Protein: JAK3
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)

Gene: JAK3
Organism: Homo sapiens
Interactions: 124
UniProt ID: P52333

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002731 - negative regulation of dendritic cell cytokine production
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005131 - growth hormone receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181826

SOCS1
Suppressor of cytokine signaling 1

4

20

Small-scale

0.851

High

854160

JAK3
Tyrosine-protein kinase JAK3

3

19

Small-scale

0.845

High

616770

JAK1
Tyrosine-protein kinase JAK1

2

19

Small-scale

0.789

High

515382

CDK4
Cyclin-dependent kinase 4

2

20

High-throughput

0.789

High

786595

STA5A
Signal transducer and activator of transcription 5A

2

20

Small-scale

0.757

High

562536

IL7RA
Interleukin-7 receptor subunit alpha

2

3

Small-scale

0.754

High

724524

IRS1
Insulin receptor substrate 1

2

20

Small-scale

0.754

High

854214

ALK
ALK tyrosine kinase receptor

2

20

Small-scale

0.754

High

682256

IL2RG
Cytokine receptor common subunit gamma

5

20

Small-scale

0.704

High

414832

CDK1
Cyclin-dependent kinase 1

1

20

High-throughput

0.698

High

129250

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.691

High

488627

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.691

High

830314

KC1E
Casein kinase I isoform epsilon

1

19

High-throughput

0.691

High

854161

DGKE
Diacylglycerol kinase epsilon

1

13

High-throughput

0.691

High

854176

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.691

High

147407

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.665

High

238388

JAK2
Tyrosine-protein kinase JAK2

1

19

Small-scale

0.665

High

669148

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

18

Small-scale

0.665

High

776620

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.665

High

786471

STAT6
Signal transducer and activator of transcription 6

1

20

Small-scale

0.665

High

499251

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.647

High

601858

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

854182

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.647

High

304082

UBR5
E3 ubiquitin-protein ligase UBR5

2

20

High-throughput

0.628

High

573184

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.628

High

770753

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.628

High

842793

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.628

High

843120

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.628

High

854215

CHIP
E3 ubiquitin-protein ligase CHIP

2

16

High-throughput

0.628

High

854216

MAGD2
Melanoma-associated antigen D2

2

8

High-throughput

0.628

High

849878

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.621

High

254460

ROCK2
Rho-associated protein kinase 2

1

20

Small-scale

0.618

High

277031

STAM2
Signal transducing adapter molecule 2

1

20

Small-scale

0.618

High

854173

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.618

High

854178

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

854198

STAM1
Signal transducing adapter molecule 1

1

20

Small-scale

0.618

High

854168

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

2

5

High-throughput

0.611

High

540456

IL2RB
Interleukin-2 receptor subunit beta

2

20

Small-scale

0.584

High

854177

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.575

High

854162

NP1L1
Nucleosome assembly protein 1-like 1

2

4

High-throughput

0.574

High

854206

NP1L4
Nucleosome assembly protein 1-like 4

2

4

High-throughput

0.574

High

448970

VILI
Villin-1

1

11

Small-scale

0.561

High

596521

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

9

Small-scale

0.561

High

854202

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

9

Small-scale

0.561

High

854223

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.561

High

854189

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

2

5

High-throughput

0.552

High

854195

LNX1
E3 ubiquitin-protein ligase LNX

2

20

High-throughput

0.542

High

156004

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

High-throughput

0.536

High

224769

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

4

High-throughput

0.536

High

323650

BAG2
BAG family molecular chaperone regulator 2

1

6

High-throughput

0.536

High

376197

ANXA1
Annexin A1

1

8

High-throughput

0.536

High

431677

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.536

High

438016

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.536

High

498235

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

11

High-throughput

0.536

High

525463

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.536

High

568958

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.536

High

685332

I5P2
Type II inositol 1,4,5-trisphosphate 5-phosphatase

1

20

High-throughput

0.536

High

737276

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.536

High

817311

LEPR
Leptin receptor

1

20

Small-scale

0.536

High

826579

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

854166

DCAF7
DDB1- and CUL4-associated factor 7

1

4

High-throughput

0.536

High

854169

TBA4A
Tubulin alpha-4A chain

1

20

High-throughput

0.536

High

854172

CENPC
Centromere protein C

1

4

High-throughput

0.536

High

854179

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

854180

RNPS1
RNA-binding protein with serine-rich domain 1

1

5

High-throughput

0.536

High

854186

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

1

High-throughput

0.536

High

854190

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

16

High-throughput

0.536

High

854191

LARP4
La-related protein 4

1

14

High-throughput

0.536

High

854192

RFIP2
Rab11 family-interacting protein 2

1

20

High-throughput

0.536

High

854194

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

5

High-throughput

0.536

High

854196

GEMI6
Gem-associated protein 6

1

1

High-throughput

0.536

High

854197

GCN1
Stalled ribosome sensor GCN1

1

18

High-throughput

0.536

High

854199

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

13

High-throughput

0.536

High

854201

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

11

High-throughput

0.536

High

854203

CCNL2
Cyclin-L2

1

5

High-throughput

0.536

High

854219

MYO5A
Unconventional myosin-Va

1

6

High-throughput

0.536

High

854222

MAGD1
Melanoma-associated antigen D1

1

8

High-throughput

0.536

High

146610

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.527

High

854211

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.527

High

622730

IL4RA
Interleukin-4 receptor subunit alpha

1

20

Small-scale

0.515

High

639563

TNR5
Tumor necrosis factor receptor superfamily member 5

1

20

Small-scale

0.515

High

854164

CXCR4
C-X-C chemokine receptor type 4

1

20

Small-scale

0.515

High

245484

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.513

High

854175

NMI
N-myc-interactor

1

0

High-throughput

0.513

High

854181

MTFR1
Mitochondrial fission regulator 1

1

0

High-throughput

0.513

High

854205

METH
Methionine synthase

1

0

High-throughput

0.513

High

854207

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.513

High

854210

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

854212

RIC8B
Synembryn-B

1

0

High-throughput

0.513

High

153613

ANM5
Protein arginine N-methyltransferase 5

1

9

Small-scale

0.501

High

317937

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

13

Small-scale

0.501

High

150193

AP3D1
AP-3 complex subunit delta-1

1

16

High-throughput

0.489

High

174064

SPTC1
Serine palmitoyltransferase 1

1

3

High-throughput

0.489

High

300088

PRP6
Pre-mRNA-processing factor 6

1

5

High-throughput

0.489

High

677813

LCN1
Lipocalin-1

1

2

High-throughput

0.489

High

854187

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

5

High-throughput

0.489

High

854213

GPTC8
G patch domain-containing protein 8

1

11

High-throughput

0.489

High

854218

MTF2
Metal-response element-binding transcription factor 2

1

2

High-throughput

0.489

High

854220

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.489

High

854221

TNPO3
Transportin-3

1

16

High-throughput

0.489

High

854163

CD81
CD81 antigen

1

10

High-throughput

0.481

High

430692

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

5

Small-scale

0.479

High

600105

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

854165

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

854167

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.479

High

854170

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.479

High

854174

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

Small-scale

0.479

High

854200

OPTN
Optineurin

1

20

Small-scale

0.479

High

361328

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.460

High

854183

RB11B
Ras-related protein Rab-11B

1

12

High-throughput

0.445

High

854188

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.445

High

171741

WDR46
WD repeat-containing protein 46

1

8

High-throughput

0.437

High

854209

TBB1
Tubulin beta-1 chain

1

16

High-throughput

0.437

High

854217

SRRM2
Serine/arginine repetitive matrix protein 2

1

18

High-throughput

0.437

High

2875

A0A0G2JJL1
WD repeat-containing protein 46

1

3

High-throughput

0.407

High

108814

H0Y9L7
TATA-box binding protein associated factor 1

1

2

High-throughput

0.407

High

313670

TIAF1
Putative TGFB1-induced anti-apoptotic factor 1

1

0

Small-scale

0.288

High

854171

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.282

High

854184

CRY1
Cryptochrome-1

1

0

High-throughput

0.279

Low

854185

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.279

Low

854193

LYSM2
LysM and putative peptidoglycan-binding domain-containing protein 2

1

0

High-throughput

0.279

Low

854204

LGMN
Legumain

1

0

High-throughput

0.279

Low

854208

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024