Protein: MK08
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)

Gene: MK08, MAPK8
Organism: Homo sapiens
Interactions: 233
UniProt ID: P45983

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004705 - JUN kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800715

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

13

20

Small-scale

0.984

High

153097

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

9

20

Small-scale

0.980

High

800827

DUS16
Dual specificity protein phosphatase 16

7

20

Small-scale

0.961

High

800770

DUS8
Dual specificity protein phosphatase 8

6

20

High-throughput

0.950

High

800714

MK09
Mitogen-activated protein kinase 9

6

19

Small-scale

0.949

High

800856

DUS10
Dual specificity protein phosphatase 10

5

20

Small-scale

0.932

High

800771

M3K1
Mitogen-activated protein kinase kinase kinase 1

5

20

Small-scale

0.928

High

800767

DUS4
Dual specificity protein phosphatase 4

4

20

Small-scale

0.878

High

338096

EGFR
Epidermal growth factor receptor

3

14

High-throughput

0.858

High

800713

MK08
Mitogen-activated protein kinase 8

3

18

Small-scale

0.834

High

616683

KS6B1
Ribosomal protein S6 kinase beta-1

2

20

Small-scale

0.826

High

724519

IRS1
Insulin receptor substrate 1

2

10

Small-scale

0.807

High

610287

CBL
E3 ubiquitin-protein ligase CBL

2

3

Small-scale

0.806

High

659258

DUS1
Dual specificity protein phosphatase 1

2

20

Small-scale

0.800

High

401592

JUN
Transcription factor Jun

82

20

Small-scale

0.773

High

435003

SP1
Transcription factor Sp1

2

10

Small-scale

0.768

High

758145

CDN1A
Cyclin-dependent kinase inhibitor 1

2

15

Small-scale

0.768

High

800855

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

16

Small-scale

0.768

High

800806

RPTOR
Regulatory-associated protein of mTOR

2

7

Small-scale

0.767

High

547742

ATF2
Cyclic AMP-dependent transcription factor ATF-2

16

20

Small-scale

0.763

High

800823

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

20

Small-scale

0.756

High

166895

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

5

High-throughput

0.754

High

800850

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

9

9

Small-scale

0.752

High

386270

P53
Cellular tumor antigen p53

9

12

Small-scale

0.750

High

201260

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

17

Small-scale

0.747

High

201913

WDR62
WD repeat-containing protein 62

6

15

Small-scale

0.742

High

800718

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

15

Small-scale

0.724

High

584217

ELK1
ETS domain-containing protein Elk-1

4

20

Small-scale

0.706

High

448301

GSTP1
Glutathione S-transferase P

4

8

Small-scale

0.702

High

373850

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.698

High

800833

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

20

High-throughput

0.698

High

149833

RFXK
DNA-binding protein RFXANK

1

7

High-throughput

0.691

High

232802

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

8

High-throughput

0.691

High

549876

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

15

High-throughput

0.691

High

586607

CSK22
Casein kinase II subunit alpha'

1

19

High-throughput

0.691

High

800730

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

800804

VRK2
Serine/threonine-protein kinase VRK2

1

14

Small-scale

0.691

High

800826

CDK19
Cyclin-dependent kinase 19

1

20

High-throughput

0.691

High

555336

H2AX
Histone H2AX

4

6

Small-scale

0.689

High

800848

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

19

Small-scale

0.676

High

203569

KCAB3
Voltage-gated potassium channel subunit beta-3

3

3

High-throughput

0.667

High

776599

STAT3
Signal transducer and activator of transcription 3

3

8

Small-scale

0.660

High

800776

BMPR2
Bone morphogenetic protein receptor type-2

1

10

High-throughput

0.656

High

800822

RBM15
RNA-binding protein 15

1

10

High-throughput

0.656

High

800839

ZN219
Zinc finger protein 219

1

1

High-throughput

0.656

High

182112

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

20

Small-scale

0.647

High

681722

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.647

High

790957

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

15

Small-scale

0.647

High

394297

A4
Amyloid-beta precursor protein

2

8

Small-scale

0.643

High

309948

ATE1
Arginyl-tRNA--protein transferase 1

3

0

High-throughput

0.638

High

800747

HSF1
Heat shock factor protein 1

2

8

Small-scale

0.633

High

800836

WWOX
WW domain-containing oxidoreductase

2

3

Small-scale

0.631

High

666856

TKT
Transketolase

2

3

High-throughput

0.628

High

800716

CRK
Adapter molecule crk

2

4

Small-scale

0.624

High

550338

ZEP1
Zinc finger protein 40

1

3

High-throughput

0.621

High

800849

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

8

High-throughput

0.618

High

305742

ELP1
Elongator complex protein 1

1

1

Small-scale

0.618

High

226778

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.618

High

349178

RASH
GTPase HRas

1

9

Small-scale

0.618

High

431635

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

682148

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.618

High

800725

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

18

Small-scale

0.618

High

800755

FAK1
Focal adhesion kinase 1

1

13

Small-scale

0.618

High

800783

KPCD1
Serine/threonine-protein kinase D1

1

20

Small-scale

0.618

High

800786

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

12

Small-scale

0.618

High

800788

MK14
Mitogen-activated protein kinase 14

1

18

Small-scale

0.618

High

800853

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

19

Small-scale

0.618

High

800782

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

12

Small-scale

0.613

High

800787

NF2L2
Nuclear factor erythroid 2-related factor 2

2

20

Small-scale

0.611

High

716853

CTNB1
Catenin beta-1

1

11

Small-scale

0.608

High

496513

TAU
Microtubule-associated protein tau

2

17

Small-scale

0.602

High

611396

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

18

Small-scale

0.602

High

800759

B2CL1
Bcl-2-like protein 1

2

13

Small-scale

0.602

High

800851

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.602

High

800778

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.598

High

800791

NFE2
Transcription factor NF-E2 45 kDa subunit

1

20

Small-scale

0.598

High

568073

JUND
Transcription factor JunD

2

20

Small-scale

0.595

High

800802

ZN605
Zinc finger protein 605

1

0

High-throughput

0.589

High

655263

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

3

Small-scale

0.588

High

790703

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

19

Small-scale

0.586

High

346172

MYC
Myc proto-oncogene protein

1

8

Small-scale

0.578

High

667925

SPB3
Serpin B3

1

3

Small-scale

0.578

High

800720

SPB4
Serpin B4

1

3

Small-scale

0.578

High

800723

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

Small-scale

0.578

High

800813

GEMI5
Gem-associated protein 5

1

6

Small-scale

0.578

High

800824

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

2

Small-scale

0.578

High

111255

J3KNB8
Mitogen-activated protein kinase kinase kinase 4

1

20

High-throughput

0.575

High

217859

PRKY
Putative serine/threonine-protein kinase PRKY

1

11

High-throughput

0.575

High

239844

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.575

High

800740

CDC42
Cell division control protein 42 homolog

1

7

Small-scale

0.575

High

800741

RHOA
Transforming protein RhoA

1

7

Small-scale

0.575

High

800742

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

Small-scale

0.575

High

800768

FADD
FAS-associated death domain protein

1

6

Small-scale

0.575

High

800781

CASP8
Caspase-8

1

11

Small-scale

0.575

High

800789

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

15

Small-scale

0.575

High

800815

CASPA
Caspase-10

1

11

Small-scale

0.575

High

278245

PIAS2
E3 SUMO-protein ligase PIAS2

1

1

Small-scale

0.573

High

800777

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

5

High-throughput

0.571

High

800852

RUVB1
RuvB-like 1

2

5

High-throughput

0.571

High

206731

B2L11
Bcl-2-like protein 11

1

3

Small-scale

0.569

High

489383

BCL2
Apoptosis regulator Bcl-2

1

13

Small-scale

0.569

High

657807

ELK4
ETS domain-containing protein Elk-4

1

20

Small-scale

0.569

High

800764

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

1

Small-scale

0.569

High

800721

PAXI
Paxillin

1

8

Small-scale

0.561

High

800748

MYT1
Myelin transcription factor 1

1

3

Small-scale

0.561

High

800816

APBB2
Amyloid beta precursor protein binding family B member 2

1

2

Small-scale

0.561

High

800818

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.561

High

800819

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

Small-scale

0.561

High

800845

HDAC9
Histone deacetylase 9

1

12

Small-scale

0.561

High

800847

FZR1
Fizzy-related protein homolog

1

6

Small-scale

0.561

High

800754

REL
Proto-oncogene c-Rel

1

10

Small-scale

0.552

High

800749

SPIB
Transcription factor Spi-B

1

11

Small-scale

0.550

High

225231

3BP5
SH3 domain-binding protein 5

1

2

Small-scale

0.549

High

800820

BMF
Bcl-2-modifying factor

1

0

Small-scale

0.545

High

400477

RLA2
Large ribosomal subunit protein P2

1

3

High-throughput

0.541

High

782868

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.541

High

196968

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

5

High-throughput

0.536

High

573163

TCPA
T-complex protein 1 subunit alpha

1

12

High-throughput

0.536

High

597485

GSTM3
Glutathione S-transferase Mu 3

1

8

High-throughput

0.536

High

770731

TCPZ
T-complex protein 1 subunit zeta

1

14

High-throughput

0.536

High

800722

TCPG
T-complex protein 1 subunit gamma

1

15

High-throughput

0.536

High

800727

TCPQ
T-complex protein 1 subunit theta

1

19

High-throughput

0.536

High

800728

TCPD
T-complex protein 1 subunit delta

1

12

High-throughput

0.536

High

800732

NUP98
Nuclear pore complex protein Nup98-Nup96

1

6

High-throughput

0.536

High

800733

CATC
Dipeptidyl peptidase 1

1

2

High-throughput

0.536

High

800744

TCPB
T-complex protein 1 subunit beta

1

16

High-throughput

0.536

High

800769

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.536

High

800784

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

800796

RM02
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.536

High

800800

CRTC3
CREB-regulated transcription coactivator 3

1

3

High-throughput

0.536

High

800807

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

7

High-throughput

0.536

High

800809

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.536

High

800810

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

3

High-throughput

0.536

High

800817

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

800840

ZO2
Tight junction protein ZO-2

1

10

High-throughput

0.536

High

734884

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

20

Small-scale

0.527

High

800752

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

Small-scale

0.527

High

800724

CAMP
Cathelicidin antimicrobial peptide

1

0

High-throughput

0.518

High

800729

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.518

High

800750

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.518

High

800756

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.518

High

261217

FLNB
Filamin-B

1

13

Small-scale

0.515

High

282773

SYUG
Gamma-synuclein

1

5

Small-scale

0.515

High

742113

SYUA
Alpha-synuclein

1

5

Small-scale

0.515

High

800775

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

800799

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

800828

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

800829

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.513

High

800830

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

800837

JKAMP
JNK1/MAPK8-associated membrane protein

1

1

Small-scale

0.512

High

503626

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.508

High

800739

SCND1
SCAN domain-containing protein 1

1

2

High-throughput

0.508

High

800838

DAPLE
Protein Daple

1

15

High-throughput

0.508

High

362066

MBP
Myelin basic protein

1

9

Small-scale

0.501

High

572547

SPI1
Transcription factor PU.1

1

16

Small-scale

0.501

High

782498

HNF4A
Hepatocyte nuclear factor 4-alpha

1

12

Small-scale

0.501

High

788159

CASP3
Caspase-3

1

11

Small-scale

0.501

High

800726

ETV1
ETS translocation variant 1

1

20

Small-scale

0.501

High

800743

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.501

High

800745

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.501

High

800753

PAX2
Paired box protein Pax-2

1

5

Small-scale

0.501

High

800757

APLP2
Amyloid beta precursor like protein 2

1

8

Small-scale

0.501

High

800760

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

13

Small-scale

0.501

High

800761

EP300
Histone acetyltransferase p300

1

15

Small-scale

0.501

High

800763

TFCP2
Alpha-globin transcription factor CP2

1

2

Small-scale

0.501

High

800772

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.501

High

800803

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

3

Small-scale

0.501

High

800854

NCOA3
Nuclear receptor coactivator 3

1

6

Small-scale

0.501

High

800779

GANAB
Neutral alpha-glucosidase AB

1

5

High-throughput

0.494

High

473051

BNIP5
Protein BNIP5

1

2

High-throughput

0.489

High

800794

RABL3
Rab-like protein 3

1

6

High-throughput

0.489

High

800795

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

5

High-throughput

0.489

High

800811

F110D
Protein FAM110D

1

1

High-throughput

0.489

High

800831

WDCP
WD repeat and coiled-coil-containing protein

1

1

High-throughput

0.489

High

800844

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.489

High

800762

PNRC1
Proline-rich nuclear receptor coactivator 1

1

0

High-throughput

0.486

High

800821

F193B
Protein FAM193B

1

0

High-throughput

0.486

High

800751

ID2
DNA-binding protein inhibitor ID-2

1

4

High-throughput

0.481

High

800766

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

11

Small-scale

0.481

High

800834

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

1

High-throughput

0.481

High

800835

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.480

High

120857

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

Small-scale

0.479

High

196742

CYB5B
Cytochrome b5 type B

1

4

High-throughput

0.479

High

229640

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

20

Small-scale

0.479

High

377173

GCR
Glucocorticoid receptor

1

17

Small-scale

0.479

High

409025

K2C8
Keratin, type II cytoskeletal 8

1

3

Small-scale

0.479

High

414209

RB
Retinoblastoma-associated protein

1

9

Small-scale

0.479

High

566734

JUNB
Transcription factor JunB

1

20

Small-scale

0.479

High

568251

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

20

Small-scale

0.479

High

589160

ANXA7
Annexin A7

1

4

High-throughput

0.479

High

683190

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

787413

MTOR
Serine/threonine-protein kinase mTOR

1

9

Small-scale

0.479

High

800717

CRKL
Crk-like protein

1

4

Small-scale

0.479

High

800734

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

Small-scale

0.479

High

800736

CTBP2
C-terminal-binding protein 2

1

4

High-throughput

0.479

High

800738

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

Small-scale

0.479

High

800758

BAX
Apoptosis regulator BAX

1

13

Small-scale

0.479

High

800765

TRAF2
TNF receptor-associated factor 2

1

2

Small-scale

0.479

High

800773

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

10

Small-scale

0.479

High

800774

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

800785

SF01
Splicing factor 1

1

1

High-throughput

0.479

High

800790

BAK
Bcl-2 homologous antagonist/killer

1

13

Small-scale

0.479

High

800797

H2A2A
Histone H2A type 2-A

1

5

High-throughput

0.479

High

800808

BANP
Protein BANP

1

1

Small-scale

0.479

High

800814

STAB2
Stabilin-2

1

7

Small-scale

0.479

High

800825

TBB2B
Tubulin beta-2B chain

1

9

High-throughput

0.479

High

800842

RLP24
Probable ribosome biogenesis protein RLP24

1

1

High-throughput

0.479

High

800843

SCOC
Short coiled-coil protein

1

0

High-throughput

0.460

High

800805

CCD50
Coiled-coil domain-containing protein 50

1

0

Small-scale

0.458

High

800832

GORS2
Golgi reassembly-stacking protein 2

1

5

Small-scale

0.457

High

72995

B4DT77
Annexin

1

4

High-throughput

0.445

High

154323

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

7

Small-scale

0.445

High

546966

EZRI
Ezrin

1

12

Small-scale

0.445

High

584343

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

7

Small-scale

0.445

High

632212

TNR6
Tumor necrosis factor receptor superfamily member 6

1

7

Small-scale

0.445

High

640062

MOES
Moesin

1

12

Small-scale

0.445

High

800731

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

Small-scale

0.445

High

800792

H2A2C
Histone H2A type 2-C

1

5

High-throughput

0.445

High

561362

LYAM2
E-selectin

1

2

Small-scale

0.437

High

800812

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

7

Small-scale

0.437

High

800719

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

Small-scale

0.426

High

800735

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.426

High

382343

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.407

High

800801

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.282

High

800746

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

800780

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

800793

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

0

High-throughput

0.279

Low

800798

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low

800841

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

800737

CLD6
Claudin-6

1

0

Small-scale

0.257

Low

800846

VANG2
Vang-like protein 2

1

0

Small-scale

0.249

Low

110822

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024