Protein: EXOS2
Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)

Gene: EXOS2, EXOSC2
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q13868

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1046343

EXOS4
Exosome complex component RRP41

9

20

Small-scale

0.974

High

1046284

EXOS7
Exosome complex component RRP42

9

20

Small-scale

0.973

High

986673

EXOS9
Exosome complex component RRP45

7

20

Small-scale

0.956

High

1046319

EXOS8
Exosome complex component RRP43

6

20

Small-scale

0.945

High

1046325

MPH6
M-phase phosphoprotein 6

6

1

Small-scale

0.937

High

1046346

EXOS5
Exosome complex component RRP46

4

20

Small-scale

0.900

High

1046290

EXOS6
Exosome complex component MTR3

4

20

Small-scale

0.892

High

1046347

EXOS3
Exosome complex component RRP40

10

5

Small-scale

0.755

High

1046362

EXOS1
Exosome complex component CSL4

6

3

Small-scale

0.730

High

966399

EXOSX
Exosome complex component 10

6

5

Small-scale

0.727

High

1046312

DI3L1
DIS3-like exonuclease 1

5

5

Small-scale

0.722

High

786945

MTREX
Exosome RNA helicase MTR4

3

5

Small-scale

0.650

High

1046364

RBM7
RNA-binding protein 7

3

0

High-throughput

0.638

High

1046278

C1D
Nuclear nucleic acid-binding protein C1D

3

0

Small-scale

0.634

High

1046361

RRP44
Exosome complex exonuclease RRP44

2

5

Small-scale

0.628

High

1046318

FUBP2
Far upstream element-binding protein 2

3

0

Small-scale

0.613

High

209971

PRC1
Protein regulator of cytokinesis 1

2

0

High-throughput

0.585

High

582285

NUCL
Nucleolin

2

0

High-throughput

0.585

High

1046293

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

0

High-throughput

0.585

High

1046317

RENT1
Regulator of nonsense transcripts 1

2

0

Small-scale

0.585

High

1046331

AICDA
Single-stranded DNA cytosine deaminase

2

0

Small-scale

0.585

High

1046332

COMD4
COMM domain-containing protein 4

2

0

High-throughput

0.585

High

1046363

HBS1L
HBS1-like protein

2

0

High-throughput

0.585

High

934746

H31
Histone H3.1

2

1

High-throughput

0.584

High

369570

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1046348

ANLN
Anillin

2

0

High-throughput

0.559

High

177500

NVL
Nuclear valosin-containing protein-like

1

2

High-throughput

0.536

High

218009

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.536

High

230355

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.536

High

613449

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.536

High

781737

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

806000

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

820915

PRC2A
Protein PRRC2A

1

1

High-throughput

0.536

High

1046286

WDR43
WD repeat-containing protein 43

1

2

High-throughput

0.536

High

1046288

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1046305

WDR75
WD repeat-containing protein 75

1

3

High-throughput

0.536

High

1046306

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.536

High

1046310

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

2

High-throughput

0.536

High

1046314

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

1046334

SLK
STE20-like serine/threonine-protein kinase

1

2

High-throughput

0.536

High

1046359

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1046360

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

110629

H3BNT4
M-phase phosphoprotein 6

1

1

High-throughput

0.514

High

212408

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

270410

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.513

High

418261

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

515276

KPSH1
Serine/threonine-protein kinase H1

1

0

High-throughput

0.513

High

828758

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

833878

CLK2
Dual specificity protein kinase CLK2

1

0

High-throughput

0.513

High

850921

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

883221

SIK1
Serine/threonine-protein kinase SIK1

1

0

High-throughput

0.513

High

907903

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

929448

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.513

High

983605

FAK1
Focal adhesion kinase 1

1

0

High-throughput

0.513

High

1033379

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.513

High

1046280

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1046287

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.513

High

1046299

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1046300

NT5D3
5'-nucleotidase domain-containing protein 3

1

0

High-throughput

0.513

High

1046302

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1046313

PHF10
PHD finger protein 10

1

0

High-throughput

0.513

High

1046321

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1046354

FBXL4
F-box/LRR-repeat protein 4

1

0

High-throughput

0.513

High

1046357

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

890657

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

1046335

PININ
Pinin

1

0

High-throughput

0.493

High

282647

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.486

High

1046339

ZN408
Zinc finger protein 408

1

0

High-throughput

0.486

High

148789

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

171771

WDR46
WD repeat-containing protein 46

1

3

High-throughput

0.479

High

237213

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

294821

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

442147

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

475736

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

801876

RECQ1
ATP-dependent DNA helicase Q1

1

3

High-throughput

0.479

High

917242

H4
Histone H4

1

1

High-throughput

0.479

High

952322

H33
Histone H3.3

1

1

High-throughput

0.479

High

1046285

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1046289

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1046292

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1046294

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.479

High

1046297

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.479

High

1046301

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1046308

PTGR2
Prostaglandin reductase 2

1

1

High-throughput

0.479

High

1046309

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

1046316

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1046330

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.479

High

1046342

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

1046350

DCA13
DDB1- and CUL4-associated factor 13

1

2

Small-scale

0.479

High

1046352

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

160558

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

244415

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

296658

SLIT2
Slit homolog 2 protein

1

0

High-throughput

0.458

High

298502

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

322599

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

346740

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

718840

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

826515

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.458

High

856998

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.458

High

877725

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

991165

TISB
mRNA decay activator protein ZFP36L1

1

0

Small-scale

0.458

High

1022087

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1046279

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

1046281

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1046282

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

1046295

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1046296

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

1046298

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1046303

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

Small-scale

0.458

High

1046307

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.458

High

1046311

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1046315

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1046320

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1046323

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1046324

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.458

High

1046326

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

1046327

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1046328

MET22
Methyltransferase-like protein 22

1

0

High-throughput

0.458

High

1046329

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1046333

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

1046336

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1046338

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1046341

RENT2
Regulator of nonsense transcripts 2

1

0

Small-scale

0.458

High

1046344

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1046345

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1046351

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1046353

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1046356

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1046358

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

0

High-throughput

0.458

High

2876

A0A0G2JJL1
WD repeat-containing protein 46

1

3

High-throughput

0.445

High

91559

E7EWD6
ASXL transcriptional regulator 2

1

3

High-throughput

0.445

High

102422

G3V3Y1
15-oxoprostaglandin 13-reductase

1

1

High-throughput

0.445

High

306164

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

1046337

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

2

High-throughput

0.445

High

401974

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1046340

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

471690

SBK3
Uncharacterized serine/threonine-protein kinase SBK3

2

0

High-throughput

0.316

High

64010

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

850469

PLXA3
Plexin-A3

1

0

High-throughput

0.279

Low

1046304

GLT13
Polypeptide N-acetylgalactosaminyltransferase 13

1

0

High-throughput

0.251

Low

1046322

RM48
Large ribosomal subunit protein mL48

1

0

High-throughput

0.251

Low

1046349

SIA7A
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

1

0

High-throughput

0.251

Low

851119

LUM
Lumican

1

0

High-throughput

0.249

Low

1046283

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.249

Low

1046355

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1046291

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024