Protein: DPOE1
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)

Gene: DPOE1, POLE
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q07864

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000166 - nucleotide binding
GO:0000278 - mitotic cell cycle
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

880342

DPOE2
DNA polymerase epsilon subunit 2

8

4

Small-scale

0.966

High

517215

PCNA
Proliferating cell nuclear antigen

4

9

Small-scale

0.878

High

992322

DPOE3
DNA polymerase epsilon subunit 3

4

2

Small-scale

0.691

High

992304

DNJC7
DnaJ homolog subfamily C member 7

3

4

High-throughput

0.667

High

346616

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.662

High

992303

MMS19
MMS19 nucleotide excision repair protein homolog

3

3

Small-scale

0.656

High

992320

DPOE4
DNA polymerase epsilon subunit 4

3

2

Small-scale

0.650

High

992316

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

3

High-throughput

0.611

High

992299

LRC46
Leucine-rich repeat-containing protein 46

3

1

High-throughput

0.609

High

992274

TEBP
Prostaglandin E synthase 3

2

0

High-throughput

0.602

High

282887

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

3

4

Small-scale

0.585

High

992267

LG3BP
Galectin-3-binding protein

2

2

High-throughput

0.574

High

279013

RAD17
Cell cycle checkpoint protein RAD17

1

2

Small-scale

0.561

High

992318

CLSPN
Claspin

1

0

Small-scale

0.537

High

126456

FOXE1
Forkhead box protein E1

1

5

High-throughput

0.536

High

149852

RFXK
DNA-binding protein RFXANK

1

3

High-throughput

0.536

High

503958

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

877603

FOXG1
Forkhead box protein G1

1

5

High-throughput

0.536

High

975419

PPARD
Peroxisome proliferator-activated receptor delta

1

2

High-throughput

0.536

High

992268

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

992269

FOXL1
Forkhead box protein L1

1

5

High-throughput

0.536

High

992298

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

992305

NPAS1
Neuronal PAS domain-containing protein 1

1

1

High-throughput

0.536

High

992306

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.536

High

992310

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.536

High

992311

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

992312

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.536

High

992325

HSPB8
Heat shock protein beta-8

1

2

High-throughput

0.536

High

992329

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.536

High

992290

SH2D3
SH2 domain-containing protein 3C

2

3

High-throughput

0.521

High

529028

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

992295

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.515

High

67755

ZBBX
Zinc finger B-box domain-containing protein 1

1

0

High-throughput

0.513

High

245680

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

726514

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.513

High

992280

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.513

High

992284

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

992279

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.501

High

992307

SLD5
DNA replication complex GINS protein SLD5

1

7

Small-scale

0.501

High

992319

DPOD4
DNA polymerase delta subunit 4

1

1

Small-scale

0.501

High

276234

CIB2
Calcium and integrin-binding family member 2

1

1

High-throughput

0.489

High

323709

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

806497

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.489

High

992291

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.489

High

836140

STK19
Inactive serine/threonine-protein kinase 19

1

0

Small-scale

0.486

High

244339

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

322519

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

377272

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

384709

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

455359

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

718788

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

720304

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

749414

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

779294

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

828207

CENPA
Histone H3-like centromeric protein A

1

7

High-throughput

0.479

High

985171

DUS2
Dual specificity protein phosphatase 2

1

3

High-throughput

0.479

High

992270

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

992271

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

5

High-throughput

0.479

High

992272

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.479

High

992273

CUL3
Cullin-3

1

3

High-throughput

0.479

High

992276

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

992277

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

992288

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

992289

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

992294

CTF18
Chromosome transmission fidelity protein 18 homolog

1

2

Small-scale

0.479

High

992302

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

992308

DUS26
Dual specificity protein phosphatase 26

1

3

High-throughput

0.479

High

992309

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

1

Small-scale

0.479

High

992313

DUS15
Dual specificity protein phosphatase 15

1

3

High-throughput

0.479

High

992315

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

992317

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

992321

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

992327

FBW1B
F-box/WD repeat-containing protein 11

1

1

High-throughput

0.479

High

992330

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

3

High-throughput

0.479

High

992332

ARI1
E3 ubiquitin-protein ligase ARIH1

1

3

High-throughput

0.479

High

205308

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

676866

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.458

High

992275

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

0

High-throughput

0.458

High

992283

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

992285

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

992286

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

0

High-throughput

0.458

High

992293

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

0

High-throughput

0.458

High

992296

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

992331

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

224678

SSX4
Protein SSX4

1

1

High-throughput

0.445

High

256965

KDM4A
Lysine-specific demethylase 4A

1

3

Small-scale

0.445

High

992278

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

992314

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

992324

MTMR4
Myotubularin-related protein 4

1

1

High-throughput

0.437

High

992328

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

883493

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

992287

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

992300

MERB1
bMERB domain-containing protein 1

2

0

High-throughput

0.328

High

992326

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

326985

ABHGA
Phosphatidylserine lipase ABHD16A

2

0

High-throughput

0.316

High

992282

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

992281

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.269

Low

118284

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

992297

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

992301

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

992323

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

992292

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024