High-throughput

0.282

High

674660

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

Small-scale

0.249

Low

1038238

EID1
EP300-interacting inhibitor of differentiation 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024