Protein: TTC3
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)

Gene: TTC3
Organism: Homo sapiens
Interactions: 116
UniProt ID: P53804

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

865028

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

14

Small-scale

0.778

High

475516

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

Small-scale

0.747

High

865068

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

14

Small-scale

0.647

High

865061

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

2

6

High-throughput

0.628

High

681754

AKT1
RAC-alpha serine/threonine-protein kinase

1

8

Small-scale

0.620

High

865058

RN214
RING finger protein 214

2

2

High-throughput

0.611

High

394393

A4
Amyloid-beta precursor protein

2

6

High-throughput

0.608

High

865086

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

20

Small-scale

0.578

High

714151

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.552

High

682153

AKT2
RAC-beta serine/threonine-protein kinase

1

8

Small-scale

0.543

High

146186

ARI1A
AT-rich interactive domain-containing protein 1A

1

11

High-throughput

0.541

High

166683

CE290
Centrosomal protein of 290 kDa

1

16

High-throughput

0.541

High

167503

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

17

High-throughput

0.541

High

319770

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.541

High

388331

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.541

High

517881

HARS1
Histidine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.541

High

542735

ETS2
Protein C-ets-2

1

3

High-throughput

0.541

High

551641

DESP
Desmoplakin

1

15

High-throughput

0.541

High

600107

TAF1
Transcription initiation factor TFIID subunit 1

1

12

High-throughput

0.541

High

616772

JAK1
Tyrosine-protein kinase JAK1

1

18

High-throughput

0.541

High

641349

PAX6
Paired box protein Pax-6

1

4

High-throughput

0.541

High

674639

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.541

High

773101

PBX2
Pre-B-cell leukemia transcription factor 2

1

1

High-throughput

0.541

High

777431

MDHC
Malate dehydrogenase, cytoplasmic

1

4

High-throughput

0.541

High

846904

SMCA4
Transcription activator BRG1

1

10

High-throughput

0.541

High

849164

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

7

High-throughput

0.541

High

856991

THOP1
Thimet oligopeptidase

1

1

High-throughput

0.541

High

865024

NR1H2
Oxysterols receptor LXR-beta

1

12

High-throughput

0.541

High

865025

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.541

High

865026

STXB1
Syntaxin-binding protein 1

1

5

High-throughput

0.541

High

865027

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.541

High

865029

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

11

High-throughput

0.541

High

865030

PRKDC
DNA-dependent protein kinase catalytic subunit

1

12

High-throughput

0.541

High

865031

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

12

High-throughput

0.541

High

865032

AK17A
A-kinase anchor protein 17A

1

6

High-throughput

0.541

High

865033

DYST
Dystonin

1

12

High-throughput

0.541

High

865035

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.541

High

865036

ZO1
Tight junction protein ZO-1

1

5

High-throughput

0.541

High

865038

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

13

High-throughput

0.541

High

865042

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

14

High-throughput

0.541

High

865043

CKAP5
Cytoskeleton-associated protein 5

1

13

High-throughput

0.541

High

865045

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

16

High-throughput

0.541

High

865049

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.541

High

865055

CAPS2
Calcium-dependent secretion activator 2

1

2

High-throughput

0.541

High

865056

LIPB1
Liprin-beta-1

1

5

High-throughput

0.541

High

865064

TITIN
Titin

1

8

High-throughput

0.541

High

865066

CSN5
COP9 signalosome complex subunit 5

1

13

High-throughput

0.541

High

865069

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.541

High

865072

LCOR
Ligand-dependent corepressor

1

2

High-throughput

0.541

High

865075

FMNL2
Formin-like protein 2

1

4

High-throughput

0.541

High

865076

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

9

High-throughput

0.541

High

865079

WAC
WW domain-containing adapter protein with coiled-coil

1

8

High-throughput

0.541

High

865082

XRN2
5'-3' exoribonuclease 2

1

6

High-throughput

0.541

High

865085

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.541

High

865088

JADE2
E3 ubiquitin-protein ligase Jade-2

1

3

High-throughput

0.541

High

865091

RAI14
Ankycorbin

1

19

High-throughput

0.541

High

865092

MO4L1
Mortality factor 4-like protein 1

1

1

High-throughput

0.541

High

865093

NUFP1
FMR1-interacting protein NUFIP1

1

1

High-throughput

0.541

High

865095

CAPS1
Calcium-dependent secretion activator 1

1

2

High-throughput

0.541

High

865098

FBX7
F-box only protein 7

1

2

High-throughput

0.541

High

865099

TRAF6
TNF receptor-associated factor 6

1

15

High-throughput

0.541

High

71091

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

10

High-throughput

0.536

High

173568

NPHP1
Nephrocystin-1

1

2

High-throughput

0.536

High

302380

CSTN1
Calsyntenin-1

1

3

High-throughput

0.536

High

318944

CEP43
Centrosomal protein 43

1

2

High-throughput

0.536

High

586635

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.536

High

844452

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.536

High

865037

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

9

High-throughput

0.536

High

865059

KI18A
Kinesin-like protein KIF18A

1

8

High-throughput

0.536

High

865071

DYL2
Dynein light chain 2, cytoplasmic

1

7

High-throughput

0.536

High

865073

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

865077

SMC6
Structural maintenance of chromosomes protein 6

1

9

High-throughput

0.536

High

865080

DUS16
Dual specificity protein phosphatase 16

1

4

High-throughput

0.536

High

865083

DSN1
Kinetochore-associated protein DSN1 homolog

1

1

High-throughput

0.536

High

865087

PAR6A
Partitioning defective 6 homolog alpha

1

9

High-throughput

0.536

High

865096

SRPK3
SRSF protein kinase 3

1

13

High-throughput

0.536

High

865097

AKT3
RAC-gamma serine/threonine-protein kinase

1

8

Small-scale

0.534

High

225234

3BP5
SH3 domain-binding protein 5

1

0

High-throughput

0.518

High

865050

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

0

High-throughput

0.518

High

865062

WHAMM
WASP homolog-associated protein with actin, membranes and microtubules

1

0

High-throughput

0.518

High

865067

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.518

High

865081

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.518

High

865084

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.518

High

865053

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.513

High

865034

UBE3A
Ubiquitin-protein ligase E3A

1

20

High-throughput

0.508

High

561535

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

6

High-throughput

0.494

High

865041

SHRM2
Protein Shroom2

1

6

High-throughput

0.494

High

865044

SPRL1
SPARC-like protein 1

1

5

High-throughput

0.494

High

865054

DAAM2
Disheveled-associated activator of morphogenesis 2

1

5

High-throughput

0.494

High

865063

CKAP2
Cytoskeleton-associated protein 2

1

2

High-throughput

0.494

High

591289

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

12

High-throughput

0.489

High

865047

KRBX4
KRAB domain-containing protein 4

1

7

High-throughput

0.489

High

865048

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

1

High-throughput

0.489

High

865060

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

771851

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.481

High

322371

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

16

High-throughput

0.479

High

377205

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

409035

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

541994

ETS1
Protein C-ets-1

1

3

High-throughput

0.479

High

779079

CCNF
Cyclin-F

1

11

High-throughput

0.479

High

817827

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

865039

BIRC3
Baculoviral IAP repeat-containing protein 3

1

13

High-throughput

0.479

High

865040

CUL3
Cullin-3

1

13

High-throughput

0.479

High

865057

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

20

High-throughput

0.479

High

865065

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

865074

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

865078

DNJC7
DnaJ homolog subfamily C member 7

1

18

High-throughput

0.479

High

865094

ANC2
Anaphase-promoting complex subunit 2

1

17

High-throughput

0.479

High

865046

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

865052

MCAF1
Activating transcription factor 7-interacting protein 1

1

13

High-throughput

0.457

High

865070

CHP3
Calcineurin B homologous protein 3

1

1

High-throughput

0.457

High

865089

DISC1
Disrupted in schizophrenia 1 protein

1

6

High-throughput

0.457

High

865090

EXOC1
Exocyst complex component 1

1

1

High-throughput

0.457

High

118248

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.437

High

865023

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.288

High

865051

LEU7
Leukemia-associated protein 7

1

0

High-throughput

0.282

High


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Last updated: 15 Jul 2024