Protein: MBK1
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 (EC 2.7.12.1) (Dual specificity Yak1-related kinase mbk-1) (Minibrain Kinase 1)

Gene: MBK1, mbk-1
Organism: Caenorhabditis elegans
Interactions: 129
UniProt ID: Q8WQL7

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

111811

G5EDL3
Aurora kinase

1

20

High-throughput

0.618

High

233888

O45494
C2H2-type domain-containing protein

1

1

High-throughput

0.618

High

814466

MPK1
Mitogen-activated protein kinase mpk-1

1

18

High-throughput

0.618

High

1355777

GSK3
Glycogen synthase kinase-3

1

19

High-throughput

0.618

High

1355782

SPTF3
Specificity protein transcription factor 3

1

5

High-throughput

0.618

High

110763

G5ECD7
cGMP-dependent protein kinase interacting domain-containing protein

1

6

High-throughput

0.553

High

1355744

RGS7
Regulator of G-protein signaling rgs-7

1

2

High-throughput

0.553

High

1355761

Q95XK4
PPM-type phosphatase domain-containing protein

1

6

High-throughput

0.553

High

1355764

Q965N4
Chimerin 2

1

6

High-throughput

0.553

High

1355771

PAR6
Partitioning defective protein 6

1

1

High-throughput

0.553

High

1018890

P91050
Ubiquitin-like domain-containing protein

1

0

High-throughput

0.517

High

110313

G5EC14
Enhancer of polycomb-like protein

1

2

High-throughput

0.479

High

110736

G5ECC0
Kinesin like protein

1

8

High-throughput

0.479

High

111970

LIN35
Retinoblastoma-like protein homolog lin-35

1

14

High-throughput

0.479

High

112905

G5EF11
E2F/DP family winged-helix DNA-binding domain-containing protein

1

13

High-throughput

0.479

High

113819

EGL18
Putative transcription factor egl-18

1

7

High-throughput

0.479

High

115762

H2L033
HAT C-terminal dimerisation domain-containing protein

1

5

High-throughput

0.479

High

145390

O01976
Enhanced RNAI

1

8

High-throughput

0.479

High

195943

GLD2
Poly(A) RNA polymerase gld-2

1

3

High-throughput

0.479

High

196444

PYC1
Pyruvate carboxylase 1

1

3

High-throughput

0.479

High

196715

O18056
RNA helicase

1

16

High-throughput

0.479

High

196780

2A51
Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1

1

3

High-throughput

0.479

High

233791

O45246
Heat shock protein 70

1

11

High-throughput

0.479

High

234171

NHR49
Nuclear hormone receptor family member nhr-49

1

11

High-throughput

0.479

High

263958

ERGO1
Piwi-like protein ergo-1

1

2

High-throughput

0.479

High

744454

CLAS2
Protein CLASP-2

1

5

High-throughput

0.479

High

759151

KLE2
Condensin-2 complex subunit kle-2

1

1

High-throughput

0.479

High

759414

TBG
Tubulin gamma chain

1

15

High-throughput

0.479

High

759608

CBP1
Protein cbp-1

1

20

High-throughput

0.479

High

1010457

CDC14
Tyrosine-protein phosphatase cdc-14

1

14

High-throughput

0.479

High

1018348

P90731
ATP-citrate synthase

1

3

High-throughput

0.479

High

1019080

P91400
Kinesin motor domain-containing protein

1

10

High-throughput

0.479

High

1083974

LIN13
Zinc finger protein lin-13

1

3

High-throughput

0.479

High

1164806

CUL3
Cullin-3

1

15

High-throughput

0.479

High

1166793

SCC3
Cohesin subunit scc-3

1

2

High-throughput

0.479

High

1169831

Q20644
Probable ATP-dependent RNA helicase spindle-E

1

8

High-throughput

0.479

High

1170130

APR1
Adenomatous polyposis coli protein-related protein 1

1

1

High-throughput

0.479

High

1170197

NFIL3
Transcription factor atf-2

1

2

High-throughput

0.479

High

1170262

Q21501
YEATS domain-containing protein

1

3

High-throughput

0.479

High

1170522

NUF2
Kinetochore protein Nuf2 homolog

1

10

High-throughput

0.479

High

1170546

NAA25
N-terminal acetyltransferase B complex subunit NAA25 homolog

1

1

High-throughput

0.479

High

1170931

Q22590
Protein ECT2

1

9

High-throughput

0.479

High

1170983

TFDP1
Transcription factor dpl-1

1

7

High-throughput

0.479

High

1171002

Q22743
GTP-binding protein

1

7

High-throughput

0.479

High

1176482

LI15B
Protein lin-15B

1

4

High-throughput

0.479

High

1201113

Q565A8
SUZ domain-containing protein

1

1

High-throughput

0.479

High

1204725

NFI1
Nuclear factor I family protein

1

4

High-throughput

0.479

High

1275084

Q7YTG9
Cleavage and polyadenylation specificity factor subunit 4

1

2

High-throughput

0.479

High

1355767

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1355769

Q9N3F4
RNA helicase

1

10

High-throughput

0.479

High

1355772

SSL1
Helicase ssl-1

1

4

High-throughput

0.479

High

1355774

TIP60
Histone acetyltransferase Tip60 homolog

1

4

High-throughput

0.479

High

1355779

Q9U3F2
DNA replication ATP-dependent helicase/nuclease DNA2

1

8

High-throughput

0.479

High

1355783

PP4C1
Serine/threonine-protein phosphatase 4 catalytic subunit 1

1

16

High-throughput

0.479

High

1355784

Q9XWJ8
Inhibitor of growth protein

1

1

High-throughput

0.479

High

92416

D3NQC0
C2H2-type domain-containing protein

1

0

High-throughput

0.458

High

145056

SBNO
Protein strawberry notch homolog

1

0

High-throughput

0.458

High

1176432

LIN26
Transcription factor lin-26

1

0

High-throughput

0.458

High

1176437

LI15A
Protein lin-15A

1

0

High-throughput

0.458

High

1320876

Q8MNW1
RNA-binding protein 5

1

0

High-throughput

0.458

High

1355756

Q93230
Vacuolar protein sorting-associated protein 72 homolog

1

0

High-throughput

0.458

High

1355778

DCN1
Defective in cullin neddylation protein 1

1

0

High-throughput

0.458

High

116224

H2L2C8
Alpha-actinin, sarcomeric

1

9

High-throughput

0.439

High

109116

G4SF97
E3 ubiquitin-protein ligase TRIP12

1

13

High-throughput

0.437

High

110102

G5EBS9
Rab-GAP TBC domain-containing protein

1

6

High-throughput

0.437

High

115177

H2KYI3
WAPL domain-containing protein

1

4

High-throughput

0.437

High

115318

H2KZ07
C-type lectin domain-containing protein

1

2

High-throughput

0.437

High

144825

O01585
Rho-GAP domain-containing protein

1

9

High-throughput

0.437

High

145323

O01918
MYND-type domain-containing protein

1

2

High-throughput

0.437

High

195454

O16393
BZIP domain-containing protein

1

3

High-throughput

0.437

High

195472

O16454
Cathepsin F

1

2

High-throughput

0.437

High

231962

O44191
EGF-like domain-containing protein

1

9

High-throughput

0.437

High

263855

O61770
CABIT domain-containing protein

1

1

High-throughput

0.437

High

264017

O62055
EGF-like domain-containing protein

1

11

High-throughput

0.437

High

721189

LIN9
Protein lin-9

1

2

High-throughput

0.437

High

758532

ECHH
Probable 3-ketoacyl-CoA thiolase

1

6

High-throughput

0.437

High

759743

SOR1
Sop-2-related protein 1

1

1

High-throughput

0.437

High

840001

CED3
Cell death protein 3

1

5

High-throughput

0.437

High

1164706

PAR3
Partitioning defective protein 3

1

8

High-throughput

0.437

High

1166448

Q19130
glutamine--fructose-6-phosphate transaminase

1

1

High-throughput

0.437

High

1166863

Q19752
Protein farnesyltransferase subunit beta

1

1

High-throughput

0.437

High

1169772

CNEP1
CTD nuclear envelope phosphatase 1 homolog

1

4

High-throughput

0.437

High

1169836

Q20652
PID domain-containing protein

1

3

High-throughput

0.437

High

1170938

Q22601
AP-2 complex subunit alpha

1

6

High-throughput

0.437

High

1171203

Q23138
NET domain-containing protein

1

3

High-throughput

0.437

High

1176853

PIMT
Protein-L-isoaspartate O-methyltransferase

1

3

High-throughput

0.437

High

1180993

Q304D5
Thioredoxin domain-containing protein

1

5

High-throughput

0.437

High

1204409

Q5FC73
Uncharacterized protein

1

3

High-throughput

0.437

High

1231302

NU301
Nucleosome-remodeling factor subunit NURF301-like

1

20

High-throughput

0.437

High

1306822

Q8ITV6
FHA domain-containing protein

1

3

High-throughput

0.437

High

1321865

Q8MYM6
REPS

1

13

High-throughput

0.437

High

1355757

Q93759
WD_REPEATS_REGION domain-containing protein

1

20

High-throughput

0.437

High

1355762

Q95XR0
protein-synthesizing GTPase

1

9

High-throughput

0.437

High

1355763

GLD3
Defective in germ line development protein 3

1

2

High-throughput

0.437

High

1355766

Q965V4
Exportin-2

1

7

High-throughput

0.437

High

1355770

Q9N592
U4/U6 small nuclear ribonucleoprotein Prp31

1

2

High-throughput

0.437

High

1355773

Q9TXM1
Uncharacterized protein

1

2

High-throughput

0.437

High

1355775

Q9TZK8
J domain-containing protein

1

2

High-throughput

0.437

High

1355776

Q9U2C2
Protein MCM10 homolog

1

1

High-throughput

0.437

High

1355780

MEX5
Zinc finger protein mex-5

1

5

High-throughput

0.437

High

1355785

PLBL1
Putative phospholipase B-like 1

1

1

High-throughput

0.437

High

1171218

Q23158
Alpha-actinin, sarcomeric

1

9

High-throughput

0.417

High

1267006

Q7K7J0
GEX Interacting protein

1

0

High-throughput

0.282

High

870905

ACH2
Acetylcholine receptor subunit beta-type unc-29

1

0

High-throughput

0.269

Low

112790

G5EEQ7
SH3 domain-containing protein

1

0

High-throughput

0.251

Low

94684

D9PTP8
Sorting nexin/Vps5-like C-terminal domain-containing protein

1

0

High-throughput

0.249

Low

110205

G5EBW5
FErroChelatase-Like

1

0

High-throughput

0.249

Low

114990

H2KML5
RING-type E3 ubiquitin transferase

1

0

High-throughput

0.249

Low

115428

H2KZ79
Ig-like domain-containing protein

1

0

High-throughput

0.249

Low

196770

O18167
INTegrator complex Subunit homolog

1

0

High-throughput

0.249

Low

263660

O61522
TransThyretin-Related family domain

1

0

High-throughput

0.249

Low

264162

DCP2
m7GpppN-mRNA hydrolase dcap-2

1

0

High-throughput

0.249

Low

759319

RETR1
Retrotransposon-like protein 1

1

0

High-throughput

0.249

Low

759706

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.249

Low

1019454

SPD2
Spindle-defective protein 2

1

0

High-throughput

0.249

Low

1070165

Q0G832
JAKMIP_CC3 domain-containing protein

1

0

High-throughput

0.249

Low

1166541

Q19276
Ferritin

1

0

High-throughput

0.249

Low

1166894

Q19816
Calponin-homology

1

0

High-throughput

0.249

Low

1166907

RPAB3
Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.249

Low

1170178

LET99
Protein let-99

1

0

High-throughput

0.249

Low

1170280

Q21504
FAD-dependent oxidoreductase domain-containing protein 1

1

0

High-throughput

0.249

Low

1170901

Q22500
Transthyretin-like family protein

1

0

High-throughput

0.249

Low

1355758

Q94314
Flocculation protein FLO11-like

1

0

High-throughput

0.249

Low

1355759

Q95Q05
MITD1 C-terminal phospholipase D-like domain-containing protein

1

0

High-throughput

0.249

Low

1355760

Q95XJ5
Cilia- and flagella-associated protein 157

1

0

High-throughput

0.249

Low

1355765

Q965Q6
Drf_GBD domain-containing protein

1

0

High-throughput

0.249

Low

1355768

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.249

Low

1355781

Q9XUU5
Armadillo repeat-containing protein 1

1

0

High-throughput

0.249

Low

1355786

ACKMT
ATP synthase subunit C lysine N-methyltransferase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025