Protein: PR15A
Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog)

Gene: PR15A, PPP1R15A
Organism: Homo sapiens
Interactions: 215
UniProt ID: O75807

Gene Ontology (top 5):
GO:0000164 - protein phosphatase type 1 complex
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

294684

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

7

5

Small-scale

0.969

High

294647

IF2A
Eukaryotic translation initiation factor 2 subunit 1

4

1

Small-scale

0.881

High

294666

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

5

Small-scale

0.737

High

294685

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

2

5

Small-scale

0.737

High

294715

PWP3A
PWWP domain-containing DNA repair factor 3A

2

0

High-throughput

0.602

High

294734

MINK1
Misshapen-like kinase 1

2

0

High-throughput

0.602

High

294753

PKHA1
Pleckstrin homology domain-containing family A member 1

2

0

High-throughput

0.602

High

294711

Q1KLZ0
HCG15971, isoform CRA_a

1

1

High-throughput

0.575

High

294721

Q53XC0
Eukaryotic translation initiation factor 2 subunit 1

1

1

High-throughput

0.575

High

294722

ACTBL
Beta-actin-like protein 2

1

1

High-throughput

0.575

High

294655

HSP7C
Heat shock cognate 71 kDa protein

2

3

Small-scale

0.571

High

294698

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.554

High

238329

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.552

High

294649

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.549

High

294679

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.549

High

294700

PPR1A
Protein phosphatase 1 regulatory subunit 1A

1

0

Small-scale

0.549

High

294748

BAG1
BAG family molecular chaperone regulator 1

1

0

Small-scale

0.549

High

294752

CUED2
CUE domain-containing protein 2

1

0

Small-scale

0.549

High

294732

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

294742

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

177636

SMAD7
Mothers against decapentaplegic homolog 7

1

0

Small-scale

0.529

High

294691

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.529

High

294680

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.518

High

167777

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.515

High

294723

Q562V5
Actin-like protein

1

1

High-throughput

0.514

High

164987

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

294701

CUL3
Cullin-3

1

0

High-throughput

0.513

High

294706

TSN
Translin

1

0

Small-scale

0.504

High

294705

PLEC
Plectin

1

0

High-throughput

0.493

High

294648

JUN
Transcription factor Jun

1

1

Small-scale

0.479

High

294759

XPO7
Exportin-7

1

1

High-throughput

0.479

High

294764

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

294745

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.464

High

294726

HABP4
Intracellular hyaluronan-binding protein 4

1

0

Small-scale

0.460

High

279082

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

294644

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

294664

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

294681

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

294689

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

294690

KPCE
Protein kinase C epsilon type

1

0

High-throughput

0.458

High

294730

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

294740

TSC1
Hamartin

1

0

Small-scale

0.458

High

73694

B2RBR9
Importin subunit beta-1

1

1

High-throughput

0.445

High

75451

B3KM81
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.445

High

76304

B4DMA8
Kinesin-like protein

1

1

High-throughput

0.445

High

76311

B4DMY3
Heterogeneous nuclear ribonucleoprotein A/B

1

2

High-throughput

0.445

High

76312

B4DMZ9
Cyclic AMP-responsive element-binding protein 3-like protein 4

1

1

High-throughput

0.445

High

133901

IPO5
Importin-5

1

1

High-throughput

0.445

High

176916

CE290
Centrosomal protein of 290 kDa

1

1

High-throughput

0.445

High

240033

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

1

1

High-throughput

0.445

High

258686

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.445

High

294654

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.445

High

294657

K1C10
Keratin, type I cytoskeletal 10

1

1

High-throughput

0.445

High

294658

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.445

High

294659

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.445

High

294661

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

High-throughput

0.445

High

294662

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

High-throughput

0.445

High

294665

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.445

High

294669

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

294671

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.445

High

294672

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

2

High-throughput

0.445

High

294673

KIF11
Kinesin-like protein KIF11

1

1

High-throughput

0.445

High

294676

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.445

High

294686

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.445

High

294687

PRS10
26S proteasome regulatory subunit 10B

1

1

High-throughput

0.445

High

294704

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

1

High-throughput

0.445

High

294717

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.445

High

294728

Q6I9V5
ADP/ATP translocase

1

1

High-throughput

0.445

High

294736

Q8TA92
Similar to AFG3 ATPase family gene 3-like 2

1

1

High-throughput

0.445

High

294737

RN138
E3 ubiquitin-protein ligase RNF138

1

1

High-throughput

0.445

High

294741

HS105
Heat shock protein 105 kDa

1

3

High-throughput

0.445

High

294743

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.445

High

294747

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.445

High

294749

MICU1
Calcium uptake protein 1, mitochondrial

1

1

High-throughput

0.445

High

294750

TBB2B
Tubulin beta-2B chain

1

1

High-throughput

0.445

High

294754

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.445

High

294760

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

High-throughput

0.445

High

294765

MAGD2
Melanoma-associated antigen D2

1

1

High-throughput

0.445

High

294766

DDX52
Probable ATP-dependent RNA helicase DDX52

1

1

High-throughput

0.445

High

48463

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.426

High

48865

A0JLN5
Translocation protein SEC62

1

0

High-throughput

0.426

High

69325

A8K0T9
F-actin-capping protein subunit alpha

1

0

High-throughput

0.426

High

69905

A8KA19
Exportin-T

1

0

High-throughput

0.426

High

72971

B1ANR0
Polyadenylate-binding protein

1

0

High-throughput

0.426

High

73260

B1Q2B0
URCC5

1

0

High-throughput

0.426

High

73616

B2R6F9
non-specific serine/threonine protein kinase

1

0

High-throughput

0.426

High

73722

B2RDI7
E3 ubiquitin-protein ligase RNF10

1

0

High-throughput

0.426

High

73729

B2RDW1
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

73738

B2RMQ4
Cytoskeleton associated protein 2

1

0

High-throughput

0.426

High

75471

B3KPC1
Protein pelota homolog

1

0

High-throughput

0.426

High

75489

B3KRS1
Gamma-tubulin complex component

1

0

High-throughput

0.426

High

76353

B4DQE5
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

76499

B4DY09
Interleukin enhancer-binding factor 2

1

0

High-throughput

0.426

High

123531

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.426

High

124872

GTPB1
GTP-binding protein 1

1

0

High-throughput

0.426

High

127841

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.426

High

140687

NOP56
Nucleolar protein 56

1

0

High-throughput

0.426

High

141236

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.426

High

156106

TRAD1
TRAF-type zinc finger domain-containing protein 1

1

0

High-throughput

0.426

High

160371

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.426

High

163025

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.426

High

184778

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.426

High

222591

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.426

High

275930

DUS11
RNA/RNP complex-1-interacting phosphatase

1

0

High-throughput

0.426

High

288876

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.426

High

294640

TOM70
Mitochondrial import receptor subunit TOM70

1

0

High-throughput

0.426

High

294641

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.426

High

294643

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.426

High

294645

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.426

High

294646

K2C1
Keratin, type II cytoskeletal 1

1

0

High-throughput

0.426

High

294650

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.426

High

294651

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.426

High

294653

COT1
COUP transcription factor 1

1

0

High-throughput

0.426

High

294656

EF2
Elongation factor 2

1

0

High-throughput

0.426

High

294663

K1C9
Keratin, type I cytoskeletal 9

1

0

High-throughput

0.426

High

294667

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.426

High

294668

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

0

High-throughput

0.426

High

294670

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.426

High

294674

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

294675

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.426

High

294677

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.426

High

294678

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.426

High

294682

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.426

High

294683

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.426

High

294688

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.426

High

294693

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.426

High

294695

Q0QEN7
ATP synthase subunit beta

1

0

High-throughput

0.426

High

294697

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.426

High

294702

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.426

High

294703

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.426

High

294708

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.426

High

294709

SMN
Survival motor neuron protein

1

0

High-throughput

0.426

High

294712

Q1MSW8
Cellular tumor antigen p53

1

0

High-throughput

0.426

High

294716

Q2TSD0
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.426

High

294718

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.426

High

294719

Q4KMX3
JPH1 protein

1

0

High-throughput

0.426

High

294720

Q53SS8
Epididymis secretory protein Li 85

1

0

High-throughput

0.426

High

294729

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.426

High

294731

SLN11
Schlafen family member 11

1

0

High-throughput

0.426

High

294733

T183A
Transmembrane protein 183A

1

0

High-throughput

0.426

High

294735

ABCF1
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.426

High

294739

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.426

High

294751

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

294755

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.426

High

294757

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.426

High

294761

STML2
Stomatin-like protein 2, mitochondrial

1

0

High-throughput

0.426

High

294762

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.426

High

294763

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.426

High

294768

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.426

High

61832

A4D110
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.407

High

62231

A4D210
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.407

High

69645

A8K5I0
Epididymis secretory protein Li 103

1

3

High-throughput

0.407

High

69673

A8K781
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.407

High

73601

B2R5W2
cDNA, FLJ92657, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein C

1

1

High-throughput

0.407

High

73624

B2R6X5
Heat shock 70 kDa protein 6

1

3

High-throughput

0.407

High

73632

B2R7J8
Transcriptional repressor RHIT

1

2

High-throughput

0.407

High

73686

B2RAX6
U3 small nucleolar RNA-associated protein 18 homolog

1

1

High-throughput

0.407

High

73691

B2RBI0
Fatty acyl-CoA reductase

1

1

High-throughput

0.407

High

73720

B2RDG1
Fatty acyl-CoA reductase

1

1

High-throughput

0.407

High

75495

B3KS98
Eukaryotic translation initiation factor 3 subunit H

1

2

High-throughput

0.407

High

75499

B3KSH1
Eukaryotic translation initiation factor 3 subunit F

1

1

High-throughput

0.407

High

75550

B3KSQ7
Drebrin 1, isoform CRA_d

1

1

High-throughput

0.407

High

75592

B3KSX3
cDNA FLJ37224 fis, clone BRAMY2000052, moderately similar to RNA-binding protein Raly

1

1

High-throughput

0.407

High

75772

B3KX11
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

76285

B4DL07
ATP-binding cassette sub-family D member 3

1

1

High-throughput

0.407

High

76328

B4DNN2
DnaJ

1

1

High-throughput

0.407

High

76455

B4DV95
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.407

High

85166

B7Z4V2
Stress-70 protein, mitochondrial

1

5

High-throughput

0.407

High

294699

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.407

High

294707

PCH2
Pachytene checkpoint protein 2 homolog

1

2

High-throughput

0.407

High

294713

Q2I0Y7
Casein kinase II subunit alpha

1

1

High-throughput

0.407

High

294724

Q59EY3
Sp1 transcription factor variant

1

1

High-throughput

0.407

High

294744

MAGD4
Melanoma-associated antigen D4

1

1

High-throughput

0.407

High

294767

ZN281
Zinc finger protein 281

1

1

High-throughput

0.407

High

294642

RPP29
Ribonuclease P protein subunit p29

2

0

High-throughput

0.328

High

294692

ZNF92
Zinc finger protein 92

2

0

High-throughput

0.328

High

294738

BBX
HMG box transcription factor BBX

2

0

High-throughput

0.328

High

294696

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

0

Small-scale

0.325

High

294660

PO3F3
POU domain, class 3, transcription factor 3

1

0

High-throughput

0.238

Low

48308

A0AVN2
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.232

Low

58639

A2A2Q9
Protein AAR2 homolog

1

0

High-throughput

0.232

Low

60144

KV229
Immunoglobulin kappa variable 2-29

1

0

High-throughput

0.232

Low

69442

A8K2R3
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.232

Low

69743

A8K8U7
Testis-specific Y-encoded-like protein 2

1

0

High-throughput

0.232

Low

72738

B0QY89
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.232

Low

72955

B1AKY9
Sodium/potassium-transporting ATPase subunit alpha

1

0

High-throughput

0.232

Low

73603

B2R5Y4
cDNA, FLJ92684, highly similar to Homo sapiens IK cytokine, down-regulator of HLA II

1

0

High-throughput

0.232

Low

73629

B2R7C5
DNA replication licensing factor MCM3

1

0

High-throughput

0.232

Low

73637

B2R806
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.232

Low

73683

B2RAR2
RNA-binding protein NOB1

1

0

High-throughput

0.232

Low

73697

B2RBS8
Albumin

1

0

High-throughput

0.232

Low

73711

B2RD09
28S rRNA

1

0

High-throughput

0.232

Low

75467

B3KNN7
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.232

Low

75470

B3KP95
cDNA FLJ31463 fis, clone NT2NE2001326, highly similar to Exonuclease 3'-5' domain-like-containing protein 2

1

0

High-throughput

0.232

Low

75490

B3KRV2
non-specific serine/threonine protein kinase

1

0

High-throughput

0.232

Low

75617

B3KU03
cDNA FLJ39022 fis, clone NT2RP7003724, weakly similar to Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.232

Low

75783

B3KY60
Cell division cycle 5-like protein

1

0

High-throughput

0.232

Low

75840

B4DDF7
cDNA FLJ53296, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.232

Low

76195

B4DIS6
ATP-dependent RNA helicase DHX33

1

0

High-throughput

0.232

Low

76283

B4DKS0
Monocarboxylate transporter 1

1

0

High-throughput

0.232

Low

76289

B4DLG2
cDNA FLJ58196, highly similar to Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.232

Low

76462

B4DWV9
cDNA FLJ53108, highly similar to Guanine nucleotide-binding protein alpha-13 subunit

1

0

High-throughput

0.232

Low

81541

B5BUB1
RuvB-like helicase

1

0

High-throughput

0.232

Low

85197

B7Z720
E74-like factor 2

1

0

High-throughput

0.232

Low

129626

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.232

Low

294652

H2A1
Histone H2A type 1

1

0

High-throughput

0.232

Low

294694

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.232

Low

294710

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.232

Low

294714

Q2M1J6
Oxidase

1

0

High-throughput

0.232

Low

294725

NOM1
Nucleolar MIF4G domain-containing protein 1

1

0

High-throughput

0.232

Low

294727

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.232

Low

294746

SNX18
Sorting nexin-18

1

0

High-throughput

0.232

Low

294756

ZN629
Zinc finger protein 629

1

0

High-throughput

0.232

Low

294758

NUFP1
FMR1-interacting protein NUFIP1

1

0

High-throughput

0.232

Low

294769

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025