Protein: I2BP1
Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)

Gene: I2BP1, IRF2BP1
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q8IU81

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

536535

IRF2
Interferon regulatory factor 2

5

3

Small-scale

0.728

High

1191125

I2BP2
Interferon regulatory factor 2-binding protein 2

4

7

Small-scale

0.694

High

548316

FOSL2
Fos-related antigen 2

3

4

High-throughput

0.667

High

1048841

VGLL4
Transcription cofactor vestigial-like protein 4

3

2

High-throughput

0.667

High

1215908

CCNL2
Cyclin-L2

3

1

High-throughput

0.667

High

1215913

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

3

7

Small-scale

0.667

High

1215899

DCP1B
mRNA-decapping enzyme 1B

2

0

High-throughput

0.602

High

1215903

JDP2
Jun dimerization protein 2

1

4

Small-scale

0.597

High

149885

RFXK
DNA-binding protein RFXANK

1

1

High-throughput

0.536

High

801233

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

818217

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.536

High

1050001

SCRIB
Protein scribble homolog

1

2

High-throughput

0.536

High

1215902

IASPP
RelA-associated inhibitor

1

1

High-throughput

0.536

High

831473

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.527

High

1215912

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.518

High

71172

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

1215905

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1215910

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

547825

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

Small-scale

0.505

High

323872

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

1078726

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.486

High

962712

IRF9
Interferon regulatory factor 9

1

3

Small-scale

0.481

High

932543

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

0

High-throughput

0.480

High

135130

NFIB
Nuclear factor 1 B-type

1

4

High-throughput

0.479

High

244633

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

301914

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

377459

GCR
Glucocorticoid receptor

1

10

High-throughput

0.479

High

569857

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

658526

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

668807

PML
Protein PML

1

1

High-throughput

0.479

High

679133

TLX1
T-cell leukemia homeobox protein 1

1

1

High-throughput

0.479

High

727891

SOX6
Transcription factor SOX-6

1

9

High-throughput

0.479

High

782589

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

High-throughput

0.479

High

785381

ELK3
ETS domain-containing protein Elk-3

1

1

High-throughput

0.479

High

799119

NKX21
Homeobox protein Nkx-2.1

1

5

High-throughput

0.479

High

878433

PAX9
Paired box protein Pax-9

1

2

High-throughput

0.479

High

884198

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

988781

PAX8
Paired box protein Pax-8

1

2

High-throughput

0.479

High

1024868

KLF10
Krueppel-like factor 10

1

2

High-throughput

0.479

High

1035253

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

1041969

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1060323

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

1215898

I2BP1
Interferon regulatory factor 2-binding protein 1

1

7

Small-scale

0.479

High

1215900

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1215901

SP7
Transcription factor Sp7

1

4

High-throughput

0.479

High

1215904

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1215907

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

1215916

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1215917

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

875092

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

885570

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

961185

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1107817

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.458

High

1215915

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.458

High

385121

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

1215906

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

High-throughput

0.437

High

1215914

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

217910

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.407

High

1070077

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.347

High

217729

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.279

Low

278636

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

1215909

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1215911

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

255903

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

257080

DJC13
DnaJ homolog subfamily C member 13

1

0

High-throughput

0.249

Low

673881

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

0

High-throughput

0.249

Low

1078944

TBCE
Tubulin-specific chaperone E

1

0

High-throughput

0.249

Low

1139220

FYB2
FYN-binding protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024