Protein: SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)

Gene: SHIP1, INPP5D
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q92835

Gene Ontology (top 5):
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 - inositol-polyphosphate 5-phosphatase activity
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666147

SHC1
SHC-transforming protein 1

9

20

Small-scale

0.962

High

924742

GRB2
Growth factor receptor-bound protein 2

5

20

Small-scale

0.909

High

986006

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

1

Small-scale

0.814

High

581171

EPOR
Erythropoietin receptor

2

2

Small-scale

0.786

High

655433

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

8

Small-scale

0.776

High

433931

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.747

High

802882

CRKL
Crk-like protein

1

20

Small-scale

0.724

High

685209

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

5

7

Small-scale

0.692

High

433436

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.647

High

499282

KIT
Mast/stem cell growth factor receptor Kit

1

7

Small-scale

0.647

High

802685

CRK
Adapter molecule crk

1

20

High-throughput

0.647

High

267532

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

3

0

High-throughput

0.646

High

1271564

DOK1
Docking protein 1

3

7

Small-scale

0.646

High

1081558

NTRK3
NT-3 growth factor receptor

1

13

High-throughput

0.646

High

1030743

SLAF1
Signaling lymphocytic activation molecule

2

16

Small-scale

0.639

High

1271565

CD244
Natural killer cell receptor 2B4

2

12

Small-scale

0.625

High

176483

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

2

High-throughput

0.618

High

442867

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

506634

BCR
Breakpoint cluster region protein

1

7

Small-scale

0.618

High

557759

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.618

High

738250

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

Small-scale

0.618

High

796620

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

984521

KPCD
Protein kinase C delta type

1

1

Small-scale

0.618

High

1075809

CIP4
Cdc42-interacting protein 4

1

6

Small-scale

0.618

High

1271571

CD2AP
CD2-associated protein

1

20

Small-scale

0.618

High

1271562

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.606

High

1216365

KRA13
Keratin-associated protein 1-3

2

3

High-throughput

0.606

High

1271568

TLR9
Toll-like receptor 9

1

0

Small-scale

0.586

High

1271570

TRAF6
TNF receptor-associated factor 6

2

3

Small-scale

0.584

High

155850

SH21B
SH2 domain-containing protein 1B

1

20

Small-scale

0.575

High

994665

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

889354

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.573

High

889853

KR109
Keratin-associated protein 10-9

1

3

High-throughput

0.573

High

1071314

K1H1
Keratin, type I cuticular Ha1

1

12

High-throughput

0.573

High

1149264

K1C40
Keratin, type I cytoskeletal 40

1

11

High-throughput

0.573

High

957748

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.552

High

557482

PECA1
Platelet endothelial cell adhesion molecule

1

4

Small-scale

0.536

High

1271561

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

2

Small-scale

0.527

High

1189385

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.523

High

622746

IL4RA
Interleukin-4 receptor subunit alpha

1

1

Small-scale

0.516

High

439846

NEP
Neprilysin

1

0

Small-scale

0.513

High

941701

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

1

Small-scale

0.501

High

957205

DAB2
Disabled homolog 2

1

4

Small-scale

0.501

High

1271566

LY9
T-lymphocyte surface antigen Ly-9

1

15

Small-scale

0.501

High

1216513

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

564985

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.493

High

1109341

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

269175

DAB1
Disabled homolog 1

1

6

Small-scale

0.481

High

888952

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.481

High

1271563

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

4

Small-scale

0.481

High

228249

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

235093

DOK2
Docking protein 2

1

8

Small-scale

0.479

High

590610

CD22
B-cell receptor CD22

1

5

Small-scale

0.479

High

610466

CBL
E3 ubiquitin-protein ligase CBL

1

3

Small-scale

0.479

High

1066482

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1105474

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

3

High-throughput

0.479

High

1146691

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1184734

DOK3
Docking protein 3

1

7

Small-scale

0.479

High

1257121

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

Small-scale

0.479

High

1271567

SLAF7
SLAM family member 7

1

15

Small-scale

0.479

High

647938

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.458

High

1115377

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

Small-scale

0.458

High

1271569

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

584444

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.445

High

632342

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

Small-scale

0.445

High

1268705

FCGRB
Putative high affinity immunoglobulin gamma Fc receptor IB

1

7

Small-scale

0.408

High

67267

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1229707

CLYBL
Citramalyl-CoA lyase, mitochondrial

1

0

Small-scale

0.249

Low

831540

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


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Last updated: 15 Jul 2024