Protein: PRP4
U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)

Gene: PRP4, PRPF4
Organism: Homo sapiens
Interactions: 216
UniProt ID: O43172

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

196913

PPIH
Peptidyl-prolyl cis-trans isomerase H

8

5

Small-scale

0.970

High

196912

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

7

4

Small-scale

0.965

High

196929

PRP6
Pre-mRNA-processing factor 6

5

18

High-throughput

0.930

High

197071

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

5

16

High-throughput

0.930

High

197041

PRP8
Pre-mRNA-processing-splicing factor 8

5

5

High-throughput

0.925

High

196981

NH2L1
NHP2-like protein 1

4

10

Small-scale

0.905

High

197012

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

6

High-throughput

0.802

High

197036

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

2

13

High-throughput

0.802

High

197023

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

6

High-throughput

0.789

High

197111

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

5

Small-scale

0.776

High

197022

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

6

20

Small-scale

0.736

High

197054

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

5

4

Small-scale

0.722

High

197061

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

5

10

Small-scale

0.721

High

197113

LSM4
U6 snRNA-associated Sm-like protein LSm4

5

20

High-throughput

0.716

High

197083

DDX23
Probable ATP-dependent RNA helicase DDX23

4

13

High-throughput

0.702

High

196935

LSM8
U6 snRNA-associated Sm-like protein LSm8

4

16

High-throughput

0.697

High

196991

LSM6
U6 snRNA-associated Sm-like protein LSm6

4

20

High-throughput

0.697

High

197088

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

4

2

High-throughput

0.694

High

196985

RS16
Small ribosomal subunit protein uS9

1

6

High-throughput

0.691

High

197072

TOE1
Target of EGR1 protein 1

1

1

High-throughput

0.691

High

197044

MEPCE
7SK snRNA methylphosphate capping enzyme

4

2

High-throughput

0.691

High

196988

RUXF
Small nuclear ribonucleoprotein F

3

20

High-throughput

0.675

High

196992

SMD2
Small nuclear ribonucleoprotein Sm D2

3

5

High-throughput

0.675

High

197015

PRP4K
Serine/threonine-protein kinase PRP4 homolog

3

20

High-throughput

0.671

High

197065

N42L2
NEDD4-binding protein 2-like 2

3

3

High-throughput

0.671

High

196911

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

3

6

Small-scale

0.662

High

197110

LSM2
U6 snRNA-associated Sm-like protein LSm2

3

19

High-throughput

0.662

High

197003

U2AF1
Splicing factor U2AF 35 kDa subunit

1

3

High-throughput

0.656

High

196926

WBP4
WW domain-binding protein 4

2

6

High-throughput

0.629

High

196927

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

2

20

High-throughput

0.628

High

196951

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

6

High-throughput

0.628

High

196987

RUXE
Small nuclear ribonucleoprotein E

2

3

High-throughput

0.628

High

196997

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

8

High-throughput

0.628

High

197112

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

13

High-throughput

0.628

High

197082

RBM42
RNA-binding protein 42

2

9

High-throughput

0.621

High

197104

LSM7
U6 snRNA-associated Sm-like protein LSm7

2

16

High-throughput

0.621

High

196910

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

17

Small-scale

0.621

High

196937

FINC
Fibronectin

1

6

High-throughput

0.618

High

196956

ARBK1
Beta-adrenergic receptor kinase 1

1

7

High-throughput

0.618

High

196967

LIFR
Leukemia inhibitory factor receptor

1

2

High-throughput

0.618

High

196984

WDR5
WD repeat-containing protein 5

1

18

High-throughput

0.618

High

196986

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

14

High-throughput

0.618

High

197009

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

11

High-throughput

0.618

High

197092

ANLN
Anillin

1

7

High-throughput

0.618

High

197099

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

7

High-throughput

0.618

High

197107

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.618

High

196932

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

3

High-throughput

0.611

High

196963

COIL
Coilin

2

1

High-throughput

0.611

High

196989

RUXG
Small nuclear ribonucleoprotein G

2

20

High-throughput

0.611

High

197019

RBM39
RNA-binding protein 39

2

11

High-throughput

0.611

High

197048

CATAC
Centrosomal AT-AC splicing factor

2

0

Small-scale

0.585

High

196917

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.584

High

197097

TMOD3
Tropomodulin-3

2

2

High-throughput

0.574

High

197068

GPKOW
G-patch domain and KOW motifs-containing protein

1

1

High-throughput

0.573

High

196942

LYN
Tyrosine-protein kinase Lyn

2

6

High-throughput

0.571

High

148157

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.553

High

196998

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.553

High

197043

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

197087

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

197090

RC3H2
Roquin-2

1

10

High-throughput

0.553

High

121550

IKBE
NF-kappa-B inhibitor epsilon

1

9

High-throughput

0.536

High

196918

NUAK1
NUAK family SNF1-like kinase 1

1

3

High-throughput

0.536

High

196920

CCNT1
Cyclin-T1

1

4

High-throughput

0.536

High

196923

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

4

High-throughput

0.536

High

196925

SF3B1
Splicing factor 3B subunit 1

1

8

High-throughput

0.536

High

196944

SNRPA
U1 small nuclear ribonucleoprotein A

1

9

High-throughput

0.536

High

196945

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

196949

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

196955

CSK22
Casein kinase II subunit alpha'

1

9

High-throughput

0.536

High

196958

U2AF2
Splicing factor U2AF 65 kDa subunit

1

16

High-throughput

0.536

High

196966

FRK
Tyrosine-protein kinase FRK

1

6

High-throughput

0.536

High

196968

MK08
Mitogen-activated protein kinase 8

1

5

High-throughput

0.536

High

196970

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

196977

CLK2
Dual specificity protein kinase CLK2

1

12

High-throughput

0.536

High

196978

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

196979

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

196990

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

15

High-throughput

0.536

High

196993

SMD3
Small nuclear ribonucleoprotein Sm D3

1

20

High-throughput

0.536

High

197000

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.536

High

197004

OTUD4
OTU domain-containing protein 4

1

2

High-throughput

0.536

High

197008

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

197016

CUL3
Cullin-3

1

20

High-throughput

0.536

High

197017

DX39B
Spliceosome RNA helicase DDX39B

1

16

High-throughput

0.536

High

197027

SF3A1
Splicing factor 3A subunit 1

1

9

High-throughput

0.536

High

197031

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

13

High-throughput

0.536

High

197039

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.536

High

197051

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

17

High-throughput

0.536

High

197062

SYNE2
Nesprin-2

1

7

High-throughput

0.536

High

197067

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.536

High

197070

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.536

High

197075

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.536

High

197089

DHX33
ATP-dependent RNA helicase DHX33

1

11

High-throughput

0.536

High

197094

DDX21
Nucleolar RNA helicase 2

1

17

High-throughput

0.536

High

197106

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

196983

PFD3
Prefoldin subunit 3

1

6

High-throughput

0.515

High

197002

TXN4A
Thioredoxin-like protein 4A

1

2

High-throughput

0.515

High

197060

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

2

High-throughput

0.515

High

197076

PFD5
Prefoldin subunit 5

1

9

High-throughput

0.515

High

197091

PFD4
Prefoldin subunit 4

1

4

High-throughput

0.515

High

197101

KDM5B
Lysine-specific demethylase 5B

1

7

High-throughput

0.515

High

196934

RPP29
Ribonuclease P protein subunit p29

1

0

High-throughput

0.513

High

197028

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

197077

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

197102

NARF
Nuclear prelamin A recognition factor

1

0

High-throughput

0.513

High

197006

SRSF1
Serine/arginine-rich splicing factor 1

1

15

Small-scale

0.501

High

196982

ATPK
ATP synthase subunit f, mitochondrial

1

1

High-throughput

0.494

High

196954

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.489

High

196964

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.489

High

196971

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.489

High

196973

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.489

High

197001

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.489

High

197007

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.489

High

197030

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.489

High

197037

FKB15
FK506-binding protein 15

1

10

High-throughput

0.489

High

197042

SAS6
Spindle assembly abnormal protein 6 homolog

1

7

High-throughput

0.489

High

197056

ENAH
Protein enabled homolog

1

8

High-throughput

0.489

High

197058

CERK1
Ceramide kinase

1

1

High-throughput

0.489

High

197066

KIFA3
Kinesin-associated protein 3

1

16

High-throughput

0.489

High

197078

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.489

High

197109

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

5

High-throughput

0.489

High

122378

MEN1
Menin

1

4

High-throughput

0.479

High

162220

XPO1
Exportin-1

1

15

High-throughput

0.479

High

196915

SPOP
Speckle-type POZ protein

1

4

High-throughput

0.479

High

196919

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

196921

BRD4
Bromodomain-containing protein 4

1

12

High-throughput

0.479

High

196928

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

196930

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

196931

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

196936

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

196938

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

196943

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

196946

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

19

Small-scale

0.479

High

196947

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.479

High

196953

CEBPB
CCAAT/enhancer-binding protein beta

1

15

High-throughput

0.479

High

196957

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.479

High

196959

PML
Protein PML

1

18

High-throughput

0.479

High

196960

STIP1
Stress-induced-phosphoprotein 1

1

12

High-throughput

0.479

High

196961

ARRB2
Beta-arrestin-2

1

4

High-throughput

0.479

High

196965

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

196969

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.479

High

196972

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

196974

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.479

High

196975

KC1E
Casein kinase I isoform epsilon

1

15

High-throughput

0.479

High

196980

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

196994

H4
Histone H4

1

7

High-throughput

0.479

High

196995

H2B1C
Histone H2B type 1-C/E/F/G/I

1

7

High-throughput

0.479

High

196999

H31
Histone H3.1

1

9

High-throughput

0.479

High

197005

ERCC6
DNA excision repair protein ERCC-6

1

17

Small-scale

0.479

High

197011

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

15

High-throughput

0.479

High

197013

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.479

High

197014

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

197018

ELOA1
Elongin-A

1

7

High-throughput

0.479

High

197020

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

15

High-throughput

0.479

High

197024

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

197025

RNPS1
RNA-binding protein with serine-rich domain 1

1

12

High-throughput

0.479

High

197026

PCBP1
Poly(rC)-binding protein 1

1

15

High-throughput

0.479

High

197029

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

197034

LARP7
La-related protein 7

1

16

High-throughput

0.479

High

197040

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

197045

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

197046

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

197047

PATL1
Protein PAT1 homolog 1

1

2

High-throughput

0.479

High

197049

THOC4
THO complex subunit 4

1

7

High-throughput

0.479

High

197050

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.479

High

197052

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

197053

SLX4
Structure-specific endonuclease subunit SLX4

1

11

High-throughput

0.479

High

197057

SNIP1
Smad nuclear-interacting protein 1

1

5

High-throughput

0.479

High

197059

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

197064

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

197069

TF3B
Transcription factor IIIB 90 kDa subunit

1

3

Small-scale

0.479

High

197079

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

197081

GCP2
Gamma-tubulin complex component 2

1

1

High-throughput

0.479

High

197085

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.479

High

197086

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

1

High-throughput

0.479

High

197095

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

197098

AKA7G
A-kinase anchor protein 7 isoform gamma

1

1

High-throughput

0.479

High

197100

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

197105

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.479

High

197114

MAFB
Transcription factor MafB

1

12

High-throughput

0.479

High

171558

PFD6
Prefoldin subunit 6

1

5

High-throughput

0.470

High

196922

PFD1
Prefoldin subunit 1

1

6

High-throughput

0.470

High

196933

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.458

High

196950

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.458

High

196952

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

197115

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

196940

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

68382

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

20

High-throughput

0.445

High

111072

I3L1H5
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.445

High

196941

JUN
Transcription factor Jun

1

18

High-throughput

0.445

High

196948

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

196962

BMI1
Polycomb complex protein BMI-1

1

19

High-throughput

0.445

High

197035

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

196916

PRIC3
Prickle planar cell polarity protein 3

1

8

High-throughput

0.437

High

196924

OBSL1
Obscurin-like protein 1

1

9

High-throughput

0.437

High

196939

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.437

High

197010

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

10

High-throughput

0.437

High

197021

CUL7
Cullin-7

1

5

High-throughput

0.437

High

197032

FSCN1
Fascin

1

2

High-throughput

0.437

High

197033

KNOP1
Lysine-rich nucleolar protein 1

1

2

High-throughput

0.437

High

197055

PTGR2
Prostaglandin reductase 2

1

3

High-throughput

0.437

High

197063

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.437

High

197073

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

197080

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.437

High

197084

CP250
Centrosome-associated protein CEP250

1

15

High-throughput

0.437

High

197096

OLA1
Obg-like ATPase 1

1

6

High-throughput

0.437

High

197108

RL26L
Ribosomal protein uL24-like

1

3

High-throughput

0.437

High

196976

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.408

High

102416

G3V3Y1
15-oxoprostaglandin 13-reductase

1

2

High-throughput

0.407

High

108772

H0Y413
Prickle planar cell polarity protein 3

1

8

High-throughput

0.407

High

196914

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

1

High-throughput

0.407

High

197093

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

4

0

High-throughput

0.366

High

196996

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.249

Low

197038

CI114
Putative methyltransferase C9orf114

1

0

High-throughput

0.249

Low

197074

RN157
E3 ubiquitin ligase RNF157

1

0

Small-scale

0.249

Low

197103

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024