Protein: ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)

Gene: ODBA, BCKDHA
Organism: Homo sapiens
Interactions: 113
UniProt ID: P12694

Gene Ontology (top 5):
GO:0003863 - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0009083 - branched-chain amino acid catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

520685

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

6

15

Small-scale

0.953

High

520724

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

5

0

High-throughput

0.688

High

417800

DPOLB
DNA polymerase beta

3

1

High-throughput

0.667

High

440320

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.618

High

520743

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

2

0

High-throughput

0.585

High

226386

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

520712

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

520763

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.584

High

520708

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.553

High

66640

ZN785
Zinc finger protein 785

1

1

High-throughput

0.536

High

135350

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

2

High-throughput

0.536

High

258654

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

270908

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

2

High-throughput

0.536

High

520690

KAD4
Adenylate kinase 4, mitochondrial

1

5

High-throughput

0.536

High

520696

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

4

High-throughput

0.536

High

520697

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

520710

RM23
Large ribosomal subunit protein uL23m

1

2

High-throughput

0.536

High

520718

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

1

High-throughput

0.536

High

520729

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

5

High-throughput

0.536

High

520737

NPS3B
Protein NipSnap homolog 3B

1

2

High-throughput

0.536

High

520760

DIC
Mitochondrial dicarboxylate carrier

1

5

High-throughput

0.536

High

520761

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

520764

DPOLL
DNA polymerase lambda

1

1

High-throughput

0.536

High

520765

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

520770

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

157289

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

9

High-throughput

0.515

High

272331

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

520711

TAZ
Tafazzin

1

0

High-throughput

0.513

High

520723

ZN444
Zinc finger protein 444

1

0

High-throughput

0.513

High

520739

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

0

High-throughput

0.513

High

520756

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

520067

BMP2
Bone morphogenetic protein 2

1

1

High-throughput

0.489

High

520681

HXB1
Homeobox protein Hox-B1

1

2

High-throughput

0.489

High

520689

S10A4
Protein S100-A4

1

2

High-throughput

0.489

High

520691

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

520706

CUL3
Cullin-3

1

2

High-throughput

0.489

High

520733

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.489

High

520759

HDAC6
Histone deacetylase 6

1

2

High-throughput

0.489

High

262692

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

264824

MPPB
Mitochondrial-processing peptidase subunit beta

1

11

High-throughput

0.479

High

266636

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.479

High

269973

RF1M
Peptide chain release factor 1, mitochondrial

1

8

High-throughput

0.479

High

319110

BRD1
Bromodomain-containing protein 1

1

2

High-throughput

0.479

High

499494

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

520688

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

520694

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

520705

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

520707

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

7

High-throughput

0.479

High

520709

PDK1
[Pyruvate dehydrogenase

1

9

High-throughput

0.479

High

520713

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

2

High-throughput

0.479

High

520714

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

520715

TENS2
Tensin-2

1

2

High-throughput

0.479

High

520717

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.479

High

520738

DHRS4
Dehydrogenase/reductase SDR family member 4

1

1

High-throughput

0.479

High

520740

TR61B
tRNA

1

2

High-throughput

0.479

High

520741

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.479

High

520744

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

4

High-throughput

0.479

High

520745

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

520751

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

520752

CQ10B
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

1

1

High-throughput

0.479

High

520754

SUCHY
Succinate--hydroxymethylglutarate CoA-transferase

1

1

High-throughput

0.479

High

520757

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

520758

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.479

High

520762

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

8

High-throughput

0.479

High

520767

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.479

High

520768

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.479

High

520726

NSUN6
tRNA

1

1

High-throughput

0.470

High

473369

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

520755

LYRM4
LYR motif-containing protein 4

1

0

High-throughput

0.458

High

520771

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.458

High

520772

BOLA1
BolA-like protein 1

1

0

High-throughput

0.458

High

520682

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.457

High

520692

EPHA3
Ephrin type-A receptor 3

1

1

High-throughput

0.457

High

520704

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

4

High-throughput

0.457

High

520774

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

520684

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.437

High

520687

SP100
Nuclear autoantigen Sp-100

1

3

High-throughput

0.437

High

520693

LTK
Leukocyte tyrosine kinase receptor

1

7

High-throughput

0.437

High

520698

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

520700

SMCA2
Probable global transcription activator SNF2L2

1

5

High-throughput

0.437

High

520702

DJB13
DnaJ homolog subfamily B member 13

1

3

High-throughput

0.437

High

520703

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.437

High

520719

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

520725

SPT20
Spermatogenesis-associated protein 20

1

1

High-throughput

0.437

High

520727

SPRY4
SPRY domain-containing protein 4

1

1

High-throughput

0.437

High

520735

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

520750

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

520769

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.437

High

520720

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

520749

GCP60
Golgi resident protein GCP60

1

0

Small-scale

0.426

High

520766

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.426

High

305933

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.407

High

520716

CP135
Centrosomal protein of 135 kDa

1

7

High-throughput

0.407

High

520742

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.407

High

520746

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.407

High

351645

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.279

Low

520683

PACA
Pituitary adenylate cyclase-activating polypeptide

1

0

High-throughput

0.279

Low

520686

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

520699

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.279

Low

520721

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

520722

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.279

Low

520731

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

520734

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.279

Low

520736

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.279

Low

520747

ZBP1
Z-DNA-binding protein 1

1

0

High-throughput

0.279

Low

520748

IL25
Interleukin-25

1

0

High-throughput

0.279

Low

520773

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

High-throughput

0.279

Low

520701

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.269

Low

520695

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

520728

PHIP
PH-interacting protein

1

0

High-throughput

0.249

Low

520730

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

520732

F136A
Protein FAM136A

1

0

High-throughput

0.249

Low

520753

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024