Protein: CD3Z
T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)

Gene: CD3Z, CD247
Organism: Homo sapiens
Interactions: 189
UniProt ID: P20963

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635813

CD3Z
T-cell surface glycoprotein CD3 zeta chain

2

1

Small-scale

0.820

High

635832

ZAP70
Tyrosine-protein kinase ZAP-70

20

7

Small-scale

0.761

High

439946

LCK
Tyrosine-protein kinase Lck

5

2

Small-scale

0.704

High

635919

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

2

Small-scale

0.586

High

302017

NCTR1
Natural cytotoxicity triggering receptor 1

2

4

Small-scale

0.584

High

635820

SHC1
SHC-transforming protein 1

2

4

Small-scale

0.571

High

635835

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.569

High

635828

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.561

High

635839

JAK3
Tyrosine-protein kinase JAK3

1

9

Small-scale

0.561

High

635817

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

Small-scale

0.559

High

258588

SH21A
SH2 domain-containing protein 1A

1

6

Small-scale

0.554

High

635868

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.513

High

635915

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.513

High

471723

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

1

Small-scale

0.501

High

635909

ATX2
Ataxin-2

1

0

High-throughput

0.493

High

168376

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

Small-scale

0.479

High

440360

FYN
Tyrosine-protein kinase Fyn

1

2

Small-scale

0.479

High

593905

NCK1
SH2/SH3 adapter protein NCK1

1

3

Small-scale

0.479

High

635829

STA5A
Signal transducer and activator of transcription 5A

1

1

Small-scale

0.479

High

635833

KSYK
Tyrosine-protein kinase SYK

1

7

Small-scale

0.479

High

635837

STA5B
Signal transducer and activator of transcription 5B

1

1

Small-scale

0.479

High

635862

SLAP1
Src-like-adapter

1

5

Small-scale

0.479

High

635903

SHC3
SHC-transforming protein 3

1

4

Small-scale

0.479

High

635914

SLAP2
Src-like-adapter 2

1

5

Small-scale

0.479

High

220352

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

460240

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

Small-scale

0.458

High

635814

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.458

High

635819

CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

1

0

Small-scale

0.458

High

635823

CCR7
C-C chemokine receptor type 7

1

0

Small-scale

0.458

High

635844

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

0

Small-scale

0.458

High

635853

TBA1B
Tubulin alpha-1B chain

1

0

Small-scale

0.458

High

635869

LY6E
Lymphocyte antigen 6E

1

0

Small-scale

0.458

High

635888

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

Small-scale

0.458

High

635904

DOCK2
Dedicator of cytokinesis protein 2

1

0

Small-scale

0.458

High

635917

CILK1
Serine/threonine-protein kinase ICK

1

0

Small-scale

0.458

High

635918

GAB2
GRB2-associated-binding protein 2

1

0

Small-scale

0.458

High

69577

A8K394
cDNA FLJ76708, highly similar to Homo sapiens nuclear mitotic apparatus protein 1

1

1

High-throughput

0.445

High

72700

MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2

1

2

High-throughput

0.445

High

192987

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

High-throughput

0.445

High

635830

CASP3
Caspase-3

1

1

Small-scale

0.445

High

635834

NSF
Vesicle-fusing ATPase

1

2

High-throughput

0.445

High

635836

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.445

High

635841

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

635854

TMF1
TATA element modulatory factor

1

1

High-throughput

0.445

High

635858

EWS
RNA-binding protein EWS

1

2

High-throughput

0.445

High

635910

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

High-throughput

0.445

High

62025

A4D1I1
Similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1

1

0

High-throughput

0.426

High

69656

A8K651
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.426

High

73635

B2R7W4
cDNA, FLJ93632, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein R

1

0

High-throughput

0.426

High

73695

B2RBR9
Importin subunit beta-1

1

0

High-throughput

0.426

High

75468

B3KNS7
Long-chain-fatty-acid--CoA ligase ACSBG1

1

0

High-throughput

0.426

High

75604

B3KTS5
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.426

High

81548

B5BUE6
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.426

High

85112

B7Z2W3
cDNA FLJ54432, highly similar to Alpha-actinin-1

1

0

High-throughput

0.426

High

123328

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.426

High

258760

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.426

High

277555

H2AY
Core histone macro-H2A.1

1

0

High-throughput

0.426

High

278013

FLNB
Filamin-B

1

0

High-throughput

0.426

High

299934

CBPD
Carboxypeptidase D

1

0

High-throughput

0.426

High

325234

O95036
Large ribosomal subunit protein uL30

1

0

High-throughput

0.426

High

418589

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

High-throughput

0.426

High

424769

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.426

High

446641

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

468062

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.426

High

482831

TPM1
Tropomyosin alpha-1 chain

1

0

High-throughput

0.426

High

518731

GRAB
Granzyme B

1

0

Small-scale

0.426

High

555810

ACE
Angiotensin-converting enzyme

1

0

High-throughput

0.426

High

635815

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.426

High

635821

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.426

High

635827

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.426

High

635840

BI1
Bax inhibitor 1

1

0

High-throughput

0.426

High

635842

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.426

High

635843

SIK1
Serine/threonine-protein kinase SIK1

1

0

High-throughput

0.426

High

635845

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.426

High

635846

H4
Histone H4

1

0

High-throughput

0.426

High

635847

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.426

High

635848

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.426

High

635849

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.426

High

635850

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.426

High

635851

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.426

High

635855

SKOR1
SKI family transcriptional corepressor 1

1

0

High-throughput

0.426

High

635856

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.426

High

635859

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.426

High

635860

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.426

High

635867

PCBP2
Poly(rC)-binding protein 2

1

0

High-throughput

0.426

High

635883

Q5U0I6
small monomeric GTPase

1

0

High-throughput

0.426

High

635886

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

0

High-throughput

0.426

High

635889

LARP1
La-related protein 1

1

0

High-throughput

0.426

High

635893

H2AV
Histone H2A.V

1

0

High-throughput

0.426

High

635899

NLGN1
Neuroligin-1

1

0

High-throughput

0.426

High

635900

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.426

High

635906

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.426

High

635907

SPTCS
Spatacsin

1

0

High-throughput

0.426

High

635908

STRBP
Spermatid perinuclear RNA-binding protein

1

0

High-throughput

0.426

High

635912

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.426

High

635922

MYH4
Myosin-4

1

0

High-throughput

0.426

High

49384

A0PJ87
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.407

High

61811

A3RJH1
ATP-dependent RNA helicase

1

1

High-throughput

0.407

High

62312

A4FU77
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

1

High-throughput

0.407

High

62727

A4QPB0
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.407

High

73602

B2R5W2
cDNA, FLJ92657, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein C

1

3

High-throughput

0.407

High

73607

B2R643
Unconventional myosin-Ia

1

2

High-throughput

0.407

High

73620

B2R6K0
DNA mismatch repair protein MLH1

1

1

High-throughput

0.407

High

73663

B2R935
Cell division control protein

1

1

High-throughput

0.407

High

74434

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.407

High

76179

B4DGR3
Vesicle-fusing ATPase

1

2

High-throughput

0.407

High

76693

B4E312
cDNA FLJ53422, highly similar to TATA-binding protein-associated factor 2N

1

1

High-throughput

0.407

High

85199

B7Z7U6
cDNA FLJ51769, highly similar to Ras GTPase-activating-like protein IQGAP2

1

1

High-throughput

0.407

High

85202

B7Z8W3
cDNA FLJ53272, highly similar to Homo sapiens LIM domain 7

1

1

High-throughput

0.407

High

586219

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.407

High

635838

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

1

High-throughput

0.407

High

635857

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.407

High

635861

Q0IIN5
VCP protein

1

1

High-throughput

0.407

High

635870

Q1JQ76
Ribosomal protein

1

1

High-throughput

0.407

High

635873

Q2M1Z1
MutL homolog 3

1

1

High-throughput

0.407

High

635876

Q4ZG72
ATP-dependent RNA helicase

1

1

High-throughput

0.407

High

635880

Q53GL6
RNA binding protein

1

3

High-throughput

0.407

High

635881

Q59FC6
Tumor rejection antigen

1

1

High-throughput

0.407

High

635890

ATAD2
ATPase family AAA domain-containing protein 2

1

1

High-throughput

0.407

High

635896

Q7Z3N6
Unconventional myosin-Id

1

2

High-throughput

0.407

High

635898

RALYL
RNA-binding Raly-like protein

1

3

High-throughput

0.407

High

635921

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

1

High-throughput

0.407

High

635863

U119A
Protein unc-119 homolog A

1

0

Small-scale

0.292

High

399544

VTNC
Vitronectin

1

0

High-throughput

0.282

High

635825

PCGF2
Polycomb group RING finger protein 2

1

0

High-throughput

0.282

High

635920

ZN281
Zinc finger protein 281

1

0

High-throughput

0.282

High

384109

CO1A1
Collagen alpha-1(I) chain

1

0

High-throughput

0.279

Low

635916

CZIB
CXXC motif containing zinc binding protein

1

0

High-throughput

0.279

Low

635913

RNF41
E3 ubiquitin-protein ligase NRDP1

1

0

Small-scale

0.249

Low

59971

A2BDK6
Microtubule-associated protein 1B

1

0

High-throughput

0.232

Low

62030

A4D1N4
Coiled-coil-helix-coiled-coil-helix domain containing 3

1

0

High-throughput

0.232

Low

69421

A8K146
p125

1

0

High-throughput

0.232

Low

69423

A8K1L8
Serine/arginine-rich splicing factor 1

1

0

High-throughput

0.232

Low

69669

A8K6V3
Splicing factor 3B subunit 3

1

0

High-throughput

0.232

Low

69712

A8K8A6
cDNA FLJ76931, highly similar to Homo sapiens testes-specific heterogenous nuclear ribonucleoprotein G-T, mRNA

1

0

High-throughput

0.232

Low

71671

IQAK1
IQ motif and ankyrin repeat domain-containing protein 1

1

0

High-throughput

0.232

Low

73583

B2R4C1
Large ribosomal subunit protein eL31

1

0

High-throughput

0.232

Low

73622

B2R6K4
cDNA, FLJ92996, highly similar to Homo sapiens guanine nucleotide binding protein

1

0

High-throughput

0.232

Low

73685

B2RAU8
cDNA, FLJ95131, highly similar to Homo sapiens nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.232

Low

73690

B2RBB2
cDNA, FLJ95416, highly similar to Homo sapiens phosphatidylinositol glycan, class S

1

0

High-throughput

0.232

Low

73705

B2RCF3
Glycylpeptide N-tetradecanoyltransferase

1

0

High-throughput

0.232

Low

73706

B2RCI8
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.232

Low

73730

B2RDW1
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.232

Low

75616

B3KTV0
cDNA FLJ38781 fis, clone LIVER2000216, highly similar to HEAT SHOCK COGNATE 71 kDa PROTEIN

1

0

High-throughput

0.232

Low

75748

B3KW06
cDNA FLJ41848 fis, clone NT2RI3003382

1

0

High-throughput

0.232

Low

75771

B3KWX7
RNA-binding protein 39

1

0

High-throughput

0.232

Low

75844

B4DDS7
Signal recognition particle 54 kDa protein

1

0

High-throughput

0.232

Low

76288

B4DLD4
cDNA FLJ56738, highly similar to Fibrillarin

1

0

High-throughput

0.232

Low

76329

B4DNQ8
Zinc finger protein 672

1

0

High-throughput

0.232

Low

76385

B4DSR6
cDNA FLJ52684, highly similar to Dynein heavy chain, cytosolic

1

0

High-throughput

0.232

Low

81542

B5BUB1
RuvB-like helicase

1

0

High-throughput

0.232

Low

91994

D0PNI1
Epididymis luminal protein 4

1

0

High-throughput

0.232

Low

97050

E9PM64
Dynein heavy chain domain 1

1

0

High-throughput

0.232

Low

99121

F1T0L7
Anoctamin-2

1

0

High-throughput

0.232

Low

104021

F5GX40
Protein kinase, DNA-activated, catalytic subunit

1

0

High-throughput

0.232

Low

131321

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.232

Low

144228

ACACB
Acetyl-CoA carboxylase 2

1

0

High-throughput

0.232

Low

336856

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.232

Low

635816

CALX
Calnexin

1

0

High-throughput

0.232

Low

635818

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.232

Low

635822

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.232

Low

635824

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.232

Low

635826

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.232

Low

635831

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.232

Low

635852

ACTS
Actin, alpha skeletal muscle

1

0

High-throughput

0.232

Low

635864

DNSL3
Deoxyribonuclease gamma

1

0

High-throughput

0.232

Low

635865

RCN2
Reticulocalbin-2

1

0

High-throughput

0.232

Low

635866

PWP2
Periodic tryptophan protein 2 homolog

1

0

High-throughput

0.232

Low

635871

Q2F834
Myosin regulatory light chain

1

0

High-throughput

0.232

Low

635872

Q2F837
Eukaryotic translation elongation factor 1 alpha 1

1

0

High-throughput

0.232

Low

635874

Q3B7A7
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.232

Low

635875

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.232

Low

635877

Q53EP4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.232

Low

635878

Q53G83
Small ribosomal subunit protein uS3

1

0

High-throughput

0.232

Low

635879

Q53GB0
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.232

Low

635882

Q5JR94
40S ribosomal protein S8

1

0

High-throughput

0.232

Low

635884

ERI6B
Glutamate-rich protein 6B

1

0

High-throughput

0.232

Low

635885

NSN5C
Putative methyltransferase NSUN5C

1

0

High-throughput

0.232

Low

635887

Q6IAX1
Squalene synthase

1

0

High-throughput

0.232

Low

635891

MPRIP
Myosin phosphatase Rho-interacting protein

1

0

High-throughput

0.232

Low

635892

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.232

Low

635894

Q7KYM9
ORF protein

1

0

High-throughput

0.232

Low

635895

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.232

Low

635897

Q7Z5A3
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.232

Low

635901

ZN439
Zinc finger protein 439

1

0

High-throughput

0.232

Low

635902

RTL9
Retrotransposon Gag-like protein 9

1

0

High-throughput

0.232

Low

635905

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.232

Low

635911

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025