Interactor 1: MASP2 (O00187)
Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]
Gene: MASP2
Interactor 2: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3
Species: Homo sapiens
Source: innatedb
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.41 | 1.00 | 0.647 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11527969 |
| Identification Methods | protease assay |
| Interaction Type | cleavage reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement, A2M_recep~Trypsin, MG1~Trypsin, MG2~Trypsin |
| Common GO terms | GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006958 - complement activation, classical pathway GO:0070062 - extracellular exosome |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
