Protein: ARHG2
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)

Gene: ARHG2, ARHGEF2
Organism: Homo sapiens
Interactions: 189
UniProt ID: Q92974

Gene Ontology (top 5):
GO:0000902 - cell morphogenesis
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900768

RHOA
Transforming protein RhoA

8

20

Small-scale

0.966

High

915884

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1273283

ANLN
Anillin

2

4

High-throughput

0.754

High

927379

1433Z
14-3-3 protein zeta/delta

7

20

Small-scale

0.745

High

647169

1433T
14-3-3 protein theta

5

20

Small-scale

0.722

High

904950

1433G
14-3-3 protein gamma

5

20

High-throughput

0.716

High

1183087

MARK2
Serine/threonine-protein kinase MARK2

4

4

Small-scale

0.699

High

683603

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.699

High

982358

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

135479

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

4

6

Small-scale

0.697

High

166988

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

11

Small-scale

0.675

High

490003

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

6

Small-scale

0.662

High

347507

MYC
Myc proto-oncogene protein

3

11

High-throughput

0.662

High

925497

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

647940

MARK3
MAP/microtubule affinity-regulating kinase 3

2

3

Small-scale

0.646

High

909883

1433E
14-3-3 protein epsilon

2

8

High-throughput

0.640

High

996503

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.638

High

672227

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

1

High-throughput

0.628

High

930944

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

5

High-throughput

0.628

High

1273290

PAK5
Serine/threonine-protein kinase PAK 5

2

20

High-throughput

0.628

High

1273302

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

3

Small-scale

0.621

High

149142

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.618

High

374640

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

557763

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.618

High

581036

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

4

Small-scale

0.618

High

674498

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.618

High

882480

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

17

High-throughput

0.618

High

1018341

MERTK
Tyrosine-protein kinase Mer

1

20

High-throughput

0.618

High

1137890

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

15

High-throughput

0.618

High

1171093

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1273254

ARHG2
Rho guanine nucleotide exchange factor 2

1

16

Small-scale

0.618

High

1273277

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.618

High

1273280

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

Small-scale

0.618

High

1273282

TRI36
E3 ubiquitin-protein ligase TRIM36

1

19

High-throughput

0.618

High

1273297

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

11

Small-scale

0.618

High

1273271

WDR83
WD repeat domain-containing protein 83

3

11

High-throughput

0.609

High

915250

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

5

Small-scale

0.601

High

262060

PEX14
Peroxisomal membrane protein PEX14

2

1

Small-scale

0.588

High

928652

DYLT1
Dynein light chain Tctex-type 1

1

1

Small-scale

0.586

High

228266

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

331058

PAK4
Serine/threonine-protein kinase PAK 4

2

17

Small-scale

0.584

High

504516

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

721080

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.584

High

779853

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

1051391

DCTN1
Dynactin subunit 1

2

5

High-throughput

0.584

High

1066488

KIF14
Kinesin-like protein KIF14

2

6

Small-scale

0.584

High

1131794

CE170
Centrosomal protein of 170 kDa

2

7

Small-scale

0.584

High

370149

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1026200

PAK1
Serine/threonine-protein kinase PAK 1

1

18

Small-scale

0.561

High

903416

WDR5
WD repeat-containing protein 5

2

11

Small-scale

0.558

High

1273298

HECD1
E3 ubiquitin-protein ligase HECTD1

2

8

High-throughput

0.558

High

206848

FOXO3
Forkhead box protein O3

1

2

High-throughput

0.554

High

1246550

IKBD
NF-kappa-B inhibitor delta

2

14

High-throughput

0.553

High

435717

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.553

High

445865

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

High-throughput

0.553

High

207651

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.546

High

472716

FBSP1
F-box/SPRY domain-containing protein 1

1

18

High-throughput

0.536

High

718077

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.536

High

804308

NOTC1
Neurogenic locus notch homolog protein 1

1

8

High-throughput

0.536

High

1039742

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1069263

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

3

High-throughput

0.536

High

1069293

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

3

High-throughput

0.536

High

1273256

SPSB4
SPRY domain-containing SOCS box protein 4

1

18

High-throughput

0.536

High

1273257

TRI52
E3 ubiquitin-protein ligase TRIM52

1

3

High-throughput

0.536

High

1273258

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1273259

ARRD3
Arrestin domain-containing protein 3

1

7

High-throughput

0.536

High

1273263

MARK4
MAP/microtubule affinity-regulating kinase 4

1

4

High-throughput

0.536

High

1273268

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1273269

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

14

High-throughput

0.536

High

1273274

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

1273278

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

553353

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.533

High

651868

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

4

High-throughput

0.533

High

257204

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

6

Small-scale

0.515

High

684253

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

1126021

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

5

Small-scale

0.515

High

790494

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

1245508

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

High-throughput

0.513

High

1273305

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

71199

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.489

High

1222351

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

6

High-throughput

0.489

High

1241823

ZBT44
Zinc finger and BTB domain-containing protein 44

1

4

High-throughput

0.489

High

1273295

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.489

High

121595

IKBE
NF-kappa-B inhibitor epsilon

1

10

High-throughput

0.479

High

125623

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

131660

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

2

High-throughput

0.479

High

150737

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.479

High

213855

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

338801

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

377558

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

383913

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

385297

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

452466

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.479

High

497395

TAU
Microtubule-associated protein tau

1

4

Small-scale

0.479

High

508135

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

533327

PLST
Plastin-3

1

13

Small-scale

0.479

High

572668

VGFR1
Vascular endothelial growth factor receptor 1

1

19

High-throughput

0.479

High

659021

MK01
Mitogen-activated protein kinase 1

1

6

Small-scale

0.479

High

729330

VGFR3
Vascular endothelial growth factor receptor 3

1

20

High-throughput

0.479

High

806363

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.479

High

823462

PAXI
Paxillin

1

14

Small-scale

0.479

High

824251

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

829045

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

861875

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

908917

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

921674

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

10

High-throughput

0.479

High

959580

VIGLN
Vigilin

1

2

High-throughput

0.479

High

969899

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

974638

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

997202

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

9

Small-scale

0.479

High

1021634

TAF10
Transcription initiation factor TFIID subunit 10

1

2

High-throughput

0.479

High

1042210

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1052121

MAP7
Ensconsin

1

20

Small-scale

0.479

High

1058701

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

Small-scale

0.479

High

1064007

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

1064559

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1077057

MARE1
Microtubule-associated protein RP/EB family member 1

1

4

Small-scale

0.479

High

1125516

PDZ11
PDZ domain-containing protein 11

1

18

Small-scale

0.479

High

1133797

CAMP1
Calmodulin-regulated spectrin-associated protein 1

1

3

Small-scale

0.479

High

1146237

MAP1S
Microtubule-associated protein 1S

1

3

Small-scale

0.479

High

1146697

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.479

High

1190176

CLAP1
CLIP-associating protein 1

1

2

Small-scale

0.479

High

1192498

CNTRL
Centriolin

1

10

High-throughput

0.479

High

1217970

KSR1
Kinase suppressor of Ras 1

1

16

Small-scale

0.479

High

1218559

MA7D3
MAP7 domain-containing protein 3

1

6

Small-scale

0.479

High

1222503

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.479

High

1236423

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1239491

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

11

Small-scale

0.479

High

1246001

NEDD1
Protein NEDD1

1

6

Small-scale

0.479

High

1269288

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1270354

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.479

High

1273255

FBXW7
F-box/WD repeat-containing protein 7

1

11

High-throughput

0.479

High

1273261

RNF31
E3 ubiquitin-protein ligase RNF31

1

13

High-throughput

0.479

High

1273264

SCLT1
Sodium channel and clathrin linker 1

1

13

High-throughput

0.479

High

1273270

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1273273

CP250
Centrosome-associated protein CEP250

1

10

High-throughput

0.479

High

1273275

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1273276

VP33B
Vacuolar protein sorting-associated protein 33B

1

3

High-throughput

0.479

High

1273281

PRD16
Histone-lysine N-methyltransferase PRDM16

1

2

High-throughput

0.479

High

1273285

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1273291

HDAC6
Histone deacetylase 6

1

12

High-throughput

0.479

High

1273292

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1273293

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

Small-scale

0.479

High

1273294

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

1273296

MTUS1
Microtubule-associated tumor suppressor 1

1

16

Small-scale

0.479

High

1273299

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

1273300

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

1273303

MARE3
Microtubule-associated protein RP/EB family member 3

1

4

High-throughput

0.479

High

1273304

C170B
Centrosomal protein of 170 kDa protein B

1

7

Small-scale

0.479

High

295085

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298694

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

875189

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

894964

SRP54
Signal recognition particle subunit SRP54

1

0

Small-scale

0.458

High

916743

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1115847

MAP9
Microtubule-associated protein 9

1

0

Small-scale

0.458

High

1163775

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1262651

CKAP2
Cytoskeleton-associated protein 2

1

0

Small-scale

0.458

High

1268848

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1273260

SKA1
Spindle and kinetochore-associated protein 1

1

0

Small-scale

0.458

High

1273262

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1273267

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1273272

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1273284

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1273288

GTSE1
G2 and S phase-expressed protein 1

1

0

Small-scale

0.458

High

167760

FYB1
FYN-binding protein 1

1

5

Small-scale

0.445

High

529512

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.445

High

1273265

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1273279

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

166594

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

Small-scale

0.437

High

169567

BET1
BET1 homolog

1

1

High-throughput

0.437

High

442366

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.437

High

738251

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

High-throughput

0.437

High

1165817

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1166855

LRC31
Leucine-rich repeat-containing protein 31

1

3

High-throughput

0.437

High

1188664

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1233396

NIN
Ninein

1

16

High-throughput

0.437

High

1273266

MA7D2
MAP7 domain-containing protein 2

1

14

Small-scale

0.437

High

831550

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

1234778

RP25L
Ribonuclease P protein subunit p25-like protein

5

0

High-throughput

0.376

High

1217024

LUR1L
Leucine rich adaptor protein 1-like

1

0

High-throughput

0.279

Low

262530

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

1273286

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

1273287

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

1273301

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.249

Low

321156

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

1150271

TBC3G
TBC1 domain family member 3G

1

0

High-throughput

0.232

Low

1174761

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.232

Low

1273289

USE1
Vesicle transport protein USE1

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024