Protein: TF3C2
General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)

Gene: TF3C2, GTF3C2
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q8WUA4

Gene Ontology (top 5):
GO:0000127 - transcription factor TFIIIC complex
GO:0000995 - RNA polymerase III general transcription initiation factor activity
GO:0005654 - nucleoplasm
GO:0006383 - transcription by RNA polymerase III
GO:0042791 - 5S class rRNA transcription by RNA polymerase III

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998585

H31
Histone H3.1

3

2

High-throughput

0.827

High

1356463

TF3C4
General transcription factor 3C polypeptide 4

3

0

Small-scale

0.825

High

980951

H2B1C
Histone H2B type 1-C/E/F/G/I

2

0

High-throughput

0.716

High

1356428

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.716

High

1356452

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

2

0

Small-scale

0.716

High

643952

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

0

High-throughput

0.682

High

1331026

DDX51
ATP-dependent RNA helicase DDX51

2

0

High-throughput

0.679

High

1085789

TF3C1
General transcription factor 3C polypeptide 1

5

0

Small-scale

0.676

High

1356470

TF3C3
General transcription factor 3C polypeptide 3

4

0

Small-scale

0.664

High

1356469

TF3C5
General transcription factor 3C polypeptide 5

4

0

Small-scale

0.648

High

1322602

RPTOR
Regulatory-associated protein of mTOR

1

1

Small-scale

0.646

High

226150

STX6
Syntaxin-6

3

0

High-throughput

0.638

High

586803

RS2
Small ribosomal subunit protein uS5

3

0

High-throughput

0.638

High

1356459

RBM27
RNA-binding protein 27

1

1

High-throughput

0.618

High

883627

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.618

High

1017052

H33
Histone H3.3

1

2

High-throughput

0.618

High

839328

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.613

High

372674

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

1356431

ZN764
Zinc finger protein 764

3

1

High-throughput

0.604

High

1134015

ZN638
Zinc finger protein 638

2

0

High-throughput

0.602

High

1351564

MIPT3
TRAF3-interacting protein 1

2

0

High-throughput

0.602

High

1356443

BAG1
BAG family molecular chaperone regulator 1

2

0

High-throughput

0.602

High

822781

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.589

High

194282

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.586

High

315807

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.586

High

342981

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.586

High

980040

H4
Histone H4

1

0

High-throughput

0.586

High

1155580

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.586

High

1356458

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.586

High

1356467

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.586

High

1356444

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.578

High

69808

ZN785
Zinc finger protein 785

2

1

High-throughput

0.574

High

760480

SDC2
Syndecan-2

2

1

High-throughput

0.574

High

1356435

PNMA5
Paraneoplastic antigen-like protein 5

2

1

High-throughput

0.574

High

396589

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1356425

ESR2
Estrogen receptor beta

2

2

High-throughput

0.571

High

487566

PARP1
Poly [ADP-ribose] polymerase 1

2

0

High-throughput

0.559

High

589249

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

696034

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

768733

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

1133551

NFIX
Nuclear factor 1 X-type

2

3

High-throughput

0.549

High

1111135

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.546

High

442770

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

920143

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.536

High

1017728

PR20A
Proline-rich protein 20A

2

1

High-throughput

0.533

High

157659

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.517

High

970833

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.517

High

1254800

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.517

High

170254

AURKA
Aurora kinase A

1

0

High-throughput

0.513

High

253210

RAD1
Cell cycle checkpoint protein RAD1

1

0

High-throughput

0.513

High

261531

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

833761

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

859002

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

1145295

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.513

High

1356430

TRM61
tRNA

1

0

High-throughput

0.513

High

1356451

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

1017600

PR20E
Proline-rich protein 20E

2

1

High-throughput

0.504

High

221947

FOXS1
Forkhead box protein S1

1

1

High-throughput

0.489

High

259010

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.489

High

726683

SDC4
Syndecan-4

1

1

High-throughput

0.489

High

1037917

HEN2
Helix-loop-helix protein 2

1

1

High-throughput

0.489

High

1214652

RBM26
RNA-binding protein 26

1

1

High-throughput

0.489

High

1356442

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.489

High

1356448

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.489

High

1356464

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.489

High

1040860

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.481

High

628818

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

951779

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

964382

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

143136

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

260207

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

406427

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

474148

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

675599

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

679217

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.479

High

755759

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.479

High

833997

HNF4A
Hepatocyte nuclear factor 4-alpha

1

2

High-throughput

0.479

High

862323

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

888202

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

1067534

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

1087888

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1153845

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1153982

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

1356450

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

129277

MEN1
Menin

1

0

High-throughput

0.458

High

279431

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

414289

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

472920

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

685279

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.458

High

831121

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

1026477

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1033735

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1045566

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1107052

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1161569

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1329766

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1332683

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.458

High

1352650

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1356426

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

1356437

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

1356441

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

1356445

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

Small-scale

0.458

High

1356449

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1356453

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1356457

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1356462

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

756284

MCM7
DNA replication licensing factor MCM7

1

2

Small-scale

0.445

High

243987

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

1

High-throughput

0.437

High

1141233

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.437

High

985781

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.426

High

1239892

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1356427

TF3C6
General transcription factor 3C polypeptide 6

1

0

Small-scale

0.426

High

1356439

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1356460

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.426

High

1058166

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

4

0

Small-scale

0.360

High

169263

CASQ2
Calsequestrin-2

3

0

High-throughput

0.347

High

288188

CLC3A
C-type lectin domain family 3 member A

2

0

High-throughput

0.328

High

591335

CD44
CD44 antigen

2

0

High-throughput

0.328

High

1332631

ZN579
Zinc finger protein 579

2

0

High-throughput

0.328

High

1356429

CPNE4
Copine-4

2

0

High-throughput

0.328

High

1356433

ZN496
Zinc finger protein 496

2

0

High-throughput

0.328

High

1356468

NGN3
Neurogenin-3

2

0

High-throughput

0.328

High

686305

RL13
Large ribosomal subunit protein eL13

2

0

High-throughput

0.318

High

693864

RL10
Large ribosomal subunit protein uL16

2

0

High-throughput

0.318

High

1065983

VAC14
Protein VAC14 homolog

2

0

High-throughput

0.316

High

838502

GRIA2
Glutamate receptor 2

1

0

High-throughput

0.282

High

74558

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

191724

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.279

Low

347205

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

428879

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.279

Low

482258

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

549012

KPSH1
Serine/threonine-protein kinase H1

1

0

High-throughput

0.279

Low

549649

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

605523

SYN1
Synapsin-1

1

0

High-throughput

0.279

Low

718435

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

785323

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.279

Low

859921

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.279

Low

960813

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.279

Low

1010451

GPSM2
G-protein-signaling modulator 2

1

0

High-throughput

0.279

Low

1064588

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.279

Low

1127443

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1128654

ZN460
Zinc finger protein 460

1

0

High-throughput

0.279

Low

1191908

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.279

Low

1203881

NOM1
Nucleolar MIF4G domain-containing protein 1

1

0

High-throughput

0.279

Low

1208315

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.279

Low

1260385

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.279

Low

1331772

RGF1A
Ras-GEF domain-containing family member 1A

1

0

High-throughput

0.279

Low

1348922

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1356438

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1356446

LS14B
Protein LSM14 homolog B

1

0

High-throughput

0.279

Low

1356447

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.279

Low

1356455

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.279

Low

1356466

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

1356471

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.279

Low

242396

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

294081

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

336997

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.249

Low

412318

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

810244

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

898249

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.249

Low

1140607

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1327096

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1356432

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1356434

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1356436

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

1356440

FEV
Protein FEV

1

0

High-throughput

0.249

Low

1356461

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.249

Low

1356465

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1356456

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

1185857

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1226434

Z385C
Zinc finger protein 385C

1

0

High-throughput

0.232

Low

1313765

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low

1313969

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.232

Low

1356454

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025