Protein: ML12B
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)

Gene: ML12B, MYL12B
Organism: Homo sapiens
Interactions: 130
UniProt ID: O14950

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005903 - brush border

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

159549

MYH9
Myosin-9

4

19

High-throughput

0.895

High

159604

MY18A
Unconventional myosin-XVIIIa

2

20

High-throughput

0.811

High

159550

MYH10
Myosin-10

2

19

High-throughput

0.789

High

159539

ML12A
Myosin regulatory light chain 12A

2

17

High-throughput

0.737

High

66578

EFCB7
EF-hand calcium-binding domain-containing protein 7

1

18

High-throughput

0.691

High

135312

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.691

High

159554

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

14

High-throughput

0.691

High

159570

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

20

High-throughput

0.691

High

159595

MYH14
Myosin-14

1

19

High-throughput

0.691

High

159599

MYO3A
Myosin-IIIa

1

17

High-throughput

0.691

High

159602

MYO3B
Myosin-IIIb

1

20

High-throughput

0.691

High

159609

MYO19
Unconventional myosin-XIX

1

20

High-throughput

0.691

High

159630

MYO6
Unconventional myosin-VI

1

20

High-throughput

0.691

High

159635

MYH15
Myosin-15

1

19

High-throughput

0.691

High

159640

MYO5A
Unconventional myosin-Va

1

13

High-throughput

0.691

High

159559

MYL6
Myosin light polypeptide 6

3

20

High-throughput

0.667

High

159518

DAPK3
Death-associated protein kinase 3

1

20

Small-scale

0.647

High

159558

DAPK1
Death-associated protein kinase 1

1

20

Small-scale

0.647

High

159586

IQCE
IQ domain-containing protein E

1

20

High-throughput

0.618

High

148135

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.618

High

159544

MYL9
Myosin regulatory light polypeptide 9

1

15

High-throughput

0.618

High

159545

CDK2
Cyclin-dependent kinase 2

1

10

High-throughput

0.618

High

159551

MYH11
Myosin-11

1

19

Small-scale

0.618

High

159577

MYLK
Myosin light chain kinase, smooth muscle

1

17

High-throughput

0.618

High

159583

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

13

Small-scale

0.618

High

159608

AURKB
Aurora kinase B

1

8

High-throughput

0.618

High

159634

NINL
Ninein-like protein

1

14

High-throughput

0.618

High

159590

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

2

5

Small-scale

0.601

High

159521

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

159621

ANLN
Anillin

2

4

High-throughput

0.584

High

159588

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

2

0

High-throughput

0.580

High

159557

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.553

High

159603

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

1

Small-scale

0.552

High

159529

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.541

High

155959

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.536

High

159517

TIF1A
Transcription intermediary factor 1-alpha

1

10

High-throughput

0.536

High

159536

MYL6B
Myosin light chain 6B

1

18

High-throughput

0.536

High

159563

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.536

High

159571

CUL1
Cullin-1

1

1

High-throughput

0.536

High

159615

SENP7
Sentrin-specific protease 7

1

1

High-throughput

0.536

High

159519

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

159522

KDM4A
Lysine-specific demethylase 4A

1

0

High-throughput

0.513

High

159555

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

159560

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.500

High

159569

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.489

High

159594

UBE3B
Ubiquitin-protein ligase E3B

1

12

High-throughput

0.489

High

159601

SETD7
Histone-lysine N-methyltransferase SETD7

1

9

High-throughput

0.489

High

159612

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

159613

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

159616

FOXP1
Forkhead box protein P1

1

4

High-throughput

0.489

High

159629

FOXD3
Forkhead box protein D3

1

2

High-throughput

0.489

High

129613

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

159520

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

159523

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

159524

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

159526

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

159527

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

159530

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

159531

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

159534

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

159538

LEG3
Galectin-3

1

1

Small-scale

0.479

High

159541

BTF3
Transcription factor BTF3

1

4

High-throughput

0.479

High

159542

CBL
E3 ubiquitin-protein ligase CBL

1

9

High-throughput

0.479

High

159543

COF1
Cofilin-1

1

4

High-throughput

0.479

High

159547

1433T
14-3-3 protein theta

1

9

High-throughput

0.479

High

159556

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

159567

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

159573

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

High-throughput

0.479

High

159575

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.479

High

159576

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

159578

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

9

High-throughput

0.479

High

159579

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

159589

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

159591

MOB2
MOB kinase activator 2

1

2

High-throughput

0.479

High

159596

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

159600

FBX25
F-box only protein 25

1

2

High-throughput

0.479

High

159606

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

159614

MEP50
Methylosome protein WDR77

1

4

High-throughput

0.479

High

159617

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

159618

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

159619

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

159622

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

159625

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

159626

HDAC6
Histone deacetylase 6

1

3

High-throughput

0.479

High

159627

TES
Testin

1

6

High-throughput

0.479

High

159633

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

159636

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

5

Small-scale

0.479

High

159637

CRYL1
Lambda-crystallin homolog

1

1

High-throughput

0.479

High

159638

PHOCN
MOB-like protein phocein

1

2

High-throughput

0.479

High

127938

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

159532

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

159548

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

159552

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

159561

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

159572

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

159580

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

159581

MIDN
Midnolin

1

0

High-throughput

0.458

High

159592

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

159607

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.458

High

159610

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

159628

DPP2
Dipeptidyl peptidase 2

1

0

High-throughput

0.458

High

159631

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

159528

FINC
Fibronectin

1

1

High-throughput

0.445

High

159533

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.445

High

159540

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.445

High

159546

S10A4
Protein S100-A4

1

1

High-throughput

0.445

High

159562

ACTA
Actin, aortic smooth muscle

1

5

Small-scale

0.445

High

159564

RHOG
Rho-related GTP-binding protein RhoG

1

7

Small-scale

0.445

High

159566

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

159587

PKHA7
Pleckstrin homology domain-containing family A member 7

1

6

High-throughput

0.445

High

159632

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

159525

KI20A
Kinesin-like protein KIF20A

1

12

High-throughput

0.437

High

159568

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.437

High

159593

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

159605

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

159611

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.437

High

159620

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.437

High

159623

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

159535

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

159574

BECN1
Beclin-1

1

0

High-throughput

0.426

High

159582

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

159553

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

159565

TF2B
Transcription initiation factor IIB

1

1

Small-scale

0.407

High

159585

Z518A
Zinc finger protein 518A

1

0

High-throughput

0.279

Low

159598

TSYL6
Testis-specific Y-encoded-like protein 6

1

0

High-throughput

0.279

Low

159624

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.279

Low

159639

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

159537

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

159597

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

159584

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024