Protein: RNC
Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)

Gene: RNC, DROSHA
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9NRR4

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding
GO:0004525 - ribonuclease III activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1264668

DGCR8
Microprocessor complex subunit DGCR8

13

1

Small-scale

0.982

High

571611

DDX5
Probable ATP-dependent RNA helicase DDX5

4

8

Small-scale

0.892

High

1271678

DDX17
Probable ATP-dependent RNA helicase DDX17

3

8

Small-scale

0.830

High

1302065

SRPK1
SRSF protein kinase 1

4

4

High-throughput

0.699

High

1019968

ILF3
Interleukin enhancer-binding factor 3

1

11

High-throughput

0.691

High

387586

P53
Cellular tumor antigen p53

3

3

Small-scale

0.656

High

942976

SRPK2
SRSF protein kinase 2

2

4

High-throughput

0.628

High

787024

MTREX
Exosome RNA helicase MTR4

1

10

High-throughput

0.618

High

877372

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

20

Small-scale

0.618

High

1220293

DHX40
Probable ATP-dependent RNA helicase DHX40

1

4

High-throughput

0.618

High

557804

NCK1
SH2/SH3 adapter protein NCK1

2

3

High-throughput

0.611

High

1044181

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.590

High

123030

MEN1
Menin

2

3

High-throughput

0.584

High

1273081

FUBP2
Far upstream element-binding protein 2

2

13

Small-scale

0.584

High

1345025

RNC
Ribonuclease 3

1

17

Small-scale

0.575

High

370518

ESR1
Estrogen receptor

2

15

High-throughput

0.571

High

1078763

SMAD1
Mothers against decapentaplegic homolog 1

1

3

Small-scale

0.554

High

262596

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

71252

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.536

High

180475

MAGB2
Melanoma-associated antigen B2

1

4

High-throughput

0.536

High

652358

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.536

High

781459

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.536

High

950884

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

985260

HME1
Homeobox protein engrailed-1

1

3

High-throughput

0.536

High

996917

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

1042628

CUL3
Cullin-3

1

7

High-throughput

0.536

High

1085693

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.536

High

1305889

SMAD5
Mothers against decapentaplegic homolog 5

1

3

Small-scale

0.536

High

1306545

EPAS1
Endothelial PAS domain-containing protein 1

1

2

Small-scale

0.536

High

1332659

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1345028

ZNFX1
NFX1-type zinc finger-containing protein 1

1

4

High-throughput

0.536

High

1345030

LCAP
Leucyl-cystinyl aminopeptidase

1

1

High-throughput

0.536

High

1345033

SRPK3
SRSF protein kinase 3

1

8

High-throughput

0.536

High

727054

FUS
RNA-binding protein FUS

1

15

Small-scale

0.515

High

1125690

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1345032

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1296254

Z512B
Zinc finger protein 512B

1

7

High-throughput

0.508

High

950301

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.500

High

125738

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

163341

XPO1
Exportin-1

1

6

High-throughput

0.479

High

164487

TRI66
Tripartite motif-containing protein 66

1

6

High-throughput

0.479

High

165582

SR140
U2 snRNP-associated SURP motif-containing protein

1

6

High-throughput

0.479

High

259794

PDCD6
Programmed cell death protein 6

1

4

High-throughput

0.479

High

374945

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

435178

SP1
Transcription factor Sp1

1

7

Small-scale

0.479

High

453643

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

8

High-throughput

0.479

High

718228

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.479

High

833044

YLPM1
YLP motif-containing protein 1

1

9

High-throughput

0.479

High

909187

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

924891

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.479

High

959702

VIGLN
Vigilin

1

12

High-throughput

0.479

High

962988

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

970016

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

991898

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

High-throughput

0.479

High

1025352

LIPA1
Liprin-alpha-1

1

1

High-throughput

0.479

High

1054611

RBM39
RNA-binding protein 39

1

7

High-throughput

0.479

High

1092920

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

9

High-throughput

0.479

High

1140799

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.479

High

1204101

CARM1
Histone-arginine methyltransferase CARM1

1

4

High-throughput

0.479

High

1251038

SNIP1
Smad nuclear-interacting protein 1

1

1

Small-scale

0.479

High

1256421

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1263220

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.479

High

1269714

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1299386

RBM14
RNA-binding protein 14

1

9

High-throughput

0.479

High

1306031

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

11

High-throughput

0.479

High

1307389

PKP2
Plakophilin-2

1

3

High-throughput

0.479

High

1314393

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.479

High

1315508

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

1345027

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

Small-scale

0.479

High

1345031

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.479

High

1345035

TR150
Thyroid hormone receptor-associated protein 3

1

10

High-throughput

0.479

High

1345036

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

11

Small-scale

0.479

High

1120818

KLH12
Kelch-like protein 12

1

0

High-throughput

0.458

High

1157911

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.458

High

1345026

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

886428

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

3

Small-scale

0.457

High

1038746

HDAC1
Histone deacetylase 1

1

4

Small-scale

0.445

High

1270464

HDAC2
Histone deacetylase 2

1

4

Small-scale

0.445

High

995455

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.437

High

1345029

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

0

High-throughput

0.347

High

1345034

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

1150276

TBC3G
TBC1 domain family member 3G

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024