Protein: CDC6
Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)

Gene: CDC6
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q99741

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000166 - nucleotide binding
GO:0000922 - spindle pole
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1033398

ORC1
Origin recognition complex subunit 1

3

15

Small-scale

0.882

High

1033435

ORC2
Origin recognition complex subunit 2

2

12

Small-scale

0.821

High

217275

ORC5
Origin recognition complex subunit 5

1

19

High-throughput

0.692

High

1306112

CDT1
DNA replication factor Cdt1

4

2

Small-scale

0.689

High

779984

CCNF
Cyclin-F

3

10

Small-scale

0.678

High

590219

CCNA2
Cyclin-A2

3

7

Small-scale

0.667

High

740050

TGFR2
TGF-beta receptor type-2

3

1

High-throughput

0.667

High

709020

MCM7
DNA replication licensing factor MCM7

3

17

Small-scale

0.661

High

1306125

FZR1
Fizzy-related protein homolog

3

4

Small-scale

0.655

High

661053

TNR8
Tumor necrosis factor receptor superfamily member 8

2

7

High-throughput

0.628

High

1306110

GRWD1
Glutamate-rich WD repeat-containing protein 1

2

5

Small-scale

0.624

High

415041

CDK1
Cyclin-dependent kinase 1

2

11

Small-scale

0.621

High

1306109

CDC6
Cell division control protein 6 homolog

1

14

Small-scale

0.618

High

861910

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.615

High

627341

MCM3
DNA replication licensing factor MCM3

2

20

Small-scale

0.611

High

832668

MCM2
DNA replication licensing factor MCM2

2

19

Small-scale

0.611

High

1204229

F131B
Protein FAM131B

2

0

High-throughput

0.602

High

1262348

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

625578

CDK2
Cyclin-dependent kinase 2

2

11

Small-scale

0.595

High

347703

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.578

High

527744

LAMP2
Lysosome-associated membrane glycoprotein 2

2

2

High-throughput

0.574

High

584460

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

8

High-throughput

0.574

High

1306129

PCDBB
Protocadherin beta-11

2

1

High-throughput

0.574

High

1192184

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

Small-scale

0.573

High

1306133

P2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

1

1

Small-scale

0.573

High

515496

CDK4
Cyclin-dependent kinase 4

1

13

Small-scale

0.569

High

960235

CDK6
Cyclin-dependent kinase 6

1

12

Small-scale

0.569

High

1036841

SQSTM
Sequestosome-1

2

2

Small-scale

0.563

High

1038163

ATR
Serine/threonine-protein kinase ATR

1

5

Small-scale

0.561

High

515300

KPSH1
Serine/threonine-protein kinase H1

1

0

Small-scale

0.537

High

790860

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

High-throughput

0.536

High

1184698

MCM10
Protein MCM10 homolog

1

4

High-throughput

0.536

High

1306117

ORC3
Origin recognition complex subunit 3

1

12

High-throughput

0.536

High

1306132

ORC6
Origin recognition complex subunit 6

1

6

High-throughput

0.536

High

121527

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

7

High-throughput

0.536

High

133631

NOP56
Nucleolar protein 56

1

5

High-throughput

0.536

High

147792

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

2

High-throughput

0.536

High

1085485

MK06
Mitogen-activated protein kinase 6

1

4

High-throughput

0.536

High

1240740

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.536

High

1271748

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

1306134

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

323445

TTC4
Tetratricopeptide repeat protein 4

1

1

Small-scale

0.526

High

896363

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

High-throughput

0.518

High

758318

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

245272

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.513

High

326345

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.513

High

796242

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.513

High

813976

GPR12
G-protein coupled receptor 12

1

0

High-throughput

0.513

High

1306116

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

986441

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

1

Small-scale

0.512

High

309736

KAT7
Histone acetyltransferase KAT7

1

3

Small-scale

0.501

High

476265

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

538599

CCNB1
G2/mitotic-specific cyclin-B1

1

8

Small-scale

0.501

High

624607

CCNE1
G1/S-specific cyclin-E1

1

8

Small-scale

0.501

High

869722

TERF1
Telomeric repeat-binding factor 1

1

1

Small-scale

0.501

High

1017426

CDC20
Cell division cycle protein 20 homolog

1

4

Small-scale

0.501

High

1031596

ATM
Serine-protein kinase ATM

1

5

Small-scale

0.501

High

1306127

CC14A
Dual specificity protein phosphatase CDC14A

1

7

Small-scale

0.501

High

172199

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

591396

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

7

High-throughput

0.489

High

644629

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

1

High-throughput

0.489

High

1100211

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.489

High

1306113

CAD23
Cadherin-23

1

1

High-throughput

0.489

High

1306122

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

1306126

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

6

High-throughput

0.489

High

1306128

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.489

High

1306130

PCDG5
Protocadherin gamma-A5

1

1

High-throughput

0.489

High

517428

PCNA
Proliferating cell nuclear antigen

1

8

Small-scale

0.481

High

175140

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

1219581

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.480

High

1263402

ATRIP
ATR-interacting protein

1

0

Small-scale

0.480

High

256990

KDM4A
Lysine-specific demethylase 4A

1

5

Small-scale

0.479

High

387381

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

475157

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

6

Small-scale

0.479

High

708744

MCM5
DNA replication licensing factor MCM5

1

19

Small-scale

0.479

High

718137

BMI1
Polycomb complex protein BMI-1

1

5

Small-scale

0.479

High

917812

H4
Histone H4

1

9

High-throughput

0.479

High

1046148

DX39B
Spliceosome RNA helicase DDX39B

1

1

Small-scale

0.479

High

1085654

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

Small-scale

0.479

High

1270888

KAT6A
Histone acetyltransferase KAT6A

1

6

High-throughput

0.479

High

1306114

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1306119

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

2

Small-scale

0.479

High

1306121

MCM8
DNA helicase MCM8

1

20

Small-scale

0.479

High

571569

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

1306124

AKP8L
A-kinase anchor protein 8-like

1

0

Small-scale

0.458

High

1306131

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

528224

CCL2
C-C motif chemokine 2

1

1

Small-scale

0.437

High

1306111

COL11
Collectin-11

1

1

High-throughput

0.437

High

1306123

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

146387

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

237837

TSN3
Tetraspanin-3

3

0

High-throughput

0.347

High

612115

PROZ
Vitamin K-dependent protein Z

2

0

High-throughput

0.328

High

1306115

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

1306120

I20RA
Interleukin-20 receptor subunit alpha

2

0

High-throughput

0.328

High

1069157

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.318

High

274694

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.282

High

70531

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

0

High-throughput

0.279

Low

269350

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

456923

FURIN
Furin

1

0

High-throughput

0.279

Low

661404

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

825086

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

1031060

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1034522

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

1115380

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

High-throughput

0.279

Low

1134278

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1139337

CDCP2
CUB domain-containing protein 2

1

0

High-throughput

0.279

Low

1306118

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

209279

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024