Protein: SIX4
Homeobox protein SIX4 (Sine oculis homeobox homolog 4)

Gene: SIX4
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q9UIU6

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

318748

EYA4
Eyes absent homolog 4

2

20

High-throughput

0.789

High

118619

EYA2
Eyes absent homolog 2

2

20

Small-scale

0.757

High

1304297

EYA1
Eyes absent homolog 1

1

20

High-throughput

0.691

High

171091

TBXT
T-box transcription factor T

1

11

High-throughput

0.618

High

515624

SRF
Serum response factor

1

2

High-throughput

0.618

High

620220

PAX7
Paired box protein Pax-7

1

18

High-throughput

0.618

High

641596

PAX6
Paired box protein Pax-6

1

19

High-throughput

0.618

High

679187

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.618

High

1354247

LHX3
LIM/homeobox protein Lhx3

1

10

High-throughput

0.618

High

1293316

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

818576

SOX2
Transcription factor SOX-2

2

16

Small-scale

0.584

High

370661

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

71271

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.536

High

402595

JUN
Transcription factor Jun

1

3

High-throughput

0.536

High

1284839

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1342587

CABP2
Calcium-binding protein 2

1

0

High-throughput

0.513

High

661474

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1302186

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

183173

KDM6A
Lysine-specific demethylase 6A

1

2

Small-scale

0.479

High

225800

SOX15
Transcription factor SOX-15

1

10

High-throughput

0.479

High

443265

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

505307

EGR2
E3 SUMO-protein ligase EGR2

1

2

High-throughput

0.479

High

620438

GATA2
Endothelial transcription factor GATA-2

1

6

High-throughput

0.479

High

620590

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

6

High-throughput

0.479

High

727606

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

918104

H4
Histone H4

1

3

High-throughput

0.479

High

1018278

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1021375

FOXL1
Forkhead box protein L1

1

17

High-throughput

0.479

High

1060385

NFIX
Nuclear factor 1 X-type

1

5

High-throughput

0.479

High

1254951

SP7
Transcription factor Sp7

1

6

High-throughput

0.479

High

1269873

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1300984

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

1304717

FEV
Protein FEV

1

4

High-throughput

0.479

High

913823

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

1027319

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1266709

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1354400

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

217961

PRKY
Putative serine/threonine-protein kinase PRKY

1

2

High-throughput

0.407

High

1238760

GG6L2
Golgin subfamily A member 6-like protein 2

1

5

High-throughput

0.407

High

1291468

LRC46
Leucine-rich repeat-containing protein 46

3

0

High-throughput

0.347

High


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Last updated: 15 Jul 2024