Protein: TRFE
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)

Gene: TRFE, TF
Organism: Homo sapiens
Interactions: 174
UniProt ID: P02787

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005769 - early endosome
GO:0005770 - late endosome
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364123

TFR1
Transferrin receptor protein 1

8

1

Small-scale

0.973

High

364522

IBP3
Insulin-like growth factor-binding protein 3

1

0

Small-scale

0.687

High

172779

MATN3
Matrilin-3

3

1

High-throughput

0.667

High

364605

SYT17
Synaptotagmin-17

3

1

High-throughput

0.667

High

364506

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

364526

GLRA2
Glycine receptor subunit alpha-2

3

0

High-throughput

0.638

High

364578

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.638

High

364575

S38A6
Solute carrier family 38 member 6

3

0

High-throughput

0.634

High

364595

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

216373

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

2

2

High-throughput

0.611

High

345642

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

364626

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

364613

SH24A
SH2 domain-containing protein 4A

3

1

High-throughput

0.609

High

199441

SPIT1
Kunitz-type protease inhibitor 1

2

1

High-throughput

0.606

High

364579

SYT2
Synaptotagmin-2

2

1

High-throughput

0.606

High

364540

CD81
CD81 antigen

2

1

Small-scale

0.601

High

364521

LEG3
Galectin-3

2

0

Small-scale

0.585

High

131300

CLD5
Claudin-5

2

0

High-throughput

0.580

High

170766

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.580

High

201081

AQP9
Aquaporin-9

2

0

High-throughput

0.580

High

364560

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

364561

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.580

High

364570

CPLX4
Complexin-4

2

0

High-throughput

0.580

High

364580

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.580

High

364583

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

364601

SORT
Sortilin

2

0

High-throughput

0.580

High

364608

S26A6
Solute carrier family 26 member 6

2

0

High-throughput

0.580

High

364614

DDX31
ATP-dependent DNA helicase DDX31

2

2

High-throughput

0.574

High

364512

CXB1
Gap junction beta-1 protein

2

3

High-throughput

0.553

High

364610

ELOV4
Very long chain fatty acid elongase 4

2

1

High-throughput

0.553

High

364513

TAU
Microtubule-associated protein tau

2

2

Small-scale

0.552

High

361286

APOA1
Apolipoprotein A-I

2

0

High-throughput

0.547

High

362659

FINC
Fibronectin

2

0

Small-scale

0.547

High

353184

KVD40
Immunoglobulin kappa variable 2D-40

1

0

High-throughput

0.546

High

126339

MATN2
Matrilin-2

1

2

High-throughput

0.536

High

198358

KLK10
Kallikrein-10

1

4

High-throughput

0.536

High

364502

ESR1
Estrogen receptor

1

1

High-throughput

0.536

High

364515

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

364520

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

364532

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

364562

FNDC1
Fibronectin type III domain-containing protein 1

1

1

High-throughput

0.536

High

364584

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

364598

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

364603

EGFL8
Epidermal growth factor-like protein 8

1

2

High-throughput

0.536

High

364625

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

352372

GAST
Gastrin [Cleaved into: Gastrin-71

1

0

Small-scale

0.531

High

364518

DRD2
D(2) dopamine receptor

1

0

High-throughput

0.518

High

181968

GPR42
G-protein coupled receptor 42

1

2

High-throughput

0.515

High

183011

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

217704

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.513

High

239694

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.513

High

328094

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

364523

CCNA2
Cyclin-A2

1

0

High-throughput

0.513

High

364538

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

364574

NRSN1
Neurensin-1

1

0

High-throughput

0.513

High

364581

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

0

High-throughput

0.513

High

364588

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.513

High

364589

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

364607

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

364621

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.513

High

352338

IGF2
Insulin-like growth factor II

1

1

Small-scale

0.501

High

364505

IGF1
Insulin-like growth factor I

1

1

Small-scale

0.501

High

364528

CALR
Calreticulin

1

1

Small-scale

0.501

High

364529

CALX
Calnexin

1

1

Small-scale

0.501

High

364628

TFR2
Transferrin receptor protein 2

1

1

Small-scale

0.501

High

364511

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

2

High-throughput

0.500

High

297219

DDHD2
Phospholipase DDHD2

1

1

High-throughput

0.489

High

312698

CXB5
Gap junction beta-5 protein

1

3

High-throughput

0.489

High

364537

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

2

High-throughput

0.489

High

364566

SFXN4
Sideroflexin-4

1

2

High-throughput

0.489

High

364582

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.489

High

364586

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.489

High

364590

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

364593

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.489

High

364596

ZN558
Zinc finger protein 558

1

1

High-throughput

0.489

High

364602

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

364630

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

364543

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.486

High

364553

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.481

High

364633

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

1

High-throughput

0.481

High

364634

LAMC3
Laminin subunit gamma-3

1

1

High-throughput

0.481

High

364510

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.480

High

336756

CERU
Ceruloplasmin

1

1

High-throughput

0.479

High

341179

HPT
Haptoglobin

1

1

High-throughput

0.479

High

344143

A1AT
Alpha-1-antitrypsin

1

2

High-throughput

0.479

High

344260

AACT
Alpha-1-antichymotrypsin

1

2

High-throughput

0.479

High

361801

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.479

High

361960

FIBG
Fibrinogen gamma chain

1

2

High-throughput

0.479

High

363989

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.479

High

364514

CLUS
Clusterin

1

1

High-throughput

0.479

High

364516

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

364525

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

4

High-throughput

0.479

High

364530

LCN1
Lipocalin-1

1

1

High-throughput

0.479

High

364531

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

364534

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

364544

HBB
Hemoglobin subunit beta

1

2

High-throughput

0.479

High

364565

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

364619

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

364620

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

364631

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

Small-scale

0.479

High

364632

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

364547

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.460

High

364563

F209A
Protein FAM209A

1

0

High-throughput

0.460

High

344611

CO3
Complement C3

1

0

High-throughput

0.458

High

363418

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

364500

HEMO
Hemopexin

1

0

High-throughput

0.458

High

364501

STAT
Statherin

1

0

High-throughput

0.458

High

364519

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

364527

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

364551

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

364556

PROL4
Proline-rich protein 4

1

0

High-throughput

0.458

High

364558

HFE
Hereditary hemochromatosis protein

1

0

Small-scale

0.458

High

364504

TBB4A
Tubulin beta-4A chain

1

2

High-throughput

0.457

High

353485

IGKC
Immunoglobulin kappa constant

1

1

High-throughput

0.445

High

353607

IGHG1
Immunoglobulin heavy constant gamma 1

1

3

High-throughput

0.445

High

354023

IGHA1
Immunoglobulin heavy constant alpha 1

1

3

High-throughput

0.445

High

363675

ALBU
Albumin

1

1

High-throughput

0.445

High

364508

HEP2
Heparin cofactor 2

1

2

High-throughput

0.445

High

364524

RYR1
Ryanodine receptor 1

1

1

High-throughput

0.445

High

364554

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

364587

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.445

High

364503

GCR
Glucocorticoid receptor

1

1

Small-scale

0.437

High

364552

SP140
Nuclear body protein SP140

1

3

High-throughput

0.437

High

364567

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

364609

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

364623

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.437

High

363549

TTHY
Transthyretin

1

0

High-throughput

0.426

High

364507

F13B
Coagulation factor XIII B chain

1

0

Small-scale

0.426

High

364509

CATL1
Procathepsin L

1

0

High-throughput

0.426

High

364541

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

364550

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.426

High

364555

K2C72
Keratin, type II cytoskeletal 72

1

0

High-throughput

0.426

High

364568

SETX
Probable helicase senataxin

1

1

High-throughput

0.407

High

364533

CAH8
Carbonic anhydrase-related protein

3

0

High-throughput

0.347

High

364576

STPG2
Sperm-tail PG-rich repeat-containing protein 2

3

0

High-throughput

0.347

High

364617

SAS10
Something about silencing protein 10

3

0

High-throughput

0.347

High

364557

MK06
Mitogen-activated protein kinase 6

2

0

High-throughput

0.328

High

364577

CCD82
Coiled-coil domain-containing protein 82

2

0

High-throughput

0.328

High

68664

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

364569

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.316

High

364594

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.316

High

364599

RMD3
Regulator of microtubule dynamics protein 3

2

0

High-throughput

0.316

High

364629

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.316

High

364585

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

364592

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

331689

NSD2
Histone-lysine N-methyltransferase NSD2

1

0

High-throughput

0.279

Low

364535

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

364539

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

364546

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.279

Low

364548

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.279

Low

364549

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.279

Low

364559

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

364564

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

0

High-throughput

0.279

Low

364571

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

364572

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

364597

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

0

High-throughput

0.279

Low

364618

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.279

Low

364624

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

364611

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

364606

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.261

Low

364604

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

364616

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.251

Low

364627

TIM
Protein timeless homolog

1

0

High-throughput

0.251

Low

364517

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.249

Low

364536

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

364542

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

364591

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.249

Low

364600

EYA1
Eyes absent homolog 1

1

0

High-throughput

0.249

Low

364615

NGB
Neuroglobin

1

0

High-throughput

0.249

Low

364622

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

364545

3BP2
SH3 domain-binding protein 2

1

0

High-throughput

0.238

Low

320941

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

364573

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

364612

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024