Protein: TRIO
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)

Gene: TRIO
Organism: Homo sapiens
Interactions: 85
UniProt ID: O75962

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

279854

RAC1
Ras-related C3 botulinum toxin substrate 1

5

20

Small-scale

0.915

High

279855

RHOG
Rho-related GTP-binding protein RhoG

4

20

Small-scale

0.867

High

279868

MARE1
Microtubule-associated protein RP/EB family member 1

3

12

Small-scale

0.853

High

279901

ZN232
Zinc finger protein 232

2

5

High-throughput

0.811

High

279851

RHOA
Transforming protein RhoA

2

20

Small-scale

0.806

High

279833

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

2

Small-scale

0.754

High

279892

MYO10
Unconventional myosin-X

2

7

Small-scale

0.754

High

279870

CDC37
Hsp90 co-chaperone Cdc37

2

3

High-throughput

0.737

High

66634

ZN785
Zinc finger protein 785

2

3

High-throughput

0.726

High

279848

NEK4
Serine/threonine-protein kinase Nek4

1

11

High-throughput

0.691

High

279872

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

3

High-throughput

0.691

High

279838

FLNA
Filamin-A

1

19

Small-scale

0.680

High

279824

TRIO
Triple functional domain protein

1

16

Small-scale

0.647

High

279850

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.647

High

279897

ITSN2
Intersectin-2

1

19

High-throughput

0.621

High

167430

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

17

Small-scale

0.618

High

279827

RASK
GTPase KRas

1

20

High-throughput

0.618

High

279829

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.618

High

279830

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

279832

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

279839

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.618

High

279842

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.618

High

279843

CCNF
Cyclin-F

1

3

High-throughput

0.618

High

279846

GSK3A
Glycogen synthase kinase-3 alpha

1

17

High-throughput

0.618

High

279847

GSK3B
Glycogen synthase kinase-3 beta

1

19

High-throughput

0.618

High

279852

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.618

High

279853

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

279860

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.618

High

279862

SQSTM
Sequestosome-1

1

9

High-throughput

0.618

High

279865

ARHG7
Rho guanine nucleotide exchange factor 7

1

16

High-throughput

0.618

High

279866

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

279867

EPHA7
Ephrin type-A receptor 7

1

8

High-throughput

0.618

High

279869

NTRK3
NT-3 growth factor receptor

1

10

High-throughput

0.618

High

279875

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

279876

NAV3
Neuron navigator 3

1

20

Small-scale

0.618

High

279877

NAV2
Neuron navigator 2

1

20

Small-scale

0.618

High

279890

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.618

High

279899

ANFY1
Rabankyrin-5

1

20

High-throughput

0.618

High

279902

MARE3
Microtubule-associated protein RP/EB family member 3

1

12

High-throughput

0.618

High

279898

PALS2
Protein PALS2

1

8

High-throughput

0.595

High

279893

DISC1
Disrupted in schizophrenia 1 protein

2

11

High-throughput

0.590

High

279894

EXOC1
Exocyst complex component 1

2

3

High-throughput

0.590

High

279903

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.586

High

279900

ZRAN1
Ubiquitin thioesterase ZRANB1

2

9

High-throughput

0.584

High

279887

CDC5L
Cell division cycle 5-like protein

2

8

High-throughput

0.576

High

279879

NAV1
Neuron navigator 1

1

16

Small-scale

0.561

High

279845

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

11

High-throughput

0.541

High

279826

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.536

High

279834

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.536

High

279880

LMO3
LIM domain only protein 3

1

8

High-throughput

0.536

High

279864

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.518

High

279874

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.517

High

279840

RBTN1
Rhombotin-1

1

8

High-throughput

0.489

High

279373

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

279831

PROF1
Profilin-1

1

4

High-throughput

0.479

High

279835

LAMP1
Lysosome-associated membrane glycoprotein 1

1

14

High-throughput

0.479

High

279837

CXA1
Gap junction alpha-1 protein

1

11

High-throughput

0.479

High

279844

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.479

High

279856

DAB2
Disabled homolog 2

1

2

Small-scale

0.479

High

279858

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

279859

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

High-throughput

0.479

High

279861

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

279863

CUL3
Cullin-3

1

12

High-throughput

0.479

High

279881

PARD3
Partitioning defective 3 homolog

1

11

High-throughput

0.479

High

279883

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.479

High

279888

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

10

High-throughput

0.479

High

279891

CENPJ
Centromere protein J

1

14

High-throughput

0.479

High

279889

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

279836

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

279885

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

13

High-throughput

0.445

High

100327

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

279825

ZFPL1
Zinc finger protein-like 1

1

4

High-throughput

0.437

High

279841

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

279857

CAV1
Caveolin-1

1

10

High-throughput

0.437

High

279871

OCLN
Occludin

1

6

High-throughput

0.437

High

279873

RL22L
Ribosomal protein eL22-like

1

1

High-throughput

0.437

High

279878

NIN
Ninein

1

20

High-throughput

0.437

High

279882

ESR2
Estrogen receptor beta

1

14

High-throughput

0.437

High

279884

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

279886

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

279849

DSCR9
Down syndrome critical region protein 9

1

4

High-throughput

0.417

High

279895

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

2

0

High-throughput

0.298

High

279828

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.279

Low

279896

ADA2
Adenosine deaminase 2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024