Protein: SIX1
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)

Gene: SIX1
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q15475

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

118562

EYA2
Eyes absent homolog 2

7

20

Small-scale

0.962

High

1074456

EYA1
Eyes absent homolog 1

6

20

Small-scale

0.952

High

318622

EYA4
Eyes absent homolog 4

5

20

High-throughput

0.915

High

944030

PO6F2
POU domain, class 6, transcription factor 2

2

17

High-throughput

0.783

High

993432

TLE5
TLE family member 5

4

20

High-throughput

0.709

High

502915

MYH3
Myosin-3

3

3

High-throughput

0.667

High

522616

MYH7
Myosin-7

3

3

High-throughput

0.667

High

1074460

MYH4
Myosin-4

3

3

High-throughput

0.667

High

263923

HYPM
Huntingtin-interacting protein M

3

0

High-throughput

0.636

High

1074449

ERC6L
DNA excision repair protein ERCC-6-like

2

11

High-throughput

0.628

High

980756

TLE3
Transducin-like enhancer protein 3

2

20

High-throughput

0.606

High

981585

REL
Proto-oncogene c-Rel

2

7

High-throughput

0.606

High

1074457

MDFI
MyoD family inhibitor

1

1

High-throughput

0.582

High

1074450

PKHG4
Puratrophin-1

2

0

High-throughput

0.580

High

92587

E9PLN6
Eyes absent homolog

1

20

High-throughput

0.575

High

1074448

CC85B
Coiled-coil domain-containing protein 85B

1

2

High-throughput

0.541

High

71133

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

126462

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

885159

FOXL2
Forkhead box protein L2

1

20

High-throughput

0.536

High

1057266

SMC1A
Structural maintenance of chromosomes protein 1A

1

6

High-throughput

0.536

High

675833

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

1074454

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

296308

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

2

Small-scale

0.479

High

499768

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.479

High

751640

GRP75
Stress-70 protein, mitochondrial

1

1

Small-scale

0.479

High

777044

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

Small-scale

0.479

High

815252

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.479

High

1074455

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1074458

FZR1
Fizzy-related protein homolog

1

1

Small-scale

0.479

High

502135

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

521275

SKI
Ski oncogene

1

0

Small-scale

0.458

High

1074459

FBX7
F-box only protein 7

1

0

Small-scale

0.458

High

451259

TPM1
Tropomyosin alpha-1 chain

1

2

Small-scale

0.437

High

473126

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

762990

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

1074451

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.279

Low

1074453

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

1074452

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.269

Low

373024

VTNC
Vitronectin

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024