Protein: UHRF1
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)

Gene: UHRF1
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q96T88

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000724 - double-strand break repair via homologous recombination
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000792 - heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641270

DNMT1
DNA

21

20

Small-scale

0.990

High

1273817

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

14

5

Small-scale

0.985

High

935151

H31
Histone H3.1

17

20

Small-scale

0.977

High

1303037

UHRF1
E3 ubiquitin-protein ligase UHRF1

9

14

Small-scale

0.969

High

1086285

H31T
Histone H3.1t

9

20

Small-scale

0.968

High

849419

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

14

Small-scale

0.946

High

1303062

FBW1A
F-box/WD repeat-containing protein 1A

5

17

Small-scale

0.931

High

895889

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

14

Small-scale

0.915

High

1174637

H32
Histone H3.2

4

20

Small-scale

0.870

High

1296399

EHMT2
Histone-lysine N-methyltransferase EHMT2

3

8

Small-scale

0.827

High

517419

PCNA
Proliferating cell nuclear antigen

2

5

Small-scale

0.825

High

1303065

ARI1
E3 ubiquitin-protein ligase ARIH1

2

4

High-throughput

0.811

High

1299580

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

15

Small-scale

0.806

High

1303042

FACD2
Fanconi anemia group D2 protein

2

5

Small-scale

0.806

High

476247

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

12

Small-scale

0.778

High

952575

H33
Histone H3.3

2

20

Small-scale

0.768

High

244830

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.754

High

779961

CCNF
Cyclin-F

2

5

High-throughput

0.754

High

850159

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

9

Small-scale

0.754

High

918629

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

1027215

CBX3
Chromobox protein homolog 3

2

17

Small-scale

0.754

High

1080262

EZH2
Histone-lysine N-methyltransferase EZH2

2

20

Small-scale

0.754

High

1259477

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

Small-scale

0.747

High

1273454

KAT5
Histone acetyltransferase KAT5

6

6

Small-scale

0.742

High

408663

KPCB
Protein kinase C beta type

2

3

High-throughput

0.737

High

1068497

KPCD1
Serine/threonine-protein kinase D1

2

4

High-throughput

0.737

High

681995

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.724

High

1271487

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.724

High

579484

DNLI1
DNA ligase 1

5

7

Small-scale

0.713

High

455786

PARP1
Poly [ADP-ribose] polymerase 1

4

15

Small-scale

0.698

High

1069219

TCAL1
Transcription elongation factor A protein-like 1

4

1

High-throughput

0.694

High

71213

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

13

High-throughput

0.691

High

301156

KDM4B
Lysine-specific demethylase 4B

1

12

High-throughput

0.691

High

470135

H2AZ
Histone H2A.Z

1

14

High-throughput

0.691

High

1087358

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1038653

HDAC1
Histone deacetylase 1

4

20

Small-scale

0.686

High

1303066

DNM3A
DNA

3

9

Small-scale

0.667

High

1303055

DNM3B
DNA

3

9

Small-scale

0.661

High

1060046

LASP1
LIM and SH3 domain protein 1

1

4

Small-scale

0.648

High

568774

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

6

Small-scale

0.647

High

896525

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

14

Small-scale

0.647

High

919835

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

14

Small-scale

0.647

High

347670

MYC
Myc proto-oncogene protein

3

14

Small-scale

0.640

High

1062431

PAF15
PCNA-associated factor

3

0

Small-scale

0.639

High

310218

CCDB1
Cyclin-D1-binding protein 1

3

0

High-throughput

0.638

High

563358

ZNF18
Zinc finger protein 18

2

5

High-throughput

0.628

High

1167236

DPPA3
Developmental pluripotency-associated protein 3

2

2

High-throughput

0.621

High

160730

AURKA
Aurora kinase A

1

8

Small-scale

0.618

High

203773

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

6

Small-scale

0.618

High

260982

H2AY
Core histone macro-H2A.1

1

16

Small-scale

0.618

High

374738

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

555610

H2AX
Histone H2AX

1

17

High-throughput

0.618

High

631558

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.618

High

668926

PML
Protein PML

1

13

Small-scale

0.618

High

707721

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

749805

BRCA1
Breast cancer type 1 susceptibility protein

1

9

Small-scale

0.618

High

828355

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

835959

GSK3B
Glycogen synthase kinase-3 beta

1

7

Small-scale

0.618

High

941343

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

Small-scale

0.618

High

1029775

TIF1B
Transcription intermediary factor 1-beta

1

13

Small-scale

0.618

High

1041158

CUL1
Cullin-1

1

8

Small-scale

0.618

High

1042354

CUL3
Cullin-3

1

9

High-throughput

0.618

High

1067109

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.618

High

1159246

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

Small-scale

0.618

High

1171360

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

1281335

FBXW7
F-box/WD repeat-containing protein 7

1

13

High-throughput

0.618

High

1302678

RSF1
Remodeling and spacing factor 1

1

18

Small-scale

0.618

High

1303038

RING2
E3 ubiquitin-protein ligase RING2

1

17

High-throughput

0.618

High

1303041

RBM4
RNA-binding protein 4

1

10

Small-scale

0.618

High

1303052

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.618

High

1303057

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.618

High

1303059

FBW1B
F-box/WD repeat-containing protein 11

1

18

Small-scale

0.618

High

1303060

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.618

High

1129427

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

3

14

High-throughput

0.609

High

1161825

FBX38
F-box only protein 38

1

0

High-throughput

0.586

High

1303054

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.586

High

402376

JUN
Transcription factor Jun

2

7

Small-scale

0.584

High

794301

MSH2
DNA mismatch repair protein Msh2

2

4

Small-scale

0.584

High

387359

P53
Cellular tumor antigen p53

1

7

Small-scale

0.578

High

265247

SAP30
Histone deacetylase complex subunit SAP30

1

3

Small-scale

0.561

High

309410

MBD4
Methyl-CpG-binding domain protein 4

1

1

Small-scale

0.561

High

377625

GCR
Glucocorticoid receptor

1

20

Small-scale

0.561

High

509098

TOP2A
DNA topoisomerase 2-alpha

1

8

Small-scale

0.561

High

1298947

MUS81
Crossover junction endonuclease MUS81

1

1

Small-scale

0.561

High

1303051

HELLS
Lymphoid-specific helicase

1

18

Small-scale

0.561

High

1303061

FZR1
Fizzy-related protein homolog

1

15

High-throughput

0.561

High

149198

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.553

High

870879

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

High-throughput

0.553

High

434594

ERCC1
DNA excision repair protein ERCC-1

1

0

Small-scale

0.537

High

241809

CCD22
Coiled-coil domain-containing protein 22

1

2

High-throughput

0.536

High

565009

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

623340

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

1

2

High-throughput

0.536

High

639056

S100P
Protein S100-P

1

15

High-throughput

0.536

High

649680

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

801328

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.536

High

853689

IMA5
Importin subunit alpha-5

1

11

High-throughput

0.536

High

962302

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

13

High-throughput

0.536

High

996851

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1069485

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1121794

ANR39
Ankyrin repeat domain-containing protein 39

1

8

High-throughput

0.536

High

1138773

ZN691
Zinc finger protein 691

1

2

High-throughput

0.536

High

1284773

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1303046

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

1303056

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

498331

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

1

High-throughput

0.521

High

1234551

SH2D3
SH2 domain-containing protein 3C

2

12

High-throughput

0.521

High

1130475

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.514

High

1164645

PADI6
Protein-arginine deiminase type-6

1

0

High-throughput

0.513

High

1193023

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1303043

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1303053

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

0

High-throughput

0.513

High

507491

ERG
Transcriptional regulator ERG

1

20

Small-scale

0.501

High

1038159

ATR
Serine/threonine-protein kinase ATR

1

8

Small-scale

0.501

High

574420

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.489

High

1085037

DREB
Drebrin

1

3

High-throughput

0.489

High

1192014

MILR1
Allergin-1

1

1

High-throughput

0.489

High

1235289

FA24B
Protein FAM24B

1

1

High-throughput

0.489

High

1303064

HBS1L
HBS1-like protein

1

5

High-throughput

0.489

High

161870

ZN263
Zinc finger protein 263

1

4

Small-scale

0.479

High

205868

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

210222

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

229471

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

18

Small-scale

0.479

High

232452

KDM1A
Lysine-specific histone demethylase 1A

1

18

Small-scale

0.479

High

233600

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

370266

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

379761

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

414360

RB
Retinoblastoma-associated protein

1

4

Small-scale

0.479

High

432188

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.479

High

487703

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

525030

XRCC5
X-ray repair cross-complementing protein 5

1

11

Small-scale

0.479

High

569986

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

595372

LMNB1
Lamin-B1

1

20

High-throughput

0.479

High

615822

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

627336

MCM3
DNA replication licensing factor MCM3

1

8

Small-scale

0.479

High

666414

3MG
DNA-3-methyladenine glycosylase

1

1

Small-scale

0.479

High

798984

GATA4
Transcription factor GATA-4

1

13

High-throughput

0.479

High

808870

YAP1
Transcriptional coactivator YAP1

1

6

Small-scale

0.479

High

855535

MSH6
DNA mismatch repair protein Msh6

1

6

Small-scale

0.479

High

868704

ATX1
Ataxin-1

1

2

High-throughput

0.479

High

877846

FOXA1
Hepatocyte nuclear factor 3-alpha

1

14

High-throughput

0.479

High

917794

H4
Histone H4

1

9

High-throughput

0.479

High

959625

VIGLN
Vigilin

1

16

High-throughput

0.479

High

969934

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

1035276

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

9

High-throughput

0.479

High

1052009

ELOA1
Elongin-A

1

8

Small-scale

0.479

High

1063573

SUZ12
Polycomb protein SUZ12

1

9

Small-scale

0.479

High

1064061

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

1081371

E2F4
Transcription factor E2F4

1

6

High-throughput

0.479

High

1240936

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1244996

TET1
Methylcytosine dioxygenase TET1

1

1

Small-scale

0.479

High

1284705

EME1
Crossover junction endonuclease EME1

1

1

Small-scale

0.479

High

1303040

TCAB1
Telomerase Cajal body protein 1

1

15

Small-scale

0.479

High

1303045

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1303048

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.479

High

1303058

PARP2
Poly [ADP-ribose] polymerase 2

1

5

Small-scale

0.479

High

1303063

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

153765

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

1272211

XPF
DNA repair endonuclease XPF

1

0

Small-scale

0.458

High

1057600

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

7

High-throughput

0.445

High

256007

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

314380

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

Small-scale

0.437

High

323033

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

18

High-throughput

0.437

High

385392

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

1018348

MERTK
Tyrosine-protein kinase Mer

1

6

High-throughput

0.437

High

1201345

SERC5
Serine incorporator 5

1

1

Small-scale

0.437

High

1303044

DDX24
ATP-dependent RNA helicase DDX24

1

18

High-throughput

0.437

High

1303047

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

542547

QCR7
Cytochrome b-c1 complex subunit 7

3

0

High-throughput

0.347

High

1303050

TRPV5
Transient receptor potential cation channel subfamily V member 5

3

0

High-throughput

0.347

High

253861

TMCC2
Transmembrane and coiled-coil domains protein 2

2

0

High-throughput

0.328

High

1303049

MRM3
rRNA methyltransferase 3, mitochondrial

2

0

High-throughput

0.328

High

1274508

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

0

High-throughput

0.279

Low

1303039

PSD2
PH and SEC7 domain-containing protein 2

1

0

High-throughput

0.279

Low

1149989

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

Small-scale

0.249

Low

1298666

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024