Protein: PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)

Gene: PK3C3, PIK3C3
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q8NEB9

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0004672 - protein kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1243070

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

11

8

Small-scale

0.977

High

592383

RAB5A
Ras-related protein Rab-5A

3

15

Small-scale

0.827

High

1054166

BECN1
Beclin-1

64

6

Small-scale

0.772

High

1169276

BAKOR
Beclin 1-associated autophagy-related key regulator

31

1

Small-scale

0.768

High

1243080

UVRAG
UV radiation resistance-associated gene protein

15

1

Small-scale

0.762

High

1243059

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

9

1

Small-scale

0.756

High

929570

RACK1
Small ribosomal subunit protein RACK1

2

4

Small-scale

0.754

High

1243073

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

4

Small-scale

0.754

High

1243063

NRBF2
Nuclear receptor-binding factor 2

8

1

Small-scale

0.754

High

904880

1433G
14-3-3 protein gamma

5

20

High-throughput

0.714

High

1243081

ZRAN1
Ubiquitin thioesterase ZRANB1

3

2

Small-scale

0.670

High

1203491

SKAP1
Src kinase-associated phosphoprotein 1

3

12

High-throughput

0.667

High

1243075

PACER
Protein associated with UVRAG as autophagy enhancer

2

1

High-throughput

0.628

High

787526

MTOR
Serine/threonine-protein kinase mTOR

1

6

Small-scale

0.618

High

845616

RAB9A
Ras-related protein Rab-9A

1

17

High-throughput

0.618

High

900702

RHOA
Transforming protein RhoA

1

19

High-throughput

0.618

High

1060518

RB39A
Ras-related protein Rab-39A

1

10

Small-scale

0.618

High

1146631

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.618

High

814997

LEG7
Galectin-7

2

1

High-throughput

0.611

High

850119

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

3

Small-scale

0.611

High

982293

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

228094

PRKN
E3 ubiquitin-protein ligase parkin

2

5

Small-scale

0.584

High

1029652

TIF1B
Transcription intermediary factor 1-beta

2

1

Small-scale

0.584

High

1243056

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

10

High-throughput

0.575

High

182183

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

2

Small-scale

0.561

High

1151617

OTU7B
OTU domain-containing protein 7B

1

2

Small-scale

0.561

High

1153709

STYK1
Tyrosine-protein kinase STYK1

1

8

Small-scale

0.561

High

318187

DIRA3
GTP-binding protein Di-Ras3

1

10

Small-scale

0.553

High

591935

RAB4A
Ras-related protein Rab-4A

1

14

High-throughput

0.553

High

255173

ATG13
Autophagy-related protein 13

2

0

Small-scale

0.547

High

1243065

FXL20
F-box/LRR-repeat protein 20

1

0

Small-scale

0.537

High

362250

GLPA
Glycophorin-A

1

2

High-throughput

0.536

High

586867

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

813617

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

934324

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.536

High

1243060

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.536

High

1243072

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

1

2

High-throughput

0.536

High

1072696

UBE3C
Ubiquitin-protein ligase E3C

1

1

Small-scale

0.528

High

1243066

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.513

High

1243078

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

647121

1433T
14-3-3 protein theta

1

20

Small-scale

0.501

High

1059327

CASP8
Caspase-8

1

1

Small-scale

0.501

High

1243085

SHLB1
Endophilin-B1

1

6

Small-scale

0.500

High

1030737

SLAF1
Signaling lymphocytic activation molecule

1

4

Small-scale

0.489

High

123659

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

131836

KRIT1
Krev interaction trapped protein 1

1

2

Small-scale

0.479

High

153731

ANM5
Protein arginine N-methyltransferase 5

1

1

Small-scale

0.479

High

205703

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

231638

KIF1B
Kinesin-like protein KIF1B

1

7

Small-scale

0.479

High

242871

TRI13
E3 ubiquitin-protein ligase TRIM13

1

2

Small-scale

0.479

High

301423

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

2

Small-scale

0.479

High

305550

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

340493

PGK1
Phosphoglycerate kinase 1

1

1

Small-scale

0.479

High

385189

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.479

High

387136

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

432070

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.479

High

451708

CLCB
Clathrin light chain B

1

2

High-throughput

0.479

High

502334

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.479

High

522561

MYH1
Myosin-1

1

5

Small-scale

0.479

High

527634

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

567178

CXA1
Gap junction alpha-1 protein

1

4

Small-scale

0.479

High

724921

MYH9
Myosin-9

1

5

Small-scale

0.479

High

927318

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1049271

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.479

High

1065230

JOS1
Josephin-1

1

2

Small-scale

0.479

High

1085003

DREB
Drebrin

1

4

Small-scale

0.479

High

1170879

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1243057

JOS2
Josephin-2

1

2

Small-scale

0.479

High

1243058

TSC1
Hamartin

1

10

Small-scale

0.479

High

1243061

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.479

High

1243062

OPTN
Optineurin

1

11

High-throughput

0.479

High

1243068

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

1

Small-scale

0.479

High

1243069

RING2
E3 ubiquitin-protein ligase RING2

1

5

Small-scale

0.479

High

1243074

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1243077

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1243083

DD19B
ATP-dependent RNA helicase DDX19B

1

1

High-throughput

0.479

High

1243084

UBP18
Ubl carboxyl-terminal hydrolase 18

1

1

Small-scale

0.479

High

310408

EPM2A
Laforin

1

0

Small-scale

0.458

High

874139

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

1061506

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1168791

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1200088

NLRX1
NLR family member X1

1

0

Small-scale

0.458

High

1223235

EXOC8
Exocyst complex component 8

1

0

Small-scale

0.458

High

1243067

EXOC2
Exocyst complex component 2

1

0

Small-scale

0.458

High

1243071

ATGA1
Autophagy-related protein 101

1

0

Small-scale

0.458

High

1243079

DACT1
Dapper homolog 1

1

0

Small-scale

0.458

High

68339

BECN2
Beclin-2

1

6

Small-scale

0.445

High

751725

GRP75
Stress-70 protein, mitochondrial

1

4

Small-scale

0.445

High

553218

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

651720

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

720944

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1151983

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

1243082

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

1243064

VMP1
Vacuole membrane protein 1

1

0

Small-scale

0.426

High

410619

CD5
T-cell surface glycoprotein CD5

1

1

Small-scale

0.348

High

1243076

JADE2
E3 ubiquitin-protein ligase Jade-2

3

0

High-throughput

0.347

High

426695

H10
Histone H1.0

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024