Protein: SF3B4
Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49)

Gene: SF3B4
Organism: Homo sapiens
Interactions: 216
UniProt ID: Q15427

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1034292

SF3B2
Splicing factor 3B subunit 2

10

6

Small-scale

0.978

High

958037

RBM10
RNA-binding protein 10

4

20

High-throughput

0.911

High

800890

MK09
Mitogen-activated protein kinase 9

4

10

High-throughput

0.911

High

1054336

RBM39
RNA-binding protein 39

3

19

High-throughput

0.873

High

453826

RU2A
U2 small nuclear ribonucleoprotein A'

3

3

High-throughput

0.861

High

268731

SF3B1
Splicing factor 3B subunit 1

3

1

Small-scale

0.847

High

1073574

SF3A2
Splicing factor 3A subunit 2

3

5

Small-scale

0.847

High

441293

RU2B
U2 small nuclear ribonucleoprotein B''

2

20

High-throughput

0.811

High

1073656

SF3B6
Splicing factor 3B subunit 6

2

20

High-throughput

0.789

High

967197

EWS
RNA-binding protein EWS

2

16

High-throughput

0.757

High

1073600

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

18

High-throughput

0.757

High

1073582

LARP7
La-related protein 7

2

19

High-throughput

0.754

High

850656

KS6A3
Ribosomal protein S6 kinase alpha-3

2

7

High-throughput

0.737

High

257473

CREST
Calcium-responsive transactivator

4

1

High-throughput

0.705

High

324408

BAG3
BAG family molecular chaperone regulator 3

4

4

High-throughput

0.699

High

129006

PLK4
Serine/threonine-protein kinase PLK4

1

8

High-throughput

0.691

High

446648

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.691

High

586768

CSK22
Casein kinase II subunit alpha'

1

6

High-throughput

0.691

High

951977

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.691

High

1072993

SF3B3
Splicing factor 3B subunit 3

1

3

High-throughput

0.691

High

1073617

SPF45
Splicing factor 45

1

16

High-throughput

0.691

High

1073651

ZN346
Zinc finger protein 346

1

8

High-throughput

0.691

High

1073653

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.691

High

738350

BMR1A
Bone morphogenetic protein receptor type-1A

2

0

Small-scale

0.678

High

1073579

C19L2
CWF19-like protein 2

3

3

High-throughput

0.675

High

911843

RUXF
Small nuclear ribonucleoprotein F

3

7

High-throughput

0.675

High

92678

E9PPJ0
Splicing factor 3b subunit 2

1

6

High-throughput

0.665

High

1073596

DDX42
ATP-dependent RNA helicase DDX42

3

9

High-throughput

0.664

High

682823

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

18

High-throughput

0.656

High

855070

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

19

High-throughput

0.656

High

1028926

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.656

High

1048072

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.656

High

1073577

SF01
Splicing factor 1

1

13

High-throughput

0.656

High

1073633

RBM4
RNA-binding protein 4

1

19

High-throughput

0.656

High

641795

U2AF2
Splicing factor U2AF 65 kDa subunit

1

19

Small-scale

0.647

High

1073640

MET17
Ribosome assembly protein METTL17, mitochondrial

2

1

High-throughput

0.646

High

209057

NCK2
Cytoplasmic protein NCK2

4

18

High-throughput

0.644

High

789117

FRK
Tyrosine-protein kinase FRK

2

9

High-throughput

0.640

High

1073630

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

2

8

High-throughput

0.640

High

1064328

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

6

High-throughput

0.631

High

1073588

PRP8
Pre-mRNA-processing-splicing factor 8

2

4

High-throughput

0.631

High

538970

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

7

High-throughput

0.628

High

927957

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

8

High-throughput

0.628

High

1073587

ANM9
Protein arginine N-methyltransferase 9

2

13

Small-scale

0.628

High

1073593

PHF5A
PHD finger-like domain-containing protein 5A

2

1

High-throughput

0.628

High

1073621

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

2

High-throughput

0.628

High

198894

RFOX2
RNA binding protein fox-1 homolog 2

1

18

High-throughput

0.621

High

613467

SFPQ
Splicing factor, proline- and glutamine-rich

1

18

High-throughput

0.621

High

851503

NEK4
Serine/threonine-protein kinase Nek4

1

7

High-throughput

0.618

High

325741

LATS1
Serine/threonine-protein kinase LATS1

1

9

High-throughput

0.618

High

442178

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

18

High-throughput

0.618

High

726840

FUS
RNA-binding protein FUS

1

20

High-throughput

0.618

High

822268

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.618

High

833442

RBM25
RNA-binding protein 25

1

2

High-throughput

0.618

High

1018802

SF3A3
Splicing factor 3A subunit 3

1

1

High-throughput

0.618

High

1073601

RB15B
Putative RNA-binding protein 15B

1

19

High-throughput

0.618

High

1073605

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

2

High-throughput

0.618

High

1073607

PSPC1
Paraspeckle component 1

1

19

High-throughput

0.618

High

1073616

AURKB
Aurora kinase B

1

14

High-throughput

0.618

High

1073620

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

3

High-throughput

0.618

High

912047

RUXG
Small nuclear ribonucleoprotein G

2

13

High-throughput

0.611

High

1073647

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

2

0

High-throughput

0.608

High

563783

ZNF3
Zinc finger protein 3

2

1

High-throughput

0.606

High

1073632

TRAF4
TNF receptor-associated factor 4

2

7

High-throughput

0.606

High

911651

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

1065795

RRS1
Ribosome biogenesis regulatory protein homolog

2

0

High-throughput

0.602

High

1073615

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.602

High

263643

PR40A
Pre-mRNA-processing factor 40 homolog A

2

19

High-throughput

0.595

High

924591

GRB2
Growth factor receptor-bound protein 2

2

14

High-throughput

0.586

High

227533

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.584

High

322674

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

20

High-throughput

0.584

High

993431

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1073619

ZNF48
Zinc finger protein 48

2

0

High-throughput

0.580

High

1073628

RAMAC
RNA guanine-N7 methyltransferase activating subunit

2

0

High-throughput

0.580

High

1073631

RPP25
Ribonuclease P protein subunit p25

2

0

High-throughput

0.580

High

1073641

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.575

High

1073626

WDR83
WD repeat domain-containing protein 83

1

9

High-throughput

0.573

High

883340

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

6

High-throughput

0.573

High

1073648

HSPB7
Heat shock protein beta-7

1

4

High-throughput

0.573

High

1073655

BAIP2
BAR/IMD domain-containing adapter protein 2

1

2

High-throughput

0.573

High

313288

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

0

Small-scale

0.569

High

1073610

TFG
Protein TFG

2

7

High-throughput

0.553

High

148855

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.553

High

195447

DHX15
ATP-dependent RNA helicase DHX15

2

5

Small-scale

0.552

High

278453

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.549

High

1073659

NUB1
NEDD8 ultimate buster 1

1

0

High-throughput

0.549

High

883719

WDR4
tRNA

1

14

High-throughput

0.541

High

236766

CCNT1
Cyclin-T1

1

3

High-throughput

0.536

High

278816

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.536

High

448664

RU1C
U1 small nuclear ribonucleoprotein C

1

4

High-throughput

0.536

High

559415

H13
Histone H1.3

1

13

High-throughput

0.536

High

759674

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

890969

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

7

High-throughput

0.536

High

912465

SMD2
Small nuclear ribonucleoprotein Sm D2

1

2

High-throughput

0.536

High

1039584

SNW1
SNW domain-containing protein 1

1

7

High-throughput

0.536

High

1040997

CUL1
Cullin-1

1

20

High-throughput

0.536

High

1041638

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1073575

SF3A1
Splicing factor 3A subunit 1

1

4

High-throughput

0.536

High

1073580

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.536

High

1073586

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.536

High

1073595

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

12

High-throughput

0.536

High

1073606

STYX
Serine/threonine/tyrosine-interacting protein

1

6

High-throughput

0.536

High

1073612

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.536

High

1073622

CDC5L
Cell division cycle 5-like protein

1

6

Small-scale

0.536

High

1073634

SF3B5
Splicing factor 3B subunit 5

1

2

High-throughput

0.536

High

1073635

NADAP
Kanadaptin

1

1

High-throughput

0.536

High

1073642

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.536

High

1052206

SRC8
Src substrate cortactin

2

5

High-throughput

0.535

High

297862

SC24D
Protein transport protein Sec24D

1

1

High-throughput

0.523

High

278942

SPF30
Survival of motor neuron-related-splicing factor 30

1

5

High-throughput

0.515

High

602842

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1019759

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.508

High

1073597

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

7

High-throughput

0.508

High

1073611

DDX17
Probable ATP-dependent RNA helicase DDX17

1

9

High-throughput

0.508

High

1073624

MEP50
Methylosome protein WDR77

1

7

High-throughput

0.508

High

120926

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.501

High

174911

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.501

High

269238

WBP4
WW domain-binding protein 4

1

10

High-throughput

0.501

High

274420

CRTAP
Cartilage-associated protein

1

1

High-throughput

0.489

High

902315

COPZ1
Coatomer subunit zeta-1

1

1

High-throughput

0.489

High

949019

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

1073589

TTC33
Tetratricopeptide repeat protein 33

1

4

High-throughput

0.489

High

300155

PRP6
Pre-mRNA-processing factor 6

1

13

High-throughput

0.481

High

314051

BAG4
BAG family molecular chaperone regulator 4

1

4

High-throughput

0.481

High

932711

EF1A1
Elongation factor 1-alpha 1

1

11

High-throughput

0.481

High

1073584

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

13

High-throughput

0.481

High

1073618

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

3

High-throughput

0.481

High

122778

MEN1
Menin

1

5

High-throughput

0.479

High

125479

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

11

High-throughput

0.479

High

130902

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

8

High-throughput

0.479

High

154812

TCRG1
Transcription elongation regulator 1

1

5

Small-scale

0.479

High

210020

PRC1
Protein regulator of cytokinesis 1

1

9

High-throughput

0.479

High

233469

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

244481

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

294864

RECQ4
ATP-dependent DNA helicase Q4

1

13

High-throughput

0.479

High

298541

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

305177

UBE4B
Ubiquitin conjugation factor E4 B

1

1

Small-scale

0.479

High

308736

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

318621

EYA4
Eyes absent homolog 4

1

9

High-throughput

0.479

High

337482

ABL1
Tyrosine-protein kinase ABL1

1

9

High-throughput

0.479

High

346857

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

369664

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

379435

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

397984

ISG15
Ubiquitin-like protein ISG15

1

16

High-throughput

0.479

High

412206

FYN
Tyrosine-protein kinase Fyn

1

9

High-throughput

0.479

High

550788

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

557702

NCK1
SH2/SH3 adapter protein NCK1

1

17

High-throughput

0.479

High

569763

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

632739

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

684750

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

718882

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

719497

MERL
Merlin

1

2

High-throughput

0.479

High

779468

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

817675

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.479

High

824041

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

877740

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

908595

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

917317

H4
Histone H4

1

4

High-throughput

0.479

High

940938

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

969721

KIF23
Kinesin-like protein KIF23

1

16

High-throughput

0.479

High

1049039

TRI14
Tripartite motif-containing protein 14

1

8

High-throughput

0.479

High

1063403

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1066156

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1073576

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

1073585

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1073590

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.479

High

1073592

MEPCE
7SK snRNA methylphosphate capping enzyme

1

7

High-throughput

0.479

High

1073594

ZCH18
Zinc finger CCCH domain-containing protein 18

1

14

High-throughput

0.479

High

1073598

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

1073599

SRRM1
Serine/arginine repetitive matrix protein 1

1

9

High-throughput

0.479

High

1073602

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

1073604

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1073608

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1073609

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1073613

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.479

High

1073614

OPTN
Optineurin

1

13

High-throughput

0.479

High

1073623

RING2
E3 ubiquitin-protein ligase RING2

1

19

High-throughput

0.479

High

1073625

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

1073636

API5
Apoptosis inhibitor 5

1

1

High-throughput

0.479

High

1073637

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

17

High-throughput

0.479

High

1073638

NSRP1
Nuclear speckle splicing regulatory protein 1

1

2

High-throughput

0.479

High

1073643

BRD7
Bromodomain-containing protein 7

1

9

High-throughput

0.479

High

1073645

ANLN
Anillin

1

8

High-throughput

0.479

High

1073649

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1073650

UBQL2
Ubiquilin-2

1

6

High-throughput

0.479

High

1073652

FZR1
Fizzy-related protein homolog

1

13

High-throughput

0.479

High

1073654

SRRM2
Serine/arginine repetitive matrix protein 2

1

15

High-throughput

0.479

High

1073657

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

1073660

MAFB
Transcription factor MafB

1

6

High-throughput

0.479

High

1012397

Q0VDC6
peptidylprolyl isomerase

1

2

High-throughput

0.470

High

1073578

ITSN1
Intersectin-1

1

3

High-throughput

0.464

High

1073646

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.460

High

1062148

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1073629

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.458

High

68422

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

13

High-throughput

0.445

High

402053

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

497073

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

1073583

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.445

High

923828

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

2

High-throughput

0.439

High

836141

STK19
Inactive serine/threonine-protein kinase 19

1

0

Small-scale

0.438

High

932176

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.437

High

1061420

CUL7
Cullin-7

1

8

High-throughput

0.437

High

1073591

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1073639

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1073644

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.437

High

891159

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.407

High

1047094

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.407

High

1073658

TCAF1
TRPM8 channel-associated factor 1

5

0

High-throughput

0.378

High

814454

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.316

High

1073603

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.299

High

532128

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

674670

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

816301

GLIP1
Glioma pathogenesis-related protein 1

1

0

Small-scale

0.249

Low

1053567

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1073581

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1073627

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024