Protein: MSH2
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)

Gene: MSH2
Organism: Homo sapiens
Interactions: 215
UniProt ID: P43246

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0001701 - in utero embryonic development
GO:0002204 - somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794216

MSH6
DNA mismatch repair protein Msh6

18

12

Small-scale

0.987

High

594174

MSH3
DNA mismatch repair protein Msh3

12

13

Small-scale

0.984

High

776261

MLH1
DNA mismatch repair protein Mlh1

7

20

Small-scale

0.951

High

794220

PMS2
Mismatch repair endonuclease PMS2

3

20

Small-scale

0.827

High

794208

MSH2
DNA mismatch repair protein Msh2

2

12

Small-scale

0.768

High

794340

EXO1
Exonuclease 1

8

6

Small-scale

0.749

High

794312

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

7

7

Small-scale

0.743

High

346161

MYC
Myc proto-oncogene protein

6

3

Small-scale

0.728

High

794278

SLX4
Structure-specific endonuclease subunit SLX4

5

4

Small-scale

0.721

High

794322

MCM9
DNA helicase MCM9

4

4

Small-scale

0.694

High

794247

ATR
Serine/threonine-protein kinase ATR

4

6

Small-scale

0.692

High

794296

OTUB1
Ubiquitin thioesterase OTUB1

4

0

Small-scale

0.664

High

794225

SUMO2
Small ubiquitin-related modifier 2

3

3

Small-scale

0.655

High

749193

BRCA1
Breast cancer type 1 susceptibility protein

3

7

Small-scale

0.647

High

386263

P53
Cellular tumor antigen p53

3

1

Small-scale

0.640

High

794329

HDAC6
Histone deacetylase 6

2

3

Small-scale

0.634

High

794335

MUTYH
Adenine DNA glycosylase

2

1

Small-scale

0.629

High

794248

SNW1
SNW domain-containing protein 1

2

1

Small-scale

0.628

High

331230

CHK2
Serine/threonine-protein kinase Chk2

2

1

Small-scale

0.624

High

794288

ESR2
Estrogen receptor beta

2

2

Small-scale

0.624

High

681720

AKT1
RAC-alpha serine/threonine-protein kinase

2

1

High-throughput

0.619

High

794219

PMS1
PMS1 protein homolog 1

1

20

Small-scale

0.618

High

239312

CC14B
Dual specificity protein phosphatase CDC14B

2

5

High-throughput

0.614

High

455186

PARP1
Poly [ADP-ribose] polymerase 1

2

6

High-throughput

0.611

High

794336

MCM8
DNA helicase MCM8

2

4

Small-scale

0.611

High

373842

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

0

High-throughput

0.606

High

552147

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.601

High

517121

PCNA
Proliferating cell nuclear antigen

2

6

Small-scale

0.595

High

794243

RFA4
Replication protein A 30 kDa subunit

2

5

Small-scale

0.595

High

244068

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

650583

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

5

High-throughput

0.584

High

719886

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

794215

CDK9
Cyclin-dependent kinase 9

2

1

High-throughput

0.584

High

794232

H31
Histone H3.1

2

10

High-throughput

0.584

High

794301

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

4

Small-scale

0.584

High

794287

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.580

High

794218

BLM
RecQ-like DNA helicase BLM

2

7

Small-scale

0.571

High

238260

RAD1
Cell cycle checkpoint protein RAD1

1

2

Small-scale

0.561

High

245889

HUS1
Checkpoint protein HUS1

1

2

Small-scale

0.561

High

369143

ESR1
Estrogen receptor

1

2

Small-scale

0.561

High

794224

MAX
Protein max

1

3

Small-scale

0.561

High

794303

RAD9A
Cell cycle checkpoint control protein RAD9A

1

2

Small-scale

0.561

High

794265

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.552

High

135894

F16P2
Fructose-1,6-bisphosphatase isozyme 2

1

1

High-throughput

0.541

High

349177

RASH
GTPase HRas

1

1

High-throughput

0.541

High

450758

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.541

High

794337

LEF1
Lymphoid enhancer-binding factor 1

1

2

High-throughput

0.541

High

217145

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

683051

CASPE
Caspase-14

1

1

High-throughput

0.536

High

794240

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

794264

H2B2E
Histone H2B type 2-E

1

9

High-throughput

0.536

High

794274

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

2

High-throughput

0.536

High

794276

RBM45
RNA-binding protein 45

1

1

High-throughput

0.536

High

794282

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

3

High-throughput

0.536

High

794283

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.536

High

794297

AURKB
Aurora kinase B

1

2

High-throughput

0.536

High

794302

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

794315

WDR76
WD repeat-containing protein 76

1

6

High-throughput

0.536

High

794342

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

794345

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.536

High

794261

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.518

High

794343

ZN510
Zinc finger protein 510

1

0

High-throughput

0.518

High

260529

TP4A3
Protein tyrosine phosphatase type IVA 3

1

5

High-throughput

0.515

High

614268

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.515

High

794237

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.515

High

794334

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

794257

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.513

High

258587

GGCT
Gamma-glutamylcyclotransferase

1

0

High-throughput

0.513

High

382587

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.513

High

505358

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

654144

CALX
Calnexin

1

0

High-throughput

0.513

High

794233

CBX1
Chromobox protein homolog 1

1

0

High-throughput

0.513

High

794235

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.513

High

794258

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

794250

TRI29
Tripartite motif-containing protein 29

1

3

Small-scale

0.512

High

794262

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

607911

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.501

High

612468

XPA
DNA repair protein complementing XP-A cells

1

2

Small-scale

0.501

High

794222

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

794304

BARD1
BRCA1-associated RING domain protein 1

1

3

Small-scale

0.501

High

449587

HMGB1
High mobility group protein B1

1

2

Small-scale

0.500

High

303789

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.486

High

378646

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

589159

ANXA7
Annexin A7

1

0

High-throughput

0.486

High

758144

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

665167

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.480

High

116666

UBXN8
UBX domain-containing protein 8

1

2

High-throughput

0.479

High

154149

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

161794

ZN263
Zinc finger protein 263

1

1

Small-scale

0.479

High

176568

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.479

High

217456

AIRE
Autoimmune regulator

1

9

Small-scale

0.479

High

226767

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

233268

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

294489

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

322297

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

326492

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

384440

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

388286

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.479

High

429844

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

434567

ERCC1
DNA excision repair protein ERCC-1

1

2

Small-scale

0.479

High

523572

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

555334

H2AX
Histone H2AX

1

5

Small-scale

0.479

High

569341

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

617465

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

625204

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

673454

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

684484

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

742109

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

750165

COIL
Coilin

1

2

High-throughput

0.479

High

794209

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

794210

RECQ1
ATP-dependent DNA helicase Q1

1

7

High-throughput

0.479

High

794211

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

794212

CDK8
Cyclin-dependent kinase 8

1

3

High-throughput

0.479

High

794226

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

794228

H4
Histone H4

1

2

High-throughput

0.479

High

794229

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.479

High

794230

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

794231

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

794234

H33
Histone H3.3

1

10

High-throughput

0.479

High

794238

KPCZ
Protein kinase C zeta type

1

3

Small-scale

0.479

High

794239

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.479

High

794241

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

794244

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

794246

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

794249

CUL3
Cullin-3

1

1

High-throughput

0.479

High

794251

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

794252

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

High-throughput

0.479

High

794255

HLTF
Helicase-like transcription factor

1

9

Small-scale

0.479

High

794259

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

794263

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

High-throughput

0.479

High

794266

FTM
Protein fantom

1

1

High-throughput

0.479

High

794267

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

794268

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

794273

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

794279

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

Small-scale

0.479

High

794280

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

794286

DGCR8
Microprocessor complex subunit DGCR8

1

1

Small-scale

0.479

High

794289

CBP
CREB-binding protein

1

6

Small-scale

0.479

High

794291

XPF
DNA repair endonuclease XPF

1

2

Small-scale

0.479

High

794292

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

794293

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

High-throughput

0.479

High

794298

CEP19
Centrosomal protein of 19 kDa

1

1

High-throughput

0.479

High

794306

RN126
E3 ubiquitin-protein ligase RNF126

1

1

High-throughput

0.479

High

794307

FACD2
Fanconi anemia group D2 protein

1

2

Small-scale

0.479

High

794308

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

794310

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.479

High

794314

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

794316

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.479

High

794317

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.479

High

794318

ANLN
Anillin

1

1

High-throughput

0.479

High

794319

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

794323

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

794324

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

794325

DTL
Denticleless protein homolog

1

2

Small-scale

0.479

High

794330

POLK
DNA polymerase kappa

1

3

Small-scale

0.479

High

794331

REV1
DNA repair protein REV1

1

3

Small-scale

0.479

High

794332

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

794339

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.479

High

794341

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

794346

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.479

High

794254

GRB7
Growth factor receptor-bound protein 7

1

1

High-throughput

0.464

High

179573

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

359733

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

393089

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

532416

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

560384

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

610284

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

794217

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.458

High

794223

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

794227

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

794253

FA50A
Protein FAM50A

1

0

High-throughput

0.458

High

794260

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

794284

NELFB
Negative elongation factor B

1

0

High-throughput

0.458

High

794285

ATRIP
ATR-interacting protein

1

0

Small-scale

0.458

High

794311

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

794320

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

794321

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

794333

TES
Testin

1

0

High-throughput

0.458

High

135225

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

246187

NBN
Nibrin

1

1

Small-scale

0.445

High

371374

ANGI
Angiogenin

1

1

High-throughput

0.445

High

401585

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

469962

H2AZ
Histone H2A.Z

1

5

Small-scale

0.445

High

722183

RFC1
Replication factor C subunit 1

1

1

Small-scale

0.445

High

794214

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.445

High

794242

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

794245

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.445

High

794256

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

794290

RAD50
DNA repair protein RAD50

1

3

Small-scale

0.445

High

794305

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

1

Small-scale

0.445

High

794309

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

73223

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

1

High-throughput

0.439

High

794236

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.437

High

794271

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

794272

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

794275

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

2

Small-scale

0.437

High

794295

FAF2
FAS-associated factor 2

1

2

High-throughput

0.437

High

794313

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

794338

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

587465

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

794327

CC180
Coiled-coil domain-containing protein 180

1

1

High-throughput

0.417

High

794213

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

794300

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.407

High

150682

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

0

High-throughput

0.282

High

794221

STX17
Syntaxin-17

1

0

High-throughput

0.282

High

794277

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

0

High-throughput

0.282

High

794281

TDRD7
Tudor domain-containing protein 7

1

0

High-throughput

0.282

High

794299

CANB2
Calcineurin subunit B type 2

1

0

High-throughput

0.282

High

794269

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

794326

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.279

Low

794270

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

794294

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

794328

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.249

Low

794344

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024