Protein: SYF1
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)

Gene: SYF1, XAB2
Organism: Homo sapiens
Interactions: 162
UniProt ID: Q9HCS7

Gene Ontology (top 5):
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0001824 - blastocyst development
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1055483

DHX8
ATP-dependent RNA helicase DHX8

4

17

High-throughput

0.895

High

1336499

PPIE
Peptidyl-prolyl cis-trans isomerase E

9

7

High-throughput

0.759

High

224847

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

15

High-throughput

0.740

High

1336497

ISY1
Pre-mRNA-splicing factor ISY1 homolog

5

6

High-throughput

0.722

High

453913

RU2A
U2 small nuclear ribonucleoprotein A'

4

11

Small-scale

0.696

High

1336503

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

2

High-throughput

0.694

High

757771

IF4A3
Eukaryotic initiation factor 4A-III

1

7

High-throughput

0.691

High

911970

RUXF
Small nuclear ribonucleoprotein F

3

20

High-throughput

0.675

High

1336498

PRP19
Pre-mRNA-processing factor 19

3

20

High-throughput

0.675

High

1197548

RALYL
RNA-binding Raly-like protein

3

20

High-throughput

0.667

High

1308996

USB1
U6 snRNA phosphodiesterase 1

3

1

High-throughput

0.667

High

1310806

WDR83
WD repeat domain-containing protein 83

3

20

High-throughput

0.667

High

1314503

YJU2
Splicing factor YJU2

3

6

High-throughput

0.667

High

1039862

SNW1
SNW domain-containing protein 1

2

8

High-throughput

0.644

High

1303773

CDC5L
Cell division cycle 5-like protein

3

13

High-throughput

0.636

High

209486

PLRG1
Pleiotropic regulator 1

2

20

High-throughput

0.628

High

327817

SYF2
Pre-mRNA-splicing factor SYF2

2

1

High-throughput

0.628

High

539159

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

11

High-throughput

0.628

High

911751

RUXE
Small nuclear ribonucleoprotein E

2

5

High-throughput

0.628

High

928028

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

13

High-throughput

0.628

High

1329849

PININ
Pinin

2

3

High-throughput

0.628

High

230804

AQR
RNA helicase aquarius

2

2

Small-scale

0.619

High

1200678

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.618

High

912115

RUXG
Small nuclear ribonucleoprotein G

2

20

High-throughput

0.611

High

1054602

RBM39
RNA-binding protein 39

2

17

High-throughput

0.611

High

1288323

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

2

20

High-throughput

0.611

High

1201692

ZCH18
Zinc finger CCCH domain-containing protein 18

3

8

High-throughput

0.609

High

625055

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

5

Small-scale

0.601

High

347956

MYC
Myc proto-oncogene protein

2

12

High-throughput

0.584

High

1159295

PRP8
Pre-mRNA-processing-splicing factor 8

2

10

High-throughput

0.584

High

1028028

ERCC8
DNA excision repair protein ERCC-8

1

20

Small-scale

0.578

High

1336493

DDX41
Probable ATP-dependent RNA helicase DDX41

1

10

High-throughput

0.575

High

1020334

ELAV2
ELAV-like protein 2

2

11

High-throughput

0.574

High

1172892

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

1273650

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

3

High-throughput

0.574

High

1284568

K1143
Uncharacterized protein KIAA1143

2

2

High-throughput

0.574

High

1336486

DJC17
DnaJ homolog subfamily C member 17

2

12

High-throughput

0.574

High

1024957

RED
Protein Red

1

2

High-throughput

0.573

High

1034413

SF3B2
Splicing factor 3B subunit 2

1

3

High-throughput

0.573

High

370484

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1298605

ZN830
Zinc finger protein 830

2

0

Small-scale

0.559

High

1317819

GLIS2
Zinc finger protein GLIS2

1

3

Small-scale

0.541

High

71247

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

17

High-throughput

0.536

High

181255

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

241370

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

17

High-throughput

0.536

High

256579

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

278541

SPF27
Pre-mRNA-splicing factor SPF27

1

3

High-throughput

0.536

High

432942

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

20

High-throughput

0.536

High

441376

RU2B
U2 small nuclear ribonucleoprotein B''

1

20

High-throughput

0.536

High

446799

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

448821

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

508726

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.536

High

534271

YJU2B
Probable splicing factor YJU2B

1

6

High-throughput

0.536

High

912738

SMD3
Small nuclear ribonucleoprotein Sm D3

1

19

High-throughput

0.536

High

952136

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.536

High

976516

ERCC6
DNA excision repair protein ERCC-6

1

13

Small-scale

0.536

High

1019653

ILF2
Interleukin enhancer-binding factor 2

1

5

High-throughput

0.536

High

1029110

SRSF6
Serine/arginine-rich splicing factor 6

1

15

High-throughput

0.536

High

1042591

CUL3
Cullin-3

1

10

High-throughput

0.536

High

1064742

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

13

High-throughput

0.536

High

1070651

RNPS1
RNA-binding protein with serine-rich domain 1

1

19

High-throughput

0.536

High

1074240

SF3A1
Splicing factor 3A subunit 1

1

5

High-throughput

0.536

High

1084421

SRSF7
Serine/arginine-rich splicing factor 7

1

15

High-throughput

0.536

High

1084631

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

13

High-throughput

0.536

High

1092915

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

5

High-throughput

0.536

High

1168958

LN28B
Protein lin-28 homolog B

1

8

High-throughput

0.536

High

1260023

CCD12
Coiled-coil domain-containing protein 12

1

3

High-throughput

0.536

High

1264431

CTBL1
Beta-catenin-like protein 1

1

1

High-throughput

0.536

High

1284815

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

1288034

HDA11
Histone deacetylase 11

1

6

High-throughput

0.536

High

1288635

PABP5
Polyadenylate-binding protein 5

1

7

High-throughput

0.536

High

1336492

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1336494

HSPB8
Heat shock protein beta-8

1

3

High-throughput

0.536

High

1336495

RALY
RNA-binding protein Raly

1

13

High-throughput

0.536

High

1336502

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

4

High-throughput

0.536

High

612504

XPA
DNA repair protein complementing XP-A cells

1

0

Small-scale

0.529

High

1063633

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.515

High

792003

HD
Huntingtin

1

3

High-throughput

0.515

High

304454

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.513

High

1153056

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

1336490

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

1019961

ILF3
Interleukin enhancer-binding factor 3

1

13

High-throughput

0.508

High

902762

SUMO2
Small ubiquitin-related modifier 2

1

8

High-throughput

0.501

High

763103

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.493

High

324058

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

1252881

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

1271807

KIFA3
Kinesin-associated protein 3

1

9

High-throughput

0.489

High

1336500

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.489

High

1336501

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.489

High

123016

MEN1
Menin

1

5

High-throughput

0.479

High

149316

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

228770

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

244967

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

266431

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

323173

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

16

High-throughput

0.479

High

374914

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

387561

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

442514

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

17

High-throughput

0.479

High

453630

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

12

Small-scale

0.479

High

487776

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

524020

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

553777

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

570083

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

652315

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

668995

PML
Protein PML

1

10

High-throughput

0.479

High

721507

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

727046

FUS
RNA-binding protein FUS

1

18

High-throughput

0.479

High

824409

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

826360

CDK8
Cyclin-dependent kinase 8

1

5

High-throughput

0.479

High

848134

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

899568

MGN
Protein mago nashi homolog

1

1

High-throughput

0.479

High

909153

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

917967

H4
Histone H4

1

4

High-throughput

0.479

High

932388

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.479

High

959693

VIGLN
Vigilin

1

11

High-throughput

0.479

High

999110

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

1024420

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.479

High

1059886

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.479

High

1081410

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

1085967

IF16
Gamma-interferon-inducible protein 16

1

8

High-throughput

0.479

High

1122730

EAPP
E2F-associated phosphoprotein

1

2

High-throughput

0.479

High

1148799

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1153934

IFIX
Pyrin and HIN domain-containing protein 1

1

8

High-throughput

0.479

High

1188894

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1221752

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1222587

SLX4
Structure-specific endonuclease subunit SLX4

1

11

High-throughput

0.479

High

1251033

SNIP1
Smad nuclear-interacting protein 1

1

4

High-throughput

0.479

High

1256410

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1269676

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1271196

RBP56
TATA-binding protein-associated factor 2N

1

11

High-throughput

0.479

High

1283853

FUBP1
Far upstream element-binding protein 1

1

8

High-throughput

0.479

High

1304119

RING2
E3 ubiquitin-protein ligase RING2

1

18

High-throughput

0.479

High

1306992

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

1315867

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

1331181

SENP3
Sentrin-specific protease 3

1

5

Small-scale

0.479

High

1336484

ANLN
Anillin

1

6

High-throughput

0.479

High

1336485

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1336487

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1336488

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1336489

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1336491

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1336496

NUP50
Nuclear pore complex protein Nup50

1

2

High-throughput

0.479

High

1222703

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

68460

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

20

High-throughput

0.445

High

1057664

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

9

High-throughput

0.445

High

1120465

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

1124631

ODFP2
Outer dense fiber protein 2

1

2

High-throughput

0.445

High

256077

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.437

High

385555

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.437

High

882584

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

High-throughput

0.437

High

1136306

RC3H1
Roquin-1

1

6

High-throughput

0.437

High

1171809

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1174003

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

4

Small-scale

0.437

High

1294026

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.437

High

1331347

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1131853

CE170
Centrosomal protein of 170 kDa

1

6

High-throughput

0.407

High

555199

CD44
CD44 antigen

2

0

High-throughput

0.328

High

252876

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

0

High-throughput

0.269

Low

81763

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low

600675

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.238

Low

886343

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

1138458

CAHD1
VWFA and cache domain-containing protein 1

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024