Protein: SPIT2
Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)

Gene: SPIT2, SPINT2
Organism: Homo sapiens
Interactions: 137
UniProt ID: O43291

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

199882

HGFA
Hepatocyte growth factor activator

2

16

High-throughput

0.811

High

199896

PRSS8
Prostasin

1

12

High-throughput

0.691

High

199981

ST14
Suppressor of tumorigenicity 14 protein

1

15

High-throughput

0.691

High

199872

AT12A
Potassium-transporting ATPase alpha chain 2

3

4

High-throughput

0.667

High

199876

CNTP1
Contactin-associated protein 1

3

4

High-throughput

0.667

High

199879

AT8B2
Phospholipid-transporting ATPase ID

3

1

High-throughput

0.667

High

199886

S39A6
Zinc transporter ZIP6

3

3

High-throughput

0.667

High

199889

CKAP5
Cytoskeleton-associated protein 5

3

2

High-throughput

0.667

High

199893

KIF14
Kinesin-like protein KIF14

3

8

High-throughput

0.667

High

199900

FND3B
Fibronectin type III domain-containing protein 3B

3

7

High-throughput

0.667

High

199905

S27A3
Long-chain fatty acid transport protein 3

3

1

High-throughput

0.667

High

199909

TBC9B
TBC1 domain family member 9B

3

4

High-throughput

0.667

High

199911

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

3

1

High-throughput

0.667

High

199913

RETST
All-trans-retinol 13,14-reductase

3

1

High-throughput

0.667

High

199918

UBR3
E3 ubiquitin-protein ligase UBR3

3

1

High-throughput

0.667

High

199922

LRP10
Low-density lipoprotein receptor-related protein 10

3

18

High-throughput

0.667

High

199923

FRMD5
FERM domain-containing protein 5

3

6

High-throughput

0.667

High

199927

VRK2
Serine/threonine-protein kinase VRK2

3

10

High-throughput

0.667

High

199928

ZDH13
Palmitoyltransferase ZDHHC13

3

4

High-throughput

0.667

High

199933

MSPD2
Motile sperm domain-containing protein 2

3

3

High-throughput

0.667

High

199934

GOGA5
Golgin subfamily A member 5

3

3

High-throughput

0.667

High

199935

TBC15
TBC1 domain family member 15

3

6

High-throughput

0.667

High

199937

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

3

6

High-throughput

0.667

High

199942

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

3

4

High-throughput

0.667

High

199949

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

3

8

High-throughput

0.667

High

199963

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

3

1

High-throughput

0.667

High

199969

EGFL7
Epidermal growth factor-like protein 7

3

5

High-throughput

0.667

High

199972

S39AA
Zinc transporter ZIP10

3

3

High-throughput

0.667

High

199976

FND3A
Fibronectin type-III domain-containing protein 3A

3

9

High-throughput

0.667

High

199977

MAN1
Inner nuclear membrane protein Man1

3

2

High-throughput

0.667

High

199978

DHRS7
Dehydrogenase/reductase SDR family member 7

3

2

High-throughput

0.667

High

199980

LRP12
Low-density lipoprotein receptor-related protein 12

3

17

High-throughput

0.667

High

199859

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.647

High

69469

UPK3L
Uroplakin-3b-like protein 1

3

0

High-throughput

0.638

High

199857

BAG3
BAG family molecular chaperone regulator 3

3

0

High-throughput

0.638

High

199877

EREP3
Protein ENTREP3

3

0

High-throughput

0.638

High

199899

CP51A
Lanosterol 14-alpha demethylase

3

0

High-throughput

0.638

High

199910

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

3

0

High-throughput

0.638

High

199926

LSR
Lipolysis-stimulated lipoprotein receptor

3

0

High-throughput

0.638

High

199931

DGLB
Diacylglycerol lipase-beta

3

0

High-throughput

0.638

High

199939

S35F5
Solute carrier family 35 member F5

3

0

High-throughput

0.638

High

199952

GCP2
Gamma-tubulin complex component 2

3

0

High-throughput

0.638

High

199973

VANG2
Vang-like protein 2

3

0

High-throughput

0.638

High

199945

SREC2
Scavenger receptor class F member 2

2

5

High-throughput

0.628

High

199968

KLK11
Kallikrein-11

1

13

High-throughput

0.618

High

177738

TMPS2
Transmembrane protease serine 2

1

16

High-throughput

0.618

High

199869

ACV1B
Activin receptor type-1B

2

3

High-throughput

0.611

High

199929

MA7D3
MAP7 domain-containing protein 3

2

4

High-throughput

0.611

High

199932

ZNT7
Zinc transporter 7

2

1

High-throughput

0.611

High

199936

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

2

1

High-throughput

0.611

High

199878

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

3

1

High-throughput

0.609

High

199895

ELF2
ETS-related transcription factor Elf-2

3

11

High-throughput

0.609

High

199901

TIGD5
Tigger transposable element-derived protein 5

3

5

High-throughput

0.609

High

199915

MZT2B
Mitotic-spindle organizing protein 2B

3

1

High-throughput

0.609

High

199916

NFRKB
Nuclear factor related to kappa-B-binding protein

3

1

High-throughput

0.609

High

199941

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

3

5

High-throughput

0.609

High

199946

P121A
Nuclear envelope pore membrane protein POM 121

3

6

High-throughput

0.609

High

199956

PRR14
Proline-rich protein 14

3

1

High-throughput

0.609

High

199965

ZDH18
Palmitoyltransferase ZDHHC18

3

1

High-throughput

0.609

High

199966

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

3

1

High-throughput

0.609

High

199985

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

3

1

High-throughput

0.609

High

199984

TX264
Testis-expressed protein 264

2

0

High-throughput

0.585

High

199961

ZN696
Zinc finger protein 696

2

11

High-throughput

0.558

High

199962

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

1

High-throughput

0.558

High

199964

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

1

High-throughput

0.558

High

199975

DJC16
DnaJ homolog subfamily C member 16

2

11

High-throughput

0.558

High

199979

TBL2
Transducin beta-like protein 2

2

3

High-throughput

0.558

High

199854

RNF13
E3 ubiquitin-protein ligase RNF13

1

4

High-throughput

0.536

High

199885

ILK
Integrin-linked protein kinase

1

1

High-throughput

0.536

High

199902

KLH22
Kelch-like protein 22

1

4

High-throughput

0.536

High

199919

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.536

High

199951

S39A3
Zinc transporter ZIP3

1

3

High-throughput

0.536

High

199863

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.515

High

199868

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

199940

CLC4D
C-type lectin domain family 4 member D

1

10

High-throughput

0.515

High

199974

CLC4E
C-type lectin domain family 4 member E

1

9

High-throughput

0.515

High

199864

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.513

High

199908

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.513

High

199866

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

3

Small-scale

0.501

High

72695

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

3

High-throughput

0.489

High

199921

MON2
Protein MON2 homolog

1

1

High-throughput

0.489

High

199930

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

1

High-throughput

0.489

High

199970

GPN3
GPN-loop GTPase 3

1

1

High-throughput

0.489

High

199861

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

199862

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

9

High-throughput

0.479

High

199865

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

1

High-throughput

0.479

High

199867

TBG1
Tubulin gamma-1 chain

1

3

High-throughput

0.479

High

199874

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

199880

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

199881

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.479

High

199883

SRBP2
Sterol regulatory element-binding protein 2

1

5

High-throughput

0.479

High

199887

CUL3
Cullin-3

1

6

High-throughput

0.479

High

199890

DIP2A
Disco-interacting protein 2 homolog A

1

3

High-throughput

0.479

High

199891

CUL7
Cullin-7

1

1

High-throughput

0.479

High

199894

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.479

High

199897

CAH9
Carbonic anhydrase 9

1

2

High-throughput

0.479

High

199917

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

199920

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.479

High

199957

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.479

High

199960

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.479

High

199967

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

1

High-throughput

0.479

High

199971

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

Small-scale

0.479

High

199982

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

1

High-throughput

0.479

High

199856

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.458

High

199870

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.458

High

199871

TSC2
Tuberin

1

0

High-throughput

0.458

High

199875

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

199950

ABCA3
Phospholipid-transporting ATPase ABCA3

1

0

High-throughput

0.458

High

199953

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.458

High

199898

MEP1B
Meprin A subunit beta

1

5

Small-scale

0.457

High

199855

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

199888

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

199858

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

1

High-throughput

0.437

High

199884

CDC20
Cell division cycle protein 20 homolog

1

4

High-throughput

0.437

High

199903

KLH26
Kelch-like protein 26

1

4

High-throughput

0.437

High

199904

WDR44
WD repeat-containing protein 44

1

2

High-throughput

0.437

High

199938

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

199948

LMF1
Lipase maturation factor 1

1

1

High-throughput

0.437

High

199955

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.437

High

199983

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

2

High-throughput

0.437

High

111529

SIM22
Small integral membrane protein 22

1

0

Small-scale

0.426

High

174179

SPTC2
Serine palmitoyltransferase 2

3

0

High-throughput

0.347

High

199860

HYEP
Epoxide hydrolase 1

3

0

High-throughput

0.347

High

199892

IQCB1
IQ calmodulin-binding motif-containing protein 1

3

0

High-throughput

0.347

High

199906

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

3

0

High-throughput

0.347

High

199912

LIN54
Protein lin-54 homolog

3

0

High-throughput

0.347

High

199925

NOP9
Nucleolar protein 9

3

0

High-throughput

0.347

High

199943

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

3

0

High-throughput

0.347

High

199958

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

3

0

High-throughput

0.347

High

199907

MARC1
Mitochondrial amidoxime-reducing component 1

2

0

High-throughput

0.328

High

199944

THA11
THAP domain-containing protein 11

2

0

High-throughput

0.318

High

199947

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.318

High

199954

RCAF1
GEL complex subunit OPTI

2

0

High-throughput

0.318

High

199959

CENPH
Centromere protein H

1

0

High-throughput

0.279

Low

199873

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.249

Low

199914

TM214
Transmembrane protein 214

1

0

High-throughput

0.249

Low

199924

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024