Protein: MCU
Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)

Gene: MCU
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q8NE86

Gene Ontology (top 5):
GO:0005262 - calcium channel activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006851 - mitochondrial calcium ion transmembrane transport
GO:0015292 - uniporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1242959

MCU
Calcium uniporter protein, mitochondrial

3

6

Small-scale

0.834

High

1242994

EMRE
Essential MCU regulator, mitochondrial

3

0

Small-scale

0.809

High

1242981

MICU1
Calcium uptake protein 1, mitochondrial

6

1

Small-scale

0.721

High

1067926

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.679

High

925445

RAC1
Ras-related C3 botulinum toxin substrate 1

3

6

High-throughput

0.650

High

723353

APJ
Apelin receptor

2

3

High-throughput

0.628

High

1016632

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

1

High-throughput

0.628

High

1223655

MICU2
Calcium uptake protein 2, mitochondrial

3

1

Small-scale

0.624

High

1243001

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

6

High-throughput

0.618

High

1087672

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

2

1

High-throughput

0.611

High

391434

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

1

High-throughput

0.609

High

1118254

S22A6
Solute carrier family 22 member 6

2

1

High-throughput

0.574

High

1242969

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.547

High

1051016

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

845082

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.513

High

1218832

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1242962

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

172128

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

173300

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.489

High

353077

IL2RA
Interleukin-2 receptor subunit alpha

1

1

High-throughput

0.489

High

782442

P2RY2
P2Y purinoceptor 2

1

3

High-throughput

0.489

High

1183408

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.489

High

1242978

SEC62
Translocation protein SEC62

1

1

High-throughput

0.489

High

1242980

CML1
Chemerin-like receptor 1

1

3

High-throughput

0.489

High

1242991

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

72613

B4DEF8
Large ribosomal subunit protein mL45

1

1

High-throughput

0.479

High

121327

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

1

High-throughput

0.479

High

135651

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

1

High-throughput

0.479

High

197516

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

1

High-throughput

0.479

High

208614

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.479

High

210763

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

3

High-throughput

0.479

High

241043

RT14
Small ribosomal subunit protein uS14m

1

1

High-throughput

0.479

High

252846

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

1

High-throughput

0.479

High

258741

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.479

High

259098

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

1

High-throughput

0.479

High

261857

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

1

High-throughput

0.479

High

266762

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.479

High

300784

GLSK
Glutaminase kidney isoform, mitochondrial

1

1

High-throughput

0.479

High

306685

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

1

High-throughput

0.479

High

307399

LETM1
Mitochondrial proton/calcium exchanger protein

1

1

High-throughput

0.479

High

335146

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.479

High

335843

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.479

High

525568

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

533495

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

545505

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

584024

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.479

High

594931

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.479

High

612034

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.479

High

623306

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

1

1

High-throughput

0.479

High

658102

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

1

High-throughput

0.479

High

687246

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

High-throughput

0.479

High

713561

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

719002

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

739196

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.479

High

833088

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

3

High-throughput

0.479

High

835200

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.479

High

846169

RT29
Small ribosomal subunit protein mS29

1

1

High-throughput

0.479

High

856738

RM12
Large ribosomal subunit protein bL12m

1

2

High-throughput

0.479

High

879902

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

1

High-throughput

0.479

High

881415

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

1

High-throughput

0.479

High

946915

RT22
Small ribosomal subunit protein mS22

1

1

High-throughput

0.479

High

947101

RT25
Small ribosomal subunit protein mS25

1

1

High-throughput

0.479

High

947265

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.479

High

947438

RT35
Small ribosomal subunit protein mS35

1

1

High-throughput

0.479

High

947613

RT05
Small ribosomal subunit protein uS5m

1

1

High-throughput

0.479

High

947835

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

1

High-throughput

0.479

High

948303

RT34
Small ribosomal subunit protein mS34

1

1

High-throughput

0.479

High

948468

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.479

High

948640

RT09
Small ribosomal subunit protein uS9m

1

1

High-throughput

0.479

High

969503

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.479

High

1023903

RM28
Large ribosomal subunit protein bL28m

1

1

High-throughput

0.479

High

1033187

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.479

High

1033795

NNTM
NAD(P) transhydrogenase, mitochondrial

1

1

High-throughput

0.479

High

1067324

OXA1L
Mitochondrial inner membrane protein OXA1L

1

1

High-throughput

0.479

High

1086441

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

1

High-throughput

0.479

High

1088565

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

1136060

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

1

High-throughput

0.479

High

1154279

PDE12
2',5'-phosphodiesterase 12

1

1

High-throughput

0.479

High

1221092

RM41
Large ribosomal subunit protein mL41

1

1

High-throughput

0.479

High

1230584

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

1

High-throughput

0.479

High

1234963

RM50
Large ribosomal subunit protein mL50

1

1

High-throughput

0.479

High

1238153

RM43
Large ribosomal subunit protein mL43

1

3

High-throughput

0.479

High

1242961

S2540
Mitochondrial glutathione transporter SLC25A40

1

1

High-throughput

0.479

High

1242965

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.479

High

1242966

RT4I1
Reticulon-4-interacting protein 1, mitochondrial

1

1

High-throughput

0.479

High

1242967

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.479

High

1242968

RT31
Small ribosomal subunit protein mS31

1

1

High-throughput

0.479

High

1242970

RM24
Large ribosomal subunit protein uL24m

1

1

High-throughput

0.479

High

1242972

P5CR2
Pyrroline-5-carboxylate reductase 2

1

3

High-throughput

0.479

High

1242973

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.479

High

1242974

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.479

High

1242979

PHB2
Prohibitin-2

1

3

High-throughput

0.479

High

1242982

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.479

High

1242983

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1242984

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1242985

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

1

High-throughput

0.479

High

1242987

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1242988

RM04
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.479

High

1242989

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1242998

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1242999

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.479

High

1243003

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.479

High

1243006

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.479

High

1243007

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

1

High-throughput

0.479

High

1243010

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

1243011

RT28
Small ribosomal subunit protein bS1m

1

1

High-throughput

0.479

High

1243012

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.479

High

1243013

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.479

High

1243014

RT02
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.479

High

1243015

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

1

High-throughput

0.479

High

1243016

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.479

High

1243018

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

1243019

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.479

High

130547

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

518173

ADT1
ADP/ATP translocase 1

1

0

High-throughput

0.458

High

602127

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.458

High

1242971

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

Small-scale

0.458

High

120544

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.437

High

436410

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.437

High

773453

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.437

High

834436

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.437

High

852559

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.437

High

894223

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.437

High

900701

RHOA
Transforming protein RhoA

1

7

High-throughput

0.437

High

915840

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.437

High

941189

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

951165

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.437

High

1051826

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.437

High

1076668

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.437

High

1162900

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

1

High-throughput

0.437

High

1183467

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.437

High

1198855

ACOT1
Acyl-coenzyme A thioesterase 1

1

3

High-throughput

0.437

High

1242975

MMAB
Corrinoid adenosyltransferase MMAB

1

1

High-throughput

0.437

High

1242993

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

1242995

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1242996

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.437

High

1243008

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.437

High

801615

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.328

High

1056221

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

1157071

ARMC6
Armadillo repeat-containing protein 6

2

0

High-throughput

0.328

High

1157169

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

1235853

SC5A8
Sodium-coupled monocarboxylate transporter 1

2

0

High-throughput

0.328

High

1242986

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

0

High-throughput

0.328

High

1242990

NYX
Nyctalopin

2

0

High-throughput

0.318

High

1242992

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

2

0

High-throughput

0.305

High

506466

RALB
Ras-related protein Ral-B

2

0

High-throughput

0.298

High

1242960

TOIP2
Torsin-1A-interacting protein 2

2

0

High-throughput

0.288

High

118976

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.279

Low

197355

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

198160

MSH5
MutS protein homolog 5

1

0

High-throughput

0.279

Low

274763

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.279

Low

347362

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.279

Low

534441

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

1

0

High-throughput

0.279

Low

795997

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

985361

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.279

Low

1083201

SYPL1
Synaptophysin-like protein 1

1

0

High-throughput

0.279

Low

1165638

EST3
Carboxylesterase 3

1

0

High-throughput

0.279

Low

1224967

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.279

Low

1242963

ZN526
Zinc finger protein 526

1

0

High-throughput

0.279

Low

1242976

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

1242977

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

0

High-throughput

0.279

Low

1243004

CC167
Coiled-coil domain-containing protein 167

1

0

High-throughput

0.279

Low

1243005

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

1243017

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

1243009

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.269

Low

149069

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

553217

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

651719

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720943

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

779765

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

824199

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

868263

ATX3
Ataxin-3

1

0

Small-scale

0.249

Low

1066419

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1081330

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1101174

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1170878

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1233379

NIN
Ninein

1

0

High-throughput

0.249

Low

1242964

TM263
Transmembrane protein 263

1

0

High-throughput

0.249

Low

1243000

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

1243002

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1243020

COL10
Collectin-10

1

0

High-throughput

0.249

Low

240101

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

1103058

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low

1242997

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024