Protein: COX1
Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I)

Gene: COX1, MT-CO1
Organism: Homo sapiens
Interactions: 67
UniProt ID: P00395

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004129 - cytochrome-c oxidase activity
GO:0005743 - mitochondrial inner membrane
GO:0005750 - mitochondrial respiratory chain complex III
GO:0005751 - mitochondrial respiratory chain complex IV

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335648

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

Small-scale

0.847

High

335647

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

2

High-throughput

0.691

High

335692

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

1

High-throughput

0.691

High

335650

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.656

High

335653

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.656

High

335690

CX7B2
Cytochrome c oxidase subunit 7B2, mitochondrial

1

0

High-throughput

0.656

High

335700

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

3

0

Small-scale

0.634

High

335655

NK1R
Substance-P receptor

2

3

High-throughput

0.628

High

335642

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.618

High

335654

EDNRA
Endothelin-1 receptor

2

4

High-throughput

0.611

High

335644

ASGR2
Asialoglycoprotein receptor 2

3

1

High-throughput

0.609

High

335649

QCR7
Cytochrome b-c1 complex subunit 7

2

0

High-throughput

0.585

High

335671

CX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

1

2

Small-scale

0.575

High

335660

OPRM
Mu-type opioid receptor

2

1

High-throughput

0.574

High

335661

APJ
Apelin receptor

2

2

High-throughput

0.574

High

335697

P2Y12
P2Y purinoceptor 12

2

3

High-throughput

0.558

High

335674

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.547

High

335651

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.536

High

335662

ATPG
ATP synthase subunit gamma, mitochondrial

1

1

High-throughput

0.536

High

335669

RAC1
Ras-related C3 botulinum toxin substrate 1

2

2

High-throughput

0.521

High

159447

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.513

High

335676

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.513

High

335688

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.513

High

335696

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.513

High

156770

FFAR1
Free fatty acid receptor 1

1

4

High-throughput

0.489

High

198085

MTLR
Motilin receptor

1

5

High-throughput

0.489

High

335652

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

2

High-throughput

0.489

High

335656

5HT1B
5-hydroxytryptamine receptor 1B

1

1

High-throughput

0.489

High

335657

GRPR
Gastrin-releasing peptide receptor

1

4

High-throughput

0.489

High

335658

NTR1
Neurotensin receptor type 1

1

3

High-throughput

0.489

High

335659

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.489

High

335665

GLR
Glucagon receptor

1

1

High-throughput

0.489

High

335673

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.489

High

335679

GP141
Probable G-protein coupled receptor 141

1

4

High-throughput

0.489

High

335683

P2RY8
P2Y purinoceptor 8

1

3

High-throughput

0.489

High

335702

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

335643

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.480

High

335678

CLC4G
C-type lectin domain family 4 member G

1

1

High-throughput

0.464

High

335672

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.460

High

306495

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

Small-scale

0.458

High

335668

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.439

High

335701

GPR52
G-protein coupled receptor 52

1

3

High-throughput

0.437

High

335645

COX6C
Cytochrome c oxidase subunit 6C

1

0

Small-scale

0.426

High

335680

COXM1
COX assembly mitochondrial protein homolog

1

0

Small-scale

0.426

High

335693

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

Small-scale

0.426

High

335695

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

Small-scale

0.426

High

335681

RETR3
Reticulophagy regulator 3

3

0

High-throughput

0.347

High

335684

S22A9
Organic anion transporter 7

2

0

High-throughput

0.328

High

335687

UXS1
UDP-glucuronic acid decarboxylase 1

2

0

High-throughput

0.328

High

335691

COX14
Cytochrome c oxidase assembly protein COX14

2

0

Small-scale

0.298

High

335670

DLG4
Disks large homolog 4

1

0

High-throughput

0.282

High

68042

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

326000

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

335664

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.279

Low

335677

I27RA
Interleukin-27 receptor subunit alpha

1

0

High-throughput

0.279

Low

335682

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

335685

SC5A8
Sodium-coupled monocarboxylate transporter 1

1

0

High-throughput

0.279

Low

335689

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.279

Low

335694

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

0

High-throughput

0.279

Low

335675

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

335666

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

335667

MEOX2
Homeobox protein MOX-2

1

0

Small-scale

0.251

Low

335686

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

335699

SIK3
Serine/threonine-protein kinase SIK3

1

0

High-throughput

0.249

Low

335698

UBQL1
Ubiquilin-1

1

0

Small-scale

0.238

Low

335646

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

335663

SYUA
Alpha-synuclein

1

0

Small-scale

0.213

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024