Protein: RFC1
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)

Gene: RFC1
Organism: Homo sapiens
Interactions: 200
UniProt ID: P35251

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003689 - DNA clamp loader activity
GO:0003690 - double-stranded DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

517101

PCNA
Proliferating cell nuclear antigen

13

15

Small-scale

0.980

High

721934

RFC4
Replication factor C subunit 4

4

17

Small-scale

0.896

High

722179

RFC5
Replication factor C subunit 5

3

20

Small-scale

0.855

High

722180

RFC3
Replication factor C subunit 3

3

20

Small-scale

0.853

High

722068

RFC2
Replication factor C subunit 2

3

17

Small-scale

0.817

High

475410

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

5

High-throughput

0.778

High

226672

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.754

High

722177

BRCA1
Breast cancer type 1 susceptibility protein

2

3

Small-scale

0.737

High

244023

BRD4
Bromodomain-containing protein 4

4

17

Small-scale

0.692

High

455150

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.691

High

722213

H31
Histone H3.1

4

20

High-throughput

0.676

High

719812

RFA3
Replication protein A 14 kDa subunit

3

7

High-throughput

0.656

High

346082

MYC
Myc proto-oncogene protein

3

6

High-throughput

0.640

High

650503

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

8

Small-scale

0.640

High

722309

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.631

High

417988

NPM
Nucleophosmin

2

3

High-throughput

0.628

High

523552

XRCC6
X-ray repair cross-complementing protein 6

1

9

High-throughput

0.618

High

524815

XRCC5
X-ray repair cross-complementing protein 5

1

9

Small-scale

0.618

High

722302

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.618

High

196034

RRP8
Ribosomal RNA-processing protein 8

2

0

High-throughput

0.602

High

503551

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

552073

RFA2
Replication protein A 32 kDa subunit

2

9

High-throughput

0.584

High

622374

CCND1
G1/S-specific cyclin-D1

2

3

Small-scale

0.584

High

722206

RS6
Small ribosomal subunit protein eS6

2

5

High-throughput

0.584

High

722207

H4
Histone H4

2

10

High-throughput

0.584

High

722208

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

722289

SPRTN
DNA-dependent metalloprotease SPRTN

2

4

Small-scale

0.584

High

722293

WDR76
WD repeat-containing protein 76

2

13

High-throughput

0.584

High

722298

ANLN
Anillin

2

4

High-throughput

0.584

High

722223

TF65
Transcription factor p65

1

6

Small-scale

0.561

High

722233

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.561

High

603373

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.559

High

722195

TSP3
Thrombospondin-3

2

3

High-throughput

0.558

High

246180

NBN
Nibrin

1

0

Small-scale

0.546

High

722263

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

1

High-throughput

0.541

High

71078

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.536

High

133347

NOP56
Nucleolar protein 56

1

4

High-throughput

0.536

High

180227

MAGB2
Melanoma-associated antigen B2

1

3

High-throughput

0.536

High

269634

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

3

High-throughput

0.536

High

273013

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

306765

VAMP5
Vesicle-associated membrane protein 5

1

1

High-throughput

0.536

High

469960

H2AZ
Histone H2A.Z

1

7

High-throughput

0.536

High

488923

H14
Histone H1.4

1

1

High-throughput

0.536

High

508368

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

722186

NOTC1
Neurogenic locus notch homolog protein 1

1

4

High-throughput

0.536

High

722187

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

722198

HDGF
Hepatoma-derived growth factor

1

3

High-throughput

0.536

High

722204

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.536

High

722217

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

722224

FAK1
Focal adhesion kinase 1

1

6

High-throughput

0.536

High

722225

SSRP1
FACT complex subunit SSRP1

1

16

High-throughput

0.536

High

722235

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.536

High

722251

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

722260

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

2

High-throughput

0.536

High

722264

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.536

High

722269

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.536

High

722290

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

722291

SENP3
Sentrin-specific protease 3

1

4

High-throughput

0.536

High

722304

H2AW
Core histone macro-H2A.2

1

9

High-throughput

0.536

High

722306

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

High-throughput

0.536

High

722307

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

722313

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

3

High-throughput

0.536

High

722279

DDRGK
DDRGK domain-containing protein 1

2

4

Small-scale

0.533

High

722311

HECD1
E3 ubiquitin-protein ligase HECTD1

2

8

Small-scale

0.533

High

722287

SSBP3
Single-stranded DNA-binding protein 3

1

0

High-throughput

0.518

High

722240

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

Small-scale

0.515

High

212367

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

532403

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

642201

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

722191

MAPK2
MAP kinase-activated protein kinase 2

1

0

High-throughput

0.513

High

722246

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

722278

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

722281

ZN668
Zinc finger protein 668

1

0

High-throughput

0.513

High

722282

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

722212

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

646676

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

722273

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

722262

OXR1
Oxidation resistance protein 1

1

0

High-throughput

0.493

High

722193

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.489

High

722242

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.489

High

722316

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

122523

MEN1
Menin

1

4

High-throughput

0.479

High

125191

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

179562

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

7

High-throughput

0.479

High

279001

RAD17
Cell cycle checkpoint protein RAD17

1

19

Small-scale

0.479

High

294452

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

312023

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

Small-scale

0.479

High

359710

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

369090

ESR1
Estrogen receptor

1

15

High-throughput

0.479

High

373788

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

377141

GCR
Glucocorticoid receptor

1

15

High-throughput

0.479

High

384380

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

386207

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

391577

H2A1B
Histone H2A type 1-B/E

1

8

High-throughput

0.479

High

414192

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

441907

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.479

High

569290

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

590660

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

631361

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

652762

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

707537

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

722181

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

722182

ETV3
ETS translocation variant 3

1

2

High-throughput

0.479

High

722184

NKX21
Homeobox protein Nkx-2.1

1

7

High-throughput

0.479

High

722185

ATRX
Transcriptional regulator ATRX

1

10

Small-scale

0.479

High

722188

SOX2
Transcription factor SOX-2

1

15

High-throughput

0.479

High

722189

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.479

High

722190

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

722192

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

722197

LHX2
LIM/homeobox protein Lhx2

1

5

High-throughput

0.479

High

722201

PMS1
PMS1 protein homolog 1

1

6

High-throughput

0.479

High

722205

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

722209

RL31
Large ribosomal subunit protein eL31

1

5

High-throughput

0.479

High

722214

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

722215

H33
Histone H3.3

1

20

High-throughput

0.479

High

722216

VIGLN
Vigilin

1

5

High-throughput

0.479

High

722220

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

722222

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

722226

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

3

High-throughput

0.479

High

722228

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

722229

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

722231

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

722232

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

722234

CUL1
Cullin-1

1

5

Small-scale

0.479

High

722236

TRI29
Tripartite motif-containing protein 29

1

6

Small-scale

0.479

High

722241

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

722243

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

722244

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

722245

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

722247

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

722248

E2F4
Transcription factor E2F4

1

6

High-throughput

0.479

High

722249

FSCN1
Fascin

1

1

High-throughput

0.479

High

722250

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

722256

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

722257

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

722258

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

722261

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

722265

NUP43
Nucleoporin Nup43

1

14

High-throughput

0.479

High

722268

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

722270

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

722274

LHX4
LIM/homeobox protein Lhx4

1

4

High-throughput

0.479

High

722275

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

722276

Q96BE0
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

722277

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.479

High

722283

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

722285

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

722286

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

3

Small-scale

0.479

High

722288

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

2

High-throughput

0.479

High

722295

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

722296

BRD7
Bromodomain-containing protein 7

1

14

High-throughput

0.479

High

722299

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

722301

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

722303

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

722305

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

722308

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

722312

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.479

High

722314

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

722315

MAFB
Transcription factor MafB

1

9

High-throughput

0.479

High

722284

MYOC
Myocilin

1

0

Small-scale

0.460

High

161789

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

182578

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

515356

CDK4
Cyclin-dependent kinase 4

1

0

Small-scale

0.458

High

719391

MERL
Merlin

1

0

High-throughput

0.458

High

722210

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

722227

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

722267

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

722310

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

401517

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

722178

MLH1
DNA mismatch repair protein Mlh1

1

6

Small-scale

0.445

High

722183

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.445

High

722199

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.445

High

722200

BLM
RecQ-like DNA helicase BLM

1

5

Small-scale

0.445

High

722211

YBOX1
Y-box-binding protein 1

1

4

High-throughput

0.445

High

722219

XPC
DNA repair protein complementing XP-C cells

1

1

High-throughput

0.445

High

722230

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.445

High

722252

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

722266

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

1

High-throughput

0.445

High

722271

ESR2
Estrogen receptor beta

1

15

High-throughput

0.445

High

722272

RAD50
DNA repair protein RAD50

1

6

Small-scale

0.445

High

722294

LN28A
Protein lin-28 homolog A

1

4

High-throughput

0.445

High

255551

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

722238

GRB7
Growth factor receptor-bound protein 7

1

2

Small-scale

0.437

High

722253

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

722254

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

722255

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

3

Small-scale

0.437

High

722292

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

722297

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

722196

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.426

High

722280

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.426

High

722300

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.426

High

722194

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

722202

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.407

High

722218

ANK2
Ankyrin-2

1

1

High-throughput

0.407

High

513409

FGF3
Fibroblast growth factor 3

1

0

High-throughput

0.279

Low

722203

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.279

Low

722221

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.279

Low

722239

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

335372

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.249

Low

722237

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

722259

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024